AR038432A2 - Derivados 1,2-dihidro de parahercuamida y marcfortina - Google Patents

Derivados 1,2-dihidro de parahercuamida y marcfortina

Info

Publication number
AR038432A2
AR038432A2 ARP030100486A ARP030100486A AR038432A2 AR 038432 A2 AR038432 A2 AR 038432A2 AR P030100486 A ARP030100486 A AR P030100486A AR P030100486 A ARP030100486 A AR P030100486A AR 038432 A2 AR038432 A2 AR 038432A2
Authority
AR
Argentina
Prior art keywords
parahercuamida
marcfortina
dihidro
derivatives
alkyl
Prior art date
Application number
ARP030100486A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21695455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR038432(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR038432A2 publication Critical patent/AR038432A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un compuesto de 1,2-dihidro de la fórmula (1) en donde n es 1 ó 2; en donde R14 es -H y alquilo C1-4; en donde R15 es -H y alquilo C1-4; en donde R16 es -OH, sus N-óxidos y sus sales farmacéuticamente aceptables.
ARP030100486A 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina AR038432A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US132495P 1995-07-21 1995-07-21

Publications (1)

Publication Number Publication Date
AR038432A2 true AR038432A2 (es) 2005-01-12

Family

ID=21695455

Family Applications (10)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b
ARP030100484A AR038430A2 (es) 1995-07-21 2003-02-13 Derivados de parahercuamida b
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina
ARP030100486A AR038432A2 (es) 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Family Applications Before (8)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b
ARP030100484A AR038430A2 (es) 1995-07-21 2003-02-13 Derivados de parahercuamida b
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Country Status (30)

Country Link
US (2) US5703078A (es)
EP (3) EP1489082B1 (es)
JP (2) JP4122447B2 (es)
KR (1) KR100428335B1 (es)
CN (2) CN1125824C (es)
AR (10) AR003466A1 (es)
AT (1) ATE311390T1 (es)
AU (1) AU699644B2 (es)
BR (7) BR9609812B8 (es)
CA (1) CA2225813C (es)
CO (1) CO4750664A1 (es)
CZ (1) CZ296008B6 (es)
DE (1) DE69635524T2 (es)
DK (2) DK1489082T3 (es)
ES (2) ES2249783T3 (es)
FI (2) FI115912B (es)
HU (1) HU226296B1 (es)
ID (1) ID30373A (es)
MX (1) MX9800625A (es)
MY (1) MY113806A (es)
NO (1) NO324287B1 (es)
NZ (1) NZ311952A (es)
PL (1) PL185007B1 (es)
PT (1) PT1489082E (es)
RU (1) RU2162090C2 (es)
SI (1) SI0871631T1 (es)
SK (2) SK285248B6 (es)
TW (1) TW334436B (es)
WO (1) WO1997003988A1 (es)
ZA (1) ZA965908B (es)

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ZA976761B (en) * 1996-09-09 1999-01-29 Upjohn Co 25 Methylene and 24,25-epoxy marcfortines and paraherquamides
WO1998021211A1 (en) * 1996-11-15 1998-05-22 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
PE20011289A1 (es) * 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
PL3050874T3 (pl) 2008-11-14 2019-07-31 Merial Inc. Wzbogacone enancjomerycznie aryloazol-2-ilocyjanoetyloaminowe związki pasożytobójcze
SG171751A1 (en) 2008-11-19 2011-07-28 Merial Ltd Compositions comprising an aryl pyrazole and/ or a formamidine methods and uses thereof
AR074482A1 (es) 2008-12-04 2011-01-19 Merial Ltd Derivados dimericos de avermectina y milbemicina
EP2314292A1 (en) 2009-10-20 2011-04-27 Novartis AG Endoparasiticidal compositions
WO2011069143A1 (en) 2009-12-04 2011-06-09 Merial Limited Pesticidal bis-organosulfur compounds
ME02432B (me) 2009-12-17 2016-09-20 Merial Inc Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže
EP2512467A1 (en) 2009-12-17 2012-10-24 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
DK2640728T3 (en) 2010-11-16 2016-11-28 Merial Inc NEW MONENSINDERIVATER FOR TREATMENT AND PREVENTION OF protozoal INFECTIONS
WO2013003168A1 (en) 2011-06-27 2013-01-03 Merial Limited Novel insect-repellent coumarin derivatives, syntheses, and methods of use
US8946270B2 (en) 2011-06-27 2015-02-03 Merial Limited Amido-pyridyl ether compounds and compositions and their use against parasites
PT3172964T (pt) 2011-09-12 2020-11-30 Boehringer Ingelheim Animal Health Usa Inc Composições parasiticidas compreendendo um agente ativo de isoxazolina, método e utilizações das mesmas
WO2013044118A2 (en) 2011-09-23 2013-03-28 Merial Limited Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
JP6249568B2 (ja) 2011-11-17 2017-12-20 メリアル インコーポレイテッド アリールピラゾールと置換イミダゾールを含む組成物、その使用方法
BR122020002199B1 (pt) 2011-12-02 2021-01-19 Merial, Inc. formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
CN104168900A (zh) 2012-02-06 2014-11-26 梅里亚有限公司 包含全身性地起作用的活性剂的杀寄生虫口服兽用组合物、方法及其用途
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
NZ711847A (en) 2012-04-20 2015-11-27 Merial Inc Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof
JP5737255B2 (ja) * 2012-09-27 2015-06-17 ダイキン工業株式会社 チオノカルボン酸エステルの製造方法
CA2891926A1 (en) 2012-11-20 2014-05-30 Merial, Inc. Anthelmintic compounds and compositions and method of using thereof
CN105873925B (zh) 2013-11-01 2019-09-10 勃林格殷格翰动物保健美国公司 抗寄生物的和杀虫的异噁唑啉化合物
ES2765405T3 (es) 2014-04-17 2020-06-09 Boehringer Ingelheim Animal Health Usa Inc Utilización de compuestos de malononitrilo para proteger animales de parásitos
MX375153B (es) 2014-05-19 2025-03-06 Boehringer Ingelheim Animal Health Usa Inc Compuestos antihelminticos.
BR122020023385B1 (pt) 2014-06-19 2021-05-25 Merial, Inc composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos
US10864193B2 (en) 2014-10-31 2020-12-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising fipronil at high concentrations
PY1609250A (es) 2015-02-26 2018-03-01 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
CN107835818B (zh) 2015-05-20 2022-04-29 勃林格殷格翰动物保健美国公司 驱虫缩酚酸肽化合物
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
EP3541789A1 (en) 2016-11-16 2019-09-25 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
ES2944616T3 (es) 2017-08-14 2023-06-22 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas
EP3749096A1 (en) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3883648A1 (en) 2018-11-20 2021-09-29 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
PY2013845A (es) 2019-03-01 2021-02-09 Boehringer Ingelheim Animal Health Usa Inc Composiciones inyectables de clorsulón, sus métodos y usos
JP7637630B2 (ja) 2019-03-19 2025-02-28 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
PH12022553222A1 (en) 2020-05-29 2024-02-12 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic heterocyclic compounds
CN111748503B (zh) * 2020-08-04 2021-12-14 华中农业大学 一种深海独岛枝芽胞杆菌培养基和剂型
JP2024504208A (ja) 2020-12-21 2024-01-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー イソオキサゾリン化合物を含む殺寄生虫首輪
JP7857414B2 (ja) 2022-02-17 2026-05-12 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
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US4873247A (en) * 1987-11-27 1989-10-10 Goegelman Robert T Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
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US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
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Also Published As

Publication number Publication date
FI115912B (fi) 2005-08-15
ES2249783T3 (es) 2006-04-01
NZ311952A (en) 1999-03-29
BR9612973B8 (pt) 2014-10-29
AR038429A2 (es) 2005-01-12
AR038433A2 (es) 2005-01-12
HUP9802221A3 (en) 2000-05-29
TW334436B (en) 1998-06-21
CN1191537A (zh) 1998-08-26
EP0871631B1 (en) 2005-11-30
PL324574A1 (en) 1998-06-08
EP1400523A3 (en) 2004-04-07
EP1489082B1 (en) 2013-11-20
ATE311390T1 (de) 2005-12-15
AR038430A2 (es) 2005-01-12
CZ11098A3 (cs) 1998-06-17
EP1400523A2 (en) 2004-03-24
BR9609812B8 (pt) 2014-10-29
JP4122447B2 (ja) 2008-07-23
AR038427A2 (es) 2005-01-12
CN1125824C (zh) 2003-10-29
NO324287B1 (no) 2007-09-17
PT1489082E (pt) 2013-12-23
JP2008007516A (ja) 2008-01-17
FI980112L (fi) 1998-01-20
US5703078A (en) 1997-12-30
CZ296008B6 (cs) 2005-12-14
DE69635524T2 (de) 2006-07-06
BR9609812A (pt) 1999-03-02
RU2162090C2 (ru) 2001-01-20
FI118471B (fi) 2007-11-30
AU6337396A (en) 1997-02-18
ES2439569T3 (es) 2014-01-23
JPH11509550A (ja) 1999-08-24
CN1277830C (zh) 2006-10-04
CA2225813A1 (en) 1997-02-06
SK284833B6 (sk) 2005-12-01
BR9612974B8 (pt) 2014-10-29
BR9612975B8 (pt) 2014-10-29
AR038431A2 (es) 2005-01-12
US5750695A (en) 1998-05-12
ZA965908B (en) 1997-01-12
FI980112A0 (fi) 1998-01-20
CO4750664A1 (es) 1999-03-31
KR100428335B1 (ko) 2004-06-16
SK285248B6 (sk) 2006-09-07
BR9612972B8 (pt) 2014-10-29
EP0871631A1 (en) 1998-10-21
AR038428A2 (es) 2005-01-12
NO980255L (no) 1998-03-20
BR9612944B8 (pt) 2014-10-29
DK1489082T3 (da) 2013-12-09
SK5498A3 (en) 1998-08-05
SI0871631T1 (sl) 2006-04-30
HUP9802221A2 (hu) 1999-02-01
AR052907A1 (es) 2007-04-11
AR003466A1 (es) 1998-08-05
CN1495183A (zh) 2004-05-12
DE69635524D1 (de) 2006-01-05
AR038434A2 (es) 2005-01-12
BR9612963B8 (pt) 2014-10-29
HU226296B1 (hu) 2008-08-28
NO980255D0 (no) 1998-01-20
EP1489082A1 (en) 2004-12-22
PL185007B1 (pl) 2003-01-31
MY113806A (en) 2002-05-31
AU699644B2 (en) 1998-12-10
DK0871631T3 (da) 2006-03-13
CA2225813C (en) 2008-02-26
HK1017883A1 (en) 1999-12-03
HK1061242A1 (en) 2004-09-10
FI20050238L (fi) 2005-03-04
WO1997003988A1 (en) 1997-02-06
ID30373A (id) 1997-01-23
MX9800625A (es) 1998-04-30

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