AR246745A1 - Procedimiento para preparar nuevos derivados de 1,4-di-desoxi-1,4-imino-d-arabinitol, sus isomeros opticos y geometricos y sus sales farmaceuticamente aceptables. - Google Patents

Procedimiento para preparar nuevos derivados de 1,4-di-desoxi-1,4-imino-d-arabinitol, sus isomeros opticos y geometricos y sus sales farmaceuticamente aceptables.

Info

Publication number
AR246745A1
AR246745A1 AR90318034A AR31803490A AR246745A1 AR 246745 A1 AR246745 A1 AR 246745A1 AR 90318034 A AR90318034 A AR 90318034A AR 31803490 A AR31803490 A AR 31803490A AR 246745 A1 AR246745 A1 AR 246745A1
Authority
AR
Argentina
Prior art keywords
glycosyl
compound
procedure
optical
eterified
Prior art date
Application number
AR90318034A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of AR246745A1 publication Critical patent/AR246745A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA (I) SUS ISOMEROS OPTICOS Y GEOMETRICOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE N ES CERO, UNO O DOS, R ES UN RADICAL GLICOSILO O UNRADICAL GLICOSILO ETERIFICADO O ACILADO QUE CONTIENE DE 1 A 3 UNIDADES DE HEXOSA O PENTOSA, CONTENIENDO DICHO RADICAL GLICOSILO ETERIFICADO O ACILADO EL RESTO ETER O ACILO EN EL GRUPO HIDROXI LOCALIZADO EN EL ATOMO DE CARBONO ANOMERICO, QUE COMPRENDE CONDENSAR UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), DONDE X ES UN HALURO O TRIFLATO, N ES CERO, UNO O DOS, R' ES UNRADICAL GLICOSILO HIDROXI-PROTEGIDO O UN RADICAL GLICOSILO ETERIFICADO O ACILADO DE 1 A 3, HEXOSAS O PENTOSAS, CONTENIENDO DICHO RADICAL GLICOSILO ETERIFICADO O ACILADO EL RESTO ETER O ACILO EN EL GRUPO HIDROXILO LOCALIZADO EN EL ATOMO DE CARBONO ANOMERICO PARA PRODUCIR UN COMPUESTO DE FORMULA (IV), COMPUESTO QUE SE DESPROTEGE POR TECNICA DE DESPROTECCION CONVENCIONALES, SEGUIDO DE UNA CONVERSION OPCIONAL ENÑ UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE.
AR90318034A 1989-10-10 1990-10-09 Procedimiento para preparar nuevos derivados de 1,4-di-desoxi-1,4-imino-d-arabinitol, sus isomeros opticos y geometricos y sus sales farmaceuticamente aceptables. AR246745A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89402794A EP0422307A1 (en) 1989-10-10 1989-10-10 Novel alpha-glucosidase inhibitors

Publications (1)

Publication Number Publication Date
AR246745A1 true AR246745A1 (es) 1994-09-30

Family

ID=8202997

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90318034A AR246745A1 (es) 1989-10-10 1990-10-09 Procedimiento para preparar nuevos derivados de 1,4-di-desoxi-1,4-imino-d-arabinitol, sus isomeros opticos y geometricos y sus sales farmaceuticamente aceptables.

Country Status (21)

Country Link
US (1) US5097023A (es)
EP (2) EP0422307A1 (es)
JP (1) JP3032266B2 (es)
KR (1) KR0183012B1 (es)
CN (1) CN1029974C (es)
AR (1) AR246745A1 (es)
AT (1) ATE109153T1 (es)
AU (1) AU632855B2 (es)
CA (1) CA2027276C (es)
DE (1) DE69011033T2 (es)
DK (1) DK0422975T3 (es)
ES (1) ES2060980T3 (es)
FI (1) FI101796B (es)
HU (1) HU209724B (es)
IE (1) IE64079B1 (es)
IL (1) IL95928A (es)
NO (1) NO174203C (es)
NZ (1) NZ235578A (es)
PT (1) PT95547B (es)
TW (1) TW225539B (es)
ZA (1) ZA907936B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5268364A (en) * 1991-12-12 1993-12-07 The Biomembrane Institute Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
US5843921A (en) 1994-03-15 1998-12-01 Childrens Hospital Of Los Angeles Therapeutic food composition and method to diminish blood sugar fluctuations
US5605893A (en) * 1994-03-15 1997-02-25 Children's Hospital Of Los Angeles Method of using a therapeutic food composition to diminish blood sugar fluctuations in diabetic patients
JP3580900B2 (ja) * 1995-04-20 2004-10-27 ホクレン農業協同組合連合会 α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料
US5929037A (en) * 1995-06-07 1999-07-27 Alberta Research Council Modified α-D-Glcρ-(1-2)-α-D-Glcρ-(1-3)-α-D-Glcρ-analogues
AU724003B2 (en) * 1995-09-08 2000-09-07 Novo Nordisk A/S 2-alkylpyrrolidines
AU4335997A (en) * 1996-09-09 1998-03-26 Wisconsin Alumni Research Foundation Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity
US6534487B1 (en) 1999-08-03 2003-03-18 Childrens Hospital Los Angeles Methods for suppressing appetite and enhancing exercise and recovery
AU1894901A (en) * 1999-12-21 2001-07-03 Ajinomoto Co., Inc. Partial ester of cellulose with nitrogenous carboxylic acid and process for producing the same
JP4486792B2 (ja) * 2003-06-12 2010-06-23 学校法人近畿大学 環状オニウム化合物およびグルコシダーゼ阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.

Also Published As

Publication number Publication date
PT95547A (pt) 1991-08-14
IE64079B1 (en) 1995-07-12
CA2027276C (en) 2000-05-16
NO174203B (no) 1993-12-20
AU6375690A (en) 1991-04-18
KR0183012B1 (ko) 1999-04-01
IL95928A (en) 1994-08-26
DE69011033T2 (de) 1994-11-17
NO174203C (no) 1994-04-06
AU632855B2 (en) 1993-01-14
EP0422307A1 (en) 1991-04-17
NO904372L (no) 1991-04-11
FI101796B1 (fi) 1998-08-31
PT95547B (pt) 1998-02-27
IE903613A1 (en) 1991-04-24
JP3032266B2 (ja) 2000-04-10
CN1029974C (zh) 1995-10-11
TW225539B (es) 1994-06-21
FI904965A0 (fi) 1990-10-09
ZA907936B (en) 1991-08-28
HU906389D0 (en) 1991-04-29
CN1050879A (zh) 1991-04-24
HUT55402A (en) 1991-05-28
HU209724B (en) 1994-10-28
IL95928A0 (en) 1991-07-18
ES2060980T3 (es) 1994-12-01
NZ235578A (en) 1992-10-28
DE69011033D1 (de) 1994-09-01
ATE109153T1 (de) 1994-08-15
JPH03127797A (ja) 1991-05-30
FI101796B (fi) 1998-08-31
NO904372D0 (no) 1990-10-09
KR910007951A (ko) 1991-05-30
EP0422975B1 (en) 1994-07-27
CA2027276A1 (en) 1991-04-11
EP0422975A1 (en) 1991-04-17
DK0422975T3 (da) 1994-08-22
US5097023A (en) 1992-03-17

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