ATE109982T1 - Prostaglandin-lipid-formulierungen. - Google Patents

Prostaglandin-lipid-formulierungen.

Info

Publication number: ATE109982T1
Authority: AT; Austria
Prior art keywords: prostaglandin; transmembrane; liposomes; lipid formulations; gradient
Prior art date: 1987-05-22

Application number

AT88401235T

Other languages

English (en)

Inventor

Robert P Lenk

Michelle M Tomsho

Robert L Suddith

Robert J Klimchak

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-20

Publication date

1994-09-15

1988-05-20 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE109982T1 publication Critical patent/ATE109982T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
-1 PROSTAGLANDIN LIPID Chemical class 0.000 title 1
239000002502 liposome Substances 0.000 abstract 4
150000003180 prostaglandins Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 1
229960000711 alprostadil Drugs 0.000 abstract 1
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT88401235T 1987-05-22 1988-05-20 Prostaglandin-lipid-formulierungen. ATE109982T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5330587A	1987-05-22	1987-05-22

Publications (1)

Publication Number	Publication Date
ATE109982T1 true ATE109982T1 (de)	1994-09-15

Family

ID=21983292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88401235T ATE109982T1 (de)	1987-05-22	1988-05-20	Prostaglandin-lipid-formulierungen.

Country Status (13)

Country	Link
US (1)	US5082664A (de)
EP (1)	EP0292403B1 (de)
KR (1)	KR970005171B1 (de)
AT (1)	ATE109982T1 (de)
AU (1)	AU617678B2 (de)
CA (1)	CA1323838C (de)
DE (1)	DE3851090T2 (de)
ES (1)	ES2058317T3 (de)
FI (1)	FI95199C (de)
HK (1)	HK1007496A1 (de)
PT (1)	PT87545B (de)
WO (1)	WO1988009170A1 (de)
ZA (1)	ZA883653B (de)

Families Citing this family (39)

