FI83837C - Foerfarande foer oekning av stabiliteten hos vattenhaltiga kompositioner som innehaoller antralin. - Google Patents

Foerfarande foer oekning av stabiliteten hos vattenhaltiga kompositioner som innehaoller antralin. Download PDF

Info

Publication number: FI83837C
Authority: FI; Finland
Prior art keywords: anthralin; composition; weight; oil; acid
Prior art date: 1983-06-09

Application number

FI842274A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI83837B (fi

FI842274L (fi

FI842274A0 (fi

Inventor

Jonas C T Wang

Original Assignee

Squibb Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-09

Filing date

1984-06-06

Publication date

1991-09-10

1984-06-06 Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co

1984-06-06 Publication of FI842274A0 publication Critical patent/FI842274A0/fi

1984-12-10 Publication of FI842274L publication Critical patent/FI842274L/fi

1991-05-31 Publication of FI83837B publication Critical patent/FI83837B/fi

1991-09-10 Application granted granted Critical

1991-09-10 Publication of FI83837C publication Critical patent/FI83837C/fi

Links

NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 claims description 95
229960002311 dithranol Drugs 0.000 claims description 93
239000000203 mixture Substances 0.000 claims description 64
238000000034 method Methods 0.000 claims description 24
-1 sulfonyl fatty acid Chemical class 0.000 claims description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
239000004094 surface-active agent Substances 0.000 claims description 16
239000002253 acid Substances 0.000 claims description 14
239000003963 antioxidant agent Substances 0.000 claims description 13
230000003078 antioxidant effect Effects 0.000 claims description 7
235000014113 dietary fatty acids Nutrition 0.000 claims description 7
239000000194 fatty acid Substances 0.000 claims description 7
229930195729 fatty acid Natural products 0.000 claims description 7
229910019142 PO4 Inorganic materials 0.000 claims description 6
239000010452 phosphate Substances 0.000 claims description 5
239000002736 nonionic surfactant Substances 0.000 claims description 4
150000008051 alkyl sulfates Chemical class 0.000 claims description 3
150000008052 alkyl sulfonates Chemical class 0.000 claims description 3
FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 2
108010077895 Sarcosine Proteins 0.000 claims description 2
229960000878 docusate sodium Drugs 0.000 claims description 2
239000000839 emulsion Substances 0.000 claims description 2
229940043230 sarcosine Drugs 0.000 claims description 2
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims description 2
229950000886 isetionate Drugs 0.000 claims 1
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 20
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 19
239000003945 anionic surfactant Substances 0.000 description 19
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239000011734 sodium Substances 0.000 description 13
229910052708 sodium Inorganic materials 0.000 description 13
239000003921 oil Substances 0.000 description 12
235000006708 antioxidants Nutrition 0.000 description 11
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239000004322 Butylated hydroxytoluene Substances 0.000 description 10
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 10
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FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 10
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DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 9
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MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 description 3
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BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
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229910052782 aluminium Inorganic materials 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
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229960001577 dantron Drugs 0.000 description 2
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SPCNPOWOBZQWJK-UHFFFAOYSA-N dimethoxy-(2-propan-2-ylsulfanylethylsulfanyl)-sulfanylidene-$l^{5}-phosphane Chemical compound COP(=S)(OC)SCCSC(C)C SPCNPOWOBZQWJK-UHFFFAOYSA-N 0.000 description 2
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239000002609 medium Substances 0.000 description 2
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 2
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GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
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229920005862 polyol Polymers 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 1
238000012154 short term therapy Methods 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
229940057950 sodium laureth sulfate Drugs 0.000 description 1
229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
238000013112 stability test Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229940098760 steareth-2 Drugs 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

FI842274A 1983-06-09 1984-06-06 Foerfarande foer oekning av stabiliteten hos vattenhaltiga kompositioner som innehaoller antralin. FI83837C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50285283A	1983-06-09	1983-06-09
US50285283		1983-06-09

Publications (4)

Publication Number	Publication Date
FI842274A0 FI842274A0 (fi)	1984-06-06
FI842274L FI842274L (fi)	1984-12-10
FI83837B FI83837B (fi)	1991-05-31
FI83837C true FI83837C (fi)	1991-09-10

Family

ID=23999686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI842274A FI83837C (fi)	1983-06-09	1984-06-06	Foerfarande foer oekning av stabiliteten hos vattenhaltiga kompositioner som innehaoller antralin.

