AR018339A1 - Un proceso mejorado para la produccion de azitromicinas, azitromicinas y una composicion farmaceutica que las comprende - Google Patents

Un proceso mejorado para la produccion de azitromicinas, azitromicinas y una composicion farmaceutica que las comprende

Info

Publication number: AR018339A1
Authority: AR; Argentina
Prior art keywords: azithromycins; production; pharmaceutical composition; azythromycins; understands
Prior art date: 1998-05-08

Application number

ARP990102127A

Other languages

English (en)

Spanish (es)

Original Assignee

Biochemie Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-08

Filing date

1999-05-06

Publication date

2001-11-14

1998-05-08 Priority claimed from GBGB9809939.3A external-priority patent/GB9809939D0/en

1998-06-12 Priority claimed from GBGB9812743.4A external-priority patent/GB9812743D0/en

1999-05-06 Application filed by Biochemie Sa filed Critical Biochemie Sa

2001-11-14 Publication of AR018339A1 publication Critical patent/AR018339A1/es

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000002904 solvent Substances 0.000 abstract 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
229960004099 azithromycin Drugs 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ARP990102127A 1998-05-08 1999-05-06 Un proceso mejorado para la produccion de azitromicinas, azitromicinas y una composicion farmaceutica que las comprende AR018339A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9809939.3A GB9809939D0 (en)	1998-05-08	1998-05-08	Organic compounds
GBGB9812743.4A GB9812743D0 (en)	1998-06-12	1998-06-12	Organic compounds

Publications (1)

Publication Number	Publication Date
AR018339A1 true AR018339A1 (es)	2001-11-14

Family

ID=26313634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP990102127A AR018339A1 (es)	1998-05-08	1999-05-06	Un proceso mejorado para la produccion de azitromicinas, azitromicinas y una composicion farmaceutica que las comprende

Country Status (14)

Country	Link
US (1)	US6420537B1 (de)
EP (1)	EP1077986B1 (de)
JP (1)	JP4518670B2 (de)
KR (1)	KR100581319B1 (de)
CN (1)	CN1299368A (de)
AR (1)	AR018339A1 (de)
AT (1)	ATE339433T1 (de)
AU (1)	AU4139799A (de)
CA (1)	CA2330007C (de)
DE (1)	DE69933207D1 (de)
ES (1)	ES2272068T3 (de)
HR (1)	HRP20000758B1 (de)
TW (1)	TW546302B (de)
WO (1)	WO1999058541A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2177373B1 (es) *	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
ATE320441T1 (de)	2000-07-25	2006-04-15	Silanes Sa De Cv Lab	Einstufiges verfahren zur herstellung von 7,16-
AU2001214115A1 (en) *	2000-08-01	2002-02-13	Habil F. Khorakiwala	Process for the preparation of anhydrous azithromycin
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
IL158591A0 (en) *	2001-05-22	2004-05-12	Pfizer Prod Inc	Crystal forms of azithromycin
US6861413B2 (en) *	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
US6764997B2 (en)	2001-10-18	2004-07-20	Teva Pharmaceutical Industries Ltd.	Stabilized azithromycin compositions
US6855813B2 (en) *	2002-07-19	2005-02-15	Alembic Limited	Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US7435805B2 (en) *	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7235646B2 (en) *	2004-06-28	2007-06-26	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
US20090093420A1 (en) *	2006-01-12	2009-04-09	Wockhardt Limited	Processes for the preparation of azithromycin
CN101418026B (zh) *	2008-10-09	2011-05-18	南京工业大学	一种晶型和粒度可控的阿奇霉素结晶工艺
WO2012080050A1 (en)	2010-12-14	2012-06-21	F. Hoffmann-La Roche Ag	Solid forms of a phenoxybenzenesulfonyl compound
CN103159811A (zh) *	2011-12-10	2013-06-19	山东方明药业集团股份有限公司	一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
RO107257B1 (ro) *	1987-07-09	1993-10-30	Pfizer	Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
SI9011409A (en) *	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
CA2065222A1 (en)	1991-04-09	1992-10-10	Robert R. Wilkening	Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0549040A1 (de) *	1991-12-20	1993-06-30	Merck & Co. Inc.	Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
ES2134284T3 (es) *	1993-04-23	1999-10-01	Hoechst Ag	Pirido-pirimidindionas, procedimiento para su preparacion y su empleo como medicamentos.
US5500423A (en) *	1994-09-09	1996-03-19	Hoechst-Roussel Pharmaceuticals Inc.	5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines
ES2122905B1 (es)	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102006B (pt) *	1997-05-19	2000-06-30	Hovione Sociedade Quimica S A	Novo processo de preparacao de azitromicina
JP2002531409A (ja) *	1998-11-30	2002-09-24	テバファーマシューティカルインダストリーズリミティド	アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤

1999
- 1999-05-05 TW TW088107298A patent/TW546302B/zh not_active IP Right Cessation
- 1999-05-06 ES ES99924899T patent/ES2272068T3/es not_active Expired - Lifetime
- 1999-05-06 HR HR20000758A patent/HRP20000758B1/xx not_active IP Right Cessation
- 1999-05-06 WO PCT/EP1999/003134 patent/WO1999058541A2/en not_active Ceased
- 1999-05-06 JP JP2000548345A patent/JP4518670B2/ja not_active Expired - Fee Related
- 1999-05-06 AR ARP990102127A patent/AR018339A1/es not_active Application Discontinuation
- 1999-05-06 AU AU41397/99A patent/AU4139799A/en not_active Abandoned
- 1999-05-06 CA CA002330007A patent/CA2330007C/en not_active Expired - Fee Related
- 1999-05-06 EP EP99924899A patent/EP1077986B1/de not_active Expired - Lifetime
- 1999-05-06 AT AT99924899T patent/ATE339433T1/de not_active IP Right Cessation
- 1999-05-06 KR KR1020007012414A patent/KR100581319B1/ko not_active Expired - Fee Related
- 1999-05-06 CN CN99805920A patent/CN1299368A/zh active Pending
- 1999-05-06 DE DE69933207T patent/DE69933207D1/de not_active Expired - Lifetime
2000
- 2000-11-07 US US09/707,566 patent/US6420537B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU4139799A (en)	1999-11-29
EP1077986A2 (de)	2001-02-28
CA2330007C (en)	2008-07-08
JP2002514653A (ja)	2002-05-21
US6420537B1 (en)	2002-07-16
HRP20000758B1 (en)	2007-04-30
EP1077986B1 (de)	2006-09-13
KR20010043392A (ko)	2001-05-25
ATE339433T1 (de)	2006-10-15
CN1299368A (zh)	2001-06-13
JP4518670B2 (ja)	2010-08-04
WO1999058541A2 (en)	1999-11-18
TW546302B (en)	2003-08-11
DE69933207D1 (de)	2006-10-26
CA2330007A1 (en)	1999-11-18
WO1999058541A3 (en)	2000-01-20
ES2272068T3 (es)	2007-04-16
HRP20000758A2 (en)	2001-06-30
KR100581319B1 (ko)	2006-05-22

Legal Events

Date	Code	Title	Description
2008-11-03	FA	Abandonment or withdrawal

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ES2189768T3 (es)	2003-07-16	Sintesis regioselectiva de derivados de rapamicina.
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DOP2002000328A (es)	2003-08-30	Pirimidinas inhibidoras de metaloproteinasas de matriz
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BR0315561A (pt)	2005-08-30	Acesso randÈmico para sistemas de comunicação sem fio de acesso múltiplo
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