ATE113832T1 - Im wasser schnell suspendierbare pharmazeutische zusammensetzung. - Google Patents
Im wasser schnell suspendierbare pharmazeutische zusammensetzung.Info
- Publication number
- ATE113832T1 ATE113832T1 AT91912620T AT91912620T ATE113832T1 AT E113832 T1 ATE113832 T1 AT E113832T1 AT 91912620 T AT91912620 T AT 91912620T AT 91912620 T AT91912620 T AT 91912620T AT E113832 T1 ATE113832 T1 AT E113832T1
- Authority
- AT
- Austria
- Prior art keywords
- water
- pct
- drug
- pharmaceutical composition
- suspendable
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000375 suspending agent Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 230000008719 thickening Effects 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B2275/00—Other engines, components or details, not provided for in other groups of this subclass
- F02B2275/14—Direct injection into combustion chamber
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02090890A IT1246350B (it) | 1990-07-11 | 1990-07-11 | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE113832T1 true ATE113832T1 (de) | 1994-11-15 |
Family
ID=11173904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91912620T ATE113832T1 (de) | 1990-07-11 | 1991-07-04 | Im wasser schnell suspendierbare pharmazeutische zusammensetzung. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5306506A (de) |
| EP (1) | EP0491910B1 (de) |
| JP (1) | JP2552785B2 (de) |
| KR (1) | KR100209175B1 (de) |
| AT (1) | ATE113832T1 (de) |
| AU (1) | AU640253B2 (de) |
| CA (1) | CA2046679C (de) |
| DE (1) | DE69105106T2 (de) |
| DK (1) | DK0491910T3 (de) |
| ES (1) | ES2064112T3 (de) |
| IE (1) | IE66048B1 (de) |
| IT (1) | IT1246350B (de) |
| NZ (1) | NZ238901A (de) |
| PT (1) | PT98272B (de) |
| WO (1) | WO1992000731A1 (de) |
| ZA (1) | ZA915284B (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5496563A (en) * | 1991-08-30 | 1996-03-05 | Showa Yakuhin Kako Co., Ltd. | Dry gel composition |
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| CZ286632B6 (cs) * | 1992-09-29 | 2000-05-17 | Inhale Therapeutic Systems | Farmaceutický prostředek |
| ES2091654T3 (es) * | 1993-04-15 | 1996-11-01 | Gergely Gerhard | Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. |
| DK0642784T3 (da) * | 1993-09-07 | 1999-11-22 | Gergely Gerhard | Bruseblanding med alkalisalte eller lysinater af uopløseligt eller tungtopløseligt aktivstof |
| FR2712809B1 (fr) * | 1993-11-26 | 1996-04-12 | Union Pharma Scient Appl | Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. |
| EP1462096B1 (de) * | 1994-03-07 | 2008-12-10 | Nektar Therapeutics | Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| NZ270906A (en) * | 1994-04-11 | 1996-04-26 | Gist Brocades Bv | Stable suspension of a polyene fungicide having no preservative; preparation and powder |
| CN1073119C (zh) * | 1994-05-18 | 2001-10-17 | 吸入治疗系统公司 | 干扰素干粉配方的方法及组合物 |
| AU2826495A (en) * | 1994-06-02 | 1996-01-04 | Enzon, Inc. | Method of solubilizing substantially water insoluble materials |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| WO1996008979A1 (en) | 1994-09-22 | 1996-03-28 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
| US5639475A (en) * | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
| BE1009380A3 (nl) * | 1995-03-14 | 1997-03-04 | Universiteit Gent Lab Voor Far | Stabiliserend samenstelling voor suspensie. |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US5560928A (en) * | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
| US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
| US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| US5712310A (en) * | 1996-06-14 | 1998-01-27 | Alpharma Uspd, Inc. | Suspension of substantially water-insoluble drugs and methods of their manufacture |
| FR2753097A1 (fr) * | 1996-09-11 | 1998-03-13 | Barrau Francois | Gel aqueux ou hydroalcoolique extemporane a viscosite controlee |
| GB2318511A (en) * | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
| US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| IN186245B (de) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| NZ333474A (en) | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| IL136899A0 (en) * | 2000-06-20 | 2001-06-14 | Caretec Ltd | Microcapsules containing arginine and the different uses thereof |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| AU2002225763A1 (en) | 2000-11-28 | 2002-06-11 | Fmc Corporation | Edible pga(propylene glycol alginate) coating composition |
