ATE118484T1 - Substituierte 3-amino-2,3,4,5-tetrahydro-1- aryloxy-3-benzazepine, verfahren zu ihrer herstellung und ihre verwendung als modulatoren der neurotransmitterfunktion. - Google Patents

Substituierte 3-amino-2,3,4,5-tetrahydro-1- aryloxy-3-benzazepine, verfahren zu ihrer herstellung und ihre verwendung als modulatoren der neurotransmitterfunktion.

Info

Publication number: ATE118484T1
Authority: AT; Austria
Prior art keywords: modulators; hydrogen; benzazepines; tetrahydro; aryloxy
Prior art date: 1991-09-23

Application number

AT92116111T

Other languages

English (en)

Inventor

Richard Charles Effland

Joseph Thomas Klein

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-23

Filing date

1992-09-21

Publication date

1995-03-15

1992-09-21 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1995-03-15 Application granted granted Critical

1995-03-15 Publication of ATE118484T1 publication Critical patent/ATE118484T1/de

Links

239000002858 neurotransmitter agent Substances 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 3
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
230000001800 adrenalinergic effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
208000022821 personality disease Diseases 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
230000000862 serotonergic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
-1 trifluoromethylcarbonyl Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT92116111T 1991-09-23 1992-09-21 Substituierte 3-amino-2,3,4,5-tetrahydro-1- aryloxy-3-benzazepine, verfahren zu ihrer herstellung und ihre verwendung als modulatoren der neurotransmitterfunktion. ATE118484T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/763,711 US5202319A (en)	1991-09-23	1991-09-23	Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines

Publications (1)

Publication Number	Publication Date
ATE118484T1 true ATE118484T1 (de)	1995-03-15

Family

ID=25068602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92116111T ATE118484T1 (de)	1991-09-23	1992-09-21	Substituierte 3-amino-2,3,4,5-tetrahydro-1- aryloxy-3-benzazepine, verfahren zu ihrer herstellung und ihre verwendung als modulatoren der neurotransmitterfunktion.

Country Status (8)

Country	Link
US (1)	US5202319A (de)
EP (1)	EP0534344B1 (de)
JP (1)	JP2665434B2 (de)
AT (1)	ATE118484T1 (de)
DE (1)	DE69201424T2 (de)
DK (1)	DK0534344T3 (de)
ES (1)	ES2068662T3 (de)
GR (1)	GR3015494T3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100710547B1 (ko) *	2002-01-02	2007-04-24	에스케이 주식회사	(ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
KR100710548B1 (ko) *	2002-12-26	2007-04-24	에스케이 주식회사	(ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
EA017308B1 (ru)	2007-05-10	2012-11-30	Олбани Молекьюлар Рисерч, Инк.	Арилокси- и гетероарилоксизамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
US4988690A (en) *	1982-06-14	1991-01-29	Hoechst-Roussel Pharmaceuticals Inc.	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
US4794181A (en) *	1982-06-14	1988-12-27	Hoechst-Roussel Pharmaceuticals, Inc.	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines
NZ234726A (en) *	1989-08-02	1992-01-29	Hoechst Roussel Pharma	2,3-dihydro-1-(pyridinylamino)-indoles and pharmaceutical compositions

1991
- 1991-09-23 US US07/763,711 patent/US5202319A/en not_active Expired - Fee Related
1992
- 1992-09-21 DK DK92116111.3T patent/DK0534344T3/da active
- 1992-09-21 AT AT92116111T patent/ATE118484T1/de not_active IP Right Cessation
- 1992-09-21 ES ES92116111T patent/ES2068662T3/es not_active Expired - Lifetime
- 1992-09-21 EP EP92116111A patent/EP0534344B1/de not_active Expired - Lifetime
- 1992-09-21 DE DE69201424T patent/DE69201424T2/de not_active Expired - Fee Related
- 1992-09-22 JP JP4251777A patent/JP2665434B2/ja not_active Expired - Fee Related
1995
- 1995-03-20 GR GR950400625T patent/GR3015494T3/el unknown

Also Published As

Publication number	Publication date
DE69201424D1 (de)	1995-03-23
DK0534344T3 (da)	1995-07-17
US5202319A (en)	1993-04-13
EP0534344B1 (de)	1995-02-15
DE69201424T2 (de)	1995-07-13
EP0534344A1 (de)	1993-03-31
GR3015494T3 (en)	1995-06-30
JP2665434B2 (ja)	1997-10-22
JPH05301859A (ja)	1993-11-16
ES2068662T3 (es)	1995-04-16

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Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2005-06-15	REN	Ceased due to non-payment of the annual fee