AR044803A1 - Metodos para la produccion de insulina - Google Patents
Metodos para la produccion de insulinaInfo
- Publication number
- AR044803A1 AR044803A1 ARP040102114A ARP040102114A AR044803A1 AR 044803 A1 AR044803 A1 AR 044803A1 AR P040102114 A ARP040102114 A AR P040102114A AR P040102114 A ARP040102114 A AR P040102114A AR 044803 A1 AR044803 A1 AR 044803A1
- Authority
- AR
- Argentina
- Prior art keywords
- nucleic acid
- acid sequence
- plant
- insulin
- seed
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
- 102000004877 Insulin Human genes 0.000 title abstract 8
- 108090001061 Insulin Proteins 0.000 title abstract 8
- 229940125396 insulin Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 12
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 10
- 238000013518 transcription Methods 0.000 abstract 3
- 230000035897 transcription Effects 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 238000010276 construction Methods 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Reivindicación 1: Un método para la expresión de insulina en semillas vegetales, caracterizado porque comprende: a) la provisión de una construcción quimérica de ácido nucleico que comprende, como componentes operativamente ligados en la dirección de transcripción 5' a 3': i) una secuencia de ácido nucleico con la capacidad de controlar la expresión en células de semillas vegetales; y ii) una secuencia de ácido nucleico que codifica para un polipéptido insulínico; b) la introducción de la construcción quimérica de ácido nucleico dentro de una célula vegetal; y c) la multiplicación de la célula vegetal dentro de una planta madura con la capacidad de producir simiente, en donde la simiente expresa insulina. Reivindicación 28: Una planta con la capacidad de producir semillas que comprenden una secuencia quimérica de ácido nucleico caracterizado porque comprende, en la dirección de transcripción 5' a 3': a) una primera secuencia de ácido nucleico con la capacidad de controlar la expresión en una célula de semilla vegetal a la que está operativamente ligada; b) una segura secuencia de ácido nucleico codificadora de un polipéptido insulínico, en donde la semilla contiene insulina. Reivindicación 31: Una semilla vegetal que comprende una secuencia quimérica de ácido nucleico caracterizado porque comprende, en la dirección de transcripción 5' a 3': a) una primera secuencia de ácido nucleico con la capacidad de controlar la expresión en una célula de semilla vegetal a la que está operativamente ligada; b) una segunda secuencia de ácido nucleico que codifica para un polipéptido insulínico. Reivindicación 33: Una secuencia de ácido nucleico codificadora de insulina, ligada a una secuencia de ácido nucleico caracterizado porque comprende un promotor con la capacidad de controlar la expresión en una célula de semilla vegetal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47881803P | 2003-06-17 | 2003-06-17 | |
| US54953904P | 2004-03-04 | 2004-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044803A1 true AR044803A1 (es) | 2005-10-05 |
Family
ID=33555509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102114A AR044803A1 (es) | 2003-06-17 | 2004-06-17 | Metodos para la produccion de insulina |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7547821B2 (es) |
| EP (2) | EP1633876B1 (es) |
| JP (2) | JP4864701B2 (es) |
| KR (1) | KR101216762B1 (es) |
| CN (1) | CN1836047B (es) |
| AR (1) | AR044803A1 (es) |
| AT (1) | ATE405660T1 (es) |
| AU (1) | AU2004247762B2 (es) |
| BR (1) | BRPI0411479A (es) |
| CA (1) | CA2528741A1 (es) |
| CY (1) | CY1108477T1 (es) |
| DE (1) | DE602004015980D1 (es) |
| DK (1) | DK1633876T3 (es) |
| EA (1) | EA014887B1 (es) |
| ES (1) | ES2313018T3 (es) |
| IL (1) | IL172469A (es) |
| MX (1) | MXPA05013723A (es) |
| NO (1) | NO20055885L (es) |
| NZ (1) | NZ544522A (es) |
| PL (1) | PL1633876T3 (es) |