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MX9203808A (es) *	1987-03-05	1992-07-01	Liposome Co Inc	Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5262168A (en) *	1987-05-22	1993-11-16	The Liposome Company, Inc.	Prostaglandin-lipid formulations
US5811118A (en) *	1987-05-22	1998-09-22	The Liposome Company, Inc.	Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations
US5925375A (en) *	1987-05-22	1999-07-20	The Liposome Company, Inc.	Therapeutic use of multilamellar liposomal prostaglandin formulations
ATE135207T1 (de) *	1989-04-04	1996-03-15	Beiersdorf Ag	Mittel zur atopieprophylaxe
DE3910761A1 (de) *	1989-04-04	1990-10-11	Bodo Dr Med Melnik	Mittel zur atopie-prophylaxe
US5591446A (en) *	1989-04-04	1997-01-07	Beiersdorf, A.G.	Methods and agents for the prophylaxis of atopy
JPH0395118A (ja) *	1989-09-07	1991-04-19	Green Cross Corp:The	プロスタグランジン含有脂肪小体製剤
US5882678A (en) *	1990-01-12	1999-03-16	The Liposome Co, Inc.	Interdigitation-fusion liposomes containing arachidonic acid metabolites
DE69228332T2 (de) *	1991-05-07	1999-09-16	The Liposome Co.,Inc.	Liposomale Prostaglandinformulierungen
DE4125255A1 (de) *	1991-07-31	1993-02-04	Knoll Ag	Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung
JP3168550B2 (ja) *	1992-12-02	2001-05-21	株式会社林原生物化学研究所	脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
US6005100A (en) *	1992-12-02	1999-12-21	Kabushiki Kaisha Hayashibara Seitbutsu Kagaku Kenkyujo	Trehalose composition for prolonging product shelf life
JPH09502700A (ja) *	1993-04-02	1997-03-18	ザリポソームカンパニー、インコーポレーテッド	リポソームの製造方法
ES2154680T3 (es)	1993-07-08	2001-04-16	Liposome Co Inc	Metodo para controlar el tamaño de los liposomas.
US5853755A (en) *	1993-07-28	1998-12-29	Pharmaderm Laboratories Ltd.	Biphasic multilamellar lipid vesicles
US5741523A (en) *	1993-10-27	1998-04-21	Pharmacia & Upjohn Company	Stabilized prostaglandin E1
JPH09504793A (ja) *	1993-11-04	1997-05-13	ザリポソームカンパニー、インコーポレーテッド	マルチラメラリポソーム性のアラキドン酸代謝物製剤
EP0729352B1 (de) *	1993-11-16	1999-02-03	The Liposome Company, Inc.	Arachidonsäuremetaboliten enthaltende interdigitations-fusions-liposomen
US5840328A (en) *	1994-01-11	1998-11-24	The Liposome Company, Inc.	Treatment using arachidonic acid metabolite and particulate formulations
US5716526A (en) *	1994-01-14	1998-02-10	The Liposome Company, Inc.	Method of separating materials from liposomes or lipid complexes
WO1996009037A1 (en) *	1994-09-23	1996-03-28	The Liposome Company, Inc.	Method of producing a lyophilized liposome product
US5718917A (en) *	1995-12-15	1998-02-17	Harvard Scientific Corporation	PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction
US6447800B2 (en) *	1996-01-18	2002-09-10	The University Of British Columbia	Method of loading preformed liposomes using ethanol
US5980551A (en) *	1997-02-07	1999-11-09	Endovasc Ltd., Inc.	Composition and method for making a biodegradable drug delivery stent
US6001333A (en) *	1997-09-12	1999-12-14	See; Jackie R.	Methods of preparing micro encapsulated agents for use in the detection of tumors by CT imaging
US6019999A (en) *	1997-12-03	2000-02-01	Miller; David F.	Process for making liposomal ion-exchange whey protein and products thereof
JP2003342196A (ja) *	2002-05-31	2003-12-03	Mukku:Kk	静脈注射用組成物、その製造法およびその製剤
US20060280789A1 (en) *	2004-12-27	2006-12-14	Eisai Research Institute	Sustained release formulations
RU2470644C2 (ru) *	2006-09-05	2012-12-27	Кью.Пи. КОПЭРЕЙШН	Стабильная жировая эмульсия (варианты), способ ее получения, эмульгирующий агент и способы стабилизации простагландина и капель жира
US20090035725A1 (en) *	2007-08-02	2009-02-05	Ondine International, Ltd.	Photodisinfection of oral cavity
US20110244028A1 (en) *	2008-09-26	2011-10-06	Steve Leigh	Method of solubilizing biologically active compounds
US9835618B1 (en) *	2009-02-06	2017-12-05	Los Alamos National Security, Llc	Discovery, detection and use of biomarkers
IT1397867B1 (it) *	2010-02-03	2013-02-04	Brotzu	Liposomi contenenti prostaglandina e1 (pge1), formulazioni che li contengono e loro uso
WO2012021107A2 (en) *	2010-08-12	2012-02-16	Nanyang Technological University	A liposomal formulation for ocular drug delivery
US9956195B2 (en)	2014-01-07	2018-05-01	Nanyang Technological University	Stable liposomal formulations for ocular drug delivery
US9962393B1 (en) *	2015-06-21	2018-05-08	Angiosoma Research, Inc.	Method for treating vascular disease by administering a liposomal prostaglandin composition
SG11202011045VA (en) *	2018-05-07	2020-12-30	Pharmosa Biopharm Inc	Pharmaceutical composition for controlled release of treprostinil
EP4312536A1 (de)	2021-04-01	2024-02-07	Vestaron Corporation	Liposomformulierungen zur pestizidabgabe und verfahren zur herstellung und verwendung davon

