AR080436A2 - Preparacion solida de desintegracion rapida, uso de una hidroxipropilcelulosa poco sustituida en dicha preparcion y metodo para mejorar la desintegrabilidad oral de la misma - Google Patents

Preparacion solida de desintegracion rapida, uso de una hidroxipropilcelulosa poco sustituida en dicha preparcion y metodo para mejorar la desintegrabilidad oral de la misma

Info

Publication number
AR080436A2
AR080436A2 ARP110100626A ARP110100626A AR080436A2 AR 080436 A2 AR080436 A2 AR 080436A2 AR P110100626 A ARP110100626 A AR P110100626A AR P110100626 A ARP110100626 A AR P110100626A AR 080436 A2 AR080436 A2 AR 080436A2
Authority
AR
Argentina
Prior art keywords
preparation
active ingredient
pharmacologically active
improve
hydroxypropilcelulose
Prior art date
Application number
ARP110100626A
Other languages
English (en)
Inventor
Toshiaki Shimizu
Yoshinori Nakano
Masae Sugaya
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16632688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR080436(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR080436A2 publication Critical patent/AR080436A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una preparacion solida de desintegracion rápida que comprende (i) un ingrediente farmacologicamente activo con excepcion de Iansoprazol, (ii) un azucar y (iii) una hidroxipropil celulosa poco sustituida que posee entre 5% o más y menos de 7% en peso de grupo hidroxipropilo. Uso de una hidroxipropilcelulosa poco sustituida en dicha preparacion y método para mejorar la rápida desintegrabilidad oral de la misma. Reivindicacion 8: Una preparacion de acuerdo con la reivindicacion 1, caracterizada porque el ingrediente farmacologicamente activo es voglibosa. Reivindicacion 9: Una preparacion de acuerdo con la reivindicacion 1, caracterizada porque el ingrediente farmacologicamente activo es hidrocloruro de manidipina. Reivindicacion 10: Una preparacion de acuerdo con la reivindicacion 1, caracterizada porque el ingrediente farmacologicamente activo es hidrocloruro de pioglitazona. Reivindicacion 11: Una preparacion de acuerdo con la reivindicacion 1, caracterizada porque el ingrediente farmacologicamente activo es candesartan cilexetil.
ARP110100626A 1998-07-28 2011-03-01 Preparacion solida de desintegracion rapida, uso de una hidroxipropilcelulosa poco sustituida en dicha preparcion y metodo para mejorar la desintegrabilidad oral de la misma AR080436A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21304998 1998-07-28

Publications (1)

Publication Number Publication Date
AR080436A2 true AR080436A2 (es) 2012-04-11

Family

ID=16632688

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990103680A AR019935A1 (es) 1998-07-28 1999-07-27 Preparacion solida de desintegracion rapida, uso de una hidroxipropil celulosa poco sustituida en dicha preparacion y metodo para mejorar la capacidad dedesintegracion rapida de la misma
ARP110100626A AR080436A2 (es) 1998-07-28 2011-03-01 Preparacion solida de desintegracion rapida, uso de una hidroxipropilcelulosa poco sustituida en dicha preparcion y metodo para mejorar la desintegrabilidad oral de la misma

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990103680A AR019935A1 (es) 1998-07-28 1999-07-27 Preparacion solida de desintegracion rapida, uso de una hidroxipropil celulosa poco sustituida en dicha preparacion y metodo para mejorar la capacidad dedesintegracion rapida de la misma

Country Status (19)

