PE52894A1 - Derivado de camptotecina soluble en agua - Google Patents

Derivado de camptotecina soluble en agua

Info

Publication number
PE52894A1
PE52894A1 PE1994241061A PE24106194A PE52894A1 PE 52894 A1 PE52894 A1 PE 52894A1 PE 1994241061 A PE1994241061 A PE 1994241061A PE 24106194 A PE24106194 A PE 24106194A PE 52894 A1 PE52894 A1 PE 52894A1
Authority
PE
Peru
Prior art keywords
soluble
water
camptotecina
derivative
variations
Prior art date
Application number
PE1994241061A
Other languages
English (en)
Inventor
Michael Joseph Luzzio
Peter Leslie Myers
Jeffrey Mark Besterman
Michael Glenn Evans
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of PE52894A1 publication Critical patent/PE52894A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) n VARIA DE 1 A 2; 2) R1 ES H, ALQUILO INFERIOR, CICLOALQUILO C3-C7, (CICLOALQUILO C3-C7)-ALQUILO INFERIOR, ALQUENILO INFERIOR, HIDROXIALQUILO INFERIOR, (CH2)t-Ar, DONDE t VARIA DE CERO A 5 Y Ar ES FENILO, FURILO, PIRIDILO, N-METILPIRROLILO, IMIDAZOLILO, SOLO O CON 1 o MAS SUSTITUYENTES COMO OH, OCH3, HALOGENO, AMINO; 3) R2 ES DIFENILMETILO, (CH2)t-Ar; o R1 Y R2 JUNTO CON EL ATOMO DE NITROGENO FORMAN N-TETRAHIDROQUINOLILO, N-TETRAHIDROISOQUINOLILO; EL CUAL A DIFERENCIA DE LA CAMPTOTECINA ES SOLUBLE EN AGUA Y PUEDE TENER ACTIVIDAD INHIBITORIA DE LA TOPOISOMERASA I - DNA IN VITRO Y ACTIVIDAD ANTITUMORAL IN VIVO
PE1994241061A 1993-04-29 1994-04-27 Derivado de camptotecina soluble en agua PE52894A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5458593A 1993-04-29 1993-04-29
US8104293A 1993-06-22 1993-06-22

Publications (1)

Publication Number Publication Date
PE52894A1 true PE52894A1 (es) 1995-01-06

Family

ID=26733234

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994241061A PE52894A1 (es) 1993-04-29 1994-04-27 Derivado de camptotecina soluble en agua

Country Status (10)

Country Link
EP (1) EP0696285A1 (es)
JP (1) JPH08509740A (es)
AP (1) AP9400638A0 (es)
AU (1) AU6777194A (es)
CA (1) CA2161681A1 (es)
IL (1) IL109470A0 (es)
IS (1) IS4152A (es)
MY (1) MY141374A (es)
PE (1) PE52894A1 (es)
WO (1) WO1994025466A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
SG88737A1 (en) * 1996-10-30 2002-05-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
IN189180B (es) * 1997-07-09 2003-01-04 Chong Kun Dang Corp
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0418099T3 (da) * 1989-09-15 2002-04-02 Res Triangle Inst Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
ATE136898T1 (de) * 1991-10-29 1996-05-15 Glaxo Wellcome Inc Wasserlösliche camptothecinderivate
EP0556585A3 (en) * 1992-01-24 1993-09-01 Takeda Chemical Industries, Ltd. Condensed camptothecin derivatives their production and use as antitumor agents

Also Published As

Publication number Publication date
CA2161681A1 (en) 1994-11-10
MY141374A (en) 2010-04-16
AU6777194A (en) 1994-11-21
JPH08509740A (ja) 1996-10-15
AP9400638A0 (en) 1995-10-28
IL109470A0 (en) 1994-07-31
EP0696285A1 (en) 1996-02-14
WO1994025466A1 (en) 1994-11-10
IS4152A (is) 1994-10-30

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Legal Events

Date Code Title Description
FX Voluntary withdrawal