ATE104671T1 - 4-methylen-1-oxa-2-oxo-8azaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. - Google Patents

4-methylen-1-oxa-2-oxo-8azaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Info

Publication number: ATE104671T1
Authority: AT; Austria
Prior art keywords: alkyl; ethynyl; fluorophenyl; bis; opt
Prior art date: 1989-08-10

Application number

AT9090308783T

Other languages

English (en)

Inventor

Edit Toth

Jozsef Toerley

Sandor Dr Goeroeg

Laszlo Dr Szporny

Bela Kiss

Eva Dr Palosi

Dora Dr Groo

Istvan Dr Laszlovszky

Erzsebet Dr Lapis

Ferenc Auth

Laszlo Dr Gaal

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1994-05-15

1990-08-09 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1994-05-15 Application granted granted Critical

1994-05-15 Publication of ATE104671T1 publication Critical patent/ATE104671T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
RAPAKELQTSIJRM-UHFFFAOYSA-N 1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CCC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 RAPAKELQTSIJRM-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
WYDMNGYRWISCLZ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)prop-2-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 WYDMNGYRWISCLZ-UHFFFAOYSA-N 0.000 abstract 1
VLVWUSGOTSWICZ-UHFFFAOYSA-N [1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-yl] n-benzylcarbamate Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)=CCCN1CCC(C#C)(OC(=O)NCC=2C=CC=CC=2)CC1 VLVWUSGOTSWICZ-UHFFFAOYSA-N 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

AT9090308783T 1989-08-10 1990-08-09 4-methylen-1-oxa-2-oxo-8azaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. ATE104671T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU894094A HU204276B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
EP90308783A EP0413516B1 (de)	1989-08-10	1990-08-09	4-Methylen-1-oxa-2-oxo-8-azaspiro[4,5]decanderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number	Publication Date
ATE104671T1 true ATE104671T1 (de)	1994-05-15

Family

ID=10966866

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT9090308783T ATE104671T1 (de)	1989-08-10	1990-08-09	4-methylen-1-oxa-2-oxo-8azaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
AT90308779T ATE113951T1 (de)	1989-08-10	1990-08-09	1-oxa-2-oxo-3,8-diazaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT90308779T ATE113951T1 (de)	1989-08-10	1990-08-09	1-oxa-2-oxo-3,8-diazaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Country Status (26)

Country	Link
US (2)	US5132309A (de)
EP (2)	EP0413516B1 (de)
JP (2)	JPH0381277A (de)
KR (2)	KR940002826B1 (de)
CN (1)	CN1025031C (de)
AT (2)	ATE104671T1 (de)
AU (2)	AU621771B2 (de)
CA (2)	CA2023015A1 (de)
DD (2)	DD299428A5 (de)
DE (2)	DE69008275T2 (de)
DK (1)	DK0413516T3 (de)
ES (2)	ES2063923T3 (de)
FI (1)	FI93456C (de)
HK (1)	HK118295A (de)
HU (2)	HU206677B (de)
IE (1)	IE902885A1 (de)
IL (2)	IL95325A (de)
IN (1)	IN170979B (de)
IS (1)	IS3612A7 (de)
MY (1)	MY107240A (de)
NO (1)	NO903511L (de)
NZ (2)	NZ234846A (de)
PL (2)	PL163899B1 (de)
SG (1)	SG59864G (de)
YU (2)	YU150489A (de)
ZA (3)	ZA906300B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0279990B1 (de) *	1986-12-17	1995-07-12	Glaxo Group Limited	Verwendung von heterocyclischen Verbindungen zur Behandlung von Bewusstseinsstörungen
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
EP0492020A1 (de) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Verwendung von bestimmten Estern von Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-on und verwandter Verbindungen zur Behandlung von kognitiven Erkrankungen
GB9206989D0 (en) *	1992-03-31	1992-05-13	Glaxo Group Ltd	Chemical compounds
US5756743A (en) *	1996-04-10	1998-05-26	Hoechst Marion Roussel Inc.	Spiro cyclopent b!indole-piperidines!
US6100256A (en) *	1996-12-02	2000-08-08	Merck Sharp & Dohme Ltd.	Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en)	1996-12-20	2005-12-13	Astrazeneca Canada Inc.	Compounds with analgesic effect
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
SE9904675D0 (sv)	1999-12-20	1999-12-20	Astra Pharma Inc	Novel compounds
SE0101770D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101771D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101769D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101773D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
KR20030087248A (ko) *	2002-05-08	2003-11-14	(주)씨엔아이	온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
AU2010260381B2 (en) *	2009-06-16	2013-10-24	Merck Sharp & Dohme Corp.	Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
GB201416346D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives
GB201416352D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL127065C (de) *	1964-04-22
CH601304A5 (de) *	1974-02-12	1978-07-14	Buskine Sa
BE790675A (fr) *	1971-10-29	1973-04-27	Science Union & Cie	Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) *	1987-05-22	1989-06-30	Adir	Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204530B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