Country Link
US (4) US20060182802A1 (es)
EP (2) EP1100469B1 (es)
JP (3) JP3404648B2 (es)
KR (1) KR100536783B1 (es)
CN (1) CN1149077C (es)
AR (2) AR019935A1 (es)
AT (2) ATE481090T1 (es)
AU (1) AU4802099A (es)
CA (3) CA2581111A1 (es)
CY (1) CY1110988T1 (es)
DE (2) DE69924381T2 (es)
DK (2) DK1561458T3 (es)
ES (2) ES2237121T3 (es)
MY (2) MY151098A (es)
PT (2) PT1561458E (es)
SI (1) SI1100469T1 (es)
TW (2) TWI257311B (es)
WO (1) WO2000006126A1 (es)
ZA (1) ZA200100285B (es)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1121103E (pt) 1998-05-18 2007-02-28 Takeda Pharmaceutical Comprimidos de desintegração oral compreendendo um benzimidazole
ES2237121T3 (es) * 1998-07-28 2005-07-16 Takeda Pharmaceutical Company Limited Preparacion solida disgregable rapidamente.
CA2374760A1 (en) 1999-06-18 2000-12-28 Takeda Chemical Industries, Ltd. Quickly disintegrating solid preparations
JP2001058944A (ja) * 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
DE60110666T2 (de) 2000-03-17 2006-02-02 Shin-Etsu Chemical Co., Ltd. Feste Zubereitung enthaltend niedersubstituierte Hydroxypropylcellulose und Herstellungsverfahren
CA2403594A1 (en) * 2000-03-27 2002-09-18 Kyowa Hakko Kogyo Co., Ltd. Granules having good taking property
AU2001248751A1 (en) * 2000-04-12 2001-10-23 Banyu Pharmaceutical Co. Ltd. Compositions disintegrating in oral cavity and preparations disintegrating in oral cavity
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
JP4840549B2 (ja) * 2000-11-20 2011-12-21 トーアエイヨー株式会社 安定な血管拡張剤及びその製造方法
WO2002045694A1 (en) * 2000-12-07 2002-06-13 Altana Pharma Ag Rapidly disintegrating tablet comprising an acid-labile active ingredient
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
JP2004525109A (ja) 2001-02-15 2004-08-19 キング・ファーマシューティカルズ・インコーポレイティッド 安定化された甲状腺ホルモン医薬組成物、及びその製法
NZ527585A (en) * 2001-02-15 2005-04-29 Tanabe Seiyaku Co Tablets quickly disintegrated in oral cavity
WO2002092058A1 (fr) * 2001-05-15 2002-11-21 Takeda Chemical Industries, Ltd. Preparation solide se desintegrant rapidement
ATE508725T1 (de) * 2001-06-20 2011-05-15 Takeda Pharmaceutical Verfahren zur herstellung von tabletten
WO2003007968A1 (en) * 2001-07-17 2003-01-30 Sun Pharmaceutical Industries Ltd. A cardiotonic composition
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
WO2003028706A1 (fr) * 2001-09-28 2003-04-10 Sanwa Kagaku Kenkyusho Co.,Ltd Double comprime a desintegration rapide
ES2426723T3 (es) 2001-10-17 2013-10-24 Takeda Pharmaceutical Company Limited Gránulos que contienen gran cantidad de compuesto químico inestable en medio ácido
WO2003041698A1 (fr) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Comprimes contenant des acides amines se desintegrant rapidement dans la cavite buccale et procede de fabrication de ces comprimes
JP2003238393A (ja) * 2002-02-15 2003-08-27 Otsuka Pharmaceut Co Ltd 施錠性が改善された錠剤及びその製造方法
DE10209982A1 (de) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
CO5400144A1 (es) * 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
EP2283864A1 (en) * 2002-07-16 2011-02-16 Elan Pharma International Ltd. Liquid dosage compositions fo stable nanoparticulate active agents
US20040018990A1 (en) * 2002-07-25 2004-01-29 Harvey Rosner Treatment of obesity
CA2500712C (en) * 2002-10-02 2011-08-09 Meiji Seika Kaisha, Ltd. Antibiotic pharmaceutical composition with improved oral absorbability
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
JP4493970B2 (ja) * 2002-10-16 2010-06-30 武田薬品工業株式会社 持続性製剤
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US8697094B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
EP1759692A3 (en) * 2003-03-10 2007-09-12 Novartis AG Taste-masked solid veterinary compositions
WO2004080439A1 (ja) 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 高濃度に活性成分を球形核に付着させた医薬組成物
KR101125268B1 (ko) 2003-06-06 2012-04-23 에띠팜 구강 분산성 다중층 정제
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US7838029B1 (en) 2003-07-31 2010-11-23 Watson Laboratories, Inc. Mirtazapine solid dosage forms
JP4601271B2 (ja) * 2003-08-01 2010-12-22 大洋薬品工業株式会社 圧縮成形製剤およびその製造方法
KR20080083071A (ko) 2003-08-08 2008-09-12 아지노모토 가부시키가이샤 나테글리니드 함유 제제
CN100563658C (zh) * 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
JP4767492B2 (ja) * 2003-12-25 2011-09-07 ライオン株式会社 高分子被覆粒子の製造方法、高分子被覆粒子、並びにこれを用いた圧縮成形品
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
EP1718303A4 (en) * 2004-02-10 2010-09-01 Santarus Inc COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG
WO2005084648A1 (en) * 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited Pharmaceutical compositions comprising candesartan cilexetil
CA2561700A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2005118166A2 (en) 2004-06-04 2005-12-15 Teva Pharmaceutical Industries, Ltd. Pharmaceutical composition containing irbesartan
WO2006037763A1 (en) * 2004-10-05 2006-04-13 Altana Pharma Ag Oral pharmaceutical preparation for proton pump antagonists
US20080095841A1 (en) * 2004-10-06 2008-04-24 Eisai R&D Management Co., Ltd. Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition
WO2006076097A2 (en) * 2004-12-07 2006-07-20 Nektar Therapeutics Stable non-crystalline formulation comprising losartan
JP2008528456A (ja) * 2005-01-26 2008-07-31 レツク・フアーマシユーテイカルズ・デー・デー 親油性結晶性物質としてカンデサルタンシレキセチルを含む新規な医薬組成物
AU2006233640B8 (en) * 2005-04-15 2011-01-06 Keme Food Engineering Ag Instant product
US20100016378A1 (en) * 2005-04-28 2010-01-21 Toshio Suzuki Method of preventing dihydropyridine compound from degradation
WO2006133349A2 (en) * 2005-06-08 2006-12-14 Alpharma, Inc. Orally disintegrable sleep aid formulations
JP5044398B2 (ja) * 2005-06-09 2012-10-10 武田薬品工業株式会社 固形製剤
KR100730393B1 (ko) * 2005-06-10 2007-06-20 한국콜마 주식회사 이부프로펜 및 아르기닌을 함유하는 약학 조성물의제조방법
CN101227894B (zh) * 2005-07-22 2013-01-09 田边三菱制药株式会社 口腔速崩片
AU2006273378B2 (en) * 2005-07-25 2011-10-13 Otsuka Pharmaceutical Co., Ltd. Oral preparation useful in measuring capacity to metabolize pyridine
US11311490B2 (en) * 2005-08-10 2022-04-26 Add Advanced Drug Delivery Technologies Ltd. Oral preparation with controlled release
CN101309917B (zh) * 2005-10-06 2013-09-11 奥斯拜客斯制药有限公司 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
DE202006020168U1 (de) * 2005-12-21 2008-07-17 Basf Se Pharmazeutische Formulierung für die Herstellung von schnell zerfallenden Tabletten
WO2007072992A2 (en) * 2005-12-22 2007-06-28 Takeda Pharmaceutical Company Limited Solid preparation containing an insulin sensitizer
CA2634232C (en) 2005-12-28 2013-08-20 Takeda Pharmaceutical Company Limited Method of producing solid preparation disintegrating in the oral cavity
CN101389316A (zh) 2005-12-28 2009-03-18 武田药品工业株式会社 控制释放固体制剂
JP3884056B1 (ja) * 2006-01-27 2007-02-21 秋山錠剤株式会社 口腔内速崩錠の製造方法
DE102006006588A1 (de) * 2006-02-13 2007-08-16 Ratiopharm Gmbh Schnell freisetzende Irbesartan-haltige pharmazeutische Zusammensetzung
CA2650498A1 (en) * 2006-03-31 2007-10-11 Rubicon Research Private Limited Orally disintegrating tablets
WO2007119771A1 (ja) * 2006-04-13 2007-10-25 Otsuka Pharmaceutical Co., Ltd. ディスペプシア診断検査薬
CL2007001194A1 (es) * 2006-04-27 2008-01-04 Takeda Pharmaceutical Preparacion farmaceutica solida que comprende particulas que comprenden (i) particulas de nucleo con excipiente y (ii) pioglitazona o una sal de la misma y un polimero soluble en acido, como copolimero de aminoalquil metacrilato e o dietilaminoacetato de polivinilacetal, ambos recubriendo el nucleo
TWI494134B (zh) * 2006-06-20 2015-08-01 Siegfried Generics Int Ag 含有坎地沙坦酯的組成物、錠劑和顆粒及該錠劑的製造方法
EP2043613A1 (en) * 2006-07-14 2009-04-08 Fmc Corporation Solid form
US20080031944A1 (en) * 2006-08-04 2008-02-07 Cima Labs Inc. Stabilization of lorazepam
MX2009001294A (es) * 2006-08-04 2009-05-21 Ethypharm Sa Granulo y tableta que se desintegra por vía oral que comprende oxicodona.
ATE462416T1 (de) 2006-08-04 2010-04-15 Ethypharm Sa Mehrschichtige im mund zerfallende tablette
BG109687A (bg) * 2006-09-26 2008-03-31 Иван ХРИСТОВ Антиастматично лекарствено средство
WO2008068727A2 (en) * 2006-12-06 2008-06-12 Ranbaxy Laboratories Limited Pharmaceutical composition comprising candesartan cilexetil
WO2008079342A2 (en) * 2006-12-21 2008-07-03 Mallinckrodt Inc. Composition of and method for preparing orally disintegrating tablets
TWI488658B (zh) * 2006-12-26 2015-06-21 Daiichi Sankyo Co Ltd 溶出性之改善方法
US9486446B2 (en) * 2006-12-28 2016-11-08 Takeda Pharmaceutical Company Limited Orally disintegrating solid preparation
WO2008094877A2 (en) * 2007-01-30 2008-08-07 Drugtech Corporation Compositions for oral delivery of pharmaceuticals
JP3967767B1 (ja) * 2007-02-08 2007-08-29 秋山錠剤株式会社 口腔内速崩錠の製造方法
KR20090119993A (ko) 2007-03-13 2009-11-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 구강내 붕괴정
US8679541B2 (en) 2007-03-14 2014-03-25 Particle Dynamics International, Llc Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals
US20080311162A1 (en) * 2007-05-16 2008-12-18 Olivia Darmuzey Solid form
US8685457B2 (en) * 2007-06-06 2014-04-01 Basf Se Pharmaceutical formulation for the production of rapidly disintegrating tablets
EP2164462B1 (de) * 2007-06-06 2017-05-31 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
US20100184785A1 (en) * 2007-06-06 2010-07-22 Basf Se Pharmaceutical formulation for the production of chewable tablets and lozenges
EP2164460B1 (de) * 2007-06-06 2017-08-09 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
WO2009022670A1 (ja) * 2007-08-10 2009-02-19 Takeda Pharmaceutical Company Limited 速崩壊性錠剤
US8323695B2 (en) * 2007-08-13 2012-12-04 Mcneil-Ppc, Inc. Method for stabilizing phenylephrine
US20100233278A1 (en) * 2007-09-27 2010-09-16 Akiko Ookawa Rapidly disintegrating solid preparation
DE102007052070A1 (de) 2007-10-30 2009-05-07 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Candesartancilexetil
ITMI20072226A1 (it) * 2007-11-23 2009-05-24 Chiesi Farma Spa Un metodo per determinare la purezza polimorfica di manidipina dicloridrato
BRPI0820997A2 (pt) * 2007-12-10 2014-12-23 Eurand Inc Comprimidos de desintegração oral compreendendo difenidramina.
