IS3612A7 - Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær - Google Patents

Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær

Info

Publication number: IS3612A7
Authority: IS; Iceland
Prior art keywords: alkyl; ethynyl; fluorophenyl; bis; opt
Prior art date: 1989-08-10

Application number

IS3612A

Other languages

English (en)

Inventor

Toth Edit

Törley Jozsef

βndor Görög DR.S

L βszlo Szporny DR.

Kiss Béla

éva P βlosi DR.

Dora Groo Dr.

Istv βn Laszlovszky DR.

Erzsébet Lapis DR.

Auth Ferenc

L βszlo Ga βl DR.

Original Assignee

Richter Gedeon Vegyészeti Gy βr Rt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1991-02-11

1990-08-09 Application filed by Richter Gedeon Vegyészeti Gy βr Rt filed Critical Richter Gedeon Vegyészeti Gy βr Rt

1991-02-11 Publication of IS3612A7 publication Critical patent/IS3612A7/is

Links

DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 title 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
229910052760 oxygen Inorganic materials 0.000 title 1
239000001301 oxygen Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
RAPAKELQTSIJRM-UHFFFAOYSA-N 1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CCC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 RAPAKELQTSIJRM-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
WYDMNGYRWISCLZ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)prop-2-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 WYDMNGYRWISCLZ-UHFFFAOYSA-N 0.000 abstract 1
VLVWUSGOTSWICZ-UHFFFAOYSA-N [1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-yl] n-benzylcarbamate Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)=CCCN1CCC(C#C)(OC(=O)NCC=2C=CC=CC=2)CC1 VLVWUSGOTSWICZ-UHFFFAOYSA-N 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

IS3612A 1989-08-10 1990-08-09 Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær IS3612A7 (is)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU894094A HU204276B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
IS3612A7 true IS3612A7 (is)	1991-02-11

Family

ID=10966866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS3612A IS3612A7 (is)	1989-08-10	1990-08-09	Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær

Country Status (26)

Country	Link
US (2)	US5132309A (is)
EP (2)	EP0413516B1 (is)
JP (2)	JPH0381277A (is)
KR (2)	KR940002826B1 (is)
CN (1)	CN1025031C (is)
AT (2)	ATE104671T1 (is)
AU (2)	AU621771B2 (is)
CA (2)	CA2023015A1 (is)
DD (2)	DD299428A5 (is)
DE (2)	DE69008275T2 (is)
DK (1)	DK0413516T3 (is)
ES (2)	ES2063923T3 (is)
FI (1)	FI93456C (is)
HK (1)	HK118295A (is)
HU (2)	HU206677B (is)
IE (1)	IE902885A1 (is)
IL (2)	IL95325A (is)
IN (1)	IN170979B (is)
IS (1)	IS3612A7 (is)
MY (1)	MY107240A (is)
NO (1)	NO903511L (is)
NZ (2)	NZ234846A (is)
PL (2)	PL163899B1 (is)
SG (1)	SG59864G (is)
YU (2)	YU150489A (is)
ZA (3)	ZA906300B (is)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0279990B1 (en) *	1986-12-17	1995-07-12	Glaxo Group Limited	Use of heterocyclic derivatives in the treatment of cognitive disorders
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) *	1992-03-31	1992-05-13	Glaxo Group Ltd	Chemical compounds
US5756743A (en) *	1996-04-10	1998-05-26	Hoechst Marion Roussel Inc.	Spiro cyclopent b!indole-piperidines!
US6100256A (en) *	1996-12-02	2000-08-08	Merck Sharp & Dohme Ltd.	Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en)	1996-12-20	2005-12-13	Astrazeneca Canada Inc.	Compounds with analgesic effect
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
SE9904675D0 (sv)	1999-12-20	1999-12-20	Astra Pharma Inc	Novel compounds
SE0101770D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101771D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101769D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101773D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
KR20030087248A (ko) *	2002-05-08	2003-11-14	(주)씨엔아이	온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
AU2010260381B2 (en) *	2009-06-16	2013-10-24	Merck Sharp & Dohme Corp.	Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
GB201416346D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives
GB201416352D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL127065C (is) *	1964-04-22
CH601304A5 (is) *	1974-02-12	1978-07-14	Buskine Sa
BE790675A (fr) *	1971-10-29	1973-04-27	Science Union & Cie	Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) *	1987-05-22	1989-06-30	Adir	Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204530B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

