ATE118041T1 - Dns, die für faktor ix oder analoges protein kodiert. - Google Patents

Dns, die für faktor ix oder analoges protein kodiert.

Info

Publication number: ATE118041T1
Authority: AT; Austria
Prior art keywords: factor; analogous protein; dna coding; protein; prosequence
Prior art date: 1988-11-09

Application number

AT89403065T

Other languages

English (en)

Inventor

Pierre Meulien

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-09

Filing date

1989-11-07

Publication date

1995-02-15

1989-11-07 Application filed by Transgene Sa filed Critical Transgene Sa

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118041T1 publication Critical patent/ATE118041T1/de

Links

229960004222 factor ix Drugs 0.000 title abstract 4
108090000623 proteins and genes Proteins 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 4
102100022641 Coagulation factor IX Human genes 0.000 abstract 3
108010076282 Factor IX Proteins 0.000 abstract 3
235000018102 proteins Nutrition 0.000 abstract 3
108020004705 Codon Proteins 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
239000004474 valine Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT89403065T 1988-11-09 1989-11-07 Dns, die für faktor ix oder analoges protein kodiert. ATE118041T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8814635A FR2638643B1 (fr)	1988-11-09	1988-11-09	Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants

Publications (1)

Publication Number	Publication Date
ATE118041T1 true ATE118041T1 (de)	1995-02-15

Family

ID=9371722

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89403065T ATE118041T1 (de)	1988-11-09	1989-11-07	Dns, die für faktor ix oder analoges protein kodiert.

Country Status (7)

Country	Link
US (1)	US5521070A (de)
EP (1)	EP0373012B1 (de)
JP (1)	JP2936201B2 (de)
AT (1)	ATE118041T1 (de)
CA (1)	CA2002540C (de)
DE (1)	DE68920980T2 (de)
FR (1)	FR2638643B1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI923347A0 (fi) *	1990-01-26	1992-07-23	Immuno Ag	Blodfaktorer producerade med rekombinant-dna-teknik och foerfarande foer expression av naemnda blodfaktorer samt i naemnda foerfarande anvaenda rekombinanta kokoppvirus.
WO1999003496A1 (en)	1997-07-21	1999-01-28	The University Of North Carolina At Chapel Hill	Factor ix antihemophilic factor with increased clotting activity
US7399751B2 (en) *	1999-11-04	2008-07-15	Sertoli Technologies, Inc.	Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
DK1266006T3 (da) *	2000-03-22	2006-01-16	Octagene Gmbh	Fremstilling af rekombinante muteiner af blodkoagulationsfaktor VIII i humane cellelinier
AU2001249389A1 (en) *	2000-03-22	2001-10-03	The Children's Hospital Of Philadelphia	Modified blood clotting factors and methods of use
WO2002040544A2 (en)	2000-11-14	2002-05-23	Board Of Regents, University Of Texas Systems	Mutant human factor ix with an increased resistance to inhibition by heparin
EP2292273A3 (de)	2001-10-10	2011-11-23	BioGeneriX AG	Remodellierung und Glycokonjugation von Peptiden
PT1587923E (pt)	2003-01-22	2011-12-07	Univ Duke	Construções melhoradas para a expressão de polipéptidos lisossomais
CA2522345A1 (en)	2003-04-09	2004-11-18	Neose Technologies, Inc.	Glycopegylation methods and proteins/peptides produced by the methods
EP1648380B1 (de) *	2003-07-03	2015-04-08	Sertoli Technologies, LLC	Zusammensetzungen mit sertoli-zellen und myoid-zellen und ihre verwendung in zellulären transplanten
EP1707634A1 (de)	2005-03-29	2006-10-04	Octapharma AG	Verfahren zur Isolierung von rekombinant hergestellten Proteinen
US20080255026A1 (en)	2005-05-25	2008-10-16	Glycopegylated Factor 1X	Glycopegylated Factor Ix
ES2503365T5 (es)	2005-12-21	2017-10-31	Cnj Holdings, Inc	Método para producir proteínas dependientes de vitamina K biológicamente activas por métodos recombinantes
EP2423307A1 (de)	2006-06-19	2012-02-29	Catalyst Biosciences, Inc.	Modifizierte Gerinnungsfaktor-IV-Polypeptide und deren Verwendung bei der Behandlung
AU2008245524A1 (en)	2007-04-26	2008-11-06	Cnj Holdings, Inc.	Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
EP2220230A2 (de) *	2007-11-09	2010-08-25	Isis Pharmaceuticals, Inc.	Modulation der expression von faktor 9
KR20110005862A (ko) *	2008-04-16	2011-01-19	바이엘 헬스케어 엘엘씨	변형된 제ｉｘ인자 폴리펩티드 및 이의 용도
WO2011053738A1 (en)	2009-10-30	2011-05-05	Inspiration Biopharmaceuticals, Inc.	Method of producing recombinant vitamin k dependent proteins
WO2011095604A1 (en)	2010-02-04	2011-08-11	Octapharma Biopharmaceuticals Gmbh	Half-life prolongation of proteins
PL2616090T3 (pl)	2010-09-17	2023-12-18	Takeda Pharmaceutical Company Limited	Stabilizowanie immunoglobulin poprzez wodną formulację z histydyną o ph od słabo kwaśnego do obojętnego
WO2014081831A1 (en)	2012-11-20	2014-05-30	The University Of North Carolina At Chapel Hill	Methods and compositions for modified factor ix proteins
WO2017070167A1 (en)	2015-10-20	2017-04-27	The University Of North Carolina At Chapel Hill	Methods and compositions for modified factor ix fusion proteins
JP7578590B2 (ja)	2018-10-18	2024-11-06	インテリアセラピューティクス，インコーポレーテッド	第ｉｘ因子を発現するための組成物及び方法
CN112175088B (zh)	2019-07-02	2023-03-28	江苏晟斯生物制药有限公司	改进的fix融合蛋白、缀合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4760025A (en) *	1984-05-29	1988-07-26	Genencor, Inc.	Modified enzymes and methods for making same
WO1986006408A1 (en) *	1985-04-22	1986-11-06	Genetics Institute, Inc.	HIGH YIElD PRODUCTION OF ACTIVE FACTOR IX
WO1988003926A1 (en) *	1986-11-17	1988-06-02	New England Medical Center	Enhancing gamma-carboxylation of recombinant vitamin k-dependent proteins