EP2233129B1 (en) * 2007-12-28 2014-05-07 Sawai Pharmaceutical Co., Ltd. Oral cavity disintegrating tablet and method of producing the same
NO2254591T3 (es) 2008-02-08 2017-12-23
EP2254556A2 (en) 2008-03-11 2010-12-01 Takeda Pharmaceutical Company Limited Orally-disintegrating solid preparation
US8303868B2 (en) 2009-01-26 2012-11-06 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
US10653235B2 (en) * 2009-07-08 2020-05-19 Wayne R Solan Toothpaste droplets
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
GB201003734D0 (en) * 2010-03-05 2010-04-21 Univ Strathclyde Delayed prolonged drug delivery
JP5031054B2 (ja) 2010-03-18 2012-09-19 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース及びこれを含む固形製剤
CA2800251A1 (en) * 2010-05-25 2011-12-01 David Kossor Compositions and methods for reduction of mercury toxicity
US20120201886A1 (en) * 2010-07-30 2012-08-09 Micro Labs Limited Coated Extended Release Pharmaceutical Compositions Containing Paliperidone
CN102379854A (zh) * 2010-08-31 2012-03-21 扬子江药业集团北京海燕药业有限公司 盐酸马尼地平口服速释制剂及其制备方法
US8623978B2 (en) 2010-11-23 2014-01-07 Basf Se Process for the preparation of low-peroxide crosslinked vinyllactam polymer
JP2011046750A (ja) * 2010-12-09 2011-03-10 Mitsubishi Tanabe Pharma Corp 口腔内速崩壊性錠
TW201304823A (zh) 2010-12-27 2013-02-01 Takeda Pharmaceutical 口腔內崩壞錠
JP2012162467A (ja) * 2011-02-04 2012-08-30 Sawai Pharmaceutical Co Ltd カンデサルタンシレキセチル含有造粒物の製造方法及びカンデサルタンシレキセチル含有錠剤の製造方法
WO2012140561A1 (en) 2011-04-12 2012-10-18 Basf Se Oxidation-sensitive, low-peroxide polymer comprising at least one inorganic phosphorus compound
EP2511331A1 (de) 2011-04-12 2012-10-17 Basf Se Peroxidarmes Polymer enthaltend Phosphorverbindung
DE202011005055U1 (de) 2011-04-12 2011-09-12 Basf Se Peroxidarmes Polymer enthaltend Phosphorverbindung
US9023931B2 (en) 2011-04-12 2015-05-05 Basf Se Oxidation-sensitive, low-peroxide polymer comprising at least one inorganic phosphorus compound
WO2013081563A2 (en) 2011-10-24 2013-06-06 Mahmut Bilgic Stable tablet formulations
CN104080446B (zh) 2011-11-30 2018-06-29 武田药品工业株式会社 干包衣片
JP6352188B2 (ja) 2012-08-20 2018-07-04 大塚製薬株式会社 糖代謝能の測定方法及びそれに使用する組成物
EP2952187A4 (en) * 2013-01-30 2016-08-17 Sawai Seiyaku Kk PHARMACEUTICAL COMPOSITION WITH CANDESARTAN CILEXETIL
KR20210014204A (ko) 2013-03-15 2021-02-08 오츠카 세이야쿠 가부시키가이샤 지방산 연소에 의한 인슐린 저항성의 측정 방법, 및 그에 사용하는 조성물
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
TW201532635A (zh) 2013-05-21 2015-09-01 Takeda Pharmaceutical 口腔內崩解錠
JP6238921B2 (ja) * 2014-02-17 2017-11-29 大原薬品工業株式会社 イルベサルタンを含有する錠剤
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
CA2962959C (en) * 2014-10-08 2023-04-04 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
JP6340325B2 (ja) * 2014-12-29 2018-06-06 沢井製薬株式会社 ナフトピジル含有口腔内崩壊錠
WO2016118515A1 (en) 2015-01-20 2016-07-28 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
US9744135B2 (en) 2015-02-27 2017-08-29 Deseret Laboratories, Inc. Fast disintegrating compositions and tablets thereof
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP7198575B2 (ja) * 2017-07-11 2023-01-04 キョーリンリメディオ株式会社 メマンチン塩酸塩含有口腔内崩壊錠
FR3099881B1 (fr) 2019-08-13 2022-08-26 Ethypharm Sa Comprimé orodispersible d’opioide à faible dosage et son procédé de préparation.
CN111012755A (zh) * 2020-01-09 2020-04-17 仁和堂药业有限公司 维生素b6片的制备工艺
JP7511596B2 (ja) * 2021-03-10 2024-07-05 日本ジェネリック株式会社 リバーロキサバン含有錠剤

