ATE405660T1 - Verfahren zur insulinproduktion in pflanzen - Google Patents
Verfahren zur insulinproduktion in pflanzenInfo
- Publication number
- ATE405660T1 ATE405660T1 AT04737835T AT04737835T ATE405660T1 AT E405660 T1 ATE405660 T1 AT E405660T1 AT 04737835 T AT04737835 T AT 04737835T AT 04737835 T AT04737835 T AT 04737835T AT E405660 T1 ATE405660 T1 AT E405660T1
- Authority
- AT
- Austria
- Prior art keywords
- plants
- insulin production
- insulin
- production
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47881803P | 2003-06-17 | 2003-06-17 | |
| US54953904P | 2004-03-04 | 2004-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405660T1 true ATE405660T1 (de) | 2008-09-15 |
Family
ID=33555509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04737835T ATE405660T1 (de) | 2003-06-17 | 2004-06-17 | Verfahren zur insulinproduktion in pflanzen |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7547821B2 (de) |
| EP (2) | EP1959017A1 (de) |
| JP (2) | JP4864701B2 (de) |
| KR (1) | KR101216762B1 (de) |
| CN (1) | CN1836047B (de) |
| AR (1) | AR044803A1 (de) |
| AT (1) | ATE405660T1 (de) |
| AU (1) | AU2004247762B2 (de) |
| BR (1) | BRPI0411479A (de) |
| CA (1) | CA2528741A1 (de) |
| CY (1) | CY1108477T1 (de) |
| DE (1) | DE602004015980D1 (de) |
| DK (1) | DK1633876T3 (de) |
| EA (1) | EA014887B1 (de) |
| ES (1) | ES2313018T3 (de) |
| IL (1) | IL172469A (de) |
| MX (1) | MXPA05013723A (de) |
| NO (1) | NO20055885L (de) |
| NZ (1) | NZ544522A (de) |
| PL (1) | PL1633876T3 (de) |
| PT (1) | PT1633876E (de) |
| TW (1) | TWI345587B (de) |
| WO (1) | WO2004111244A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393998B2 (en) | 2002-03-08 | 2008-07-01 | Prodigene, Inc. | Commercial production of insulin and insulin-like proteins in plants |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| AU2003280870A1 (en) * | 2002-11-12 | 2004-06-03 | Ckd Bio Corp. | Plasmids expressing human insulin and the preparation method for human insuling thereby |
| US20040173547A1 (en) * | 2003-03-06 | 2004-09-09 | Roth Michael Carl | Bolt on attachment to facilitate hanging of pneumatic tool |
| TWI345587B (en) * | 2003-06-17 | 2011-07-21 | Sembiosys Genetics Inc | Methods for the production of insulin in plants |
| JP2007535896A (ja) * | 2003-06-20 | 2007-12-13 | セムバイオシス ジェネティクス インコーポレイテッド | 修飾されたオレオシン |
| TW200526778A (en) * | 2003-11-14 | 2005-08-16 | Sembiosys Genetics Inc | Methods for the production of apolipoproteins in transgenic plants |
| CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
| NZ563676A (en) | 2005-05-23 | 2011-01-28 | Arcadia Biosciences Inc | Safflower with elevated gamma-linolenic acid |
| US20080274143A1 (en) * | 2005-05-27 | 2008-11-06 | Henry Daniell | Chloroplasts Engineering to Express Pharmaceutical Proteins |
| BRPI0613726A2 (pt) | 2005-07-01 | 2011-02-01 | Cornell Res Foundation Inc | molécula de ácido nucléico de café (coffea spp), molécula de mrna e cdna, oligonucleotìdeo, vetor, método para modular o sabor ou aroma de grãos de café, promotor, gene quimérico |
| US8343914B2 (en) * | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| WO2008028121A1 (en) | 2006-08-31 | 2008-03-06 | Monsanto Technology Llc | Plant transformation without selection |
| EP2074140B8 (de) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillationsresistentes insulin und insulinanaloga |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9394571B2 (en) | 2007-04-27 | 2016-07-19 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| WO2009129250A2 (en) * | 2008-04-14 | 2009-10-22 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| AU2009240636A1 (en) * | 2008-04-22 | 2009-10-29 | Case Western Reserve University | Isoform-specific insulin analogues |
| PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| CN101736029B (zh) * | 2008-11-21 | 2013-01-02 | 复旦大学 | 一种利用植物油体蛋白表达系统生产人胰岛素样生长因子-i的方法 |
| US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| RU2012123642A (ru) | 2009-12-11 | 2014-01-20 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| CN102268451B (zh) * | 2010-06-01 | 2014-03-12 | 安胜军 | 一种含有人胰岛素基因的表达载体及其构建方法与应用 |
| US20130097731A1 (en) | 2010-06-16 | 2013-04-18 | Futuragene Israel Ltd. | Pest-resistant plants containing a combination of a spider toxin and a chitinase |
| US20130164288A1 (en) | 2010-09-07 | 2013-06-27 | Protalix Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
