ATE102197T1 - Arylthiazolylimidazole als 5ht3-antagonisten. - Google Patents

Arylthiazolylimidazole als 5ht3-antagonisten.

Info

Publication number: ATE102197T1
Authority: AT; Austria
Prior art keywords: het; mono; antagonists; arylthiazolylimidazole; phenyl
Prior art date: 1989-05-09

Application number

AT90304685T

Other languages

English (en)

Inventor

Arthur Adam Nagel

James Patrick Rizzi

Terry Jay Rosen

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-09

Filing date

1990-04-30

Publication date

1994-03-15

1990-04-30 Application filed by Pfizer filed Critical Pfizer

1994-03-15 Application granted granted Critical

1994-03-15 Publication of ATE102197T1 publication Critical patent/ATE102197T1/de

Links

239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 title abstract 2
-1 3-indolyl Chemical group 0.000 abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
YSWBFLWKAIRHEI-UHFFFAOYSA-N 4,5-dimethyl-1h-imidazole Chemical compound CC=1N=CNC=1C YSWBFLWKAIRHEI-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010028813 Nausea Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000008693 nausea Effects 0.000 abstract 1
230000036407 pain Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT90304685T 1989-05-09 1990-04-30 Arylthiazolylimidazole als 5ht3-antagonisten. ATE102197T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/349,278 US4914207A (en)	1989-05-09	1989-05-09	Arylthiazolylimidazoles

Publications (1)

Publication Number	Publication Date
ATE102197T1 true ATE102197T1 (de)	1994-03-15

Family

ID=23371665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90304685T ATE102197T1 (de)	1989-05-09	1990-04-30	Arylthiazolylimidazole als 5ht3-antagonisten.

Country Status (10)

Country	Link
US (1)	US4914207A (de)
EP (1)	EP0397365B1 (de)
JP (1)	JPH0692404B2 (de)
AT (1)	ATE102197T1 (de)
CA (1)	CA2016181C (de)
DE (1)	DE69006907T2 (de)
DK (1)	DK0397365T3 (de)
ES (1)	ES2062354T3 (de)
FI (1)	FI94639C (de)
IE (1)	IE62936B1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5140034A (en) *	1989-03-14	1992-08-18	Merck Sharp & Dohme Ltd.	Five-membered ring systems with bonded imidazolyl ring substituents
JPH07121917B2 (ja) *	1989-07-31	1995-12-25	四国化成工業株式会社	４（５）―チオカルバモイル―イミダゾール化合物及びその合成方法
WO1992016527A1 (fr) *	1991-03-22	1992-10-01	Nippon Soda Co., Ltd.	Derive de pyridine substitue en position 2, sa production, et bactericide d'agrohorticulture
TW294595B (de) *	1992-11-20	1997-01-01	Janssen Pharmaceutica Nv
WO1995024406A1 (en) *	1994-03-10	1995-09-14	Yamanouchi Pharmaceutical Co., Ltd.	Novel 2-(imidazolylmethyl)thiazole derivative and medicinal comp osition thereof
US5874452A (en) *	1996-04-03	1999-02-23	Merck & Co., Inc.	Biheteroaryl inhibitors of farnesyl-protein transferase
US6093737A (en) *	1996-12-30	2000-07-25	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
AU6013998A (en) *	1996-12-30	1998-07-31	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6127390A (en) *	1997-10-02	2000-10-03	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
US6426356B1 (en)	1998-11-18	2002-07-30	Ortho-Mcneil Pharmaceutical, Inc.	Imidazoethyl thiophenes
HU228783B1 (en) *	2001-07-26	2013-05-28	Greenearth Cleaning	Dry cleaning apparatus and method capable of utilizing a siloxane solvent
WO2004014881A2 (en)	2002-08-09	2004-02-19	Astra Zeneca Ab	'1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5
US8106070B2 (en) *	2006-10-20	2012-01-31	Merck Sharp & Dohme Corp.	Substituted imidazoles as bombesin receptor subtype-3 modulators
ES2432618T3 (es)	2009-05-20	2013-12-04	Inserm (Institut National De La Santé Et De La Recherche Medicale)	Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
EP2432467B1 (de)	2009-05-20	2018-02-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin-5-ht3-rezeptor-antagonisten zur verwendung bei der behandlung von vestibulären läsionsstörungen
JP6105594B2 (ja)	2011-09-30	2017-03-29	エンドゥファーマシューティカルズ，インコーポレイティド	癌処置用ｃｙｐ１７阻害剤としてのイミダゾール誘導体
JP6130383B2 (ja)	2011-09-30	2017-05-17	エンドゥファーマシューティカルズ，インコーポレイティド	ピリジン誘導体
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
WO2019033201A1 (en)	2017-08-14	2019-02-21	Gestion Claude Boivin Inc.	MECHANICAL ARM SYSTEM FOR COLLECTING GARBAGE FROM A GARBAGE CONTAINER