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
JPS5411226A (en) 1977-06-24 1979-01-27 Shin Etsu Chem Co Ltd Disintegratable granule
SE8404808L (sv) 1983-10-03 1985-04-04 Avner Rotman Mikrokapslat lekemedel i sot matris
US4749575A (en) * 1983-10-03 1988-06-07 Bio-Dar Ltd. Microencapsulated medicament in sweet matrix
US4612345A (en) * 1985-02-28 1986-09-16 The Dow Chemical Company Hydroxypropyl methyl cellulose ethers useful as suspending agents for suspension polymerization of vinyl chloride
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
SE450087B (sv) 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
US5433959A (en) * 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
CA1327010C (en) 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5030447A (en) 1988-03-31 1991-07-09 E. R. Squibb & Sons, Inc. Pharmaceutical compositions having good stability
JPH0720858B2 (ja) 1988-04-19 1995-03-08 三菱化学株式会社 被覆固形薬剤
JPH0723304B2 (ja) 1988-04-19 1995-03-15 三菱化学株式会社 薬剤成分固定化組成物
US4910023A (en) 1988-06-09 1990-03-20 Warner-Lambert Company Drug in combination with flavor masking agent and method for making same
JPH0819003B2 (ja) * 1988-09-27 1996-02-28 武田薬品工業株式会社 有核顆粒およびその製造法
CA1338596C (en) * 1988-09-27 1996-09-17 Hiroyoshi Koyama Granules having core and their production
GB8824392D0 (en) 1988-10-18 1988-11-23 Ciba Geigy Ag Dispersible formulation
IT1238072B (it) 1990-01-19 1993-07-03 Sclavo Spa Composizioni farmaceutiche e forme di dosaggio per la somministrazione orale di calcitonina
EP0452862B1 (en) 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Spherical seed cores, spherical granules and process for production thereof
JPH0466538A (ja) 1990-07-04 1992-03-02 Suntory Ltd 抗潰瘍剤
US5316772A (en) 1990-12-19 1994-05-31 Solvay & Cie, S.A. (Societe Anonyme) Bilayered oral pharmaceutical composition with pH dependent release
JP2820829B2 (ja) 1991-03-07 1998-11-05 武田薬品工業株式会社 有核散剤およびその製造方法
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
JP2682353B2 (ja) * 1991-11-20 1997-11-26 武田薬品工業株式会社 経口用医薬組成物およびその製造法
US5200194A (en) * 1991-12-18 1993-04-06 Alza Corporation Oral osmotic device
JP3069458B2 (ja) 1992-01-29 2000-07-24 武田薬品工業株式会社 口腔内崩壊型錠剤およびその製造法
JPH05310558A (ja) 1992-05-07 1993-11-22 Lion Corp 固形製剤組成物
JP3059004B2 (ja) 1992-09-18 2000-07-04 ダイセル化学工業株式会社 アルカリ水溶液に対する溶解性の高い低置換度ヒドロキシプロピルセルロース及びその製造法
JP2647338B2 (ja) * 1993-02-10 1997-08-27 武田薬品工業株式会社 素錠およびその製造方法
JPH06305962A (ja) 1993-04-21 1994-11-01 Taisho Pharmaceut Co Ltd アトピー性皮膚炎治療剤
JP3502951B2 (ja) 1993-07-06 2004-03-02 大正製薬株式会社 高脂血症治療剤
IL110376A (en) 1993-08-02 1998-08-16 Bristol Myers Squibb Co Pharmaceutical compositions containing ifetroban salts and methods for the preparation thereof