| PT (1) | PT1633876E (es) |
| TW (1) | TWI345587B (es) |
| WO (1) | WO2004111244A2 (es) |
Families Citing this family (42)
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| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
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| CN1836047B (zh) * | 2003-06-17 | 2010-12-22 | 赛姆生物系统遗传公司 | 在植物中生产胰岛素的方法 |
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| US8603824B2 (en) | 2004-07-26 | 2013-12-10 | Pfenex, Inc. | Process for improved protein expression by strain engineering |
| NZ563676A (en) | 2005-05-23 | 2011-01-28 | Arcadia Biosciences Inc | Safflower with elevated gamma-linolenic acid |
| US20080274143A1 (en) * | 2005-05-27 | 2008-11-06 | Henry Daniell | Chloroplasts Engineering to Express Pharmaceutical Proteins |
| AP2007004262A0 (en) * | 2005-07-01 | 2007-12-31 | Cornell Res Foundation Inc | Oleosin genes and promoters from coffee |
| WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| CN104357535B (zh) | 2006-08-31 | 2018-03-27 | 孟山都技术有限公司 | 植物无选择转化 |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| JP5444553B2 (ja) | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法 |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| CN102037008B (zh) * | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| RU2010147076A (ru) * | 2008-04-22 | 2012-05-27 | Кейз Вестерн Ризев Юнивесити (Us) | Аналоги инсулина специфичные к изоформам |
| PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| CN101736029B (zh) * | 2008-11-21 | 2013-01-02 | 复旦大学 | 一种利用植物油体蛋白表达系统生产人胰岛素样生长因子-i的方法 |
| US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| EA201200717A1 (ru) | 2009-12-11 | 2013-03-29 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| CN102268451B (zh) * | 2010-06-01 | 2014-03-12 | 安胜军 | 一种含有人胰岛素基因的表达载体及其构建方法与应用 |
| US20130097731A1 (en) | 2010-06-16 | 2013-04-18 | Futuragene Israel Ltd. | Pest-resistant plants containing a combination of a spider toxin and a chitinase |
| WO2012032520A1 (en) | 2010-09-07 | 2012-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
| EP2768520A4 (en) * | 2011-10-18 | 2015-07-15 | AmideBio LLC | CHEMICAL AND THERMODYNAMIC STABLE INSULIN ANALOGUE AND IMPROVED PROCESS FOR THEIR PREPARATION |
| US9352456B2 (en) | 2011-10-26 | 2016-05-31 | Black & Decker Inc. | Power tool with force sensing electronic clutch |
| US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
| EP2986315A4 (en) | 2013-04-17 | 2017-03-01 | AmideBio LLC | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| KR101625746B1 (ko) | 2013-09-23 | 2016-05-31 | 순천대학교 산학협력단 | 프로미니인슐린 재조합 단백질이 발현된 형질전환 식물 및 이의 제조방법 |
| AU2015328222B9 (en) | 2014-10-06 | 2020-12-24 | Case Western Reserve University | Biphasic single-chain insulin analogues |
| US20220096607A1 (en) * | 2015-04-09 | 2022-03-31 | Kinetiq Therapeutics, Llc | Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof |
| TWI700091B (zh) | 2016-12-16 | 2020-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 含胰島素醫藥組成物 |
| KR102642178B1 (ko) * | 2017-08-08 | 2024-02-29 | 중앙대학교 산학협력단 | 돌연변이에 의해, 혈중 반감기 및 공수병 바이러스 중화 효능이 증대된 공수병 바이러스 중화 항체 |
| US20210032307A1 (en) * | 2018-02-09 | 2021-02-04 | Jiangsu Hengrui Medicine Co., Ltd. | Codon optimized precursor gene and signal peptide gene of human insulin analogue |
| CN114144426A (zh) * | 2019-04-19 | 2022-03-04 | 印地安纳大学理事会 | 餐时或基础胰岛素类似物通过内部二硒桥的稳定化 |
| PL4069278T3 (pl) | 2019-12-06 | 2025-10-06 | Dr. Mary Morris & Associates, Llc | Sposoby i kompozycje do zapobiegania cukrzycy typu 1 |
| US20240279300A1 (en) * | 2020-07-03 | 2024-08-22 | Kriya Therapeutics, Inc. | Modified insulin and glucokinase nucleic acids for treating diabetes |
| EP4190905A1 (en) | 2021-12-01 | 2023-06-07 | Core Biogenesis | Method for the purification of recombinant proteins using oil body proteins |
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