AR016957A1 - Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+ - Google Patents
Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+Info
- Publication number
- AR016957A1 AR016957A1 ARP980105064A ARP980105064A AR016957A1 AR 016957 A1 AR016957 A1 AR 016957A1 AR P980105064 A ARP980105064 A AR P980105064A AR P980105064 A ARP980105064 A AR P980105064A AR 016957 A1 AR016957 A1 AR 016957A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- formula
- lower alkyl
- alkyl groups
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241000670727 Amida Species 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- -1 thiophenediyl group Chemical group 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27909397 | 1997-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016957A1 true AR016957A1 (es) | 2001-08-01 |
Family
ID=17606326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105064A AR016957A1 (es) | 1997-10-13 | 1998-10-13 | Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+ |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US6348480B1 (de) |
| EP (1) | EP1024138B1 (de) |
| KR (1) | KR100589868B1 (de) |
| CN (1) | CN1107671C (de) |
| AR (1) | AR016957A1 (de) |
| AT (1) | ATE360618T1 (de) |
| AU (2) | AU751139B2 (de) |
| BR (1) | BR9803883A (de) |
| CA (1) | CA2304979A1 (de) |
| DE (1) | DE69837675T2 (de) |
| ES (1) | ES2285784T3 (de) |
| HU (1) | HUP9802310A1 (de) |
| NO (1) | NO317417B1 (de) |
| PL (1) | PL192411B1 (de) |
| PT (1) | PT1024138E (de) |
| RU (1) | RU2185381C2 (de) |
| TW (1) | TW495498B (de) |
| WO (1) | WO1999019303A1 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU751139B2 (en) * | 1997-10-13 | 2002-08-08 | Astellas Pharma Inc. | Amide derivative |
| EP1068187A1 (de) * | 1998-04-08 | 2001-01-17 | Abbott Laboratories | Pyrazole als inhibitoren der cytokinproduktion |
| CA2332957A1 (en) * | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
| JP2002521441A (ja) * | 1998-07-28 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | Ｃｃｒ５モジュレーターとしてのプロペンアミド |
| EP1101759A4 (de) * | 1998-07-31 | 2001-12-12 | Nippon Soda Co | Phenylazol-derivate, verfahren zu ihrer herstellung und medikamente für hyperlipemie |
| JP2001031509A (ja) * | 1999-07-15 | 2001-02-06 | Nippon Bayer Agrochem Co Ltd | チエニル−ピラゾール類の有害生物防除剤としての利用 |
| AU2001231143A1 (en) * | 2000-01-27 | 2001-08-07 | Cytovia, Inc. | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US6451820B1 (en) * | 2000-03-23 | 2002-09-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents |
| US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
| EP1186661A1 (de) * | 2000-09-05 | 2002-03-13 | Warner-Lambert Company | Identifizierung eines kapazitativen Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
| EP1184457A1 (de) * | 2000-09-05 | 2002-03-06 | Warner-Lambert Company | Identifizierung eines kapazitiven Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
| US7132546B2 (en) | 2000-12-22 | 2006-11-07 | Ishihara Sangyo Kaisha, Ltd. | Aniline derivatives or salts thereof and cytokine production inhibitors containing the same |
| MXPA03011002A (es) * | 2001-06-06 | 2004-10-28 | Agouron Pharma | Agentes gnrh no peptidicos, composiciones farmaceuticas y procedimientos para su uso y procesos para prepararlos a ellos y a sus intermedios. |