DE69430921T2 (de) 1993-10-12 2003-02-13 Mitsubishi Pharma Corp., Osaka Darmlösliche grannulatkörner enthaltende tablette
US5549911A (en) * 1994-01-14 1996-08-27 Laboratoires Des Produits Ethiques Ethypharm Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract
TW391880B (en) * 1994-01-31 2000-06-01 Yamanouchi Pharma Co Ltd An oral soluble type compression moulding and its preparation
US5380234A (en) * 1994-05-25 1995-01-10 Ledford; Kevin D. Inflatable and deflatable combatant action toy
SE9402431D0 (sv) 1994-07-08 1994-07-08 Astra Ab New tablet formulation
JPH0827033A (ja) 1994-07-14 1996-01-30 Nikken Chem Co Ltd エリスリトール含有固形剤
SE9500422D0 (sv) 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
US20010003751A1 (en) * 1995-02-22 2001-06-14 Terashita Zen-Ichi Pharmaceutical composition for treating transient ischemic attack
SE9501881D0 (sv) * 1995-05-19 1995-05-19 Astra Ab New pharmacological use of AII-receptor antagonists
JPH08310969A (ja) 1995-05-22 1996-11-26 Lion Corp 固形薬品組成物及びその製造方法
US5658583A (en) 1995-07-28 1997-08-19 Zhang; Jie Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
JPH0948726A (ja) 1995-08-07 1997-02-18 Tanabe Seiyaku Co Ltd 口腔内速崩壊性製剤およびその製法
JPH0971523A (ja) 1995-09-07 1997-03-18 Riyuukakusan:Kk 口腔内で崩壊性の速い錠剤
US5824339A (en) 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600072D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients II
SE512835C2 (sv) * 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
SE9600071D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients I
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
TW473393B (en) * 1996-02-29 2002-01-21 Fujisawa Pharmaceutical Co Beta-lactam antibiotic-containing tablet and production thereof
EP0799616A1 (en) 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
PT914818E (pt) 1996-06-14 2005-08-31 Kyowa Hakko Kogyo Kk Comprimido de desintegracao rapida por via intraoral
RU2189227C2 (ru) * 1996-07-12 2002-09-20 Дайити Фармасьютикал Ко., Лтд. Быстро распадающиеся прессованные в формах материалы и способ их получения
EP0839526A3 (en) * 1996-10-31 1999-01-07 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with fast buccal disintegration or dissolution
PT1586314E (pt) * 1996-11-15 2011-07-01 Ajinomoto Kk Composição de comprimidos de nateglinida
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
JP3718341B2 (ja) * 1998-05-12 2005-11-24 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロースとその製造方法
PT1121103E (pt) 1998-05-18 2007-02-28 Takeda Pharmaceutical Comprimidos de desintegração oral compreendendo um benzimidazole
ES2237121T3 (es) * 1998-07-28 2005-07-16 Takeda Pharmaceutical Company Limited Preparacion solida disgregable rapidamente.
US6531152B1 (en) * 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system

Also Published As

Publication number Publication date
ZA200100285B (en) 2002-01-10
DK1561458T3 (da) 2010-10-25
JP4573397B2 (ja) 2010-11-04
TWI257311B (en) 2006-07-01
EP1561458B1 (en) 2010-09-15
TW585786B (en) 2004-05-01
PT1100469E (pt) 2005-06-30
EP1561458A1 (en) 2005-08-10
ES2347968T3 (es) 2010-11-26
CA2338792A1 (en) 2000-02-10
JP2010132709A (ja) 2010-06-17
MY154010A (en) 2015-04-30
CY1110988T1 (el) 2015-06-11
JP3404648B2 (ja) 2003-05-12
DK1100469T3 (da) 2005-04-18
CA2525555A1 (en) 2000-02-10
AU4802099A (en) 2000-02-21
KR20010071026A (ko) 2001-07-28
PT1561458E (pt) 2010-10-11
US20070254031A1 (en) 2007-11-01
DE69942777D1 (de) 2010-10-28
HK1035501A1 (en) 2001-11-30
CA2581111A1 (en) 2000-02-10
DE69924381D1 (de) 2005-04-28
US7070805B2 (en) 2006-07-04
US20060182802A1 (en) 2006-08-17
ATE291418T1 (de) 2005-04-15
EP1100469B1 (en) 2005-03-23
CN1149077C (zh) 2004-05-12
EP1100469A1 (en) 2001-05-23
SI1100469T1 (es) 2005-08-31
AR019935A1 (es) 2002-03-27
US20010010825A1 (en) 2001-08-02
JP2000103731A (ja) 2000-04-11
US7399485B1 (en) 2008-07-15
HK1077742A1 (en) 2006-02-24
KR100536783B1 (ko) 2005-12-14
ATE481090T1 (de) 2010-10-15
MY151098A (en) 2014-04-15
CA2338792C (en) 2006-01-17
TW200302742A (en) 2003-08-16
CN1310613A (zh) 2001-08-29
JP2000344660A (ja) 2000-12-12
WO2000006126A1 (en) 2000-02-10
DE69924381T2 (de) 2006-04-20
ES2237121T3 (es) 2005-07-16

Similar Documents

Publication Publication Date Title
AR019935A1 (es) Preparacion solida de desintegracion rapida, uso de una hidroxipropil celulosa poco sustituida en dicha preparacion y metodo para mejorar la capacidad dedesintegracion rapida de la misma
ES2177346T3 (es) Formulaciones de ranolazina de liberacion lenta.
AR059324A2 (es) Una forma solida de dosificacion oral
ATE311227T1 (de) Schnell-wirkende, gefrier-trocknete, orale, pharmazeutische formulierung für die behandlung von migräne
BR0109779A (pt) Soluções moleculares hidrofìlicas dispersas de carvedilol
UY24308A1 (es) Tabletas exentas de aglutinante que contienen tramadol o una sal de tramadol, para administracion oral
AR084101A2 (es) Comprimido de carga de droga alta y proceso para su preparacion
IT1276689B1 (it) Forma farmaceutica solida ad uso orale
EE05022B1 (et) Eelthelatineeritud tärklise kasutamine hüdrofiilses kontrollitud vabanemisega preparaadis ja hüdrofiilne kontrollitud vabanemisega preparaat
BR0014142A (pt) Composição de vacina e método de empregar a mesma
CO5160287A1 (es) Formulacion de liberacion controlada de divalproex sodico
ES2195638T3 (es) Preparaciones de combinaciones farmaceuticas en forma solida de dosificacion que contienen cardevilol e hidroclorotiazida.
KR920003971A (ko) 점안액 조성물
CO5070643A1 (es) Formulacion en tabletas comprimidas
BR0213522B1 (pt) compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
EA200000487A1 (ru) Композиция пролонгированного высвобождения
EE05054B1 (et) 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis
CO4940406A1 (es) Composiciones de paracetamol de accion rapida
BR0116060A (pt) Composição farmacêutica de dronedarona para administração parenteral
BR9916887A (pt) Uso de derivados de pirimidina
BR0317623A (pt) Escitalopram, composição farmacêutica, e, uso de hidrobrometo de escitalopram
ATE331502T1 (de) 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure enthaltende direktkomprimierte tablette
HRP20050342B1 (hr) Farmaceutska formulacija olanzapina
HRP20080255A2 (hr) Upotreba cikletanina i drugih furopiridina za liječenje pretežno sistolsne hipertenzije, izolirane sistolne hipertenzije, povišenog pulsnog tlaka i opće hipertenzije
AR019981A1 (es) Una composicion farmaceutica de liberacion sostenida solida, y un procedimiento para preparar una forma de dosificacion solida.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal