ATA903993A - Pth-analoga - Google Patents

Pth-analoga

Info

Publication number
ATA903993A
ATA903993A AT0903993A AT903993A ATA903993A AT A903993 A ATA903993 A AT A903993A AT 0903993 A AT0903993 A AT 0903993A AT 903993 A AT903993 A AT 903993A AT A903993 A ATA903993 A AT A903993A
Authority
AT
Austria
Prior art keywords
pth analog
pth
analog
Prior art date
Application number
AT0903993A
Other languages
English (en)
Other versions
AT408100B (de
Inventor
Wilfried Bauer
Robin Dr Breckenridge
Francois Dr Cardinaux
Frank Dr Gombert
Hermann Dr Gram
Paul Dr Ramage
Helmut Dr Schneider
Rudolf Dr Waelchli
Rainer Dr Albert
Ian Dr Lewis
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929215009A external-priority patent/GB9215009D0/en
Priority claimed from GB929226415A external-priority patent/GB9226415D0/en
Priority claimed from GB929226861A external-priority patent/GB9226861D0/en
Priority claimed from GB929226859A external-priority patent/GB9226859D0/en
Priority claimed from GB939301691A external-priority patent/GB9301691D0/en
Priority claimed from GB939301692A external-priority patent/GB9301692D0/en
Priority claimed from GB939307673A external-priority patent/GB9307673D0/en
Priority claimed from GB939308033A external-priority patent/GB9308033D0/en
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Publication of ATA903993A publication Critical patent/ATA903993A/de
Application granted granted Critical
Publication of AT408100B publication Critical patent/AT408100B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10211—Podoviridae
    • C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0903993A 1992-07-15 1993-07-06 Pth-analoga AT408100B (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB929215009A GB9215009D0 (en) 1992-07-15 1992-07-15 Organic compounds
GB929226415A GB9226415D0 (en) 1992-12-18 1992-12-18 Organic compounds
GB929226861A GB9226861D0 (en) 1992-12-23 1992-12-23 Organic compounds
GB929226859A GB9226859D0 (en) 1992-12-23 1992-12-23 Organic compounds
GB939301691A GB9301691D0 (en) 1993-01-28 1993-01-28 Organic compounds
GB939301692A GB9301692D0 (en) 1993-01-28 1993-01-28 Organic compounds
GB939307673A GB9307673D0 (en) 1993-04-14 1993-04-14 Organic compounds
GB939308033A GB9308033D0 (en) 1993-04-19 1993-04-19 Organic compounds
PCT/EP1993/001749 WO1994002510A2 (en) 1992-07-15 1993-07-06 Analogs of pth

Publications (2)

Publication Number Publication Date
ATA903993A true ATA903993A (de) 2001-01-15
AT408100B AT408100B (de) 2001-08-27

Family

ID=27571302

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0903993A AT408100B (de) 1992-07-15 1993-07-06 Pth-analoga

Country Status (25)

Country Link
US (2) US20050009147A1 (de)
EP (1) EP0672057B1 (de)
JP (1) JP3164463B2 (de)
KR (1) KR100321651B1 (de)
CN (1) CN1051769C (de)
AT (1) AT408100B (de)
AU (1) AU672790B2 (de)
CA (1) CA2100423C (de)
CH (1) CH688195A5 (de)
CZ (1) CZ286889B6 (de)
DE (2) DE4393381B4 (de)
DK (1) DK0672057T3 (de)
ES (1) ES2150948T3 (de)
FI (1) FI113872B (de)
GB (1) GB2269176B (de)
GR (1) GR3035089T3 (de)
HK (1) HK1004896A1 (de)
HU (2) HUT70459A (de)
IL (1) IL106326A (de)
NO (1) NO319448B1 (de)
NZ (1) NZ248137A (de)
PT (1) PT672057E (de)
SG (1) SG63625A1 (de)
SK (1) SK283485B6 (de)
WO (1) WO1994002510A2 (de)