1989
- 1989-07-27 YU YU150489A patent/YU150489A/sh unknown
- 1989-08-10 HU HU903233A patent/HU206677B/hu not_active IP Right Cessation
- 1989-08-10 HU HU894094A patent/HU204276B/hu not_active IP Right Cessation
1990
- 1990-08-08 KR KR1019900012168A patent/KR940002826B1/ko not_active Expired - Fee Related
- 1990-08-08 KR KR1019900012169A patent/KR940000830B1/ko not_active Expired - Fee Related
- 1990-08-09 NZ NZ234846A patent/NZ234846A/en unknown
- 1990-08-09 IL IL9532590A patent/IL95325A/en not_active IP Right Cessation
- 1990-08-09 ES ES90308779T patent/ES2063923T3/es not_active Expired - Lifetime
- 1990-08-09 DD DD90343354A patent/DD299428A5/de not_active IP Right Cessation
- 1990-08-09 ZA ZA906300A patent/ZA906300B/xx unknown
- 1990-08-09 EP EP90308783A patent/EP0413516B1/en not_active Expired - Lifetime
- 1990-08-09 DE DE69008275T patent/DE69008275T2/de not_active Expired - Fee Related
- 1990-08-09 IL IL9532490A patent/IL95324A/en not_active IP Right Cessation
- 1990-08-09 AU AU60803/90A patent/AU621771B2/en not_active Ceased
- 1990-08-09 NZ NZ234843A patent/NZ234843A/en unknown
- 1990-08-09 SG SG1995903969A patent/SG59864G/en unknown
- 1990-08-09 NO NO90903511A patent/NO903511L/no unknown
- 1990-08-09 DK DK90308783.1T patent/DK0413516T3/da active
- 1990-08-09 YU YU154090A patent/YU154090A/sh unknown
- 1990-08-09 AU AU60804/90A patent/AU621238B2/en not_active Ceased
- 1990-08-09 AT AT9090308783T patent/ATE104671T1/de not_active IP Right Cessation
- 1990-08-09 JP JP2209362A patent/JPH0381277A/ja active Pending
- 1990-08-09 IN IN687/CAL/90A patent/IN170979B/en unknown
- 1990-08-09 ZA ZA906304A patent/ZA906304B/xx unknown
- 1990-08-09 ZA ZA906299A patent/ZA906299B/xx unknown
- 1990-08-09 CA CA002023015A patent/CA2023015A1/en not_active Abandoned
- 1990-08-09 EP EP90308779A patent/EP0412821B1/en not_active Expired - Lifetime
- 1990-08-09 IS IS3612A patent/IS3612A7/is unknown
- 1990-08-09 DD DD90343359A patent/DD299431A5/de not_active IP Right Cessation
- 1990-08-09 AT AT90308779T patent/ATE113951T1/de not_active IP Right Cessation
- 1990-08-09 CA CA002023018A patent/CA2023018C/en not_active Expired - Fee Related
- 1990-08-09 DE DE69014008T patent/DE69014008T2/de not_active Expired - Fee Related
- 1990-08-09 JP JP2209363A patent/JPH0383985A/ja active Pending
- 1990-08-09 ES ES90308783T patent/ES2052179T3/es not_active Expired - Lifetime
- 1990-08-09 IE IE288590A patent/IE902885A1/en unknown
- 1990-08-10 FI FI903974A patent/FI93456C/fi not_active IP Right Cessation
- 1990-08-10 US US07/566,279 patent/US5132309A/en not_active Expired - Fee Related
- 1990-08-10 US US07/566,278 patent/US5132303A/en not_active Expired - Fee Related
- 1990-08-10 MY MYPI90001343A patent/MY107240A/en unknown
- 1990-08-10 CN CN90106974A patent/CN1025031C/zh not_active Expired - Fee Related
- 1990-08-10 PL PL90286443A patent/PL163899B1/pl unknown
- 1990-08-10 PL PL90291648A patent/PL164662B1/pl unknown
1995
- 1995-07-20 HK HK118295A patent/HK118295A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5132303A (en)	1992-07-21
IL95325A0 (en)	1991-06-30
CA2023018C (en)	1995-11-28
DD299428A5 (de)	1992-04-16
JPH0383985A (ja)	1991-04-09
IL95325A (en)	1994-06-24
FI93456B (fi)	1994-12-30
NZ234846A (en)	1992-03-26
KR940000830B1 (ko)	1994-02-02
IL95324A (en)	1994-02-27
AU6080390A (en)	1991-02-14
US5132309A (en)	1992-07-21
IL95324A0 (en)	1991-06-30
EP0413516A2 (en)	1991-02-20
CA2023018A1 (en)	1991-02-11
CA2023015A1 (en)	1991-02-11
HU903233D0 (en)	1990-10-28
EP0412821A2 (en)	1991-02-13
IE902885A1 (en)	1991-02-27
PL286443A1 (en)	1992-01-13
HUT59375A (en)	1992-05-28
ZA906299B (en)	1991-06-26
CN1049349A (zh)	1991-02-20
DD299431A5 (de)	1992-04-16
HK118295A (en)	1995-07-28
FI93456C (fi)	1995-04-10
FI903974A0 (fi)	1990-08-10
MY107240A (en)	1995-10-31
ES2052179T3 (es)	1994-07-01
YU154090A (sh)	1992-12-21
CN1025031C (zh)	1994-06-15
EP0413516B1 (en)	1994-04-20
IN170979B (is)	1992-06-27
EP0412821A3 (en)	1991-11-27
DK0413516T3 (da)	1994-05-24
PL291648A1 (en)	1992-06-01
KR910004631A (ko)	1991-03-29
ATE113951T1 (de)	1994-11-15
ES2063923T3 (es)	1995-01-16
EP0413516A3 (en)	1991-11-27
DE69014008T2 (de)	1995-03-23
KR940002826B1 (ko)	1994-04-04
JPH0381277A (ja)	1991-04-05
ATE104671T1 (de)	1994-05-15
NO903511D0 (no)	1990-08-09
PL164662B1 (pl)	1994-09-30
ZA906304B (en)	1991-06-26
PL163899B1 (pl)	1994-05-31
AU6080490A (en)	1991-02-14
KR910004630A (ko)	1991-03-29
DE69008275T2 (de)	1994-08-04
HU206677B (en)	1992-12-28
YU150489A (sh)	1992-12-21
EP0412821B1 (en)	1994-11-09
SG59864G (en)	1995-09-01
DE69008275D1 (de)	1994-05-26
AU621238B2 (en)	1992-03-05
HU204276B (en)	1991-12-30
ZA906300B (en)	1991-05-29
NO903511L (no)	1991-02-11
DE69014008D1 (de)	1994-12-15
AU621771B2 (en)	1992-03-19
NZ234843A (en)	1992-03-26
HUT55785A (en)	1991-06-28

