AR023065A1 - Bi-pirrolidinilvinil(carba)cefalosporinas - Google Patents
Bi-pirrolidinilvinil(carba)cefalosporinasInfo
- Publication number
- AR023065A1 AR023065A1 ARP990106105A ARP990106105A AR023065A1 AR 023065 A1 AR023065 A1 AR 023065A1 AR P990106105 A ARP990106105 A AR P990106105A AR P990106105 A ARP990106105 A AR P990106105A AR 023065 A1 AR023065 A1 AR 023065A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- lower alkyl
- hydrogen
- halogen
- compounds
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 208000035473 Communicable disease Diseases 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- -1 carbamoylmethyl Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de(carba) cefalosporina de formula (1) en las que R es R4 -Ys-(CR5R6)m- o formula a; R1 y R2 son cada uno independientemente hidrogeno o alquiloinferior; R3 es hidrogeno, hidroxi-alquilo inferior o carbamoilmetilo; Z es fenileno, heterociclileno no naftileno; R4 es halogeno, fenilo, bencilo, naftilo oheterociclilo estando opcionalmente sustituidos el fenilo, bencilo, naftilo o heterociclilo por al menos uno de halogeno, hidroxi, alquilo inferioropcionalmente sustituido, alcoxi inferior, amino, alquilamino inferior, di-alquilo-inferior-amino, carboxi, alcoxi-inferior-carbonilo o carbamoilo; Q es S oCH2; Y es S, O, NH o CH2; m es 0 o 1; s es 0 o 1; R5 y R6 son cada uno independientemente hidrogeno o alquilo inferior; X es CR8 o N; R7 es hidrogeno, alquiloinferior, cicloalquilo inferior, formilo, acetilo o pivaloílo; R8 es hidrogeno o halogeno; y ésteres directamente hidrolizables de los mismos, salesfarmacéuticamente aceptables de dichos compuestos e hidratos de los compuestosde formula 1 y de sus ésteres y sales. La invencion se refiere adicionalmente ala fabricacion de compuestos de formula 1, a su uos como sustancias farmacéuticamente activas, en particular para el tratamiento y profilaxis de enfermedadesinfecciosas, ya preparacines farmacéuticas que contienen un compuesto de formula 1 para el tratamiento y profilaxis de enfermedades infecciosas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98122965 | 1998-12-03 | ||
| EP99119895 | 1999-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023065A1 true AR023065A1 (es) | 2002-09-04 |
Family
ID=26149851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106105A AR023065A1 (es) | 1998-12-03 | 1999-12-01 | Bi-pirrolidinilvinil(carba)cefalosporinas |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR023065A1 (es) |
| AU (1) | AU1654900A (es) |
| CO (1) | CO5150174A1 (es) |
| PE (1) | PE20001402A1 (es) |
| WO (1) | WO2000032605A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE370146T1 (de) * | 1999-07-05 | 2007-09-15 | Basilea Pharmaceutica Ag | Verfahren zur herstellung von cephalosporin- derivaten |
| AU6267100A (en) * | 1999-07-07 | 2001-01-30 | F. Hoffmann-La Roche Ag | Vinylpyrrolidinone derivatives with substituted thiazole ring |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883247A (en) * | 1996-06-10 | 1999-03-16 | Hoffmann-La Roche Inc. | Preparation of cephem and isooxacephem derivatives |
| EP0831093A1 (en) * | 1996-09-23 | 1998-03-25 | F. Hoffmann-La Roche Ag | 1-Carba-(dethia)-Cephalosporin Derivatives |
| EP0838465A1 (en) * | 1996-10-22 | 1998-04-29 | F. Hoffmann-La Roche Ag | Pyridinium-substituted (lactamylvinyl)cephalosporin derivatives, their preparation and their use as antibiotics |
| DE69737382T2 (de) * | 1996-11-06 | 2007-10-31 | Basilea Pharmaceutica Ag | Vinylpyrrolidinon-Cephalosporin-Derivate |
| TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
| US6150350A (en) * | 1997-09-15 | 2000-11-21 | Hoffman-La Roche Inc. | Antimicrobial compositions |
-
1999
- 1999-11-25 AU AU16549/00A patent/AU1654900A/en not_active Abandoned
- 1999-11-25 WO PCT/EP1999/009120 patent/WO2000032605A1/en not_active Ceased
- 1999-11-29 PE PE1999001191A patent/PE20001402A1/es not_active Application Discontinuation
- 1999-11-30 CO CO99075208A patent/CO5150174A1/es unknown
- 1999-12-01 AR ARP990106105A patent/AR023065A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000032605A1 (en) | 2000-06-08 |
| PE20001402A1 (es) | 2000-12-15 |
| CO5150174A1 (es) | 2002-04-29 |
| AU1654900A (en) | 2000-06-19 |
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