AR240833A1 - Metodo para preparar derivados de 6-o-metil-eritromicina a por metilacion selectiva de derivados 6-hidroxi de eritromicina a. - Google Patents

Metodo para preparar derivados de 6-o-metil-eritromicina a por metilacion selectiva de derivados 6-hidroxi de eritromicina a.

Info

Publication number: AR240833A1
Authority: AR; Argentina
Prior art keywords: erythromycin; derivatives; methyl; preparing; selective methylation
Prior art date: 1984-04-06

Application number

AR299984A

Other languages

English (en)

Spanish (es)

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-06

Filing date

1985-04-03

Publication date

1991-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR240833(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-04-03 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1991-02-28 Application granted granted Critical

1991-02-28 Publication of AR240833A1 publication Critical patent/AR240833A1/es

Links

229930006677 Erythromycin A Natural products 0.000 title 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title 1
229960003276 erythromycin Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011935 selective methylation Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AR299984A 1984-04-06 1985-04-03 Metodo para preparar derivados de 6-o-metil-eritromicina a por metilacion selectiva de derivados 6-hidroxi de eritromicina a. AR240833A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59068509A JPS60214796A (ja)	1984-04-06	1984-04-06	６−０−メチルエリスロマイシン類の製法

Publications (1)

Publication Number	Publication Date
AR240833A1 true AR240833A1 (es)	1991-02-28

Family

ID=13375748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR299984A AR240833A1 (es)	1984-04-06	1985-04-03	Metodo para preparar derivados de 6-o-metil-eritromicina a por metilacion selectiva de derivados 6-hidroxi de eritromicina a.

Country Status (17)

Country	Link
US (1)	US4672109A (de)
EP (1)	EP0158467B1 (de)
JP (1)	JPS60214796A (de)
KR (1)	KR910007572B1 (de)
AR (1)	AR240833A1 (de)
AT (1)	ATE44384T1 (de)
AU (1)	AU567803B2 (de)
CA (1)	CA1225637A (de)
DE (1)	DE3571323D1 (de)
DK (1)	DK172481B1 (de)
ES (1)	ES8602839A1 (de)
FI (1)	FI77250C (de)
GE (1)	GEP19960318B (de)
HK (1)	HK99694A (de)
PT (1)	PT80237B (de)
SU (1)	SU1577700A3 (de)
ZA (1)	ZA852349B (de)

Families Citing this family (57)

