AT393959B - Verfahren zur erhoehung der stabilitaet von anthralin enthaltenden waessrigen zusammensetzungen - Google Patents

Verfahren zur erhoehung der stabilitaet von anthralin enthaltenden waessrigen zusammensetzungen Download PDF

Info

Publication number: AT393959B
Authority: AT; Austria
Prior art keywords: anthralin; water; weight; oil; stability
Prior art date: 1983-06-09

Application number

AT0189784A

Other languages

German (de)

English (en)

Other versions

ATA189784A (de

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-09

Filing date

1984-06-08

Publication date

1992-01-10

1984-06-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1991-07-15 Publication of ATA189784A publication Critical patent/ATA189784A/de

1992-01-10 Application granted granted Critical

1992-01-10 Publication of AT393959B publication Critical patent/AT393959B/de

Links

239000000203 mixture Substances 0.000 title claims description 64
238000000034 method Methods 0.000 title claims description 18
230000001965 increasing effect Effects 0.000 title claims description 4
NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 claims description 99
229960002311 dithranol Drugs 0.000 claims description 99
239000004094 surface-active agent Substances 0.000 claims description 26
239000000499 gel Substances 0.000 claims description 20
238000011282 treatment Methods 0.000 claims description 20
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 19
239000003963 antioxidant agent Substances 0.000 claims description 19
235000006708 antioxidants Nutrition 0.000 claims description 19
-1 sulfonyl fatty acids Chemical class 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
201000004681 Psoriasis Diseases 0.000 claims description 16
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 16
239000003921 oil Substances 0.000 claims description 13
125000000129 anionic group Chemical group 0.000 claims description 12
230000003078 antioxidant effect Effects 0.000 claims description 12
239000006071 cream Substances 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 10
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DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 9
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OXLXSOPFNVKUMU-UHFFFAOYSA-N 1,4-dioctoxy-1,4-dioxobutane-2-sulfonic acid Chemical class CCCCCCCCOC(=O)CC(S(O)(=O)=O)C(=O)OCCCCCCCC OXLXSOPFNVKUMU-UHFFFAOYSA-N 0.000 claims description 3
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DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 3
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SPCNPOWOBZQWJK-UHFFFAOYSA-N dimethoxy-(2-propan-2-ylsulfanylethylsulfanyl)-sulfanylidene-$l^{5}-phosphane Chemical compound COP(=S)(OC)SCCSC(C)C SPCNPOWOBZQWJK-UHFFFAOYSA-N 0.000 description 2
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CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
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229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 description 1
DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229940098760 steareth-2 Drugs 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229940029614 triethanolamine stearate Drugs 0.000 description 1
229960004418 trolamine Drugs 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT0189784A 1983-06-09 1984-06-08 Verfahren zur erhoehung der stabilitaet von anthralin enthaltenden waessrigen zusammensetzungen AT393959B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US50285283A	1983-06-09	1983-06-09

Publications (2)

Publication Number	Publication Date
ATA189784A ATA189784A (de)	1991-07-15
AT393959B true AT393959B (de)	1992-01-10

Family

ID=23999686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0189784A AT393959B (de)	1983-06-09	1984-06-08	Verfahren zur erhoehung der stabilitaet von anthralin enthaltenden waessrigen zusammensetzungen

Country Status (21)

Country	Link
JP (1)	JPS608222A (fr)
AT (1)	AT393959B (fr)
AU (1)	AU569085B2 (fr)
BE (1)	BE899874A (fr)
CH (1)	CH659945A5 (fr)
CY (1)	CY1531A (fr)
DE (1)	DE3421510A1 (fr)
DK (1)	DK163028C (fr)
ES (1)	ES8707107A1 (fr)
FI (1)	FI83837C (fr)
FR (1)	FR2547725B1 (fr)
GB (1)	GB2142534B (fr)
HK (1)	HK66490A (fr)
IE (1)	IE57562B1 (fr)
IT (1)	IT1183058B (fr)
LU (1)	LU85411A1 (fr)
NO (1)	NO171623C (fr)
NZ (1)	NZ208338A (fr)
OA (1)	OA07720A (fr)
PT (1)	PT78713A (fr)
SE (1)	SE465205B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4551480A (en) *	1983-06-21	1985-11-05	Stiefel Laboratories, Inc.	Compositions for the treatment of psoriasis
DE3413569A1 (de) *	1984-04-11	1985-10-24	Röhm Pharma GmbH, 6108 Weiterstadt	Pharmazeutisches mittel zur psoriasis-therapie
GB8729855D0 (en) *	1987-12-22	1988-02-03	Drythanol Ltd	New dithranol compositions
AT408067B (de) *	1995-03-17	2001-08-27	Gebro Pharma Gmbh	Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2526321A1 (fr) *	1982-05-10	1983-11-10	Salomon & Fils F	Frein de ski
AT384745B (de) *	1980-03-07	1987-12-28	Unger Paul	Skibremse

