ES2052179T3 - Derivados de 4-metilen-1-oxa-2-oxo-8-azaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos. - Google Patents

Derivados de 4-metilen-1-oxa-2-oxo-8-azaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos.

Info

Publication number
ES2052179T3
ES2052179T3 ES90308783T ES90308783T ES2052179T3 ES 2052179 T3 ES2052179 T3 ES 2052179T3 ES 90308783 T ES90308783 T ES 90308783T ES 90308783 T ES90308783 T ES 90308783T ES 2052179 T3 ES2052179 T3 ES 2052179T3
Authority
ES
Spain
Prior art keywords
group
azaespiro
dean
oxa
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308783T
Other languages
English (en)
Inventor
Edit Toth
Jozsef Torley
Sandor Dr Gorog
Laszlo Dr Szporny
Bela Kiss
Eva Dr Palosi
Dora Dr Groo
Istvan Dr Laszlovszky
Erzsebet Dr Lapis
Ferenc Auth
Laszlo Dr Gaal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of ES2052179T3 publication Critical patent/ES2052179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

ESTA INVENCION ES RELATIVA A DERIVADOS 4-METILENO-1-OXA-2-OXO -8-AZAESPIRO[4,5]DECANO DE LA FORMULA (I), EN DONDE -X REPRESENTA UN ATOMO DE OXIGENO O UN GRUPO NR, EN DONDE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-12 O CICLOALQUILO C3-6, O UN GRUPO ARILO C6-10 CARBOCICLICO O ARILO C6-10 CARBOCICLICO ALQUILO C1-4, OPCIONALMENTE SUSTITUIDO SOBRE EL ANILLO AROMATICO POR UNO O MAS ATOMOS HALOGENOS, GRUPOS ALQUILO C1-4 O GRUPOS ALCOXILO C1-4. PH1 Y PH2, LOS CUALES PUEDEN SER EL MISMO O DIFERENTES, REPRESENTA CADA UNO UN GRUPO FENILO SUSTITUIDO O NO SUSTITUIDO POR UNO O MAS ATOMOS HALOGENOS O ALQUILO C1-4, ALCOXILO C1-4, GRUPOS TRIHALOMETILO O GRUPOS HIDROXILO OPCIONALMENTE ESTERIFICADOS POR UN ACIDO ALCANOICO C1-4; Y N ES 1 O 2; E ISOMEROS OPTICOS Y MEZCLAS DE ELLOS, Y TODAS LAS DISOLUCIONES, HIDRATOS Y SALES AMONIO-CUATERNARIAS O DE ADICION ACIDA DE ELLOS. LA INVENCION ADEMAS ES RELATIVA A COMPOSICIONES FARMACEUTICAS CONTENIENDO ESTOS COMPUESTOS Y PROCESOS PARA SU PREPARACION. LOS COMPUESTOS DE LA FORMULA (I) POSEEN PROPIEDADES ANTIPSICOTICAS. POR ESTO, SE EMPLEAN PARA EL TRATAMIENTO DE DESORDENES PSIQUIATRICOS.
ES90308783T 1989-08-10 1990-08-09 Derivados de 4-metilen-1-oxa-2-oxo-8-azaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos. Expired - Lifetime ES2052179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2052179T3 true ES2052179T3 (es) 1994-07-01

Family

ID=10966866

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90308779T Expired - Lifetime ES2063923T3 (es) 1989-08-10 1990-08-09 Derivados de 1-oxa-2-oxo-3,8-diazaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos.
ES90308783T Expired - Lifetime ES2052179T3 (es) 1989-08-10 1990-08-09 Derivados de 4-metilen-1-oxa-2-oxo-8-azaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES90308779T Expired - Lifetime ES2063923T3 (es) 1989-08-10 1990-08-09 Derivados de 1-oxa-2-oxo-3,8-diazaespiro(4,5)decano, composiciones farmaceuticas que los contienen y procesos para prepararlos.

Country Status (26)