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JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
EP0201166B1 (de)	1985-03-12	1990-02-07	Beecham Group Plc	Erythromycin-Derivate
GB8506380D0 (en) *	1985-03-12	1985-04-11	Beecham Group Plc	Chemical compounds
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JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
DE3782994T2 (de) *	1986-09-18	1993-04-08	Taisho Pharma Co Ltd	Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) *	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives
IT1276901B1 (it) *	1994-12-13	1997-11-03	Zambon Spa	Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
US5756473A (en) *	1995-11-21	1998-05-26	Abbott Laboratories	6-O-methyl erythromycin D and process for making
US5872229A (en) *	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) *	1996-04-02	1998-02-17	Abbott Laboratories	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) *	1996-04-10	1998-09-15	Abbott Laboratories	Process for preparing erythromycin A oxime
US5858986A (en) *	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
PT915899E (pt)	1996-07-29	2004-11-30	Abbott Lab	Preparacao da forma cristalina ii da eritromicina
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
US5864023A (en) *	1997-02-13	1999-01-26	Abbott Laboratories	3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) *	1997-09-10	1999-07-27	Abbott Laboratories	9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) *	1997-11-17	1998-12-22	Abbott Laboratories	Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en)	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) *	1997-12-01	2001-05-20	Abbott Lab	6-o-alkyl derivatives of erythronolide b
IL124084A0 (en) *	1998-04-14	1999-04-11	Chemagis Ltd	Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) *	1998-07-15	1999-03-12	Chemagis Ltd	Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) *	1998-12-29	2001-03-02	민경윤	에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) *	1999-02-19	2000-08-31	Lek, Tovarna Farmacevtskih In	Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) *	1999-07-01	2001-02-05	유충식	6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
CZ20021999A3 (cs) *	1999-12-16	2003-02-12	Teva Pharmaceutical Industries Ltd.	Způsob přípravy klaritromycinových polymorfních forem a nového polymorfu IV
CA2397092A1 (en)	2000-01-11	2001-07-19	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
WO2001064224A1 (en)	2000-02-29	2001-09-07	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
DE60122791T2 (de) *	2000-03-15	2007-10-04	Hanmi Pharm. Co., Ltd.	Verfahren zur Herstellung von Clarythromycin mit nicht pharmazeutischer Qualität
ES2217153T3 (es)	2000-05-15	2004-11-01	Ranbaxy Laboratories, Ltd.	Procedimiento eficaz en coste para la metilacion selectiva de derivados de eritromicina a.
AU2001280000A1 (en) *	2000-08-23	2002-03-04	Jaweed Mukarram, Siddiqui Mohammed	Process for preparation of anhydrous azithromycin
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
BR0308989A (pt) *	2002-04-03	2005-01-04	Ranbaxy Lab Ltd	Formulações de claritromicina com biodisponibilidade aperfeiçoada e processo de preparação das mesmas
US6843854B2 (en)	2002-05-31	2005-01-18	Purdue Research Foundation	Method and apparatus for separating a component from a mixture
ES2221807B1 (es) *	2003-06-24	2005-12-16	Ercros Industrial, S.A.	Un procedimiento para la obtencion de claritromicina.
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
CA2533178C (en)	2003-07-21	2014-03-11	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
JP2006528190A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
WO2005016311A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
AU2004264356B2 (en)	2003-08-12	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP5686494B2 (ja)	2003-08-29	2015-03-18	シオノギインコーポレイテッド	抗生物質製剤、その使用法及び作成方法
EP1663169A4 (de)	2003-09-15	2010-11-24	Middlebrook Pharmaceuticals In	Antibiotisches produkt, seine verwendung und formulierung
WO2006014427A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US20060111560A1 (en) *	2004-11-01	2006-05-25	Glenmark Pharmaceuticals Limited	Process for the preparation of crystalline form II of clarithromycin
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
JP5126685B2 (ja)	2006-05-01	2013-01-23	大正製薬株式会社	マクロライド誘導体
US8299052B2 (en) *	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

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Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) *	1978-01-03	1979-09-04	Pfizer Inc.	4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) *	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS5896095A (ja) *	1981-11-30	1983-06-07	Taisho Pharmaceut Co Ltd	１１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) *	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS5896098A (ja) *	1981-12-03	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンａ誘導体
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) *	1984-08-31	1985-12-31	Abbott Lab	Macrolide alkylation process

1984
- 1984-04-06 JP JP59068509A patent/JPS60214796A/ja active Granted
1985
- 1985-03-22 AT AT85301997T patent/ATE44384T1/de not_active IP Right Cessation
- 1985-03-22 DE DE8585301997T patent/DE3571323D1/de not_active Expired
- 1985-03-22 EP EP85301997A patent/EP0158467B1/de not_active Expired
- 1985-03-26 CA CA000477464A patent/CA1225637A/en not_active Expired
- 1985-03-26 AU AU40378/85A patent/AU567803B2/en not_active Expired
- 1985-03-28 ZA ZA852349A patent/ZA852349B/xx unknown
- 1985-04-02 ES ES541898A patent/ES8602839A1/es not_active Expired
- 1985-04-03 DK DK198501523A patent/DK172481B1/da not_active IP Right Cessation
- 1985-04-03 AR AR299984A patent/AR240833A1/es active
- 1985-04-04 FI FI851376A patent/FI77250C/fi not_active IP Right Cessation
- 1985-04-04 PT PT80237A patent/PT80237B/pt unknown
- 1985-04-05 SU SU853878949A patent/SU1577700A3/ru active
- 1985-04-05 US US06/720,383 patent/US4672109A/en not_active Expired - Lifetime
- 1985-04-06 KR KR1019850002325A patent/KR910007572B1/ko not_active Expired
1993
- 1993-07-28 GE GEAP19931269A patent/GEP19960318B/en unknown
1994
- 1994-09-15 HK HK99694A patent/HK99694A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR910007572B1 (ko)	1991-09-28
ZA852349B (en)	1985-11-27
AU4037885A (en)	1985-10-10
GEP19960318B (en)	1996-06-24
PT80237B (pt)	1987-06-17
US4672109A (en)	1987-06-09
CA1225637A (en)	1987-08-18
JPS60214796A (ja)	1985-10-28
ES541898A0 (es)	1985-12-01
AU567803B2 (en)	1987-12-03
ES8602839A1 (es)	1985-12-01
FI77250B (fi)	1988-10-31
EP0158467A3 (en)	1986-03-19
EP0158467B1 (de)	1989-07-05
ATE44384T1 (de)	1989-07-15
PT80237A (en)	1985-05-01
DK172481B1 (da)	1998-11-23
DE3571323D1 (en)	1989-08-10
HK99694A (en)	1994-09-23
DK152385A (da)	1985-10-07
JPH053475B2 (de)	1993-01-14
SU1577700A3 (ru)	1990-07-07
EP0158467A2 (de)	1985-10-16
FI851376L (fi)	1985-10-07
DK152385D0 (da)	1985-04-03
FI851376A0 (fi)	1985-04-04
KR850007434A (ko)	1985-12-04
FI77250C (fi)	1989-02-10