1989
- 1989-07-27 YU YU150489A patent/YU150489A/sh unknown
- 1989-08-10 HU HU903233A patent/HU206677B/hu not_active IP Right Cessation
- 1989-08-10 HU HU894094A patent/HU204276B/hu not_active IP Right Cessation
1990
- 1990-08-08 KR KR1019900012168A patent/KR940002826B1/ko not_active Expired - Fee Related
- 1990-08-08 KR KR1019900012169A patent/KR940000830B1/ko not_active Expired - Fee Related
- 1990-08-09 NZ NZ234846A patent/NZ234846A/en unknown
- 1990-08-09 IL IL9532590A patent/IL95325A/en not_active IP Right Cessation
- 1990-08-09 ES ES90308779T patent/ES2063923T3/es not_active Expired - Lifetime
- 1990-08-09 DD DD90343354A patent/DD299428A5/de not_active IP Right Cessation
- 1990-08-09 ZA ZA906300A patent/ZA906300B/xx unknown
- 1990-08-09 EP EP90308783A patent/EP0413516B1/de not_active Expired - Lifetime
- 1990-08-09 DE DE69008275T patent/DE69008275T2/de not_active Expired - Fee Related
- 1990-08-09 IL IL9532490A patent/IL95324A/en not_active IP Right Cessation
- 1990-08-09 AU AU60803/90A patent/AU621771B2/en not_active Ceased
- 1990-08-09 NZ NZ234843A patent/NZ234843A/en unknown
- 1990-08-09 SG SG1995903969A patent/SG59864G/en unknown
- 1990-08-09 NO NO90903511A patent/NO903511L/no unknown
- 1990-08-09 DK DK90308783.1T patent/DK0413516T3/da active
- 1990-08-09 YU YU154090A patent/YU154090A/sh unknown
- 1990-08-09 AU AU60804/90A patent/AU621238B2/en not_active Ceased
- 1990-08-09 AT AT9090308783T patent/ATE104671T1/de not_active IP Right Cessation
- 1990-08-09 JP JP2209362A patent/JPH0381277A/ja active Pending
- 1990-08-09 IN IN687/CAL/90A patent/IN170979B/en unknown
- 1990-08-09 ZA ZA906304A patent/ZA906304B/xx unknown
- 1990-08-09 ZA ZA906299A patent/ZA906299B/xx unknown
- 1990-08-09 CA CA002023015A patent/CA2023015A1/en not_active Abandoned
- 1990-08-09 EP EP90308779A patent/EP0412821B1/de not_active Expired - Lifetime
- 1990-08-09 IS IS3612A patent/IS3612A7/is unknown
- 1990-08-09 DD DD90343359A patent/DD299431A5/de not_active IP Right Cessation
- 1990-08-09 AT AT90308779T patent/ATE113951T1/de not_active IP Right Cessation
- 1990-08-09 CA CA002023018A patent/CA2023018C/en not_active Expired - Fee Related
- 1990-08-09 DE DE69014008T patent/DE69014008T2/de not_active Expired - Fee Related
- 1990-08-09 JP JP2209363A patent/JPH0383985A/ja active Pending
- 1990-08-09 ES ES90308783T patent/ES2052179T3/es not_active Expired - Lifetime
- 1990-08-09 IE IE288590A patent/IE902885A1/en unknown
- 1990-08-10 FI FI903974A patent/FI93456C/fi not_active IP Right Cessation
- 1990-08-10 US US07/566,279 patent/US5132309A/en not_active Expired - Fee Related
- 1990-08-10 US US07/566,278 patent/US5132303A/en not_active Expired - Fee Related
- 1990-08-10 MY MYPI90001343A patent/MY107240A/en unknown
- 1990-08-10 CN CN90106974A patent/CN1025031C/zh not_active Expired - Fee Related
- 1990-08-10 PL PL90286443A patent/PL163899B1/pl unknown
- 1990-08-10 PL PL90291648A patent/PL164662B1/pl unknown
1995
- 1995-07-20 HK HK118295A patent/HK118295A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5132303A (en)	1992-07-21
