AT401057B - Dioxancarbonsäuren, formylderivate ihrer ester und verfahren zu deren herstellung - Google Patents

Dioxancarbonsäuren, formylderivate ihrer ester und verfahren zu deren herstellung Download PDF

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Publication number
AT401057B
AT401057B AT0036189A AT36189A AT401057B AT 401057 B AT401057 B AT 401057B AT 0036189 A AT0036189 A AT 0036189A AT 36189 A AT36189 A AT 36189A AT 401057 B AT401057 B AT 401057B
Authority
AT
Austria
Prior art keywords
alkyl
formula
hydrogen
cyclohexyl
compound
Prior art date
Application number
AT0036189A
Other languages
German (de)
English (en)
Other versions
ATA36189A (de
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to AT0000394A priority Critical patent/AT404724B/de
Publication of ATA36189A publication Critical patent/ATA36189A/de
Application granted granted Critical
Publication of AT401057B publication Critical patent/AT401057B/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
AT0036189A 1988-02-18 1989-02-17 Dioxancarbonsäuren, formylderivate ihrer ester und verfahren zu deren herstellung AT401057B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0000394A AT404724B (de) 1988-02-18 1994-01-03 Neue zwischenverbindung und verfahren zur herstellung von antihypercholesterinämisch wirkenden tetrazolverbindungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds

Publications (2)

Publication Number Publication Date
ATA36189A ATA36189A (de) 1995-10-15
AT401057B true AT401057B (de) 1996-06-25

Family

ID=22561419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0036189A AT401057B (de) 1988-02-18 1989-02-17 Dioxancarbonsäuren, formylderivate ihrer ester und verfahren zu deren herstellung

Country Status (32)

Country Link
US (1) US4824959A (fr)
JP (2) JP2871707B2 (fr)
KR (1) KR970002233B1 (fr)
CN (1) CN1025619C (fr)
AT (1) AT401057B (fr)
AU (1) AU621586B2 (fr)
BE (1) BE1002136A5 (fr)
CA (1) CA1340430C (fr)
CH (1) CH680792A5 (fr)
CY (1) CY1874A (fr)
DD (4) DD285600A5 (fr)
DE (1) DE3904899A1 (fr)
DK (1) DK75289A (fr)
EG (1) EG19217A (fr)
ES (1) ES2017810A6 (fr)
FI (1) FI890725A7 (fr)
FR (1) FR2630112B1 (fr)
GB (1) GB2216121B (fr)
GR (1) GR1000664B (fr)
HK (3) HK129395A (fr)
HU (2) HU204045B (fr)
IE (1) IE65090B1 (fr)
IT (1) IT1230750B (fr)
LU (1) LU87456A1 (fr)
MY (1) MY106279A (fr)
NL (1) NL8900397A (fr)
NO (1) NO172439C (fr)
NZ (1) NZ227935A (fr)
PT (1) PT89748B (fr)
SE (2) SE503179C2 (fr)
YU (1) YU34189A (fr)
ZA (1) ZA891239B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244706B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole intermediates
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2137049A1 (fr) * 1993-12-15 1995-06-16 John K. Thottathil Sels d'acides amines de composes antihypercholesterolemiques a base de tetrazole et leur methode de preparation
DE10147030A1 (de) * 2001-09-04 2003-03-27 Forschungszentrum Juelich Gmbh Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale
US20050272808A1 (en) * 2004-05-11 2005-12-08 Nadav Zamir Compositions and methods for the treatment of hypertension
EP1746988A1 (fr) * 2004-05-11 2007-01-31 Darley Pharmaceuticals Ltd. Spiroderives pour le traitement de l'hypertension
CN104303915B (zh) * 2014-08-25 2016-05-25 李世峰 一种机插水稻水浮式育秧技术

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103684A1 (fr) * 1982-06-24 1984-03-28 Nippon Kayaku Kabushiki Kaisha Dérivés du dioxanne-1,3 contenant les groupements acryloyloxy et procédé pour leur préparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
DE3807929A1 (de) * 1988-03-10 1989-09-28 Basf Ag Verfahren zur herstellung von reliefformen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103684A1 (fr) * 1982-06-24 1984-03-28 Nippon Kayaku Kabushiki Kaisha Dérivés du dioxanne-1,3 contenant les groupements acryloyloxy et procédé pour leur préparation

Also Published As

Publication number Publication date
DD285600A5 (de) 1990-12-19
MY106279A (en) 1995-04-29
JP2871707B2 (ja) 1999-03-17
CA1340430C (fr) 1999-03-09
LU87456A1 (fr) 1989-09-20
CN1025619C (zh) 1994-08-10
YU34189A (en) 1991-02-28
ZA891239B (en) 1991-12-24
BE1002136A5 (fr) 1990-07-24
KR890012992A (ko) 1989-09-20
AU3007589A (en) 1989-08-24
FI890725L (fi) 1989-08-19
SE503179C2 (sv) 1996-04-15
HUT50809A (en) 1990-03-28
HUT50167A (en) 1989-12-28
NL8900397A (nl) 1989-09-18
NZ227935A (en) 1990-07-26
SE9300595D0 (sv) 1993-02-23
CH680792A5 (fr) 1992-11-13
SE8900565D0 (sv) 1989-02-17
SE9300595A0 (sv) 1993-02-23
NO890661L (no) 1989-08-21
DD283618A5 (de) 1990-10-17
NO172439C (no) 1993-07-21
IE65090B1 (en) 1995-10-04
FR2630112A1 (fr) 1989-10-20
DE3904899A1 (de) 1989-08-31
ATA36189A (de) 1995-10-15
IE890523L (en) 1989-08-18
GR1000664B (el) 1992-09-25
JP2922887B2 (ja) 1999-07-26
EG19217A (en) 1995-09-30
FI890725A7 (fi) 1989-08-19
DD285603A5 (de) 1990-12-19
AU621586B2 (en) 1992-03-19
HK129295A (en) 1995-08-24
HK47596A (en) 1996-03-29
HK129395A (en) 1995-08-24
SE8900565L (sv) 1989-08-19
NO890661D0 (no) 1989-02-16
HU204045B (en) 1991-11-28
DD285602A5 (de) 1990-12-19
PT89748B (pt) 1994-05-31
US4824959A (en) 1989-04-25
IT8919474A0 (it) 1989-02-17
PT89748A (pt) 1989-10-04
CN1036013A (zh) 1989-10-04
IT1230750B (it) 1991-10-29
GB2216121B (en) 1992-07-15
JPH01249771A (ja) 1989-10-05
ES2017810A6 (es) 1991-03-01
NO172439B (no) 1993-04-13
JPH115791A (ja) 1999-01-12
KR970002233B1 (ko) 1997-02-26
GB2216121A (en) 1989-10-04
GB8903604D0 (en) 1989-04-05
DK75289D0 (da) 1989-02-17
CY1874A (en) 1996-04-05
DK75289A (da) 1989-08-19
FI890725A0 (fi) 1989-02-15
HU209905B (en) 1994-11-28
FR2630112B1 (fr) 1994-07-29

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee
RZN Patent revoked
ELJ Ceased due to non-payment of the annual fee