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3519637A (en) *	1966-12-06	1970-07-07	Hoffmann La Roche	1-(4-thiazolylmethyl)nitroimidazole derivatives
NL7017486A (de) *	1969-12-15	1971-06-17
DE1964995A1 (de) *	1969-12-24	1971-07-01	Bayer Ag	N-Benzyltriazole,Verfahren zu ihrer Herstellung und ihre Verwendung zur Regulierung des Pflanzenwachstums
US4468399A (en) *	1981-12-28	1984-08-28	Eli Lilly And Company	2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
US4746669A (en) *	1985-12-23	1988-05-24	Merck & Co., Inc.	Substituted thiazoles as immunoregulants
JPH0725754B2 (ja) *	1986-01-30	1995-03-22	富山化学工業株式会社	新規なチアゾール化合物またはその塩
DE3830240A1 (de) *	1987-10-14	1989-04-27	Bayer Ag	Substituierte 1-aryl-1-(thiazol-2-yl)-2-(1,2,4-triazol-1-yl)- und -(imidazol-1-yl)-ethanole, verfahren sowie substituierte 1-aryl-1-(thiazol-2-yl)-2-bromethanole als zwischenprodukte zu ihrer herstellung, und sie enthaltende fungizide und pflanzenwuchsregulierende mittel

1989
- 1989-05-09 US US07/349,278 patent/US4914207A/en not_active Expired - Lifetime
1990
- 1990-04-30 EP EP90304685A patent/EP0397365B1/de not_active Expired - Lifetime
- 1990-04-30 AT AT90304685T patent/ATE102197T1/de not_active IP Right Cessation
- 1990-04-30 DK DK90304685.2T patent/DK0397365T3/da active
- 1990-04-30 DE DE69006907T patent/DE69006907T2/de not_active Expired - Fee Related
- 1990-04-30 ES ES90304685T patent/ES2062354T3/es not_active Expired - Lifetime
- 1990-05-07 CA CA002016181A patent/CA2016181C/en not_active Expired - Fee Related
- 1990-05-08 FI FI902292A patent/FI94639C/fi not_active IP Right Cessation
- 1990-05-08 IE IE166590A patent/IE62936B1/en unknown
- 1990-05-09 JP JP2119644A patent/JPH0692404B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI902292A0 (fi)	1990-05-08
US4914207A (en)	1990-04-03
CA2016181C (en)	1999-03-23
FI94639B (fi)	1995-06-30
DK0397365T3 (da)	1994-05-24
DE69006907D1 (de)	1994-04-07
IE901665L (en)	1990-11-09
JPH0692404B2 (ja)	1994-11-16
CA2016181A1 (en)	1990-11-09
DE69006907T2 (de)	1994-06-09
EP0397365A1 (de)	1990-11-14
IE62936B1 (en)	1995-03-08
JPH032180A (ja)	1991-01-08
EP0397365B1 (de)	1994-03-02
FI94639C (fi)	1995-10-10
ES2062354T3 (es)	1994-12-16

Legal Events

Date	Code	Title	Description
1994-12-15	UEP	Publication of translation of european patent specification
2000-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69006907D1 (de)	1994-04-07	Arylthiazolylimidazole als 5HT3-Antagonisten.
DE58909248D1 (de)	1995-06-29	Heterocyclisch substituierte alfa-Aryl-acrylsäureester und Fungizide, die diese Verbindungen enthalten.
ATE116317T1 (de)	1995-01-15	Chinuclidinderivate.
NO913785D0 (no)	1991-09-26	Fremgangsmaate for fremstilling av fibrinogenreseptorantagonister.
ATE196141T1 (de)	2000-09-15	Heterocyclisch substituierte phenyl-cyclohexan- carbonsäurederivate als angiotensin ii antagonisten
DE60011895D1 (de)	2004-08-05	Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung
DE3750443D1 (de)	1994-10-06	Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und antibakterielle Mittel.
NO924949D0 (no)	1992-12-21	Piperidylsubstituerte indoler
FR2683819B1 (fr)	1994-02-11	Derives de quinoleine, leur procede de preparation et leur application en therapeutique.
DE69302646D1 (de)	1996-06-20	Benzimidazolverbindungen als Antibiotika gegen Campylobacter pylon
ATE194338T1 (de)	2000-07-15	Diphenylthiazolderivate mit antiinflammatorischer aktivität
DE69002384D1 (de)	1993-09-02	Heterocyclische guanidine als 5ht-3-antagonisten.
DE69029954D1 (de)	1997-03-27	Pyridinderivate
DE69708484D1 (de)	2002-01-10	Pyridinderivate,als Arzneimittel zur Behandlung von Geschwüren und als antibakterielle Mittel
DE59206593D1 (de)	1996-07-25	Verwendung von 2-Iminothiazolidin-4-onderivaten als neuartige Arzneimittelwirkstoffe
ATE169917T1 (de)	1998-09-15	Imidazo (4,5-c)pyridinderivate als paf antagonisten
KR940009186A (ko)	1994-05-20	이미다조피리딘
ATE56213T1 (de)	1990-09-15	Substituierte carbonsaeureamide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
EP2266566A3 (de)	2011-01-12	Nicotinamid Derivate und ihrer Verwendung als Therapeutika
FI921298A7 (fi)	1992-03-25	Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi