ATE161840T1 - Substituierte 3-(pyridinylamino)-indole und benzo(b>thiophene, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Substituierte 3-(pyridinylamino)-indole und benzo(b>thiophene, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number: ATE161840T1
Authority: AT; Austria
Prior art keywords: loweralkyl; hydrogen; chem; arylloweralkyl; pyridinylamino
Prior art date: 1991-04-17

Application number

AT92106162T

Other languages

English (en)

Inventor

Richard Charles Effland

Joseph Thomas Klein

Lawrence Leo Martin

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-17

Filing date

1992-04-09

Publication date

1998-01-15

1992-04-09 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161840T1 publication Critical patent/ATE161840T1/de

Links

YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
150000002431 hydrogen Chemical class 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
230000001800 adrenalinergic effect Effects 0.000 abstract 1
230000003474 anti-emetic effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
229940125683 antiemetic agent Drugs 0.000 abstract 1
239000002111 antiemetic agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
229940127236 atypical antipsychotics Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
208000022821 personality disease Diseases 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000000862 serotonergic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92106162T 1991-04-17 1992-04-09 Substituierte 3-(pyridinylamino)-indole und benzo(b>thiophene, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel ATE161840T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/688,964 US5177088A (en)	1991-04-17	1991-04-17	Substituted 3-(pyridinylamino)-indoles

Publications (1)

Publication Number	Publication Date
ATE161840T1 true ATE161840T1 (de)	1998-01-15

Family

ID=24766519

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92106162T ATE161840T1 (de)	1991-04-17	1992-04-09	Substituierte 3-(pyridinylamino)-indole und benzo(b>thiophene, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (25)

Country	Link
US (1)	US5177088A (de)
EP (1)	EP0509402B1 (de)
JP (1)	JP2617650B2 (de)
KR (1)	KR100254027B1 (de)
AT (1)	ATE161840T1 (de)
AU (1)	AU655253B2 (de)
BG (1)	BG61034B1 (de)
CA (1)	CA2066332C (de)
CS (1)	CS117192A3 (de)
DE (1)	DE69223837T2 (de)
DK (1)	DK0509402T3 (de)
ES (1)	ES2111580T3 (de)
FI (1)	FI105096B (de)
GR (1)	GR3026317T3 (de)
HU (1)	HU215113B (de)
IE (1)	IE921235A1 (de)
IL (1)	IL101599A (de)
MX (1)	MX9201759A (de)
NO (1)	NO180486C (de)
NZ (1)	NZ242359A (de)
PL (1)	PL168905B1 (de)
RO (1)	RO109847B1 (de)
RU (1)	RU2060254C1 (de)
TW (1)	TW200477B (de)
ZA (1)	ZA922807B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5264442A (en) *	1990-08-13	1993-11-23	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5328920A (en) *	1991-04-17	1994-07-12	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted (pyridinylamino)-indoles
US5185350A (en) *	1991-09-23	1993-02-09	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en)	1993-07-19	1994-10-18	Hoechst-Roussel Pharmaceuticals Inc.	Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
ES2157442T3 (es) *	1995-06-06	2001-08-16	Aventis Pharma Inc	Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos.
US5668154A (en) *	1995-06-06	1997-09-16	Hoechst Marion Roussel Inc.	Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
DE69715668T2 (de) *	1996-12-27	2003-07-31	Aventis Pharmaceuticals Inc., Bridgewater	N-(pyridinylamino)isoindoline und verwandte verbindungen
US7125903B1 (en)	1999-09-14	2006-10-24	Aventis Pharmaceuticals Inc.	Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en)	1999-09-14	2006-08-15	Aventis Pharmaceuticals Inc.	Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) *	1999-09-14	2007-08-07	Aventis Pharmaceuticals Inc.	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
ATE247110T1 (de) *	1999-09-14	2003-08-15	Aventis Pharma Inc	Benzisoxazolyl-, pyridoisoxazolyl- und benzthienyl-phenoxy derivate als d4 antagonisten
DE10029371A1 (de)	2000-06-20	2002-01-03	Merck Patent Gmbh	Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
GB0217920D0 (en) *	2002-04-23	2002-09-11	Aventis Pharm Prod Inc	Interleukin-4 Gene Expression inhibitors
DE602005020280D1 (de)	2004-06-01	2010-05-12	Hoffmann La Roche	3-amino-1-arylpropyl-indole als monoamin-wiederaufnahmehemmer
EP1957488B1 (de)	2005-11-30	2009-09-09	F.Hoffmann-La Roche Ag	3-amino-2-arylpropylazaindole und anwendungen davon
BRPI0619263A2 (pt)	2005-11-30	2011-09-27	Hoffmann La Roche	indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
EP2351737A1 (de) *	2005-11-30	2011-08-03	F. Hoffmann-La Roche AG	3-Amino-1-arylpropyl-Indole und aza-substituierte Indole
KR101098583B1 (ko) *	2008-01-04	2011-12-26	주식회사 엘지생명과학	세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3166987D1 (en) *	1980-09-18	1984-12-06	Asahi Chemical Ind	3-aminoindazole derivatives and process for preparation thereof
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
US4717658A (en) *	1985-12-03	1988-01-05	Miles Inc.	Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US4970218A (en) *	1987-04-24	1990-11-13	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyridinyl)-1H-indol-1-amines
US4806554A (en) *	1988-01-11	1989-02-21	Hoechst-Roussel Pharmaceuticals, Inc.	Pyrazol and indazolpyridinamines
US4954502A (en) *	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
ES2076253T3 (es) *	1989-05-19	1995-11-01	Hoechst Roussel Pharma	N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US4983615A (en) *	1989-06-28	1991-01-08	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US4954503A (en) *	1989-09-11	1990-09-04	Hoechst-Roussel Pharmaceuticals, Inc.	3-(1-substituted-4-piperazinyl)-1H-indazoles
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives

1991
- 1991-04-17 US US07/688,964 patent/US5177088A/en not_active Expired - Lifetime
1992
- 1992-04-09 BG BG96202A patent/BG61034B1/bg unknown
- 1992-04-09 AT AT92106162T patent/ATE161840T1/de not_active IP Right Cessation
- 1992-04-09 EP EP92106162A patent/EP0509402B1/de not_active Expired - Lifetime
- 1992-04-09 ES ES92106162T patent/ES2111580T3/es not_active Expired - Lifetime
- 1992-04-09 DE DE69223837T patent/DE69223837T2/de not_active Expired - Fee Related
- 1992-04-09 DK DK92106162T patent/DK0509402T3/da active
- 1992-04-14 MX MX9201759A patent/MX9201759A/es unknown
- 1992-04-14 NZ NZ242359A patent/NZ242359A/en unknown
- 1992-04-14 RO RO92-200519A patent/RO109847B1/ro unknown
- 1992-04-15 FI FI921693A patent/FI105096B/fi active
- 1992-04-15 IL IL10159992A patent/IL101599A/en not_active IP Right Cessation
- 1992-04-15 NO NO921505A patent/NO180486C/no unknown
- 1992-04-15 PL PL92294239A patent/PL168905B1/pl unknown
- 1992-04-16 KR KR1019920006338A patent/KR100254027B1/ko not_active Expired - Fee Related
- 1992-04-16 HU HU9201297A patent/HU215113B/hu not_active IP Right Cessation
- 1992-04-16 IE IE123592A patent/IE921235A1/en not_active IP Right Cessation
- 1992-04-16 CA CA002066332A patent/CA2066332C/en not_active Expired - Fee Related
- 1992-04-16 ZA ZA922807A patent/ZA922807B/xx unknown
- 1992-04-16 RU SU925011369A patent/RU2060254C1/ru active
- 1992-04-16 CS CS921171A patent/CS117192A3/cs unknown
- 1992-04-16 JP JP4096304A patent/JP2617650B2/ja not_active Expired - Fee Related
- 1992-04-21 AU AU15121/92A patent/AU655253B2/en not_active Ceased
- 1992-04-24 TW TW081103218A patent/TW200477B/zh active
1998
- 1998-03-11 GR GR980400508T patent/GR3026317T3/el unknown

Also Published As

Publication number	Publication date
NZ242359A (en)	1995-03-28
KR920019777A (ko)	1992-11-20
JPH05117266A (ja)	1993-05-14
HUT62572A (en)	1993-05-28
DE69223837D1 (de)	1998-02-12
JP2617650B2 (ja)	1997-06-04
AU1512192A (en)	1992-10-22
KR100254027B1 (ko)	2000-05-01
HU9201297D0 (en)	1992-07-28
EP0509402B1 (de)	1998-01-07
IL101599A0 (en)	1992-12-30
TW200477B (de)	1993-02-21
IL101599A (en)	1996-05-14
IE921235A1 (en)	1992-10-21
DE69223837T2 (de)	1998-06-25
RU2060254C1 (ru)	1996-05-20
MX9201759A (es)	1992-10-01
US5177088A (en)	1993-01-05
BG61034B1 (bg)	1996-09-30
GR3026317T3 (en)	1998-06-30
FI921693A0 (fi)	1992-04-15
FI105096B (fi)	2000-06-15
PL294239A1 (en)	1993-06-14
DK0509402T3 (da)	1998-09-07
NO180486C (no)	1997-04-30
PL168905B1 (pl)	1996-05-31
ZA922807B (en)	1992-11-25
NO921505D0 (no)	1992-04-15
BG96202A (bg)	1993-12-24
ES2111580T3 (es)	1998-03-16
FI921693A7 (fi)	1992-10-18
RO109847B1 (ro)	1995-06-30
AU655253B2 (en)	1994-12-08
NO180486B (no)	1997-01-20
NO921505L (no)	1992-10-19
CA2066332C (en)	2003-07-29
CA2066332A1 (en)	1992-10-18
EP0509402A1 (de)	1992-10-21
HU215113B (hu)	1998-12-28
CS117192A3 (en)	1992-11-18

Legal Events

Date	Code	Title
1998-07-15	UEP	Publication of translation of european patent specification
2005-03-15	EEFA	Change of the company name
2008-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69223837D1 (de)	1998-02-12	Substituierte 3-(Pyridinylamino)-indole und Benzo[b]thiophene, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
SG48059A1 (en)	1998-04-17	1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments
ATE160346T1 (de)	1997-12-15	Substituierte pyridinylamino-1h-indole, 1h- indazole, 2h-indazole, benzo(b)thiophen und 1,2- benzisothiazole, verfahren zu ihren herstellung und ihre verwendung als arzneimittel
ATE136297T1 (de)	1996-04-15	Substituierte 4-amino-3-pyridinolen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE140006T1 (de)	1996-07-15	1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE168689T1 (de)	1998-08-15	Substituierte (pyridinylamino)-benzisoxazole und -benzisothiazole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE118484T1 (de)	1995-03-15	Substituierte 3-amino-2,3,4,5-tetrahydro-1- aryloxy-3-benzazepine, verfahren zu ihrer herstellung und ihre verwendung als modulatoren der neurotransmitterfunktion.
DE69114404D1 (de)	1995-12-14	1-(Pyridinylalkyl)-1H-indole, -indoline und Analoge.