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Publication number	Priority date	Publication date	Assignee	Title
FR2274122A1 (fr) *	1974-06-07	1976-01-02	Cgr Mev	Procede de centrage d'un faisceau de balayage a rayonnement ionisant et dispositif permettant la mise en oeuvre de ce procede
US3993754A (en) *	1974-10-09	1976-11-23	The United States Of America As Represented By The United States Energy Research And Development Administration	Liposome-encapsulated actinomycin for cancer chemotherapy
US4086257A (en) *	1976-10-12	1978-04-25	Sears Barry D	Phosphatidyl quaternary ammonium compounds
GB1575343A (en) *	1977-05-10	1980-09-17	Ici Ltd	Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) *	1977-08-05	1981-02-13	Battelle Memorial Institute
US4235871A (en) *	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
JPS55153713A (en) *	1979-05-02	1980-11-29	Kureha Chem Ind Co Ltd	Pharmaceutical preparation of ribosome containing active substance
US4522803A (en) *	1983-02-04	1985-06-11	The Liposome Company, Inc.	Stable plurilamellar vesicles, their preparation and use
JPS58222014A (ja) *	1982-06-18	1983-12-23	Taisho Pharmaceut Co Ltd	プロスタグランジンｅ↓１脂肪乳剤
US4588578A (en) *	1983-08-08	1986-05-13	The Liposome Company, Inc.	Lipid vesicles prepared in a monophase
EP0153955A1 (de) *	1983-09-06	1985-09-11	Health Research, Inc.	Verfahren zum verabreichen von liposomen zum herabsetzen der toxizität eines antitumor-arzneimittels
JPH0818989B2 (ja) *	1984-01-12	1996-02-28	株式会社ミドリ十字	脂肪乳剤中のプロスタグランジンの安定化方法
US4721612A (en) *	1984-04-12	1988-01-26	The Liposome Company, Inc.	Steroidal liposomes
CA1264668C (en) *	1984-06-20	1990-01-23		EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
CA1270198A (en) *	1984-08-08	1990-06-12	Marcel B. Bally	Encapsulation of antineoplastic agents in liposomes
US4880635B1 (en) *	1984-08-08	1996-07-02	Liposome Company	Dehydrated liposomes
JPS61100518A (ja) *	1984-10-22	1986-05-19	Ono Pharmaceut Co Ltd	ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤
DE3689769T2 (de) *	1985-07-05	1994-07-21	Liposome Co Inc	Multilamellare liposome mit verbesserter einschliessungswirkung.

1988
- 1988-05-18 US US07/195,228 patent/US5082664A/en not_active Expired - Lifetime
- 1988-05-18 WO PCT/US1988/001714 patent/WO1988009170A1/en not_active Ceased
- 1988-05-18 AU AU19545/88A patent/AU617678B2/en not_active Ceased
- 1988-05-18 KR KR1019890700041A patent/KR970005171B1/ko not_active Expired - Fee Related
- 1988-05-20 AT AT88401235T patent/ATE109982T1/de not_active IP Right Cessation
- 1988-05-20 CA CA000567474A patent/CA1323838C/en not_active Expired - Fee Related
- 1988-05-20 ES ES88401235T patent/ES2058317T3/es not_active Expired - Lifetime
- 1988-05-20 DE DE3851090T patent/DE3851090T2/de not_active Expired - Fee Related
- 1988-05-20 EP EP88401235A patent/EP0292403B1/de not_active Expired - Lifetime
- 1988-05-20 PT PT87545A patent/PT87545B/pt active IP Right Grant
- 1988-05-23 ZA ZA883653A patent/ZA883653B/xx unknown
1989
- 1989-11-21 FI FI895554A patent/FI95199C/fi not_active IP Right Cessation
1998
- 1998-06-25 HK HK98106741A patent/HK1007496A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI895554A0 (fi)	1989-11-21
KR970005171B1 (ko)	1997-04-14
DE3851090D1 (de)	1994-09-22
FI95199C (fi)	1996-01-10
PT87545A (pt)	1989-05-31
DE3851090T2 (de)	1995-01-12
ZA883653B (en)	1989-03-29
EP0292403A2 (de)	1988-11-23
AU1954588A (en)	1988-12-21
FI95199B (fi)	1995-09-29
AU617678B2 (en)	1991-12-05
ES2058317T3 (es)	1994-11-01
WO1988009170A1 (en)	1988-12-01
KR890701093A (ko)	1989-12-19
HK1007496A1 (en)	1999-04-16
EP0292403B1 (de)	1994-08-17
EP0292403A3 (en)	1988-12-21
CA1323838C (en)	1993-11-02
PT87545B (pt)	1992-12-31
US5082664A (en)	1992-01-21

