ATE120370T1 - Behandlung von glaukom. - Google Patents

Behandlung von glaukom.

Info

Publication number: ATE120370T1
Authority: AT; Austria
Prior art keywords: methyl; loweralkyl; inhibiting compound; choh; naphthyl
Prior art date: 1987-10-06

Application number

AT88116399T

Other languages

English (en)

Inventor

Herman H Stein

Steven R Crowley

Jacob J Plattner

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-06

Filing date

1988-10-04

Publication date

1995-04-15

1988-10-04 Application filed by Abbott Lab filed Critical Abbott Lab

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120370T1 publication Critical patent/ATE120370T1/de

Links

208000010412 Glaucoma Diseases 0.000 title abstract 2
-1 (2-naphthyl)methyl Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 3
102100028255 Renin Human genes 0.000 abstract 2
108090000783 Renin Proteins 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
230000004410 intraocular pressure Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
PHRABVHYUHIYGY-UHFFFAOYSA-N 1-methylnaphthalene Chemical group C1=CC=C2C([CH2])=CC=CC2=C1 PHRABVHYUHIYGY-UHFFFAOYSA-N 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000006277 halobenzyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002294 steroidal antiinflammatory agent Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT88116399T 1987-10-06 1988-10-04 Behandlung von glaukom. ATE120370T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10563687A	1987-10-06	1987-10-06
US07/240,567 US4927807A (en)	1987-10-06	1988-09-08	Glaucoma treatment

Publications (1)

Publication Number	Publication Date
ATE120370T1 true ATE120370T1 (de)	1995-04-15

Family

ID=26802775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88116399T ATE120370T1 (de)	1987-10-06	1988-10-04	Behandlung von glaukom.

Country Status (11)

Country	Link
US (1)	US4927807A (de)
EP (1)	EP0311012B1 (de)
JP (1)	JPH0381257A (de)
KR (1)	KR890006229A (de)
AT (1)	ATE120370T1 (de)
AU (1)	AU611953B2 (de)
CA (1)	CA1328608C (de)
DE (1)	DE3853459T2 (de)
DK (1)	DK560688A (de)
IL (1)	IL87858A (de)
NZ (1)	NZ226479A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE107658T1 (de) *	1988-01-26	1994-07-15	Sankyo Co	Renin inhibierende polypeptide, ihre herstellung und anwendung.
US5268374A (en) *	1988-10-04	1993-12-07	Abbott Laboratories	Non-peptide renin inhibitors
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
FR2647675B1 (fr) *	1989-06-05	1994-05-20	Sanofi	Utilisation d'un derive de la statine dans le traitement des affections oculaires
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
US5114937A (en) *	1989-11-28	1992-05-19	Warner-Lambert Company	Renin inhibiting nonpeptides
DK167813B1 (da) *	1989-12-07	1993-12-20	Carlbiotech Ltd As	Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
US5332742A (en) *	1990-05-11	1994-07-26	Abbott Laboratories	Renin inhibitors
JPH04243835A (ja) *	1990-08-29	1992-08-31	Pfizer Inc	高眼圧症又は緑内障治療用薬剤組成物及び治療方法
US5442044A (en) *	1991-01-04	1995-08-15	Pfizer Inc.	Orally active renin inhibitors
GB9127041D0 (en) *	1991-12-20	1992-02-19	Fujisawa Pharmaceutical Co	New use
DK0708085T3 (da) *	1994-10-19	2002-11-11	Novartis Ag	Antivirale ethere af aspartatproteasesubstrat-isostere
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
US6867203B2 (en)	1998-12-29	2005-03-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
WO2000044030A1 (fr)	1999-01-19	2000-07-27	Hamamatsu Photonics K.K.	Photomultiplicateur
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
EP2147679B1 (de)	2001-07-25	2014-06-25	Raptor Pharmaceutical, Inc.	Zusammensetzungen für den Blut-Hirn-Schrankentransport
EP2392258B1 (de)	2005-04-28	2014-10-08	Proteus Digital Health, Inc.	Pharma-Informatiksystem
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
PL3395372T3 (pl)	2009-02-20	2022-07-25	EnhanX Biopharm Inc.	Układ do dostarczania leków na bazie glutationu
CN102458374A (zh)	2009-05-06	2012-05-16	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA817261B (en) *	1980-10-23	1982-09-29	Schering Corp	Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4442089A (en) *	1982-07-06	1984-04-10	E. R. Squibb & Sons, Inc.	Method for treating glaucoma with topical or systemic ACE inhibitor compositions
EP0114333B1 (de) *	1982-12-27	1990-08-29	Schering Corporation	Pharmazeutische Zusammensetzung
GB8422165D0 (en) *	1984-09-01	1984-10-03	Wellcome Found	Compounds
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
KR900004800B1 (ko) *	1985-07-03	1990-07-06	쉐링 코포레이션	항녹내장 조성물 및 이의 제조방법
US4914090A (en) *	1985-11-01	1990-04-03	Schering Corporation	Ophthalmic compositions
US4906613A (en) *	1985-11-05	1990-03-06	Schering Corporation	Antiglaucoma compositions and methods
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
MY103189A (en) *	1986-10-31	1993-05-29	Pfizer	Nor-statine and nor-cyclostatine polypeptides

1988
- 1988-09-08 US US07/240,567 patent/US4927807A/en not_active Expired - Fee Related
- 1988-09-27 IL IL87858A patent/IL87858A/xx not_active IP Right Cessation
- 1988-09-30 AU AU23308/88A patent/AU611953B2/en not_active Ceased
- 1988-10-04 CA CA000579269A patent/CA1328608C/en not_active Expired - Fee Related
- 1988-10-04 EP EP88116399A patent/EP0311012B1/de not_active Expired - Lifetime
- 1988-10-04 DE DE3853459T patent/DE3853459T2/de not_active Expired - Fee Related
- 1988-10-04 AT AT88116399T patent/ATE120370T1/de not_active IP Right Cessation
- 1988-10-05 KR KR1019880012965A patent/KR890006229A/ko not_active Ceased
- 1988-10-06 JP JP63252887A patent/JPH0381257A/ja active Pending
- 1988-10-06 NZ NZ226479A patent/NZ226479A/en unknown
- 1988-10-06 DK DK560688A patent/DK560688A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0311012A2 (de)	1989-04-12
DK560688A (da)	1989-04-07
IL87858A (en)	1993-04-04
KR890006229A (ko)	1989-06-12
US4927807A (en)	1990-05-22
AU2330888A (en)	1989-04-06
IL87858A0 (en)	1989-03-31
DE3853459D1 (de)	1995-05-04
EP0311012A3 (en)	1990-07-11
JPH0381257A (ja)	1991-04-05
EP0311012B1 (de)	1995-03-29
DK560688D0 (da)	1988-10-06
AU611953B2 (en)	1991-06-27
DE3853459T2 (de)	1995-11-09
CA1328608C (en)	1994-04-19
NZ226479A (en)	1991-04-26

Legal Events

Date	Code	Title	Description
1995-11-15	UEP	Publication of translation of european patent specification
1997-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE120370T1 (de)	1995-04-15	Behandlung von glaukom.
ES2059313T3 (es)	1994-11-16	Peptidilaminodioles.
IE873548L (en)	1988-06-30	Peptidylaminodiols
PH31263A (en)	1998-06-18	Methods of inhibiting vascular smooth muscle cell proliferation and restinosis.
UA43391C2 (uk)	2001-12-17	Спосіб інгібування міжклітинного зчеплення і спосіб інгібування запального процесу та порушеного процесу нормальної коагуляції у пацієнтів з розладами васкулярного ендотелію
MY112973A (en)	2001-10-31	Methods for inhibiting vascular smooth muscle cell migration
WO2002009702A3 (en)	2002-12-27	Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
WO2001012169A3 (en)	2002-02-14	Method of cancer treatment
KR870007204A (ko)	1987-08-17	작용화 펩티딜 아미노디올 및-트리올
CA2321188A1 (en)	1999-09-02	Derivatives of azetidine and pyrrolidine
GEP20012389B (en)	2001-03-25	Benzoxazinone Dopamine D4 Receptor Antagonists, Pharmaceutical Composition Containing the Same and Method for Treatment of Psychosis or Schizophrenia
DE69125216D1 (de)	1997-04-24	Aminoalkanesulfonsäurederivate und pharmazeutische Zusammensetzungen davon zur Prävention oder Behandlung von Herzerkrankungen
PT986393E (pt)	2004-06-30	Utilizacao de um nitroxido ou de um seu pro-farmaco no tratamento profilactico e terapeutico do cancro
NZ293691A (en)	1999-07-29	Use of a medicament containing an anilide compound for treatment of type i allergic diseases
EA199800665A1 (ru)	1999-08-26	Способы лечения и предупреждения неблагоприятного воздействия активных форм кислорода