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1070949A (en) *	1964-10-16	1967-06-07	Hyman Yarrow	Topical compositions for the treatment of psoriasis
GB1574090A (en) *	1977-07-06	1980-09-03	Drythanol Ltd	Dithranol composition for the treatment of psoriasis
CA1179271A (fr) *	1981-10-23	1984-12-11	Jean-Francois Grollier	Composition epaissie anhydre, stable a l'oxydation, a base d'anthraline ou de l'un de ses derives dans un support constitue d'un alkyl ester d'acide gras et d'un agent epaississant, et son utilisation dans le traitement des maladies de la peau
FR2520233A1 (fr) *	1982-01-28	1983-07-29	Oreal	Composition d'anthraline ou de l'un de ses derives dans un ester aromatique et son utilisation dans le traitement des maladies de la peau

1984
- 1984-05-31 NZ NZ208338A patent/NZ208338A/en unknown
- 1984-06-04 FR FR8408718A patent/FR2547725B1/fr not_active Expired
- 1984-06-06 FI FI842274A patent/FI83837C/fi not_active IP Right Cessation
- 1984-06-06 ES ES533186A patent/ES8707107A1/es not_active Expired
- 1984-06-08 DE DE19843421510 patent/DE3421510A1/de not_active Withdrawn
- 1984-06-08 NO NO842326A patent/NO171623C/no unknown
- 1984-06-08 DK DK283884A patent/DK163028C/da not_active IP Right Cessation
- 1984-06-08 AU AU29237/84A patent/AU569085B2/en not_active Ceased
- 1984-06-08 IE IE1440/84A patent/IE57562B1/en not_active IP Right Cessation
- 1984-06-08 BE BE0/213108A patent/BE899874A/fr not_active IP Right Cessation
- 1984-06-08 AT AT0189784A patent/AT393959B/de not_active IP Right Cessation
- 1984-06-08 PT PT78713A patent/PT78713A/pt not_active IP Right Cessation
- 1984-06-08 GB GB08414653A patent/GB2142534B/en not_active Expired
- 1984-06-08 LU LU85411A patent/LU85411A1/fr unknown
- 1984-06-08 CH CH2813/84A patent/CH659945A5/de not_active IP Right Cessation
- 1984-06-08 JP JP59116766A patent/JPS608222A/ja active Pending
- 1984-06-08 OA OA58314A patent/OA07720A/fr unknown
- 1984-06-08 IT IT21331/84A patent/IT1183058B/it active
- 1984-06-08 SE SE8403110A patent/SE465205B/sv not_active IP Right Cessation
1990
- 1990-08-23 HK HK664/90A patent/HK66490A/xx unknown
- 1990-11-16 CY CY1531A patent/CY1531A/en unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT384745B (de) *	1980-03-07	1987-12-28	Unger Paul	Skibremse
FR2526321A1 (fr) *	1982-05-10	1983-11-10	Salomon & Fils F	Frein de ski

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
H. V. CZETSCH-LINDEWALD, H. P . FIEDLER, HILFSTOFFE FÜR PHARMAZIE UND ANGRENYENDE GEBIETE, 2. AUFLAGE, EDITIO CANTOR K. G. AULENDORF 1963, SEITEN 34 UND 35 *

Also Published As

Publication number	Publication date
FI842274L (fi)	1984-12-10
JPS608222A (ja)	1985-01-17
HK66490A (en)	1990-08-31
NO171623C (no)	1993-04-21
FR2547725B1 (fr)	1987-12-04
FR2547725A1 (fr)	1984-12-28
NO171623B (no)	1993-01-04
OA07720A (fr)	1985-08-30
IE841440L (en)	1984-12-09
DK163028C (da)	1992-06-09
GB2142534A (en)	1985-01-23
SE465205B (sv)	1991-08-12
IE57562B1 (en)	1992-12-16
DK283884D0 (da)	1984-06-08
PT78713A (en)	1984-07-01
FI83837C (fi)	1991-09-10
CH659945A5 (de)	1987-03-13
DK163028B (da)	1992-01-13
GB8414653D0 (en)	1984-07-11
LU85411A1 (fr)	1985-03-26
FI842274A0 (fi)	1984-06-06
AU569085B2 (en)	1988-01-21
SE8403110L (sv)	1984-12-10
SE8403110D0 (sv)	1984-06-08
NO842326L (no)	1984-12-10
DE3421510A1 (de)	1984-12-20
AU2923784A (en)	1984-12-13
GB2142534B (en)	1987-06-03
BE899874A (fr)	1984-12-10
ES533186A0 (es)	1987-07-16
NZ208338A (en)	1987-11-27
ES8707107A1 (es)	1987-07-16
DK283884A (da)	1984-12-10
ATA189784A (de)	1991-07-15
FI83837B (fi)	1991-05-31
IT1183058B (it)	1987-10-05
CY1531A (en)	1990-11-16
IT8421331A0 (it)	1984-06-08

Legal Events

Date	Code	Title	Description
1995-04-15	ELJ	Ceased due to non-payment of the annual fee
2000-07-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
EP0098843B1 (fr)	1986-07-23	Cosmetiques sebosuppresseurs contenant des alcanols a chaine longue et des antioxygenes
DE69128653T2 (de)	1998-07-23	Verwendung von Alphatocopherol phosphate oder eines Derivates davon zur Herstellung kosmetischer, dermatologischer oder pharmazeutischer Präparate mit anti-radikaler Aktivität und Zusammensetzungen
DE69415491T2 (de)	1999-05-12	Wasser in Öl Emulsion enthaltend Retinol
DE3102181C2 (de)	1986-05-22	Oxidationsbeständige Lösung mindestens einer essentiellen Fettsäure und eines pflanzlichen Öls sowie sie enthaltende kosmetische Zubereitungen
DE69100724T2 (de)	1994-04-28	Zusammensetzungen essentieller Fettsäuren und Therapie.
DE3382637T2 (de)	1993-04-22	Eine lipidloesliche substanz enthaltende waessrige fluessigkeit.
DE3620674A1 (de)	1987-12-23	Salbe zur behandlung von hauterkrankungen
DE69800170T2 (de)	2000-09-28	System bestehend aus Phosphonsäurederivate und Metabisulfit zur Stabilisierung von Ascorbinsäure
DE3402880A1 (de)	1984-08-02	Oel-in-wasser-creme und verfahren zu ihrer herstellung
DE3302739A1 (de)	1983-08-04	Oxidationsstabiles mittel
DE3603859A1 (de)	1987-08-13	Abwaschbare topische zubereitung zur therapie der psoriasis
DE3411225C2 (fr)	1991-11-07
DE3643330A1 (de)	1987-06-25	Waessrige ubichinone enthaltende pharmazeutische zubereitungen
AT393959B (de)	1992-01-10	Verfahren zur erhoehung der stabilitaet von anthralin enthaltenden waessrigen zusammensetzungen
DE4121945C2 (de)	1993-11-04	Verfahren zur herstellung von stabilen, hydrophilen oder ambiphilen creme-zubereitungen, enthaltend vesikulaere bestandteile, stabile creme-zubereitungen mit vesikulaeren bestandteilen und deren verwendung
DE69402259T2 (de)	1997-07-24	Zusammensetzungen enthaltend 8-Hydroxychinolin zur Behandlung hyperproliferativer Hautkrankheiten
DE69031569T2 (de)	1998-02-19	Podophyllotoxinzubereitung enthaltend triglyceride
DE3402877C2 (fr)	1991-08-29
DE3632359C2 (fr)	1989-08-17
DE3784821T2 (de)	1993-06-24	Zusammensetzung zur anwendung an haaren.
DE3615396A1 (de)	1987-11-12	Mittel zur behandlung der haare und der kopfhaut
DE68907755T2 (de)	1994-03-10	Mittel zur Verhinderung der Ergrauung der Haare und Repigmentierung ergrauter Haare.
EP0740930B1 (fr)	2004-03-31	Agent ameliorant le debit sanguin et produit cosmetique
DE19810999A1 (de)	1999-09-16	Verwendung von Sphingosin, Sphingosin-1-Phosphat, Sphingosin-1-Phosphat-Derivaten und/oder deren Gemischen zur Behandlung von entzündlichen Hautkrankheiten
DE60106014T2 (de)	2005-10-06	Verwendung von n,n'-dibenzylethylendiamindiessigsäurederivaten zum schutz gegen verschmutzung