Publication	Publication Date	Title
IS3612A7 (is)	1991-02-11	Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær
GR3029408T3 (en)	1999-05-28	Novel piperidine derivatives, useful as neurokinin receptor antagonists
DK202888D0 (da)	1988-04-13	2-beta-morfolino-androstanderivater og fremgangsmaade til fremstilling deraf
DK491285D0 (da)	1985-10-25	1,4-dihydropyridin-hydroxyaminer, deres fremstilling og anvendelse i laegemidler
DK372586A (da)	1987-07-18	Dihydropyridinlactoler samt deres fremstilling og anvendelse i laegemidler
PT82812A (en)	1986-07-01	Process for the preparation of new para-substituted 3-phenoxy-1-piperidinecarbonylaminoalkylaminopropanol-2-s having beta receptor blocking properties and of pharmaceutical compositions containing the same
HU9302260D0 (en)	1993-10-28	Tetrahydro-naphtaline derivatives and methods for producing these compounds and for preparing pharmaceutical preparatives containing them
IL115028A0 (en)	1995-12-08	Cyclohexadiene derivatives their pharmaceutical compositions containing them
IT1217657B (it)	1990-03-30	Composti con attivita' analgesica centrale
IT1230754B (it)	1991-10-29	Camposti con attivita' analgesica centrale.