| WO2013059213A1 (en) * | 2011-10-18 | 2013-04-25 | Amidebio, Llc | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| US9352456B2 (en) | 2011-10-26 | 2016-05-31 | Black & Decker Inc. | Power tool with force sensing electronic clutch |
| EP2836508B1 (de) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulinformulierungen |
| US9163073B2 (en) | 2013-04-17 | 2015-10-20 | Amidebio, Llc | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| KR101625746B1 (ko) | 2013-09-23 | 2016-05-31 | 순천대학교 산학협력단 | 프로미니인슐린 재조합 단백질이 발현된 형질전환 식물 및 이의 제조방법 |
| AU2015328222B9 (en) | 2014-10-06 | 2020-12-24 | Case Western Reserve University | Biphasic single-chain insulin analogues |
| US20220096607A1 (en) * | 2015-04-09 | 2022-03-31 | Kinetiq Therapeutics, Llc | Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| KR102642178B1 (ko) * | 2017-08-08 | 2024-02-29 | 중앙대학교 산학협력단 | 돌연변이에 의해, 혈중 반감기 및 공수병 바이러스 중화 효능이 증대된 공수병 바이러스 중화 항체 |
| US20210032307A1 (en) * | 2018-02-09 | 2021-02-04 | Jiangsu Hengrui Medicine Co., Ltd. | Codon optimized precursor gene and signal peptide gene of human insulin analogue |
| US20220144915A1 (en) * | 2019-04-19 | 2022-05-12 | The Trustees Of Indiana University | Stabilization of prandial or basal insulin analogues by an internal diselenide bridge |
| FI4069278T3 (fi) * | 2019-12-06 | 2025-07-16 | Dr Mary Morris & Ass Llc | Menetelmiä ja koostumuksia tyypin 1 diabeteksen ehkäisemiseksi |
| IL299545A (en) * | 2020-07-03 | 2023-02-01 | Kriya Therapeutics Inc | Different insulin and glucokinase nucleic acids for the treatment of diabetes |
| EP4190905A1 (de) | 2021-12-01 | 2023-06-07 | Core Biogenesis | Verfahren zur reinigung von rekombinanten proteinen unter verwendung von ölkörperproteinen |
| WO2026076425A1 (en) | 2024-10-04 | 2026-04-09 | Biodrive, Inc. | Oral biodelivery platform |
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| US7393998B2 (en) * | 2002-03-08 | 2008-07-01 | Prodigene, Inc. | Commercial production of insulin and insulin-like proteins in plants |
| CN1382734A (zh) * | 2002-03-15 | 2002-12-04 | 林忠平 | 利用转基因生菜生产人胰岛素的方法 |
| TWI345587B (en) * | 2003-06-17 | 2011-07-21 | Sembiosys Genetics Inc | Methods for the production of insulin in plants |
-
2004
- 2004-06-17 TW TW093117421A patent/TWI345587B/zh not_active IP Right Cessation
- 2004-06-17 DE DE602004015980T patent/DE602004015980D1/de not_active Expired - Lifetime
- 2004-06-17 EP EP08007159A patent/EP1959017A1/de not_active Withdrawn
- 2004-06-17 PL PL04737835T patent/PL1633876T3/pl unknown
- 2004-06-17 NZ NZ544522A patent/NZ544522A/en not_active IP Right Cessation
- 2004-06-17 WO PCT/CA2004/000896 patent/WO2004111244A2/en not_active Ceased
- 2004-06-17 PT PT04737835T patent/PT1633876E/pt unknown
- 2004-06-17 CN CN2004800236023A patent/CN1836047B/zh not_active Expired - Fee Related
- 2004-06-17 BR BRPI0411479-5A patent/BRPI0411479A/pt not_active IP Right Cessation
- 2004-06-17 MX MXPA05013723A patent/MXPA05013723A/es active IP Right Grant
- 2004-06-17 EA EA200600050A patent/EA014887B1/ru not_active IP Right Cessation
- 2004-06-17 US US10/869,040 patent/US7547821B2/en not_active Expired - Fee Related
- 2004-06-17 DK DK04737835T patent/DK1633876T3/da active
- 2004-06-17 JP JP2006515598A patent/JP4864701B2/ja not_active Expired - Fee Related
- 2004-06-17 ES ES04737835T patent/ES2313018T3/es not_active Expired - Lifetime
- 2004-06-17 KR KR1020057024281A patent/KR101216762B1/ko not_active Expired - Fee Related
- 2004-06-17 CA CA002528741A patent/CA2528741A1/en not_active Abandoned
- 2004-06-17 AR ARP040102114A patent/AR044803A1/es active IP Right Grant
- 2004-06-17 AU AU2004247762A patent/AU2004247762B2/en not_active Ceased
- 2004-06-17 EP EP04737835A patent/EP1633876B1/de not_active Expired - Lifetime
- 2004-06-17 AT AT04737835T patent/ATE405660T1/de active
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2005
- 2005-12-08 IL IL172469A patent/IL172469A/en not_active IP Right Cessation
- 2005-12-12 NO NO20055885A patent/NO20055885L/no not_active Application Discontinuation
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2008
- 2008-11-03 CY CY20081101246T patent/CY1108477T1/el unknown
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2009
- 2009-05-12 US US12/464,207 patent/US20090282583A1/en not_active Abandoned
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2011
- 2011-06-03 JP JP2011124794A patent/JP2011200251A/ja active Pending
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