ATE106742T1 - Hemmung von hiv mittels transformationswachstumsfaktor beta. - Google Patents

Hemmung von hiv mittels transformationswachstumsfaktor beta.

Info

Publication number: ATE106742T1
Authority: AT; Austria
Prior art keywords: beta; tgf; inhibition; growth factor; factor beta
Prior art date: 1988-08-25

Application number

AT89115719T

Other languages

English (en)

Inventor

Vera Brankovan

Mario Lioubin

Anthony Purchio

Original Assignee

Oncogen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-25

Filing date

1989-08-25

Publication date

1994-06-15

1989-08-25 Application filed by Oncogen filed Critical Oncogen

1994-06-15 Application granted granted Critical

1994-06-15 Publication of ATE106742T1 publication Critical patent/ATE106742T1/de

Links

239000003102 growth factor Substances 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 6
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89115719T 1988-08-25 1989-08-25 Hemmung von hiv mittels transformationswachstumsfaktor beta. ATE106742T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/236,698 US5236905A (en)	1988-08-25	1988-08-25	In vitro method of inhibition of HIV using transforming growth factor-.beta.

Publications (1)

Publication Number	Publication Date
ATE106742T1 true ATE106742T1 (de)	1994-06-15

Family

ID=22890582

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89115719T ATE106742T1 (de)	1988-08-25	1989-08-25	Hemmung von hiv mittels transformationswachstumsfaktor beta.

Country Status (7)

Country	Link
US (1)	US5236905A (de)
EP (1)	EP0356935B1 (de)
JP (1)	JPH02160723A (de)
KR (1)	KR900002798A (de)
AT (1)	ATE106742T1 (de)
DE (1)	DE68915899T2 (de)
IL (1)	IL91389A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5262319A (en) *	1985-04-19	1993-11-16	Oncogene Science, Inc.	Method for obtaining bone marrow free of tumor cells using transforming growth factor β3
EP0502036B1 (de) *	1989-11-22	1995-12-20	Genentech, Inc.	Latenz assoziierte peptide und deren verwendung
US5824297A (en) *	1990-06-25	1998-10-20	Oncogene Science, Inc.	Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
US5661127A (en) *	1995-05-01	1997-08-26	The Regents Of The University Of California	Peptide compositions with growth factor-like activity
US6638912B2 (en)	1995-05-01	2003-10-28	The Regents Of The University Of California	Peptide compositions mimicking TGF-β activity
US5780436A (en) *	1995-05-01	1998-07-14	The Regents Of The University Of California	Peptide compositions with growth factor-like activity
WO1999062535A2 (en)	1998-06-01	1999-12-09	University Of Maryland Biotechnology Institute	Receptor ligand antagonist complexes and their use in treating or preventing receptor mediated diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4929442A (en) *	1986-09-26	1990-05-29	Exovir, Inc.	Compositions suitable for human topical application including a growth factor and/or related materials
PT86144B (pt) *	1986-11-17	1990-08-31	Sandoz Sa	Processo para a preparacao de uma proteina tendo actividade semelhante a factor g-tsf humano e de composicoes farmaceuticas que o contem

1988
- 1988-08-25 US US07/236,698 patent/US5236905A/en not_active Expired - Lifetime
1989
- 1989-08-23 IL IL9138989A patent/IL91389A/en not_active IP Right Cessation
- 1989-08-23 KR KR1019890012030A patent/KR900002798A/ko not_active Withdrawn
- 1989-08-24 JP JP1218452A patent/JPH02160723A/ja active Pending
- 1989-08-25 EP EP89115719A patent/EP0356935B1/de not_active Expired - Lifetime
- 1989-08-25 DE DE68915899T patent/DE68915899T2/de not_active Expired - Fee Related
- 1989-08-25 AT AT89115719T patent/ATE106742T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0356935A3 (de)	1991-04-03
IL91389A0 (en)	1990-04-29
US5236905A (en)	1993-08-17
DE68915899T2 (de)	1994-10-13
EP0356935A2 (de)	1990-03-07
EP0356935B1 (de)	1994-06-08
DE68915899D1 (de)	1994-07-14
KR900002798A (ko)	1990-03-23
IL91389A (en)	1994-06-24
JPH02160723A (ja)	1990-06-20

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Legal Events

Date	Code	Title	Description
1995-01-15	UEP	Publication of translation of european patent specification
1998-05-15	REN	Ceased due to non-payment of the annual fee