ATA15372000A - Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes - Google Patents

Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes

Info

Publication number: ATA15372000A
Authority: AT; Austria
Prior art keywords: lamonium; butyl; salts; cefuroxime; producing
Prior art date: 2000-09-11

Application number

AT0153700A

Other languages

English (en)

Other versions

AT411996B (de

Inventor

Peter Dr Kremminger

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-11

Filing date

2000-09-11

Publication date

2004-01-15

2000-09-11 Priority to AT0153700A priority Critical patent/AT411996B/de

2000-09-11 Application filed by Sandoz Ag filed Critical Sandoz Ag

2001-09-10 Priority to DK01967326T priority patent/DK1319009T3/da

2001-09-10 Priority to CNB018154212A priority patent/CN1200941C/zh

2001-09-10 Priority to US10/363,962 priority patent/US6894162B2/en

2001-09-10 Priority to TW090122340A priority patent/TWI282339B/zh

2001-09-10 Priority to DE60136285T priority patent/DE60136285D1/de

2001-09-10 Priority to JP2002525153A priority patent/JP2004508378A/ja

2001-09-10 Priority to HK03108285.4A priority patent/HK1057542B/en

2001-09-10 Priority to CA002419258A priority patent/CA2419258C/en

2001-09-10 Priority to EP01967326A priority patent/EP1319009B1/de

2001-09-10 Priority to AU2001287725A priority patent/AU2001287725A1/en

2001-09-10 Priority to KR1020037002344A priority patent/KR100864405B1/ko

2001-09-10 Priority to PCT/EP2001/010447 priority patent/WO2002020532A1/en

2001-09-10 Priority to AT01967326T priority patent/ATE412001T1/de

2004-01-15 Publication of ATA15372000A publication Critical patent/ATA15372000A/de

2004-08-26 Application granted granted Critical

2004-08-26 Publication of AT411996B publication Critical patent/AT411996B/de

Links

JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 title 1
229960001668 cefuroxime Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT0153700A 2000-09-11 2000-09-11 Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes AT411996B (de)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
AT0153700A AT411996B (de)	2000-09-11	2000-09-11	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
CA002419258A CA2419258C (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production
US10/363,962 US6894162B2 (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production
TW090122340A TWI282339B (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production
DE60136285T DE60136285D1 (de)	2000-09-11	2001-09-10	Zwischenprodukte bei der cephalosoprinherstellung
JP2002525153A JP2004508378A (ja)	2000-09-11	2001-09-10	セファロスポリンの製造における中間体
DK01967326T DK1319009T3 (da)	2000-09-11	2001-09-10	Mellemprodukter ved cephalosporinfremstilling
CNB018154212A CN1200941C (zh)	2000-09-11	2001-09-10	头孢菌素的制备方法、制备过程中的中间体及中间体的用途
EP01967326A EP1319009B1 (de)	2000-09-11	2001-09-10	Zwischenprodukte bei der cephalosoprinherstellung
AU2001287725A AU2001287725A1 (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production
KR1020037002344A KR100864405B1 (ko)	2000-09-11	2001-09-10	세팔로스포린 제조에서의 중간체
PCT/EP2001/010447 WO2002020532A1 (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production
AT01967326T ATE412001T1 (de)	2000-09-11	2001-09-10	Zwischenprodukte bei der cephalosoprinherstellung
HK03108285.4A HK1057542B (en)	2000-09-11	2001-09-10	Intermediates in cephalosporin production

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0153700A AT411996B (de)	2000-09-11	2000-09-11	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes

Publications (2)

Publication Number	Publication Date
ATA15372000A true ATA15372000A (de)	2004-01-15
AT411996B AT411996B (de)	2004-08-26

Family

ID=3688325

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0153700A AT411996B (de)	2000-09-11	2000-09-11	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
AT01967326T ATE412001T1 (de)	2000-09-11	2001-09-10	Zwischenprodukte bei der cephalosoprinherstellung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT01967326T ATE412001T1 (de)	2000-09-11	2001-09-10	Zwischenprodukte bei der cephalosoprinherstellung

Country Status (12)

Country	Link
US (1)	US6894162B2 (de)
EP (1)	EP1319009B1 (de)
JP (1)	JP2004508378A (de)
KR (1)	KR100864405B1 (de)
CN (1)	CN1200941C (de)
AT (2)	AT411996B (de)
AU (1)	AU2001287725A1 (de)
CA (1)	CA2419258C (de)
DE (1)	DE60136285D1 (de)
DK (1)	DK1319009T3 (de)
TW (1)	TWI282339B (de)
WO (1)	WO2002020532A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN190849B (de) *	2000-07-17	2003-08-23	Ranbaxy Lab Ltd
US20040092735A1 (en) *	2002-11-08	2004-05-13	Orchid Chemicals & Pharmaceuticals Limited	Process for the preparation of cefuroxime sodium
WO2004050663A2 (en) *	2002-12-05	2004-06-17	Orchid Chemicals & Pharmaceuticals Ltd	An improved process for the preparation of cefuroxime sodium
AU2003294161A1 (en) *	2003-03-20	2004-10-11	Orchid Chemicals And Pharmaceuticals Ltd	An improved process for the preparation of cefoxitin
WO2006103686A1 (en) *	2005-03-29	2006-10-05	Hetero Drugs Limited	An improved process for the preparation of cefixime
ITMI20050871A1 (it)	2005-05-13	2006-11-14	Acs Dobfar Spa	Solvato cristallino di cefuroxima acido
CN104961749B (zh) *	2015-06-15	2016-01-13	海南灵康制药有限公司	一种头孢呋辛钠的新型工业结晶方法及其制剂
CN105440052A (zh) *	2016-01-13	2016-03-30	广东立国制药有限公司	一种头孢呋辛酸的制备方法
CN106554361B (zh) *	2016-09-30	2018-10-09	华北制药河北华民药业有限责任公司	一种头孢呋辛酯口服制剂的制备方法
CN112745338B (zh) *	2020-12-30	2022-08-16	山东金城昆仑药业有限公司	消除头孢呋辛酸中内酯杂质的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US391589A (en) *		1888-10-23		Variety wood-worker
GB1474519A (de) *	1973-05-14	1977-05-25
US4122259A (en) *	1974-08-23	1978-10-24	Glaxo Laboratories Limited	7β-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted carbamoyloxymethylceph-3-em-4-carboxylic acids
CA1094545A (en) *	1976-02-16	1981-01-27	Michael Gregson	Cephalosporin antibiotics
GB1575905A (en) *	1976-04-28	1980-10-01	Glaxo Lab Ltd	Salt of cefuroxime
GB2018764B (en) *	1978-04-07	1982-09-02	Glaxo Group Ltd	Cephalosporin compounds
JPS5559194A (en) *	1978-09-21	1980-05-02	Glaxo Group Ltd	Manufacture of cephalosporin compound
IT1144037B (it) *	1979-02-15	1986-10-29	Glaxo Group Ltd	Procedimento per preparare sodico cefurossima e prodotto ottenuto in forma di solvato
DK159155C (da) *	1979-04-06	1991-02-11	Glaxo Group Ltd	Fremgangsmaade til fremstilling af 3-karbamoyloxymetylcephalosporinforbindelser
DK165118C (da)	1980-11-22	1993-03-01	Gema Sa	Fremgangsmaade til fremstilling af oploesninger af 7-aminocephalosporansyrer
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
ES8505362A1 (es)	1983-05-26	1985-06-01	Gema Sa	"sales de acidos amino-beta-lactamicos, para su aplicacion a la obtencion de n-acil derivados de los mismos, y procedimiento para la obtencion de dichas sales"
GB8320520D0 (en) *	1983-07-29	1983-09-01	Glaxo Group Ltd	Chemical process
GB8320521D0 (en)	1983-07-29	1983-09-01	Glaxo Group Ltd	Chemical process
IT1214587B (it) *	1986-12-23	1990-01-18	Giovanni Bonfanti	Metodo per la produzione diprodotti cristallini puri.
PL151670B1 (pl) *	1987-03-19	1990-09-28		Sposób otrzymywania półsyntetycznych cefalosporyn
JP3121903B2 (ja) *	1992-02-07	2001-01-09	塩野義製薬株式会社	デアセチルセファロスポラン酸のカルバモイル化方法
AT400717B (de) *	1993-07-30	1996-03-25	Biochemie Gmbh	Neue guanidin- und amidinsalze von 7-amino-3- hydroxymethyl-3-cephem-4-carbonsäure
AU2820700A (en)	1999-03-09	2000-09-28	Ranbaxy Laboratories Limited	Process for the preparation of cefuroxime
IT1313569B1 (it)	1999-07-27	2002-09-09	Antibioticos Spa	Processo per la sintesi di derivati beta-lattamici.
IN190849B (de) *	2000-07-17	2003-08-23	Ranbaxy Lab Ltd

2000
- 2000-09-11 AT AT0153700A patent/AT411996B/de not_active IP Right Cessation
2001
- 2001-09-10 KR KR1020037002344A patent/KR100864405B1/ko not_active Expired - Fee Related
- 2001-09-10 US US10/363,962 patent/US6894162B2/en not_active Expired - Fee Related
- 2001-09-10 TW TW090122340A patent/TWI282339B/zh not_active IP Right Cessation
- 2001-09-10 CN CNB018154212A patent/CN1200941C/zh not_active Expired - Fee Related
- 2001-09-10 WO PCT/EP2001/010447 patent/WO2002020532A1/en not_active Ceased
- 2001-09-10 EP EP01967326A patent/EP1319009B1/de not_active Expired - Lifetime
- 2001-09-10 AU AU2001287725A patent/AU2001287725A1/en not_active Abandoned
- 2001-09-10 JP JP2002525153A patent/JP2004508378A/ja not_active Withdrawn
- 2001-09-10 DK DK01967326T patent/DK1319009T3/da active
- 2001-09-10 DE DE60136285T patent/DE60136285D1/de not_active Expired - Lifetime
- 2001-09-10 AT AT01967326T patent/ATE412001T1/de not_active IP Right Cessation
- 2001-09-10 CA CA002419258A patent/CA2419258C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1319009A1 (de)	2003-06-18
DK1319009T3 (da)	2009-02-16
HK1057542A1 (en)	2004-04-08
CN1454212A (zh)	2003-11-05
DE60136285D1 (de)	2008-12-04
KR20030040404A (ko)	2003-05-22
WO2002020532A1 (en)	2002-03-14
US6894162B2 (en)	2005-05-17
CA2419258A1 (en)	2002-03-14
AU2001287725A1 (en)	2002-03-22
AT411996B (de)	2004-08-26
US20030171577A1 (en)	2003-09-11
KR100864405B1 (ko)	2008-10-20
CA2419258C (en)	2009-12-29
JP2004508378A (ja)	2004-03-18
CN1200941C (zh)	2005-05-11
ATE412001T1 (de)	2008-11-15
EP1319009B1 (de)	2008-10-22
TWI282339B (en)	2007-06-11

Legal Events

Date	Code	Title	Description
2011-09-15	ELJ	Ceased due to non-payment of the annual fee

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