Country Status (21)

Country	Link
JP (1)	JPS608222A (fr)
AT (1)	AT393959B (fr)
AU (1)	AU569085B2 (fr)
BE (1)	BE899874A (fr)
CH (1)	CH659945A5 (fr)
CY (1)	CY1531A (fr)
DE (1)	DE3421510A1 (fr)
DK (1)	DK163028C (fr)
ES (1)	ES8707107A1 (fr)
FI (1)	FI83837C (fr)
FR (1)	FR2547725B1 (fr)
GB (1)	GB2142534B (fr)
HK (1)	HK66490A (fr)
IE (1)	IE57562B1 (fr)
IT (1)	IT1183058B (fr)
LU (1)	LU85411A1 (fr)
NO (1)	NO171623C (fr)
NZ (1)	NZ208338A (fr)
OA (1)	OA07720A (fr)
PT (1)	PT78713A (fr)
SE (1)	SE465205B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4551480A (en) *	1983-06-21	1985-11-05	Stiefel Laboratories, Inc.	Compositions for the treatment of psoriasis
DE3413569A1 (de) *	1984-04-11	1985-10-24	Röhm Pharma GmbH, 6108 Weiterstadt	Pharmazeutisches mittel zur psoriasis-therapie
GB8729855D0 (en) *	1987-12-22	1988-02-03	Drythanol Ltd	New dithranol compositions
AT408067B (de) *	1995-03-17	2001-08-27	Gebro Pharma Gmbh	Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1070949A (en) *	1964-10-16	1967-06-07	Hyman Yarrow	Topical compositions for the treatment of psoriasis
GB1574090A (en) *	1977-07-06	1980-09-03	Drythanol Ltd	Dithranol composition for the treatment of psoriasis
DE3008805A1 (de) *	1980-03-07	1981-09-24	Paul 8501 Oberasbach Unger	Skibremse
CH655004A5 (fr) *	1981-10-23	1986-03-27	Oreal	Composition anhydre, stable a l'oxydation, d'un compose d'anthraline dans un alkyl-ester d'acide gras en vue du traitement des maladies de la peau.
FR2520233A1 (fr) *	1982-01-28	1983-07-29	Oreal	Composition d'anthraline ou de l'un de ses derives dans un ester aromatique et son utilisation dans le traitement des maladies de la peau
FR2526321A1 (fr) *	1982-05-10	1983-11-10	Salomon & Fils F	Frein de ski

1984
- 1984-05-31 NZ NZ208338A patent/NZ208338A/en unknown
- 1984-06-04 FR FR8408718A patent/FR2547725B1/fr not_active Expired
- 1984-06-06 FI FI842274A patent/FI83837C/fi not_active IP Right Cessation
- 1984-06-06 ES ES533186A patent/ES8707107A1/es not_active Expired
- 1984-06-08 JP JP59116766A patent/JPS608222A/ja active Pending
- 1984-06-08 BE BE0/213108A patent/BE899874A/fr not_active IP Right Cessation
- 1984-06-08 DE DE19843421510 patent/DE3421510A1/de not_active Withdrawn
- 1984-06-08 IT IT21331/84A patent/IT1183058B/it active
- 1984-06-08 DK DK283884A patent/DK163028C/da not_active IP Right Cessation
- 1984-06-08 IE IE1440/84A patent/IE57562B1/en not_active IP Right Cessation
- 1984-06-08 AU AU29237/84A patent/AU569085B2/en not_active Ceased
- 1984-06-08 CH CH2813/84A patent/CH659945A5/de not_active IP Right Cessation
- 1984-06-08 SE SE8403110A patent/SE465205B/sv not_active IP Right Cessation
- 1984-06-08 LU LU85411A patent/LU85411A1/fr unknown
- 1984-06-08 AT AT0189784A patent/AT393959B/de not_active IP Right Cessation
- 1984-06-08 GB GB08414653A patent/GB2142534B/en not_active Expired
- 1984-06-08 PT PT78713A patent/PT78713A/pt not_active IP Right Cessation
- 1984-06-08 OA OA58314A patent/OA07720A/fr unknown
- 1984-06-08 NO NO842326A patent/NO171623C/no unknown
1990
- 1990-08-23 HK HK664/90A patent/HK66490A/xx unknown
- 1990-11-16 CY CY1531A patent/CY1531A/en unknown

Also Published As

Publication number	Publication date
GB8414653D0 (en)	1984-07-11
CH659945A5 (de)	1987-03-13
FI83837B (fi)	1991-05-31
NO842326L (no)	1984-12-10
PT78713A (en)	1984-07-01
IT1183058B (it)	1987-10-05
DK283884A (da)	1984-12-10
NO171623C (no)	1993-04-21
DK283884D0 (da)	1984-06-08
DK163028B (da)	1992-01-13
LU85411A1 (fr)	1985-03-26
GB2142534A (en)	1985-01-23
OA07720A (fr)	1985-08-30
DE3421510A1 (de)	1984-12-20
BE899874A (fr)	1984-12-10
HK66490A (en)	1990-08-31
CY1531A (en)	1990-11-16
AU569085B2 (en)	1988-01-21
NO171623B (no)	1993-01-04
ES8707107A1 (es)	1987-07-16
DK163028C (da)	1992-06-09
IE57562B1 (en)	1992-12-16
SE465205B (sv)	1991-08-12
ATA189784A (de)	1991-07-15
SE8403110L (sv)	1984-12-10
IT8421331A0 (it)	1984-06-08
GB2142534B (en)	1987-06-03
FI842274L (fi)	1984-12-10
AU2923784A (en)	1984-12-13
JPS608222A (ja)	1985-01-17
IE841440L (en)	1984-12-09
NZ208338A (en)	1987-11-27
SE8403110D0 (sv)	1984-06-08
FR2547725B1 (fr)	1987-12-04
AT393959B (de)	1992-01-10
FI842274A0 (fi)	1984-06-06
FR2547725A1 (fr)	1984-12-28
ES533186A0 (es)	1987-07-16

Legal Events

Date	Code	Title	Description
1995-01-11	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: BRISTOL-MYERS SQUIBB COMPANY

Publication	Publication Date	Title
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CA2306040C (fr)	2005-01-11	Compositions de bronzage sans soleil contenant un colorant
CA1207668A (fr)	1986-07-15	Creme de type huile-dans-l'eau contenant du propionate butyrate d'hydrocortisone
PL192543B1 (pl)	2006-11-30	Środek kosmetyczny i dermatologiczny zawierający twarde cząstki magnetyczne i sposób jego wytwarzania
US4203969A (en)	1980-05-20	Dithranol compositions for topical applications
EP0218410A2 (fr)	1987-04-15	Utilisation des 1-hydroxy-2-pyridones pour le traitement de l'acné
FI83837C (fi)	1991-09-10	Foerfarande foer oekning av stabiliteten hos vattenhaltiga kompositioner som innehaoller antralin.
FI87527C (fi)	1993-01-25	Foerfarande foer framstaellning av primycinhaltig kolloidal basgel
AU674411B2 (en)	1996-12-19	Compositions for the treatment of inflammatory proliferative skin disease and their use
US4837213A (en)	1989-06-06	Pharmaceutical vehicle for active substances in the form of an anhydrous gel
KR102147642B1 (ko)	2020-08-25	여드름 개선용 화장료 조성물
US5034420A (en)	1991-07-23	Compositions and method for stabilization of anthralin comprising the addition of an oil soluble antioxidant and an anionic surfactant
EP0131790A2 (fr)	1985-01-23	Préparation à base d'étofénamate
IL96903A (en)	1995-03-15	Topical pharmaceutical compositions comprising 1 alpha, 25-dihydroxychole-calciferol.
JP2002505273A (ja)	2002-02-19	刺激作用を低下させる担体としての水中油型局所用組成物
KR950003611B1 (ko)	1995-04-17	항진균 외용 이미다졸 제제
EP4257127A1 (fr)	2023-10-11	Composition en émulsion à usage externe
RU2107492C1 (ru)	1998-03-27	Мазь для лечения тромбофлебита
DE3904674A1 (de)	1990-08-23	Verwendung einer wirkstoffkombination zur behandlung rheumatischer erkrankungen
RU2036640C1 (ru)	1995-06-09	Мазь для лечения заболеваний с нарушением керотинизации и целостности кожи
KR100517728B1 (ko)	2005-09-28	토코페롤 3중 안정화 화장료 조성물 및 그 제조 방법
RU2148998C1 (ru)	2000-05-20	Фармацевтическая или ветеринарная композиция (варианты) и способ получения композиции
JP7709827B2 (ja)	2025-07-17	外用組成物
JPS62263109A (ja)	1987-11-16	リン脂質を安定に配合する方法
Semkina et al.	2005	Auxiliary substances used in technology of soft medicinal forms: ointments, gels, liniments, and creams (a review)