ATE139569T1 - Modifizierter, menschlicher gewebeplasminogenaktivator und seine herstellung - Google Patents

Modifizierter, menschlicher gewebeplasminogenaktivator und seine herstellung

Info

Publication number
ATE139569T1
ATE139569T1 AT87302267T AT87302267T ATE139569T1 AT E139569 T1 ATE139569 T1 AT E139569T1 AT 87302267 T AT87302267 T AT 87302267T AT 87302267 T AT87302267 T AT 87302267T AT E139569 T1 ATE139569 T1 AT E139569T1
Authority
AT
Austria
Prior art keywords
human tissue
production
plasminogen activator
tissue plasminogen
modified human
Prior art date
Application number
AT87302267T
Other languages
English (en)
Inventor
Adair John Hotchkiss
Michael Walter Spellman
John Vincent O'connor
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE139569T1 publication Critical patent/ATE139569T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87302267T 1986-03-18 1987-03-17 Modifizierter, menschlicher gewebeplasminogenaktivator und seine herstellung ATE139569T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84107586A 1986-03-18 1986-03-18
US2189387A 1987-03-04 1987-03-04

Publications (1)

Publication Number Publication Date
ATE139569T1 true ATE139569T1 (de) 1996-07-15

Family

ID=26695219

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87302267T ATE139569T1 (de) 1986-03-18 1987-03-17 Modifizierter, menschlicher gewebeplasminogenaktivator und seine herstellung

Country Status (19)

Country Link
EP (1) EP0238304B1 (de)
JP (1) JP2972812B2 (de)
AT (1) ATE139569T1 (de)
AU (1) AU602510B2 (de)
CA (1) CA1341597C (de)
DD (1) DD258999A5 (de)
DE (2) DE3751842T2 (de)
DK (1) DK175490B1 (de)
ES (1) ES2088860T3 (de)
FI (1) FI100802B (de)
FR (1) FR2597883B1 (de)
GB (1) GB2189249B (de)
GR (1) GR3020850T3 (de)
HU (1) HU202276B (de)
IE (1) IE81073B1 (de)
IL (1) IL81937A (de)
NO (1) NO172133C (de)
NZ (1) NZ219654A (de)
PT (1) PT84493B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8702945A1 (es) * 1984-10-01 1987-01-16 Integrated Genetics Inc Un metodo de producir activador de plasminogeno de tejido uterino humano
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
DE3684680D1 (de) * 1985-12-23 1992-05-07 Chiron Corp Peptidplasminogenaktivatoren.
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
ZA883958B (en) * 1987-06-04 1989-07-26 Zymogenetics Inc Mutant t-pa with ringle replacement
IL86909A0 (en) * 1987-07-01 1988-11-30 Beecham Group Plc Hybrid plasminogen activator,dna coding therefor,derivatives of said plasminogen activator and pharmaceutical compositions containing said plasminogen activator or said derivatives
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3841296A1 (de) * 1988-12-08 1990-06-13 Bosch Gmbh Robert Antiblockierregelsystem
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
CA2368797C (en) 1999-04-26 2010-08-17 Genentech, Inc. Cell culture process
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA833174B (en) * 1982-05-05 1984-08-29 Genentech Inc Human tissue plasminogen activator
EP0125254A1 (de) * 1982-10-28 1984-11-21 Beecham Group Plc Enzymderivate und deren verwendung bei der behandlung von trombosen
EP0125269A1 (de) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmazeutisch aktive verbindungen
ES8702945A1 (es) * 1984-10-01 1987-01-16 Integrated Genetics Inc Un metodo de producir activador de plasminogeno de tejido uterino humano
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
DE3613390C2 (de) * 1985-04-22 2001-10-11 Genentech Inc Einkettige Human-Gewebeplasminogen-Aktivator (t-PA)-Mutanten, kodierende DNA, Expressionsvektor, Mikroorganismus, Zellkultur und pharmazeutische Zusammensetzung
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
DE3684680D1 (de) * 1985-12-23 1992-05-07 Chiron Corp Peptidplasminogenaktivatoren.
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
DE3751842T2 (de) 1996-11-28
CA1341597C (en) 2009-06-23
HUT43108A (en) 1987-09-28
GR3020850T3 (en) 1996-11-30
FI871175A0 (fi) 1987-03-18
FI871175L (fi) 1987-09-19
DE3751842D1 (de) 1996-07-25
NO172133B (no) 1993-03-01
IL81937A0 (en) 1987-10-20
DD258999A5 (de) 1988-08-10
GB2189249B (en) 1990-10-31
DK175490B1 (da) 2004-11-08
HU202276B (en) 1991-02-28
IE870691L (en) 1987-09-18
FI100802B (fi) 1998-02-27
DE3708681A1 (de) 1987-10-01
AU602510B2 (en) 1990-10-18
NO871086D0 (no) 1987-03-17
JP2972812B2 (ja) 1999-11-08
JPS62282582A (ja) 1987-12-08
PT84493A (en) 1987-04-01
EP0238304A3 (en) 1988-07-06
ES2088860T3 (es) 1996-10-01
GB2189249A (en) 1987-10-21
GB8706249D0 (en) 1987-04-23
NO871086L (no) 1987-09-21
AU7008887A (en) 1987-09-24
EP0238304A2 (de) 1987-09-23
DE3708681C2 (de) 1995-08-17
PT84493B (pt) 1989-11-10
DK135887D0 (da) 1987-03-17
NZ219654A (en) 1990-08-28
DK135887A (da) 1987-09-19
EP0238304B1 (de) 1996-06-19
IL81937A (en) 1994-07-31
FR2597883B1 (fr) 1990-04-20
IE81073B1 (en) 2000-01-12
FR2597883A1 (fr) 1987-10-30
NO172133C (no) 1993-06-09

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time