ES2064670T3 - Nuevos derivados de los bisaril-olefinas, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de los bisaril-olefinas, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2064670T3
ES2064670T3 ES90400056T ES90400056T ES2064670T3 ES 2064670 T3 ES2064670 T3 ES 2064670T3 ES 90400056 T ES90400056 T ES 90400056T ES 90400056 T ES90400056 T ES 90400056T ES 2064670 T3 ES2064670 T3 ES 2064670T3
Authority
ES
Spain
Prior art keywords
radical
equal
bisaril
olefins
piridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400056T
Other languages
English (en)
Inventor
Gilbert Lavielle
Francis Colpaert
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2064670T3 publication Critical patent/ES2064670T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE M = 2-4; N Y P, IGUALES O DIFERENTES REPRESENTAN UN NUMERO ENTERO IGUAL A 1, 2 O 3, CON LA CONDICION DE QUE LA SUMA DE N Y P SEA SUPERIOR O IGUAL A 3, E INFERIOR O IGUAL A 5; Q = 0 O 1; R ES UN RADICAL TETRAHIDRO-1,2,3,4-QUINAZOLILO-3, UN RADICAL DIHIDRO-1,2-OXO-1 FTALAZINILO-2 EVENTUALMENTE SUSTITUIDO, UN RADICAL DIOXO-2,6 PIPERAZINIL-1 DE FORMULA W (R3 REPRESENTA UN RADICAL PIRIDILO-2 O UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO), UN RADICAL DE FORMULA Z (R4 REPRESENTA UN RADICAL CARBAMOILO, CIANO, HIDROXICARBONILO O ALCOXICARBONILO C1-C6), O UN RADICAL DE FORMULA Y (R5 REPRESENTA UN RADICAL PIRIMIDINILO-2, ISOQUINOLILO-1, QUINOLILO-2, PIRIDILO-2, BENCILO EVENTUALMENTE SUSTITUIDO, TIAZOLILO-2 EVENTUALMENTE SUSTITUIDO O BENZOTIAZOLILO-2); R1 Y R2, IGUALES O DIFERENTES, REPRESENTAN CADA UNO UN RADICAL FENILO SUSTITUIDO, O R1 REPRESENTA UN RADICAL FENILO Y R2 UN RADICAL PIRIDILO-2 (PUDIENDO ESTAR SUSTITUIDOS CADA UNO DE ESTOSRADICALES), O R1 Y R2 FORMAN, JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS, UN RADICAL FLUORENO. MEDICAMENTOS.
ES90400056T 1989-01-10 1990-01-09 Nuevos derivados de los bisaril-olefinas, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2064670T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8900213A FR2643373B1 (fr) 1989-01-10 1989-01-10 Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2064670T3 true ES2064670T3 (es) 1995-02-01

Family

ID=9377578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400056T Expired - Lifetime ES2064670T3 (es) 1989-01-10 1990-01-09 Nuevos derivados de los bisaril-olefinas, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
US (3) US5028607A (es)
EP (1) EP0378468B1 (es)
JP (1) JPH06102659B2 (es)
AT (1) ATE112775T1 (es)
AU (1) AU620195B2 (es)
CA (1) CA2007401A1 (es)
DE (1) DE69013173T2 (es)
DK (1) DK0378468T3 (es)
ES (1) ES2064670T3 (es)
FR (1) FR2643373B1 (es)
IE (1) IE64792B1 (es)
NZ (1) NZ231823A (es)
OA (1) OA09435A (es)
PT (1) PT92813B (es)
ZA (1) ZA9055B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP3333878B2 (ja) * 1992-04-23 2002-10-15 メレルダウファーマスーティカルズ インコーポレイテッド セロトニン５ｈｔ２拮抗剤としての４‐イミドメチル‐１‐［２’フェニル‐２’オキソエチル‐］ピペリジン類，それらの製法及び治療用途
FR2699176B1 (fr) * 1992-12-11 1995-03-03 Adir Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
JP2000507269A (ja) * 1996-03-15 2000-06-13 イーライ・リリー・アンド・カンパニー 一般かぜまたはアレルギー性鼻炎の処置方法
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
US7244843B2 (en) 2003-10-07 2007-07-17 Bristol-Myers Squibb Company Modulators of serotonin receptors
WO2023003497A1 (ru) * 2021-07-23 2023-01-26 Общество С Ограниченной Ответственностью "Валента-Интеллект" Соединения с лизосомотропной и противовирусной активностью

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
FR2571722B1 (fr) * 1984-10-16 1986-12-26 Synthelabo Derives de benzimidazolone, leur preparation et leur application en therapeutique
DE3677322D1 (de) * 1985-11-11 1991-03-07 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
FR2605008B1 (fr) * 1986-10-08 1988-12-02 Synthelabo Derives d'imidazo (4,5-b)pyridinone-2, leur preparation et leur application en therapeutique
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
US5028607A (en) 1991-07-02
EP0378468B1 (fr) 1994-10-12
IE64792B1 (en) 1995-09-06
PT92813B (pt) 1995-12-29
NZ231823A (en) 1992-03-26
ATE112775T1 (de) 1994-10-15
JPH02225481A (ja) 1990-09-07
FR2643373A1 (fr) 1990-08-24
EP0378468A3 (fr) 1991-09-11
DK0378468T3 (da) 1995-03-20
DE69013173D1 (de) 1994-11-17
IE900027L (en) 1990-07-10
CA2007401A1 (fr) 1990-07-10
US5079249A (en) 1992-01-07
AU4781090A (en) 1990-08-30
AU620195B2 (en) 1992-02-13
ZA9055B (en) 1990-10-31
US5071847A (en) 1991-12-10
OA09435A (fr) 1992-10-15
PT92813A (pt) 1990-07-31
JPH06102659B2 (ja) 1994-12-14
DE69013173T2 (de) 1995-05-24
EP0378468A2 (fr) 1990-07-18
FR2643373B1 (fr) 1993-12-31

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