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AU8002994A (en) * 1993-10-27 1995-05-22 Chugai Seiyaku Kabushiki Kaisha Cure accelerator in chondroplasty
US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
PT915911E (pt) * 1996-08-02 2004-03-31 Ca Nat Research Council Analogos da hormona paratiroideia para o tratamento de osteoporose
EP1352912A1 (de) * 1996-08-02 2003-10-15 National Research Council Of Canada Analoge des Parathormons zur Behandlung der Osteoporose
EA002819B1 (ru) 1997-05-14 2002-10-31 Авентис Фармасьютикалз Продактс Инк. Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция
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AU3673699A (en) 1998-05-05 1999-11-23 Beth Israel Deaconess Medical Center Pth2 receptor selective compounds
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
US6417333B1 (en) 1998-11-25 2002-07-09 The General Hospital Corporation Modified human parathyroid hormone
US7057012B1 (en) 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
US7169567B1 (en) 1998-12-31 2007-01-30 The General Hospital Corporation Screening assay utilizing the PTH receptor
DE69939275D1 (de) * 1998-12-31 2008-09-18 Gen Hospital Corp Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon
US20050272652A1 (en) * 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
DE19916419B4 (de) * 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
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AU2003239869A1 (en) 2002-05-23 2003-12-12 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
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AU2003220380A1 (en) 2003-03-19 2004-11-19 Bristol-Myers Squibb Company CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
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US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
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US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
CA2597649A1 (en) 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Inc. Gip analog and hybrid polypeptides with selectable properties
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
US20090170762A1 (en) * 2005-09-08 2009-07-02 Uutech Limited Treatment of Diabetes Related Obesity
EP1937716A2 (de) * 2005-09-08 2008-07-02 Uutech Limited Analoga des gastric inhibitory polypeptide als behandlung für die altersbedingte verminderte pankreas-betazellen-funktion
WO2007059470A2 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
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BRPI0814962B8 (pt) 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
AU2009303389B2 (en) 2008-10-17 2014-10-16 Wisconsin Alumni Research Foundation Method of making biologically active alpha-beta peptides
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2011071480A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
CN103002906B (zh) 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
EP2680871A4 (de) * 2011-03-01 2015-04-22 Sloan Kettering Inst Cancer Nebenschilddrüsen-hormonanaloga, zusammensetzungen damit und verwendungen davon
US20170037086A1 (en) * 2014-04-09 2017-02-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with pth activity
WO2020132269A1 (en) 2018-12-20 2020-06-25 KSQ Therapeutics, Inc. Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors
ES3025474T3 (en) 2020-01-15 2025-06-09 Ksq Therapeutics Inc Compositions of substituted pyrazolopyrimidines and uses thereof
EP4236958A4 (de) 2020-10-30 2024-09-11 KSQ Therapeutics, Inc. Feste formen von substituierten pyrazolopyrimidinen und verwendungen davon
WO2023066881A1 (en) 2021-10-18 2023-04-27 Astrazeneca Ab Inhibition of map3k15 for treating and preventing diabetes

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Also Published As

Publication number Publication date
ES2150948T3 (es) 2000-12-16
AU672790B2 (en) 1996-10-17
GB2269176A (en) 1994-02-02
HUT70459A (en) 1995-10-30
KR940005670A (ko) 1994-03-22
FI950171A7 (fi) 1995-03-13
KR100321651B1 (ko) 2002-05-13
WO1994002510A3 (en) 1994-05-26
EP0672057A1 (de) 1995-09-20
FI950171A0 (fi) 1995-01-13
AU4156693A (en) 1994-01-20
NO319448B1 (no) 2005-08-15
WO1994002510A2 (en) 1994-02-03
FI113872B (fi) 2004-06-30
DK0672057T3 (da) 2000-12-27
GR3035089T3 (en) 2001-03-30
PT672057E (pt) 2001-02-28
IL106326A (en) 1997-09-30
CA2100423C (en) 2005-06-14
AT408100B (de) 2001-08-27
HU9500115D0 (en) 1995-03-28
JP3164463B2 (ja) 2001-05-08
SG63625A1 (en) 1999-03-30
CN1099801A (zh) 1995-03-08
DE4393381T1 (de) 1995-04-27
US20050009147A1 (en) 2005-01-13
US20080318838A1 (en) 2008-12-25
GB2269176B (en) 1997-01-08
HU211856A9 (en) 1995-12-28
JPH06184198A (ja) 1994-07-05
CH688195A5 (de) 1997-06-13
IL106326A0 (en) 1994-04-12
GB9314384D0 (en) 1993-08-25
HK1004896A1 (en) 1998-12-11
NO950123L (no) 1995-03-15
CA2100423A1 (en) 1994-01-16
EP0672057B1 (de) 2000-09-20
SK283485B6 (sk) 2003-08-05
NZ248137A (en) 1995-12-21
CZ286889B6 (en) 2000-07-12
CN1051769C (zh) 2000-04-26
NO950123D0 (no) 1995-01-12
SK4395A3 (en) 1995-06-07
CZ8895A3 (en) 1995-10-18
DE4393381B4 (de) 2008-07-17

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