| WO2003002555A1 (en) * | 2001-06-29 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods of using soluble epoxide hydrolase inhibitors |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| CA2495437A1 (en) * | 2002-08-27 | 2004-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Novel crystal |
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| US7790724B2 (en) * | 2003-04-25 | 2010-09-07 | Janssen Pharmaceutica N.V. | c-fms kinase inhibitors |
| EP1653968A4 (de) * | 2003-07-23 | 2006-09-06 | Synta Pharmaceuticals Corp | Verfahren zur modulierung von durch calciumionen-freisetzung aktivierten calciumionen-kanälen |
| NZ547696A (en) | 2003-12-23 | 2009-12-24 | Astex Therapeutics Ltd | Pyrazole derivatives as protein kinase modulators |
| SI1725544T1 (sl) * | 2004-03-09 | 2009-10-31 | Boehringer Ingelheim Pharma | 3-(4-heterociklil-1,2,3-triazol-1-il)-N-aril-benzamidi kot inhibitorji proizvodnje citokinov za zdravljenje kroničnih vnetnih bolezni |
| WO2005091752A2 (en) * | 2004-03-25 | 2005-10-06 | Synta Pharmaceuticals Corp. | Acrylonitrile derivatives for inflammation and immune-related uses |
| TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| US20090131484A1 (en) * | 2005-04-22 | 2009-05-21 | Astellas Pharma Inc | Preventive or remedy for bowel disease |
| GB2427406A (en) * | 2005-06-21 | 2006-12-27 | Astex Technology Ltd | Silicon-containing PKB/PKA kinase inhibitors |
| EP1902032A1 (de) | 2005-06-22 | 2008-03-26 | Astex Therapeutics Limited | Pharmazeutische verbindungen |
| EP1933832A2 (de) | 2005-06-23 | 2008-06-25 | Astex Therapeutics Limited | Pharmazeutische kombinationen mit pyrazol-derivaten als proteinkinase-modulatoren |
| CA2640091A1 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| JP5503874B2 (ja) * | 2006-02-28 | 2014-05-28 | ダート ニューロサイエンス （ケイマン） エルティーディー | 治療化合物 |
| AU2013200480B2 (en) * | 2006-02-28 | 2016-06-09 | Dart Neuroscience (Cayman) Ltd. | Therapeutic compounds |
| BRPI0708337A2 (pt) | 2006-02-28 | 2011-05-24 | Helicon Therapeutics Inc | pipirazinas terapêutica como inibidores pde4 |
| US7803799B2 (en) * | 2006-07-07 | 2010-09-28 | National Health Research Institutes | Selenophene compounds |
| US20100029619A1 (en) * | 2006-08-04 | 2010-02-04 | Takeda Pharmaceutical Company Limted | Fused heterocyclic compound |
| RU2009110254A (ru) * | 2006-08-24 | 2010-09-27 | Новартис АГ (CH) | Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений |
| ES2549862T3 (es) | 2006-08-30 | 2015-11-02 | Cellzome Limited | Derivados de triazol como inhibidores de quinasa |
| TWI339205B (en) * | 2006-10-02 | 2011-03-21 | Nat Health Research Institutes | Pyrazole compounds and pharmaceutical composition |
| TWI408136B (zh) * | 2006-10-02 | 2013-09-11 | Nat Health Research Institutes | 噻吩化合物及其醫藥組成物 |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| US8431536B2 (en) | 2007-03-05 | 2013-04-30 | The University Of Queensland | Target for breast cancer therapy and/or diagnosis |
| GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| ES2663517T3 (es) | 2007-08-27 | 2018-04-13 | Dart Neuroscience (Cayman) Ltd | Compuestos terapéuticos de isoxazol |
| GB0801888D0 (en) * | 2008-02-01 | 2008-03-12 | Isis Innovation | Treatment of mast cell related disorders |
| DE102008014523A1 (de) * | 2008-03-15 | 2009-09-17 | Robert Bosch Gmbh | Heizgerät |
| US8598355B2 (en) * | 2008-05-14 | 2013-12-03 | Astellas Pharma Inc. | Amide compound |
| JP2010030970A (ja) * | 2008-07-31 | 2010-02-12 | Bayer Cropscience Ag | 殺虫性ベンゼンジカルボキサミド誘導体 |
| TWI434686B (zh) * | 2008-11-03 | 2014-04-21 | Nat Health Research Institutes | 咪唑－４－酮及咪唑－４－硫酮化合物 |
| CA2750565C (en) * | 2009-01-30 | 2015-10-20 | Glaxosmithkline Llc | Crystalline n-{(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
| JP2012524755A (ja) * | 2009-04-24 | 2012-10-18 | グラクソ グループ リミテッド | Ｃｒａｃチャネル阻害剤としてのｎ−ピラゾリルカルボキサミド |
| EP2421834A1 (de) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazol- und triazolcarbonsäureamide als inhibitoren des crac-kanals |
| WO2010126002A1 (ja) * | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
| US8470773B2 (en) * | 2009-06-12 | 2013-06-25 | Merck Sharp & Dohme Corp. | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| US8993612B2 (en) * | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2563759B1 (de) | 2010-04-27 | 2022-04-06 | Calcimedica, Inc. | Verbindungen als modulatoren von intrazellulärem calcium |
| HUE029570T2 (en) | 2010-04-27 | 2017-03-28 | Calcimedica Inc | Intracellular calcium modifying compounds |
| CN103180316A (zh) * | 2010-08-27 | 2013-06-26 | 钙医学公司 | 调节细胞内钙的化合物 |
| EP2630126B1 (de) | 2010-10-21 | 2015-01-07 | Glaxo Group Limited | Pyrazolverbindungen gegen allergie-, immun- und entzündungserkrankungen |
| WO2012052459A1 (en) | 2010-10-21 | 2012-04-26 | Glaxo Group Limited | Pyrazole compounds acting against allergic, inflammatory and immune disorders |
| EP2704701B1 (de) * | 2011-05-03 | 2018-01-03 | PRCL Research Inc. | Verbindungen zur verwendung gegen entzündungs- und immunspezifische erkrankungen |
| US20120316182A1 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| AU2012325901A1 (en) * | 2011-10-19 | 2014-05-15 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CA2871222A1 (en) * | 2012-05-02 | 2013-11-07 | Lupin Limited | Substituted pyrazole compounds as crac modulators |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2943197A1 (de) | 2013-01-10 | 2015-11-18 | Grünenthal GmbH | Pyrazolylbasierte carboxamide ii als crac-kanal-hemmer |
| EP2943196A1 (de) | 2013-01-10 | 2015-11-18 | Grünenthal GmbH | Pyrazolylbasierte carboxamide i als crac-kanal-hemmer |
| AU2014296278C1 (en) | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| WO2015090599A1 (en) * | 2013-12-19 | 2015-06-25 | Grünenthal GmbH | Fluoromethyl-substituted pyrrole carboxamides iv |
| ES2660760T3 (es) * | 2013-12-19 | 2018-03-26 | Grünenthal GmbH | Pirrolocarboxamidas fluorometil-sustituidas como bloqueantes del canal de Ca CaV2.2 |
| CN104926801B (zh) * | 2014-03-22 | 2019-06-04 | 浙江大学 | 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用 |
| WO2015197187A1 (en) | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides v |
| CN114642735A (zh) | 2015-01-21 | 2022-06-21 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
| CN114712513B (zh) | 2015-02-27 | 2026-02-10 | 钙医学公司 | 胰腺炎治疗 |
| AU2016306301B2 (en) | 2015-08-07 | 2021-02-11 | Calcimedica, Inc. | Use of CRAC channel inhibitors for the treatment of stroke and traumatic brain injury |
| CN105503832B (zh) * | 2015-12-18 | 2018-03-27 | 浙江大学 | 取代吡唑环类衍生物及其用途 |
| US11684584B2 (en) | 2016-12-30 | 2023-06-27 | Genevant Sciences Gmbh | Branched peg molecules and related compositions and methods |
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| CN111187204B (zh) * | 2020-01-13 | 2022-11-08 | 海利尔药业集团股份有限公司 | 一种啶虫脒共晶及其制备方法、用途 |
| CA3169697A1 (en) * | 2020-02-28 | 2021-09-02 | Dominic Reynolds | Thiophenyl derivatives useful for modulating nucleic acid splicing |
| US12544371B2 (en) | 2020-03-20 | 2026-02-10 | Calcimedica, Inc. | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome |
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| DE3401911A1 (de) * | 1984-01-20 | 1985-08-01 | A. Nattermann & Cie GmbH, 5000 Köln | Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung |
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-
1998
- 1998-09-29 AU AU87139/98A patent/AU751139B2/en not_active Ceased
- 1998-10-06 BR BR9803883-4A patent/BR9803883A/pt not_active IP Right Cessation
- 1998-10-09 RU RU98118557/04A patent/RU2185381C2/ru not_active IP Right Cessation
- 1998-10-12 ES ES98947818T patent/ES2285784T3/es not_active Expired - Lifetime
- 1998-10-12 AT AT98947818T patent/ATE360618T1/de not_active IP Right Cessation
- 1998-10-12 HU HU9802310A patent/HUP9802310A1/hu unknown
- 1998-10-12 WO PCT/JP1998/004583 patent/WO1999019303A1/ja not_active Ceased
- 1998-10-12 CA CA002304979A patent/CA2304979A1/en not_active Abandoned
- 1998-10-12 US US09/529,131 patent/US6348480B1/en not_active Expired - Fee Related
- 1998-10-12 PL PL329150A patent/PL192411B1/pl not_active IP Right Cessation
- 1998-10-12 TW TW087116918A patent/TW495498B/zh not_active IP Right Cessation
- 1998-10-12 PT PT98947818T patent/PT1024138E/pt unknown
- 1998-10-12 EP EP98947818A patent/EP1024138B1/de not_active Expired - Lifetime
- 1998-10-12 DE DE69837675T patent/DE69837675T2/de not_active Expired - Fee Related
- 1998-10-12 KR KR1019980042475A patent/KR100589868B1/ko not_active Expired - Fee Related
- 1998-10-12 AU AU94593/98A patent/AU9459398A/en not_active Abandoned
- 1998-10-13 CN CN98121354A patent/CN1107671C/zh not_active Expired - Fee Related
- 1998-10-13 AR ARP980105064A patent/AR016957A1/es unknown
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2000
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2001
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2005
- 2005-06-17 US US11/154,591 patent/US7247635B2/en not_active Expired - Fee Related
-
2006
- 2006-04-07 US US11/399,379 patent/US7285554B2/en not_active Expired - Fee Related
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| DE69837675D1 (en) | 2007-06-06 |
| CA2304979A1 (en) | 1999-04-22 |
| AU9459398A (en) | 1999-05-03 |
| TW495498B (en) | 2002-07-21 |
| ATE360618T1 (de) | 2007-05-15 |
| HU9802310D0 (en) | 1998-12-28 |
| KR19990037018A (ko) | 1999-05-25 |
| AU8713998A (en) | 1999-04-29 |
| PL329150A1 (en) | 1999-04-26 |
| EP1024138A4 (de) | 2002-02-06 |
| US7247635B2 (en) | 2007-07-24 |
| ES2285784T3 (es) | 2007-11-16 |
| BR9803883A (pt) | 2000-05-16 |
| DE69837675T2 (de) | 2008-01-10 |
| US6348480B1 (en) | 2002-02-19 |
| AU751139B2 (en) | 2002-08-08 |
| US7285554B2 (en) | 2007-10-23 |
| NO20001907D0 (no) | 2000-04-12 |
| EP1024138B1 (de) | 2007-04-25 |
| NO20001907L (no) | 2000-06-09 |
| US20010011090A1 (en) | 2001-08-02 |
| PT1024138E (pt) | 2007-08-01 |
| WO1999019303A1 (en) | 1999-04-22 |
| US20050234055A1 (en) | 2005-10-20 |
| HUP9802310A1 (hu) | 2000-03-28 |
| NO317417B1 (no) | 2004-10-25 |
| US6958339B2 (en) | 2005-10-25 |
| PL192411B1 (pl) | 2006-10-31 |
| EP1024138A1 (de) | 2000-08-02 |
| KR100589868B1 (ko) | 2006-10-24 |
| RU2185381C2 (ru) | 2002-07-20 |
| CN1107671C (zh) | 2003-05-07 |
| CN1218046A (zh) | 1999-06-02 |
| US20060264430A1 (en) | 2006-11-23 |
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