IL95325A0 (en)	1991-06-30
CA2023018C (en)	1995-11-28
DD299428A5 (de)	1992-04-16
JPH0383985A (ja)	1991-04-09
IL95325A (en)	1994-06-24
FI93456B (fi)	1994-12-30
NZ234846A (en)	1992-03-26
KR940000830B1 (ko)	1994-02-02
IL95324A (en)	1994-02-27
AU6080390A (en)	1991-02-14
US5132309A (en)	1992-07-21
IL95324A0 (en)	1991-06-30
EP0413516A2 (de)	1991-02-20
CA2023018A1 (en)	1991-02-11
CA2023015A1 (en)	1991-02-11
HU903233D0 (en)	1990-10-28
EP0412821A2 (de)	1991-02-13
IE902885A1 (en)	1991-02-27
PL286443A1 (en)	1992-01-13
HUT59375A (en)	1992-05-28
ZA906299B (en)	1991-06-26
CN1049349A (zh)	1991-02-20
DD299431A5 (de)	1992-04-16
HK118295A (en)	1995-07-28
FI93456C (fi)	1995-04-10
FI903974A0 (fi)	1990-08-10
MY107240A (en)	1995-10-31
ES2052179T3 (es)	1994-07-01
YU154090A (sh)	1992-12-21
CN1025031C (zh)	1994-06-15
EP0413516B1 (de)	1994-04-20
IN170979B (de)	1992-06-27
EP0412821A3 (en)	1991-11-27
DK0413516T3 (da)	1994-05-24
PL291648A1 (en)	1992-06-01
KR910004631A (ko)	1991-03-29
ATE113951T1 (de)	1994-11-15
ES2063923T3 (es)	1995-01-16
EP0413516A3 (en)	1991-11-27
DE69014008T2 (de)	1995-03-23
KR940002826B1 (ko)	1994-04-04
IS3612A7 (is)	1991-02-11
JPH0381277A (ja)	1991-04-05
NO903511D0 (no)	1990-08-09
PL164662B1 (pl)	1994-09-30
ZA906304B (en)	1991-06-26
PL163899B1 (pl)	1994-05-31
AU6080490A (en)	1991-02-14
KR910004630A (ko)	1991-03-29
DE69008275T2 (de)	1994-08-04
HU206677B (en)	1992-12-28
YU150489A (sh)	1992-12-21
EP0412821B1 (de)	1994-11-09
SG59864G (en)	1995-09-01
DE69008275D1 (de)	1994-05-26
AU621238B2 (en)	1992-03-05
HU204276B (en)	1991-12-30
ZA906300B (en)	1991-05-29
NO903511L (no)	1991-02-11
DE69014008D1 (de)	1994-12-15
AU621771B2 (en)	1992-03-19
NZ234843A (en)	1992-03-26
HUT55785A (en)	1991-06-28

Legal Events

Date	Code	Title	Description
1995-01-15	UEP	Publication of translation of european patent specification
1996-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE104671T1 (de)	1994-05-15	4-methylen-1-oxa-2-oxo-8azaspiro(4,5>decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
FR2725986B1 (fr)	1996-11-29	Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69210029D1 (de)	1996-05-23	Azacyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69201956D1 (de)	1995-05-11	Pyrrolidin- und thiazolidinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE160338T1 (de)	1997-12-15	Alpha aminosäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE69710909D1 (de)	2002-04-11	Substituierte tetrahydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ATE125538T1 (de)	1995-08-15	Thiochromanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
ATE112267T1 (de)	1994-10-15	Diacylglycerol-nicotinate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
DE3875543D1 (de)	1992-12-03	1-(2-(phenylmethyl)phenyl)-piperazin-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
DE3867705D1 (de)	1992-02-27	2-anilino-chinoline, verfahren zu ihrer herstellung und diese enthaltende fungizide.
ATE138641T1 (de)	1996-06-15	P-(di(2-chloroethyl)amino>phenylalanin-derivate verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen