AT73479B - Process for the production of an easily absorbable, durable, non-hygroscopic calcium preparation. - Google Patents
Process for the production of an easily absorbable, durable, non-hygroscopic calcium preparation.Info
- Publication number
- AT73479B AT73479B AT73479DA AT73479B AT 73479 B AT73479 B AT 73479B AT 73479D A AT73479D A AT 73479DA AT 73479 B AT73479 B AT 73479B
- Authority
- AT
- Austria
- Prior art keywords
- production
- durable
- calcium preparation
- easily absorbable
- hygroscopic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title description 4
- 239000011575 calcium Substances 0.000 title description 4
- 229910052791 calcium Inorganic materials 0.000 title description 4
- 238000004519 manufacturing process Methods 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 3
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 3
- 229960002401 calcium lactate Drugs 0.000 description 3
- 239000001527 calcium lactate Substances 0.000 description 3
- 235000011086 calcium lactate Nutrition 0.000 description 3
- ZZUUMCMLIPRDPI-UHFFFAOYSA-N 2-hydroxypropanoic acid;sodium Chemical compound [Na].CC(O)C(O)=O ZZUUMCMLIPRDPI-UHFFFAOYSA-N 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung eines leicht resorbierbaren, haltbaren, nichthygroskopischen
Kalkpräparates.
Wie Emmerieh und Loew beobachteten, wird Calcium aus seinen Sätzen vom Organismus besser resorbiert, wenn das Blut eine gewisse erhöhte Alkalescenz besitzt.
Dieses könnte am besten durch Zuführung des Natriumsalzes der dem menschlichen
EMI1.1
Natrium, das im Handel nur in Form einer hochkonzentrierten, wässerigen Lösung vorrätig gehalten wird, wegen seiner Hygroskopizität nicht verwendbar.
Es wurde nun beobachtet, dass die hochkonzentrierte Lösung des Handels beim Zusammenmischen mit nicht zu geringen Mengen des für die Kalktherapio als besonders brauchbar erfundenen Calciumlactats unter Erwärmung ein krümliges Produkt gibt, das sich an der Luft auf einen bestimmten Wassergehalt einstellt und ihn dann festhält.
Geht man im Zusatz des Calciumlactats unter das Verhältnis von 1/2 Molekül Calciumsalz für 1 Molekül Natriumsalz herab, so resultieren wieder hygroskopischProdukte. Bei Verwendung von 1 Molekül Calciumlactat auf 2 Moleküle Natriumlaetat
EMI1.2
einstellt.
Ein ähnliches, allerdings nur 2 Moleküle Kristallwasser enthaltendes Doppelsalz ist vor mehr als 50 Jahren bereits einmal in der Literatur beschrieben worden. Es wurde aus der wässerigen Lösung der Komponenten durch Auskristallisierenlassen erhalten.
Über die physikalischen Eigenschaften des Produktes, insbesondere seine Haltbarkeit an der Luft finden sich dort aber keine Angaben, auch nicht über die Ausbeute, die aber, weil sich das Doppelsalz in Wasser leicht löst, technisch natürlich völlig unzulänglich ist
Beispiel1.
238 g eines 9% Wasser enthaltenden milchsauren Kalkes werden mit 280 g eines milchsauren Natriums mit SO/o Wasser zusammengemischt, wobei das mehlige Calciumlaetai
EMI1.3
308 Teile eines 5 Moleküle Kristallwasser enthaltenden milchsauren lialkes werden m't 280 ölen eines milchsauren Natriums mit 20% Wassergehalt innig gemischt, das unter Temperaturänderung erstarrende Produkt wird durch ein Sieb gedrückt und bei zirka 60
EMI1.4
zurTablettenherstellungverwendetwerden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the production of an easily absorbable, durable, non-hygroscopic
Lime preparation.
As Emmerieh and Loew observed, calcium from its deposits is better absorbed by the organism when the blood has a certain increased alkalinity.
This could best be done by adding the sodium salt to the human
EMI1.1
Sodium, which is only available commercially in the form of a highly concentrated aqueous solution, cannot be used due to its hygroscopicity.
It has now been observed that the highly concentrated commercial solution when mixed with not too small amounts of the calcium lactate invented to be particularly useful for calcium therapy gives a crumbly product when heated, which adjusts to a certain water content in the air and then holds it.
If the addition of calcium lactate goes below the ratio of 1/2 molecule of calcium salt to 1 molecule of sodium salt, the result is again hygroscopic products. When using 1 molecule of calcium lactate to 2 molecules of sodium acetate
EMI1.2
adjusts.
A similar double salt containing only 2 molecules of water of crystallization was already described in the literature more than 50 years ago. It was obtained from the aqueous solution of the components by allowing it to crystallize out.
There is no information there about the physical properties of the product, especially its durability in air, nor about the yield, which is of course completely inadequate technically because the double salt dissolves easily in water
Example 1.
238 g of a lactic acid lime containing 9% water are mixed together with 280 g of a lactic acid sodium with SO / o water, the floury calcium lay
EMI1.3
308 parts of a lactic acid liqueur containing 5 molecules of water of crystallization are intimately mixed with oils of lactic acid sodium with 20% water content
EMI1.4
be used for tablet production.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT73479T | 1915-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT73479B true AT73479B (en) | 1917-06-25 |
Family
ID=3595150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT73479D AT73479B (en) | 1915-12-01 | 1915-12-01 | Process for the production of an easily absorbable, durable, non-hygroscopic calcium preparation. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT73479B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2856326A (en) * | 1956-03-19 | 1958-10-14 | Nat Dairy Prod Corp | Lactate composition for treatment of bovine ketosis |
-
1915
- 1915-12-01 AT AT73479D patent/AT73479B/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2856326A (en) * | 1956-03-19 | 1958-10-14 | Nat Dairy Prod Corp | Lactate composition for treatment of bovine ketosis |
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