Legal Events

Date	Code	Title	Description
2006-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3851090D1 (de)	1994-09-22	Prostaglandin-Lipid-Formulierungen.
DK98189D0 (da)	1989-03-01	Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold
EP0100910A3 (en)	1985-11-21	Lung surfactant
AR241117A2 (es)	1991-11-15	Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos
NO172729C (no)	1993-09-01	Fremgangsmaate for fremstilling av en suspensjon av fosfolipidvesikler.
DK86988D0 (da)	1988-02-19	Liposompraeparat og anvendelse deraf
FI883597A7 (fi)	1989-02-05	Menetelmä sytotoksisten aineiden kasvainsoluihin toimittamiseen käyttökelpoisen vasta-aine-entsyymikonjugaatin valmistamiseksi
FI883249A7 (fi)	1989-01-11	Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
DE3878239D1 (de)	1993-03-18	Kristalle aus menschlichem serumalbumin und verfahren zu deren herstellung.
SE8603582D0 (sv)	1986-08-26	Komposition innehallande l-dopa
SE8403487D0 (sv)	1984-06-29	Farmaceutisk komposition
BG38639A3 (en)	1986-01-15	Method for preparing ester derivatives of 6- beta- hydroxymethylpenicillanic acid
TR199902025T2 (xx)	1999-11-22	Suda ileri derecede ��z�nmez olan bir etken maddeyi hapseden liyofilize lipozomlar i�eren farmas�tik preparasyon ve bu preparasyonu haz�rlamak i�in i�lem.
ES8307240A1 (es)	1983-06-16	Un procedimiento para la preparacion de un dihidroxi-compuesto.
NO861533L (no)	1986-11-21	Griseolsyrederivater og fremgangsmaate til fremstilling derav.
Armato et al.	1983	Prostaglandins of the F series are extremely powerful growth factors for primary neonatal rat hepatocytes
BG42352A3 (en)	1987-11-14	Method for preparing derivatives of cyclopropane- carbonic acid esters
EP0150710A3 (de)	1985-11-13	7-Oxabicycloheptan-Prostaglandin-Analoge
SE8303719D0 (sv)	1983-06-29	Novel eburnane oxime derivatives and process for preparing same
McClenaghan et al.	1997	Induction of a glucose-dependent insulin secretory response by the nonmetabolizable amino acid α-aminoisobutyric acid
DK183788A (da)	1988-10-07	Fremgangsmaade til foroegelse af levedygtigheden af frysetoerrede, maelkesyreproducerende bakteriekulturkoncentrater
BG44029A3 (en)	1988-09-15	Method for preparing of n- dimethyl morphinanic derivatives
FR2325634A1 (fr)	1977-04-22	Nouveaux esters derives d'acides 4,5-benzospiro(2,4)heptane-1-carboxyliques utiles dans la lutte contre les parasites
GB2001995A (en)	1979-02-14	An immunostimulant, a process for preparing it, and compositions containing it
FR2617185B1 (fr)	1990-03-09	Procede de stabilisation de membranes cellulaires et son app lication a la conservation des cellules sous une forme protegeant l'essentiel de leurs antigenes de surface