ATE112775T1 - Bisarylalkenderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die sie enthalten. - Google Patents
Bisarylalkenderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die sie enthalten.Info
- Publication number
- ATE112775T1 ATE112775T1 AT90400056T AT90400056T ATE112775T1 AT E112775 T1 ATE112775 T1 AT E112775T1 AT 90400056 T AT90400056 T AT 90400056T AT 90400056 T AT90400056 T AT 90400056T AT E112775 T1 ATE112775 T1 AT E112775T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- optionally substituted
- formula
- image
- pyridyl
- Prior art date
Links
- 150000001344 alkene derivatives Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 1,2,3,4-tetrahydro-3-quinazolinyl radical Chemical group 0.000 abstract 10
- 150000003254 radicals Chemical class 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical compound O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- AFNJMVYFZNHDRX-UHFFFAOYSA-N [C]1=NC=CC=N1 Chemical group [C]1=NC=CC=N1 AFNJMVYFZNHDRX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8900213A FR2643373B1 (fr) | 1989-01-10 | 1989-01-10 | Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE112775T1 true ATE112775T1 (de) | 1994-10-15 |
Family
ID=9377578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90400056T ATE112775T1 (de) | 1989-01-10 | 1990-01-09 | Bisarylalkenderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die sie enthalten. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5028607A (de) |
| EP (1) | EP0378468B1 (de) |
| JP (1) | JPH06102659B2 (de) |
| AT (1) | ATE112775T1 (de) |
| AU (1) | AU620195B2 (de) |
| CA (1) | CA2007401A1 (de) |
| DE (1) | DE69013173T2 (de) |
| DK (1) | DK0378468T3 (de) |
| ES (1) | ES2064670T3 (de) |
| FR (1) | FR2643373B1 (de) |
| IE (1) | IE64792B1 (de) |
| NZ (1) | NZ231823A (de) |
| OA (1) | OA09435A (de) |
| PT (1) | PT92813B (de) |
| ZA (1) | ZA9055B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2644786B1 (fr) * | 1989-03-21 | 1993-12-31 | Adir Cie | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2134077C (en) * | 1992-04-23 | 2002-05-21 | Thaddeus R. Nieduzak | 4-imidomethyl-1-[2'phenyl-2'oxoethyl-]piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy |
| FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
| US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
| AU724646B2 (en) * | 1996-03-15 | 2000-09-28 | Eli Lilly And Company | Method of treating common cold or allergic rhinitis |
| US7244843B2 (en) | 2003-10-07 | 2007-07-17 | Bristol-Myers Squibb Company | Modulators of serotonin receptors |
| WO2023003497A1 (ru) * | 2021-07-23 | 2023-01-26 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Соединения с лизосомотропной и противовирусной активностью |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794596A (fr) * | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Piperidinoalcanone-oximes substituees et leur procede de preparation |
| US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4540780A (en) * | 1983-06-02 | 1985-09-10 | Warner-Lambert Company | Diphenylmethylene piperidines |
| EP0181793B1 (de) * | 1984-10-16 | 1988-07-27 | Synthelabo | Piperidinderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung |
| FR2571722B1 (fr) * | 1984-10-16 | 1986-12-26 | Synthelabo | Derives de benzimidazolone, leur preparation et leur application en therapeutique |
| ES2031813T3 (es) * | 1985-11-11 | 1993-01-01 | Asta Pharma Ag | Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona. |
| EP0228893A3 (de) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Durch Aryloxyalkyl-Gruppen N-substituierte Arylalkyl heterozyklische Amine in Allergieheilverfahren |
| FR2605008B1 (fr) * | 1986-10-08 | 1988-12-02 | Synthelabo | Derives d'imidazo (4,5-b)pyridinone-2, leur preparation et leur application en therapeutique |
| FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
-
1989
- 1989-01-10 FR FR8900213A patent/FR2643373B1/fr not_active Expired - Lifetime
- 1989-12-18 NZ NZ231823A patent/NZ231823A/en unknown
-
1990
- 1990-01-04 ZA ZA9055A patent/ZA9055B/xx unknown
- 1990-01-04 IE IE2790A patent/IE64792B1/en not_active IP Right Cessation
- 1990-01-04 US US07/460,751 patent/US5028607A/en not_active Expired - Fee Related
- 1990-01-09 AT AT90400056T patent/ATE112775T1/de not_active IP Right Cessation
- 1990-01-09 EP EP90400056A patent/EP0378468B1/de not_active Expired - Lifetime
- 1990-01-09 JP JP2002408A patent/JPH06102659B2/ja not_active Expired - Lifetime
- 1990-01-09 DE DE69013173T patent/DE69013173T2/de not_active Expired - Fee Related
- 1990-01-09 ES ES90400056T patent/ES2064670T3/es not_active Expired - Lifetime
- 1990-01-09 DK DK90400056.9T patent/DK0378468T3/da active
- 1990-01-09 AU AU47810/90A patent/AU620195B2/en not_active Ceased
- 1990-01-09 CA CA002007401A patent/CA2007401A1/fr not_active Abandoned
- 1990-01-09 PT PT92813A patent/PT92813B/pt not_active IP Right Cessation
- 1990-01-10 OA OA59724A patent/OA09435A/xx unknown
- 1990-08-24 US US07/573,338 patent/US5071847A/en not_active Expired - Fee Related
- 1990-08-24 US US07/572,858 patent/US5079249A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE900027L (en) | 1990-07-10 |
| NZ231823A (en) | 1992-03-26 |
| ZA9055B (en) | 1990-10-31 |
| PT92813A (pt) | 1990-07-31 |
| AU4781090A (en) | 1990-08-30 |
| IE64792B1 (en) | 1995-09-06 |
| FR2643373A1 (fr) | 1990-08-24 |
| OA09435A (fr) | 1992-10-15 |
| ES2064670T3 (es) | 1995-02-01 |
| DE69013173T2 (de) | 1995-05-24 |
| AU620195B2 (en) | 1992-02-13 |
| JPH06102659B2 (ja) | 1994-12-14 |
| DK0378468T3 (da) | 1995-03-20 |
| JPH02225481A (ja) | 1990-09-07 |
| FR2643373B1 (fr) | 1993-12-31 |
| PT92813B (pt) | 1995-12-29 |
| CA2007401A1 (fr) | 1990-07-10 |
| EP0378468A3 (de) | 1991-09-11 |
| US5071847A (en) | 1991-12-10 |
| US5079249A (en) | 1992-01-07 |
| DE69013173D1 (de) | 1994-11-17 |
| EP0378468A2 (de) | 1990-07-18 |
| EP0378468B1 (de) | 1994-10-12 |
| US5028607A (en) | 1991-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |