PT95344A - Processo para a preparacao de novos antagonistas do n-metil-d-aspartato (nmda) e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos antagonistas do n-metil-d-aspartato (nmda) e de composicoes farmaceuticas que os contem

Info

Publication number
PT95344A
PT95344A PT95344A PT9534490A PT95344A PT 95344 A PT95344 A PT 95344A PT 95344 A PT95344 A PT 95344A PT 9534490 A PT9534490 A PT 9534490A PT 95344 A PT95344 A PT 95344A
Authority
PT
Portugal
Prior art keywords
nmda
aspartate
antagonists
methyl
pharmaceutical compositions
Prior art date
Application number
PT95344A
Other languages
English (en)
Other versions
PT95344B (pt
Inventor
Jeffrey Paul Whitten
Bruce Michael Baron
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/553,431 external-priority patent/US5095009A/en
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT95344A publication Critical patent/PT95344A/pt
Publication of PT95344B publication Critical patent/PT95344B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT95344A 1989-09-19 1990-09-18 Processo para a preparacao de novos antagonistas do n-metil-d-aspartato (nmda) e de composicoes farmaceuticas que os contem PT95344B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40947889A 1989-09-19 1989-09-19
US50833390A 1990-04-11 1990-04-11
US07/553,431 US5095009A (en) 1990-04-11 1990-07-20 NMDA antagonists

Publications (2)

Publication Number Publication Date
PT95344A true PT95344A (pt) 1991-06-25
PT95344B PT95344B (pt) 1998-02-27

Family

ID=27410806

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95344A PT95344B (pt) 1989-09-19 1990-09-18 Processo para a preparacao de novos antagonistas do n-metil-d-aspartato (nmda) e de composicoes farmaceuticas que os contem

Country Status (20)

Country Link
EP (1) EP0418863B1 (pt)
JP (1) JP2934295B2 (pt)
KR (2) KR100191116B1 (pt)
CN (1) CN1027694C (pt)
AR (2) AR247889A1 (pt)
AT (1) ATE116653T1 (pt)
AU (1) AU632362B2 (pt)
CA (1) CA2025326C (pt)
DE (1) DE69015745T2 (pt)
DK (1) DK0418863T3 (pt)
ES (1) ES2069644T3 (pt)
FI (1) FI102613B1 (pt)
GR (1) GR3015656T3 (pt)
HU (1) HU207523B (pt)
IE (1) IE65118B1 (pt)
IL (1) IL95718A (pt)
MX (1) MX9203696A (pt)
NO (1) NO178375C (pt)
NZ (1) NZ235322A (pt)
PT (1) PT95344B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI942248A0 (fi) * 1991-11-15 1994-05-13 Merrell Dow Pharma N-trityyliasparagiinihapon johdannaiset fosfonaatti-NMDA-antagonistien valmistamiseksi
US5554773A (en) * 1991-11-15 1996-09-10 Merrell Pharmaceuticals Inc. N-trityl protected aspartic acid derivatives for the preparation of phosphonate NMDA antagonists
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
EP0684238A3 (en) * 1994-04-27 1997-01-15 Hoffmann La Roche Process for the preparation of dicarboxamides.
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970684A (en) * 1973-07-06 1976-07-20 Syntex (U.S.A.) Inc. Polyunsaturated prostaglandin derivatives
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids

Also Published As

Publication number Publication date
HU207523B (en) 1993-04-28
FI102613B (fi) 1999-01-15
EP0418863A3 (en) 1991-06-12
JPH03130295A (ja) 1991-06-04
IL95718A (en) 1998-03-10
AR247889A1 (es) 1995-04-28
FI904588A0 (fi) 1990-09-18
HUT54699A (en) 1991-03-28
KR100191116B1 (ko) 1999-06-15
NO904061D0 (no) 1990-09-18
DE69015745T2 (de) 1995-05-11
PT95344B (pt) 1998-02-27
NO904061L (no) 1991-03-20
GR3015656T3 (en) 1995-07-31
FI102613B1 (fi) 1999-01-15
AU6247490A (en) 1991-03-28
IE903380A1 (en) 1991-04-10
NO178375C (no) 1996-03-13
CN1027694C (zh) 1995-02-22
EP0418863A2 (en) 1991-03-27
AR248028A1 (es) 1995-05-31
IE65118B1 (en) 1995-10-04
ES2069644T3 (es) 1995-05-16
DK0418863T3 (da) 1995-03-20
JP2934295B2 (ja) 1999-08-16
NZ235322A (en) 1993-02-25
EP0418863B1 (en) 1995-01-04
CN1050387A (zh) 1991-04-03
AU632362B2 (en) 1992-12-24
NO178375B (no) 1995-12-04
CA2025326A1 (en) 1991-03-20
CA2025326C (en) 2001-04-24
KR100196265B1 (ko) 1999-06-15
DE69015745D1 (de) 1995-02-16
MX9203696A (es) 1992-09-01
ATE116653T1 (de) 1995-01-15
KR910006311A (ko) 1991-04-29

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910207

FG3A Patent granted, date of granting

Effective date: 19971111

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20030531