Publication	Publication Date	Title
AU567803B2 (en)	1987-12-03	A method for selective methylation of erythromycin a derivatives
ES553048A0 (es)	1987-11-16	Un metodo para la metilacion selectiva del grupo hidroxi de la posicion 6 de derivados de eritromicina a
FI900087L (fi)	1990-01-08	Menetelmä atsitromysiinidihydraatin valmistamiseksi
PT80870B (pt)	1987-09-18	Processo para a preparacao de derivados de 1-aril-5h-2,3-benzodiazepina
IL82005A (en)	1991-08-16	Process for preparing tylosin derivatives
ES539349A0 (es)	1986-04-01	Un metodo para la preparacion del compuesto antibiotico, estearato de acetil-eritromicina
ES546048A0 (es)	1986-10-01	Un procedimiento para producir derivados de propargiloxiacetonitrilo sustituido.
KR860005574A (ko)	1986-07-23	뉴클레오시드 유도체의 제조방법
ES549180A0 (es)	1987-07-16	Un metodo para preparar nuevos derivados de cefem
ES546060A0 (es)	1987-06-16	Un procedimiento para preparar un derivado de uridina.
DK96983D0 (da)	1983-02-28	Fremgangsmade til fremstilling af 9-dihydro-11,12-ketalderivater af erythromycin a eller epi-erythromycin a
ES524475A0 (es)	1984-07-16	Procedimiento para preparar derivados de dibenzo(de,g)quinoleina
ES550467A0 (es)	1987-03-01	Un metodo para preparar derivados de 9-bencilpurina
KR860004919A (ko)	1986-07-16	뉴클레오시드 유도체의 제조방법
MX171122B (es)	1993-10-01	Proceso mejorado para recuperacion de alcoholes
MX160841A (es)	1990-05-30	Procedimiento para preparar derivados de ciclopropano
ES555459A0 (es)	1987-12-01	Procedimiento para preparar derivados de saframicina a.
ES541594A0 (es)	1987-07-16	Procedimiento para preparar derivados de ciclopropano
FI821514A7 (fi)	1982-11-02	Menetelmä liikajännitteisyyttä vastustavien kromonijohdannaisten valmistamiseksi.
ES549095A0 (es)	1987-01-16	Un metodo para producir derivados de bromodicloroimidazol.
ES529582A0 (es)	1985-08-01	Metodo de preparar 11, 12-carbonato ciclico de eritromicina a
ES539846A0 (es)	1987-05-01	Un procedimiento para preparar derivados de benzopirano.
ES554602A0 (es)	1987-04-16	Procedimiento para preparar derivados de 3,4-diazol
ES557095A0 (es)	1987-12-16	Metodo para preparar derivados de estireno substituido
FI853969A7 (fi)	1986-04-13	Menetelmä uusien, herpeksen vastaisia ominaisuuksia omaavien nukleosidijohdannaisten valmistamiseksi.