1988
- 1988-11-09 FR FR8814635A patent/FR2638643B1/fr not_active Expired - Fee Related
1989
- 1989-11-07 AT AT89403065T patent/ATE118041T1/de not_active IP Right Cessation
- 1989-11-07 DE DE68920980T patent/DE68920980T2/de not_active Expired - Fee Related
- 1989-11-07 EP EP89403065A patent/EP0373012B1/de not_active Expired - Lifetime
- 1989-11-08 CA CA002002540A patent/CA2002540C/fr not_active Expired - Fee Related
- 1989-11-09 JP JP1293766A patent/JP2936201B2/ja not_active Expired - Fee Related
1994
- 1994-03-14 US US08/209,489 patent/US5521070A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE68920980D1 (de)	1995-03-16
EP0373012A1 (de)	1990-06-13
JPH02265487A (ja)	1990-10-30
CA2002540C (fr)	2000-04-04
FR2638643B1 (fr)	1991-04-12
CA2002540A1 (fr)	1990-05-09
US5521070A (en)	1996-05-28
DE68920980T2 (de)	1995-07-06
FR2638643A1 (fr)	1990-05-11
EP0373012B1 (de)	1995-02-01
JP2936201B2 (ja)	1999-08-23

Legal Events

Date	Code	Title	Description
1995-07-15	UEP	Publication of translation of european patent specification
2005-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68920980D1 (de)	1995-03-16	DNS, die für Faktor IX oder analoges Protein kodiert.
DE3684078D1 (de)	1992-04-09	Reinigung und aktivierung von proteinen aus unloeslichen einschlusskoerpern.
GR3021198T3 (en)	1996-12-31	Interleukin-4 protein having bcgf and tcgf activity on human cells (human interleukin-4)
ES8506089A1 (es)	1985-06-16	Un procedimiento para preparar una celula u organismo recombinante
DE3687763D1 (de)	1993-03-25	Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.
ATE142692T1 (de)	1996-09-15	Herstellung von hämoglobin und analogen davon durch bakterien oder hefen
EP1160327A3 (de)	2002-11-06	Proteolytische Enzyme und ihre Verwendung in Waschmitteln
NO863458L (no)	1987-03-02	Undertrykkbare gjaerpromotorer.
DK135488D0 (da)	1988-03-11	Il-3-protein, isaer humant il-3, dets fremstilling og anvendelse i farmaceutica, vektor, som koder proteinet, samt celler transformeret med vektoren
GR3005040T3 (de)	1993-05-24
CA2095852A1 (en)	1992-06-06	Proteins with changed epitopes and methods for the production thereof
EP0246307A4 (de)	1989-06-13	Durch cys-kodon modifizierte dns.
ATA192895A (de)	1998-07-15	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
MX9203879A (es)	1994-01-31	Muteina de il-6 con cisteina parcialmente suprimida.
ES2055149T3 (es)	1994-08-16	Derivado de hirudina.
ES2058479T3 (es)	1994-11-01	Compuestos peptidicos.
EP0336779A3 (de)	1991-08-21	Durch kovalenten Ersatz von Wasserstoffbrücken stabilisierte Polypeptide
ES2052513T3 (es)	1994-07-16	Nuevos polipeptidos, su fabricacion y empleo.
ATE139571T1 (de)	1996-07-15	Rekombinante dna-expressionsvektoren und dna- zusammensetzungen, die isopenizillin n-epimerase- aktivität kodieren
FI882238A0 (fi)	1988-05-12	Foerbaettringar i samband med organiska foereningar
PT942978E (pt)	2003-01-31	Metodos para produzir o complexos promotor da anafase
AU525042B2 (en)	1982-10-14	Ovulation enhancing peptides
PT84011A (fr)	1987-01-01	Procede de preparation de nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant de calcium de l:organisme