AR043111A1 - Derivados monoacilados de o-fenilendiaminas - Google Patents

Derivados monoacilados de o-fenilendiaminas

Info

Publication number
AR043111A1
AR043111A1 ARP040100348A ARP040100348A AR043111A1 AR 043111 A1 AR043111 A1 AR 043111A1 AR P040100348 A ARP040100348 A AR P040100348A AR P040100348 A ARP040100348 A AR P040100348A AR 043111 A1 AR043111 A1 AR 043111A1
Authority
AR
Argentina
Prior art keywords
diyl
alkyl
pyridine
hydroxy
cycloalkyl
Prior art date
Application number
ARP040100348A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR043111A1 publication Critical patent/AR043111A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuesto de la fórmula (1), en la que: Ar es tiofeno-2,5-diilo, piridina-2,5-diilo, piridina-5,2-diilo, piridina-2,6-diilo, piridina-2,4-diilo o 1,4-fenileno; R1, R2 independientemente uno de otro significan hidrógeno, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, cicloalquilo C3-12, los grupos alquilo, alquenilo, alquinilo y cicloalquilo están eventualmente mono- o multisustituido con hidroxi, halógeno, cicloalquilo C3-12, alcoxi, alquilsulfanilo, aciloxi, alcoxicarbonilo, acilo, (alquilo (C1-6))-NH-C(O)-, (alquilo (C1-6))-C(O)NH- o -NR3R4, o como alternativa R1 es hidrógeno y R2 es hidroxilo, alcoxi, alqueniloxi C2-12 o fenoxi, dicho grupo fenoxi está eventualmente sustituido con metilo, metoxi, halógeno, nitro, ciano, trifluormetilo, etenilo o -C(O)-O-CH3, con la condición de que si R2 es hidroxi, Ar no sea tiofeno-2,5-diilo; y R3 y R4 independientemente uno de otro significan hidrógeno o alquilo C1-6, o en la que R3 y R4 junto con el átomo de nitrógeno al que están unidos forman un anillo, dicho anillo está monosustituido con oxo y puede contener un heteroátomo adicional, y sales farmacéuticamente aceptables de los mismos, así como los procesos de fabricación de estos compuestos, las composiciones farmacéuticas que contienen dichos compuestos y su utilización para la fabricación de fármacos destinados al tratamiento de enfermedades, por ejemplo el cáncer
ARP040100348A 2003-02-06 2004-02-04 Derivados monoacilados de o-fenilendiaminas AR043111A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002545 2003-02-06
EP03016692 2003-08-04

Publications (1)

Publication Number Publication Date
AR043111A1 true AR043111A1 (es) 2005-07-20

Family

ID=32852233

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100348A AR043111A1 (es) 2003-02-06 2004-02-04 Derivados monoacilados de o-fenilendiaminas

Country Status (8)

Country Link
US (2) US7071219B2 (es)
EP (1) EP1592667A2 (es)
JP (1) JP2006516553A (es)
AR (1) AR043111A1 (es)
CA (1) CA2513408A1 (es)
CL (1) CL2004000194A1 (es)
TW (1) TW200424174A (es)
WO (1) WO2004069803A2 (es)

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US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
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BRPI0814441A2 (pt) * 2007-07-19 2015-07-14 Schering Corp Compostos de amida heterocíclica como inibidores de proteína cinase
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Also Published As

Publication number Publication date
US7071219B2 (en) 2006-07-04
JP2006516553A (ja) 2006-07-06
CA2513408A1 (en) 2004-08-19
WO2004069803A2 (en) 2004-08-19
EP1592667A2 (en) 2005-11-09
WO2004069803A3 (en) 2004-11-18
CL2004000194A1 (es) 2005-01-14
US20060089403A1 (en) 2006-04-27
US20040162317A1 (en) 2004-08-19
US7501451B2 (en) 2009-03-10
TW200424174A (en) 2004-11-16

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