MY141374A - Water soluble camptothecin derivatives - Google Patents

Water soluble camptothecin derivatives

Info

Publication number: MY141374A
Authority: MY; Malaysia
Prior art keywords: lower alkyl; amino; water soluble; camptothecin derivatives; methylpyrrolyl
Prior art date: 1993-04-29

Application number

MYPI94001039A

Other languages

English (en)

Inventor

Michael Joseph Luzzio

Jeffrey Mark Besterman

Michael G Evans

Peter Leslie Myers

Original Assignee

Glaxo Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-29

Filing date

1994-04-27

Publication date

2010-04-16

1994-04-27 Application filed by Glaxo Inc filed Critical Glaxo Inc

2010-04-16 Publication of MY141374A publication Critical patent/MY141374A/en

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
-1 AMINO Chemical class 0.000 abstract 10
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical group C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 abstract 1
239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

MYPI94001039A 1993-04-29 1994-04-27 Water soluble camptothecin derivatives MY141374A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5458593A	1993-04-29	1993-04-29
US8104293A	1993-06-22	1993-06-22

Publications (1)

Publication Number	Publication Date
MY141374A true MY141374A (en)	2010-04-16

Family

ID=26733234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI94001039A MY141374A (en)	1993-04-29	1994-04-27	Water soluble camptothecin derivatives

Country Status (10)

Country	Link
EP (1)	EP0696285A1 (fr)
JP (1)	JPH08509740A (fr)
AP (1)	AP9400638A0 (fr)
AU (1)	AU6777194A (fr)
CA (1)	CA2161681A1 (fr)
IL (1)	IL109470A0 (fr)
IS (1)	IS4152A (fr)
MY (1)	MY141374A (fr)
PE (1)	PE52894A1 (fr)
WO (1)	WO1994025466A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
US5663177A (en) *	1995-05-31	1997-09-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs
SG103322A1 (en) *	1996-10-30	2004-04-29	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) *	1997-05-27	2000-04-04	Smithkline Beecham Corporation	Water soluble camptothecin analogs
IN189180B (fr) *	1997-07-09	2003-01-04	Chong Kun Dang Corp
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0418099T3 (da) *	1989-09-15	2002-04-02	Res Triangle Inst	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
EP0540099B1 (fr) *	1991-10-29	1996-04-17	Glaxo Wellcome Inc.	Dérivés de camptothécine solubles dans l'eau
CA2087898A1 (fr) *	1992-01-24	1993-07-25	Hiroshi Akimoto	Composes heterocycliques condenses, leur preparation et leur utilisation

1994
- 1994-04-25 IS IS4152A patent/IS4152A/is unknown
- 1994-04-27 MY MYPI94001039A patent/MY141374A/en unknown
- 1994-04-27 PE PE1994241061A patent/PE52894A1/es not_active Application Discontinuation
- 1994-04-28 WO PCT/US1994/004681 patent/WO1994025466A1/fr not_active Ceased
- 1994-04-28 AU AU67771/94A patent/AU6777194A/en not_active Abandoned
- 1994-04-28 EP EP94915931A patent/EP0696285A1/fr not_active Withdrawn
- 1994-04-28 IL IL10947094A patent/IL109470A0/xx unknown
- 1994-04-28 AP APAP/P/1994/000638A patent/AP9400638A0/en unknown
- 1994-04-28 CA CA002161681A patent/CA2161681A1/fr not_active Abandoned
- 1994-04-28 JP JP6524540A patent/JPH08509740A/ja active Pending

Also Published As

Publication number	Publication date
IS4152A (is)	1994-10-30
PE52894A1 (es)	1995-01-06
EP0696285A1 (fr)	1996-02-14
CA2161681A1 (fr)	1994-11-10
AU6777194A (en)	1994-11-21
WO1994025466A1 (fr)	1994-11-10
IL109470A0 (en)	1994-07-31
AP9400638A0 (en)	1995-10-28
JPH08509740A (ja)	1996-10-15

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