ES2086374T3 - Vectores de expresion de adn recombinante y compuestos de adn que codifican la actividad aciltransferasa de aspergillus. - Google Patents

Vectores de expresion de adn recombinante y compuestos de adn que codifican la actividad aciltransferasa de aspergillus.

Info

Publication number
ES2086374T3
ES2086374T3 ES90310448T ES90310448T ES2086374T3 ES 2086374 T3 ES2086374 T3 ES 2086374T3 ES 90310448 T ES90310448 T ES 90310448T ES 90310448 T ES90310448 T ES 90310448T ES 2086374 T3 ES2086374 T3 ES 2086374T3
Authority
ES
Spain
Prior art keywords
aspergillus
expression vectors
compounds
activity
aciltransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90310448T
Other languages
English (en)
Inventor
James Robert Miller
Paul Luther Skatrud
Matthew Barry Tobin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2086374T3 publication Critical patent/ES2086374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL PRESENTE INVENTO PROVEE COMPONENTES DNA QUE CODIFICAN EL ISOPENICILIN N:ACILCOA DE ACTIVIDAD ACILTRANSFERASA DEL ASPERGILLUS NIDULANS. LOS COMPONENTES PUEDEN SER USADOS PARA CONSTRUIR LOS VECTORES DE EXPRESION DNA RECOMBINANTES PARA UNA ANCHA VARIEDAD DE CELULAS HUESPED, INCLUYENDO E.COLI, PENICILLIUM, Y ASPERGILLUS. EL INVENTO TAMBIEN PROVEE METODOS PARA PRODUCIR CEFALOSPORINES EN HONGOS QUE PRODUCEN-N PENICILIN.
ES90310448T 1989-09-27 1990-09-25 Vectores de expresion de adn recombinante y compuestos de adn que codifican la actividad aciltransferasa de aspergillus. Expired - Lifetime ES2086374T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41340189A 1989-09-27 1989-09-27

Publications (1)

Publication Number Publication Date
ES2086374T3 true ES2086374T3 (es) 1996-07-01

Family

ID=23637073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90310448T Expired - Lifetime ES2086374T3 (es) 1989-09-27 1990-09-25 Vectores de expresion de adn recombinante y compuestos de adn que codifican la actividad aciltransferasa de aspergillus.

Country Status (9)

Country Link
EP (1) EP0422790B1 (es)
JP (1) JPH03133384A (es)
AT (1) ATE135399T1 (es)
CA (1) CA2026262A1 (es)
DE (1) DE69025845T2 (es)
DK (1) DK0422790T3 (es)
ES (1) ES2086374T3 (es)
GR (1) GR3019852T3 (es)
IL (1) IL95766A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
UA47385C2 (uk) * 1991-10-15 2002-07-15 Гіст-Брокейдс Б.В. Спосіб одержання 7-амінодеацетилцефалоспоранової кислоти, спосіб одержання 7-аміноцефалоспоранової кислоти, вектор експресії рекомбінантної днк (варіанти), клітина-хазяїн penicillium chrysogenum (варіанти), спосіб культивування рекомбінантної клітини-хазяїна penicillium chrysogenum (варіанти)
WO1996010084A1 (en) * 1994-09-28 1996-04-04 Novo Nordisk A/S Process for the production of secondary metabolites
EP0914463A2 (en) * 1996-07-16 1999-05-12 Gist-Brocades B.V. NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58907667D1 (de) * 1988-04-08 1994-06-23 Biochemie Gmbh Gen und Genprodukt zur Herstellung von beta-lactamverbindungen.

Also Published As

Publication number Publication date
IL95766A (en) 1996-12-05
EP0422790B1 (en) 1996-03-13
DE69025845T2 (de) 1996-10-31
DK0422790T3 (da) 1996-05-06
JPH03133384A (ja) 1991-06-06
GR3019852T3 (en) 1996-08-31
EP0422790A3 (en) 1991-08-21
IL95766A0 (en) 1991-06-30
CA2026262A1 (en) 1991-03-28
DE69025845D1 (de) 1996-04-18
ATE135399T1 (de) 1996-03-15
EP0422790A2 (en) 1991-04-17

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