AR005995A1 - Procedimiento para la purificación de proteasas similares a trombina a partir de venenos de serpiente. - Google Patents

Procedimiento para la purificación de proteasas similares a trombina a partir de venenos de serpiente.

Info

Publication number
AR005995A1
AR005995A1 ARP970100755A ARP970100755A AR005995A1 AR 005995 A1 AR005995 A1 AR 005995A1 AR P970100755 A ARP970100755 A AR P970100755A AR P970100755 A ARP970100755 A AR P970100755A AR 005995 A1 AR005995 A1 AR 005995A1
Authority
AR
Argentina
Prior art keywords
proteases
thrombin
purification
procedure
snake
Prior art date
Application number
ARP970100755A
Other languages
English (en)
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR005995A1 publication Critical patent/AR005995A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Procedimiento para la purificación de proteasas similares a trombina a partir de venenos de serpiente y proteasas purificadas con dichoprocedimiento. Se describe un procedimiento para la purificación de proteasas similares a trombina, quecons iste en separar las proteasas en tres etapascromatográficas consecutivas.
ARP970100755A 1996-02-26 1997-02-25 Procedimiento para la purificación de proteasas similares a trombina a partir de venenos de serpiente. AR005995A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19607210A DE19607210A1 (de) 1996-02-26 1996-02-26 Verfahren zur Reinigung von thrombinähnlichen Proteasen aus Schlangengiften

Publications (1)

Publication Number Publication Date
AR005995A1 true AR005995A1 (es) 1999-07-21

Family

ID=7786490

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100755A AR005995A1 (es) 1996-02-26 1997-02-25 Procedimiento para la purificación de proteasas similares a trombina a partir de venenos de serpiente.

Country Status (31)

Country Link
US (1) US6200791B1 (es)
EP (1) EP0883684B1 (es)
JP (1) JP3817269B2 (es)
KR (1) KR100493835B1 (es)
CN (1) CN1188517C (es)
AR (1) AR005995A1 (es)
AT (1) ATE283350T1 (es)
AU (1) AU711650B2 (es)
BG (1) BG64875B1 (es)
BR (1) BR9707738A (es)
CO (1) CO4771158A1 (es)
CZ (1) CZ292482B6 (es)
DE (2) DE19607210A1 (es)
ES (1) ES2233997T3 (es)
HR (1) HRP970108B1 (es)
HU (1) HU225489B1 (es)
ID (1) ID16046A (es)
IL (1) IL125395A (es)
MX (1) MX9806304A (es)
MY (1) MY130458A (es)
NO (1) NO319561B1 (es)
NZ (1) NZ331120A (es)
PL (1) PL186211B1 (es)
PT (1) PT883684E (es)
RU (1) RU2186849C2 (es)
SK (1) SK284874B6 (es)
TR (1) TR199801668T2 (es)
TW (1) TW505696B (es)
UA (1) UA46831C2 (es)
WO (1) WO1997032015A1 (es)
ZA (1) ZA971597B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102173C (zh) * 1999-03-26 2003-02-26 福建医科大学 蕲蛇酶及其生产工艺
US20030219431A1 (en) * 2002-05-24 2003-11-27 Empire Pharmaceuticals, Inc. Treatment of neuronal and neurological damage associated with spinal cord injury
CN100506983C (zh) * 2006-05-25 2009-07-01 齐鲁制药有限公司 一种从矛头蝮蛇毒中提取单一成份巴曲酶的方法
EP2043767B1 (en) 2006-07-14 2020-03-25 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
CN103160486A (zh) * 2013-04-02 2013-06-19 黑龙江迪龙制药有限公司 一种猪凝血酶的制备方法
CN109929020A (zh) * 2017-12-15 2019-06-25 浙江京新药业股份有限公司 一种眼镜蛇毒的纯化方法及其产品
CN108559740B (zh) * 2018-05-12 2021-05-18 吉林天衡康泰生物技术有限公司 重组安克洛酶及工业规模制备方法和治疗急性脑梗的应用
CN109652398B (zh) * 2018-12-29 2021-07-20 上海太阳生物技术有限公司 凝血因子ⅹ激活剂rvv-ⅹ的制备方法及制得的rvv-ⅹ
CN110016471B (zh) * 2019-04-10 2020-10-02 北京博康宁生物医药科技有限公司 重组安克洛酶及工业规模制备和纯化方法及其组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094301A (en) * 1964-02-21 1967-12-06 Nat Res Dev Improvements relating to anticoagulants
GB1177506A (en) 1964-02-21 1970-01-14 Nat Res Dev Improvements relating to Anticoagulants.
GB1293793A (en) 1969-04-28 1972-10-25 Chrysler United Kingdom Ltd Fo Improvements in or relating to valves
US3743722A (en) * 1971-07-14 1973-07-03 Abbott Lab Anti-coagulant isolation
US3879369A (en) * 1972-05-12 1975-04-22 Abbott Lab Anti-coagulant isolation from malayan pit viper using affinity chromatography
GB1472574A (en) 1973-09-03 1977-05-04 Biochimici Fargal Pharmasint S Process for the extraction of components having anticoagulant activity -in vivo- from snake venoms and related products
NL7605805A (nl) * 1976-05-28 1977-11-30 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
CH626917A5 (es) 1976-08-17 1981-12-15 Pentapharm Ag
JPS5569595A (en) * 1978-11-20 1980-05-26 Suguru Abe Novel substance having fibrinolytic activity, remedy for thrombotic embolic disease comprising it, and its preparation
EP0328256A1 (en) * 1988-01-21 1989-08-16 Owens-Corning Fiberglas Corporation Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations
US5712117A (en) * 1995-02-08 1998-01-27 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and coding sequences

Also Published As

Publication number Publication date
MY130458A (en) 2007-06-29
JP3817269B2 (ja) 2006-09-06
JP2000505304A (ja) 2000-05-09
NO983893D0 (no) 1998-08-25
ES2233997T3 (es) 2005-06-16
KR19990087247A (ko) 1999-12-15
IL125395A (en) 2001-04-30
EP0883684A1 (de) 1998-12-16
RU2186849C2 (ru) 2002-08-10
CN1188517C (zh) 2005-02-09
PT883684E (pt) 2005-04-29
DE19607210A1 (de) 1997-08-28
EP0883684B1 (de) 2004-11-24
BG102663A (en) 1999-04-30
ZA971597B (en) 1998-08-25
CO4771158A1 (es) 1999-04-30
SK113298A3 (en) 1999-01-11
HUP9900505A2 (hu) 1999-06-28
AU711650B2 (en) 1999-10-21
SK284874B6 (sk) 2006-01-05
AU1791397A (en) 1997-09-16
HRP970108B1 (en) 2002-02-28
PL186211B1 (pl) 2003-11-28
HUP9900505A3 (en) 2001-03-28
HK1017380A1 (en) 1999-11-19
MX9806304A (es) 1998-11-30
ATE283350T1 (de) 2004-12-15
NO319561B1 (no) 2005-08-29
NO983893L (no) 1998-08-25
HU225489B1 (en) 2006-12-28
BG64875B1 (bg) 2006-07-31
DE59712093D1 (de) 2004-12-30
BR9707738A (pt) 1999-07-27
CZ292482B6 (cs) 2003-09-17
HRP970108A2 (en) 1998-04-30
ID16046A (id) 1997-08-28
IL125395A0 (en) 1999-03-12
US6200791B1 (en) 2001-03-13
CN1212013A (zh) 1999-03-24
CZ269798A3 (cs) 1999-01-13
KR100493835B1 (ko) 2005-12-21
PL328568A1 (en) 1999-02-01
WO1997032015A1 (de) 1997-09-04
UA46831C2 (uk) 2002-06-17
TR199801668T2 (xx) 1999-02-22
NZ331120A (en) 2000-01-28
TW505696B (en) 2002-10-11

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