Country Link
US (2) US5132309A (es)
EP (2) EP0413516B1 (es)
JP (2) JPH0383985A (es)
KR (2) KR940000830B1 (es)
CN (1) CN1025031C (es)
AT (2) ATE113951T1 (es)
AU (2) AU621771B2 (es)
CA (2) CA2023018C (es)
DD (2) DD299428A5 (es)
DE (2) DE69014008T2 (es)
DK (1) DK0413516T3 (es)
ES (2) ES2063923T3 (es)
FI (1) FI93456C (es)
HK (1) HK118295A (es)
HU (2) HU204276B (es)
IE (1) IE902885A1 (es)
IL (2) IL95324A (es)
IN (1) IN170979B (es)
IS (1) IS3612A7 (es)
MY (1) MY107240A (es)
NO (1) NO903511L (es)
NZ (2) NZ234843A (es)
PL (2) PL163899B1 (es)
SG (1) SG59864G (es)
YU (2) YU150489A (es)
ZA (3) ZA906299B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0551963A3 (en) * 1986-12-17 1993-09-01 Glaxo Group Limited Use of heterocyclic derivatives for the manufacture of medicaments
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5756743A (en) 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
KR20030087248A (ko) * 2002-05-08 2003-11-14 (주)씨엔아이 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
CA2765415A1 (en) * 2009-06-16 2010-12-23 Merck Sharp & Dohme Corp. Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (es) * 1964-04-22
CH601304A5 (es) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH0381277A (ja) 1991-04-05
EP0412821A2 (en) 1991-02-13
HU903233D0 (en) 1990-10-28
AU6080390A (en) 1991-02-14
JPH0383985A (ja) 1991-04-09
ZA906300B (en) 1991-05-29
AU6080490A (en) 1991-02-14
US5132303A (en) 1992-07-21
ES2063923T3 (es) 1995-01-16
PL164662B1 (pl) 1994-09-30
DD299428A5 (de) 1992-04-16
SG59864G (en) 1995-09-01
NO903511D0 (no) 1990-08-09
KR910004630A (ko) 1991-03-29
CN1049349A (zh) 1991-02-20
FI93456B (fi) 1994-12-30
CA2023015A1 (en) 1991-02-11
IL95324A (en) 1994-02-27
CA2023018A1 (en) 1991-02-11
HUT59375A (en) 1992-05-28
YU154090A (sh) 1992-12-21
CN1025031C (zh) 1994-06-15
EP0412821B1 (en) 1994-11-09
IN170979B (es) 1992-06-27
HUT55785A (en) 1991-06-28
ZA906299B (en) 1991-06-26
DD299431A5 (de) 1992-04-16
IL95324A0 (en) 1991-06-30
NZ234846A (en) 1992-03-26
AU621238B2 (en) 1992-03-05
IL95325A0 (en) 1991-06-30
HU204276B (en) 1991-12-30
IE902885A1 (en) 1991-02-27
AU621771B2 (en) 1992-03-19
PL291648A1 (en) 1992-06-01
DK0413516T3 (da) 1994-05-24
FI93456C (fi) 1995-04-10
MY107240A (en) 1995-10-31
IS3612A7 (is) 1991-02-11
DE69014008D1 (de) 1994-12-15
EP0412821A3 (en) 1991-11-27
ZA906304B (en) 1991-06-26
HK118295A (en) 1995-07-28
EP0413516A2 (en) 1991-02-20
CA2023018C (en) 1995-11-28
PL286443A1 (en) 1992-01-13
ATE113951T1 (de) 1994-11-15
KR940000830B1 (ko) 1994-02-02
IL95325A (en) 1994-06-24
DE69008275T2 (de) 1994-08-04
NZ234843A (en) 1992-03-26
ATE104671T1 (de) 1994-05-15
YU150489A (sh) 1992-12-21
KR910004631A (ko) 1991-03-29
DE69014008T2 (de) 1995-03-23
PL163899B1 (pl) 1994-05-31
DE69008275D1 (de) 1994-05-26
US5132309A (en) 1992-07-21
HU206677B (en) 1992-12-28
NO903511L (no) 1991-02-11
EP0413516A3 (en) 1991-11-27
FI903974A0 (fi) 1990-08-10
KR940002826B1 (ko) 1994-04-04
EP0413516B1 (en) 1994-04-20

Similar Documents

Publication Publication Date Title
PA8517101A1 (es) Derivados de tropano ùtiles en terapia
YU46738B (sh) Postupak za dobijanje benzodiazepina
ES2058292T3 (es) Derivados de indol.
ES512842A0 (es) "procedimiento de preparar derivados carboxamidicos".
ES2011210T3 (es) Derivados de gem-difosfonato substituido, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
BR9703447A (pt) Novos compostos 3-(piperid-4-il)-1,2-benzisoxazol e 3-(piperazin-4-il) 1,2-benzisoxazol processos para a preparação dos mesmos e composições farmacêuticas contendo os mesmo
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
AR034009A1 (es) Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos
ES2052181T3 (es) Derivados de 2-oxo-1-oxa-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos.
ES2098248T3 (es) Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
PT83725B (pt) Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
ATE243209T1 (de) Tetrahydro gamma-carboline
MX19637A (es) 2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos substituidos en el anillo y procedimiento para su preparacion.
ES2063117T3 (es) Derivados del tieno(2,3-d)acepina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2089255T3 (es) N-(ariloxialquil)heteroaril-8-azabiciclo(3.2.1)octanos, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos.
ES2152237T3 (es) Pirazolo(4,3-c)piridinas, un procedimiento para su preparacion y su uso como inhibidores de la recaptacion de serotonina.
ES2063282T3 (es) Derivados de piperidina 4,4-disubstituidos, procesos para su preparacion y composiciones farmaceuticas de los mismos.
ES8601211A1 (es) Procedimiento para la preparacion de nuevos derivados de sinergistinas
ES2052180T3 (es) Derivados de 1-oxa-2-oxo-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos.
AR033624A1 (es) Derivados del dihidro-imidazo[4,5-e]indol y de la 7h-pirrolo[3,2-f]quinoxalina en calidad de ligandos nicotinicos del receptor para acetilcolina y/o de ligandos serotoninergicos, un procedimiento para su preparacion, las composiciones farmaceuticas que los contienen, y el empleo de los mismos para p
ES2063771T3 (es) Nuevos derivados de amida del acido 4-oxo-4h-pirido (1,2-a) pirimidin-3-carboxilicos, su preparacion y elaboracion de medicamentos que contienen estos compuestos, asi como la preparacion de los mismos.
MX9205921A (es) Derivados de bis(fenil)etano, proceso para su preparacion y composicion farmaceutica que los contiene
ES8601141A1 (es) Un procedimiento para la produccion de derivados de isoquinolina sustituidos
DK0468445T3 (da) Fremgangsmåde til fremstilling af 6-(substitueret aminopropionyl)-derivater af forskolin
ES547962A0 (es) Procedimiento para la fabricacion de derivados de tiadiazol activos sobre el sistema nervioso central

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 413516

Country of ref document: ES