| US6932861B2 (en) * | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| TWI327474B (en) * | 2001-04-06 | 2010-07-21 | Neochemir Inc | Kit for preparation of carbon dioxide agent for external use. |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| EP1429749A2 (de) | 2001-09-26 | 2004-06-23 | Baxter International Inc. | Herstellung von nanopartikeln im submikrometerbereich durch dispersion und entzug des lösungsmittels oder der flüssigen phase |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| ITMI20022358A1 (it) * | 2002-11-07 | 2004-05-08 | Bsd Bioscience Dev Snc | Composizioni farmaceutiche effervescenti per la realizzazione di sospensioni non convenzionali. |
| US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
| US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
| US20050095320A1 (en) * | 2003-10-29 | 2005-05-05 | Richard Botteri | [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition] |
| US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
| US20060134210A1 (en) * | 2004-12-22 | 2006-06-22 | Astrazeneca Ab | Solid dosage form comprising proton pump inhibitor and suspension made thereof |
| US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
| AR065405A1 (es) * | 2007-02-20 | 2009-06-03 | Eurand Pharmaceuticals Ltd | Composiciones estables de enzimas digestivas |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| US7782646B2 (en) * | 2008-06-30 | 2010-08-24 | International Business Machines Corporation | High density content addressable memory using phase change devices |
| EP2621476B8 (de) | 2010-10-01 | 2020-12-23 | Société des Produits Nestlé S.A. | Enterale beschichtete pancrelipase-formulierungen mit geringer festigkeit |
| CN103732245B (zh) | 2011-08-08 | 2016-07-06 | 阿普塔利斯制药有限公司 | 用于含有消化酶的组合物的溶出度测试的方法 |
| KR101383908B1 (ko) | 2012-10-29 | 2014-04-10 | 씨앤텍 주식회사 | 이산화탄소를 피부에 공급하는 팩과 그 제조방법 |
| JP5993336B2 (ja) * | 2013-04-26 | 2016-09-14 | 株式会社メディオン・リサーチ・ラボラトリーズ | 二酸化炭素経皮・経粘膜吸収用組成物 |
| MX2016001593A (es) | 2013-08-09 | 2016-09-29 | Allergan Pharmaceuticals Int Ltd | Composicion de enzima digestiva adecuada para administracion enterica. |
| EP3157568A1 (de) | 2014-06-19 | 2017-04-26 | Aptalis Pharma Limited | Verfahren zur entfernung von viralen verunreinigungen aus pankreatischen extrakten |
| CN108368527B (zh) | 2015-11-26 | 2023-07-18 | 诺维信公司 | 研磨方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2125577A (en) * | 1936-09-10 | 1938-08-02 | Matsumae Akiyoshi | Auxiliary medical agent and method of preparing the same |
| US3928252A (en) * | 1971-12-10 | 1975-12-23 | Adolph S Ltd | Thickened food |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| IT1183574B (it) * | 1985-05-08 | 1987-10-22 | Eurand Spa | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
| GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
-
1990
- 1990-07-11 IT IT02090890A patent/IT1246350B/it active IP Right Grant
-
1991
- 1991-07-04 ES ES91912620T patent/ES2064112T3/es not_active Expired - Lifetime
- 1991-07-04 EP EP91912620A patent/EP0491910B1/de not_active Expired - Lifetime
- 1991-07-04 WO PCT/EP1991/001268 patent/WO1992000731A1/en not_active Ceased
- 1991-07-04 AT AT91912620T patent/ATE113832T1/de not_active IP Right Cessation
- 1991-07-04 US US07/838,818 patent/US5306506A/en not_active Expired - Fee Related
- 1991-07-04 DK DK91912620.1T patent/DK0491910T3/da active
- 1991-07-04 DE DE69105106T patent/DE69105106T2/de not_active Expired - Fee Related
- 1991-07-04 KR KR1019920700541A patent/KR100209175B1/ko not_active Expired - Fee Related
- 1991-07-04 AU AU81833/91A patent/AU640253B2/en not_active Ceased
- 1991-07-04 JP JP3511640A patent/JP2552785B2/ja not_active Expired - Lifetime
- 1991-07-08 ZA ZA915284A patent/ZA915284B/xx unknown
- 1991-07-08 IE IE238291A patent/IE66048B1/en not_active IP Right Cessation
- 1991-07-10 CA CA002046679A patent/CA2046679C/en not_active Expired - Fee Related
- 1991-07-10 NZ NZ238901A patent/NZ238901A/en unknown
- 1991-07-10 PT PT98272A patent/PT98272B/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2046679C (en) | 2001-11-20 |
| CA2046679A1 (en) | 1992-01-12 |
| ZA915284B (en) | 1993-03-31 |
| JPH05501421A (ja) | 1993-03-18 |
| PT98272B (pt) | 1999-01-29 |
| DE69105106T2 (de) | 1995-04-27 |
| EP0491910B1 (de) | 1994-11-09 |
| IT9020908A1 (it) | 1992-01-11 |
| WO1992000731A1 (en) | 1992-01-23 |
| DK0491910T3 (da) | 1995-01-09 |
| AU640253B2 (en) | 1993-08-19 |
| AU8183391A (en) | 1992-02-04 |
| EP0491910A1 (de) | 1992-07-01 |
| ES2064112T3 (es) | 1995-01-16 |
| PT98272A (pt) | 1992-05-29 |
| IE66048B1 (en) | 1995-12-13 |
| US5306506A (en) | 1994-04-26 |
| JP2552785B2 (ja) | 1996-11-13 |
| KR100209175B1 (ko) | 1999-07-15 |
| DE69105106D1 (de) | 1994-12-15 |
| IE912382A1 (en) | 1992-01-15 |
| IT1246350B (it) | 1994-11-17 |
| NZ238901A (en) | 1992-08-26 |
| IT9020908A0 (it) | 1990-07-11 |
| KR920702215A (ko) | 1992-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |