DK560688A - Praeparat til behandling af glaukom - Google Patents

Praeparat til behandling af glaukom

Info

Publication number: DK560688A
Authority: DK; Denmark
Prior art keywords: methyl; loweralkyl; inhibiting compound; choh; naphthyl
Prior art date: 1987-10-06

Application number

DK560688A

Other languages

Danish (da)

English (en)

Other versions

DK560688D0 (da

Inventor

Herman H Stein

Jacob J Plattner

Steven R Crowley

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-06

Filing date

1988-10-06

Publication date

1989-04-07

1988-10-06 Application filed by Abbott Lab filed Critical Abbott Lab

1988-10-06 Publication of DK560688D0 publication Critical patent/DK560688D0/da

1989-04-07 Publication of DK560688A publication Critical patent/DK560688A/da

Links

208000010412 Glaucoma Diseases 0.000 title abstract 2
-1 (2-naphthyl)methyl Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 3
102100028255 Renin Human genes 0.000 abstract 2
108090000783 Renin Proteins 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
230000004410 intraocular pressure Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
PHRABVHYUHIYGY-UHFFFAOYSA-N 1-methylnaphthalene Chemical group C1=CC=C2C([CH2])=CC=CC2=C1 PHRABVHYUHIYGY-UHFFFAOYSA-N 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000006277 halobenzyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002294 steroidal antiinflammatory agent Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK560688A 1987-10-06 1988-10-06 Praeparat til behandling af glaukom DK560688A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10563687A	1987-10-06	1987-10-06
US07/240,567 US4927807A (en)	1987-10-06	1988-09-08	Glaucoma treatment

Publications (2)

Publication Number	Publication Date
DK560688D0 DK560688D0 (da)	1988-10-06
DK560688A true DK560688A (da)	1989-04-07

Family

ID=26802775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK560688A DK560688A (da)	1987-10-06	1988-10-06	Praeparat til behandling af glaukom

Country Status (11)

Country	Link
US (1)	US4927807A (de)
EP (1)	EP0311012B1 (de)
JP (1)	JPH0381257A (de)
KR (1)	KR890006229A (de)
AT (1)	ATE120370T1 (de)
AU (1)	AU611953B2 (de)
CA (1)	CA1328608C (de)
DE (1)	DE3853459T2 (de)
DK (1)	DK560688A (de)
IL (1)	IL87858A (de)
NZ (1)	NZ226479A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0326364B1 (de) *	1988-01-26	1994-06-22	Sankyo Company Limited	Renin inhibierende Polypeptide, ihre Herstellung und Anwendung
US5268374A (en) *	1988-10-04	1993-12-07	Abbott Laboratories	Non-peptide renin inhibitors
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
FR2647675B1 (fr) *	1989-06-05	1994-05-20	Sanofi	Utilisation d'un derive de la statine dans le traitement des affections oculaires
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
US5114937A (en) *	1989-11-28	1992-05-19	Warner-Lambert Company	Renin inhibiting nonpeptides
DK167813B1 (da) *	1989-12-07	1993-12-20	Carlbiotech Ltd As	Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5332742A (en) *	1990-05-11	1994-07-26	Abbott Laboratories	Renin inhibitors
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
JPH04243835A (ja) *	1990-08-29	1992-08-31	Pfizer Inc	高眼圧症又は緑内障治療用薬剤組成物及び治療方法
US5442044A (en) *	1991-01-04	1995-08-15	Pfizer Inc.	Orally active renin inhibitors
GB9127041D0 (en) *	1991-12-20	1992-02-19	Fujisawa Pharmaceutical Co	New use
DK0708085T3 (da) *	1994-10-19	2002-11-11	Novartis Ag	Antivirale ethere af aspartatproteasesubstrat-isostere
AU4093799A (en)	1998-05-22	1999-12-13	Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6867203B2 (en)	1998-12-29	2005-03-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
AU1891399A (en)	1999-01-19	2000-08-07	Hamamatsu Photonics K.K.	Photomultiplier
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP1945240B1 (de)	2005-09-16	2016-12-28	Raptor Pharmaceutical Inc	Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA817261B (en) *	1980-10-23	1982-09-29	Schering Corp	Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4442089A (en) *	1982-07-06	1984-04-10	E. R. Squibb & Sons, Inc.	Method for treating glaucoma with topical or systemic ACE inhibitor compositions
DE3381850D1 (de) *	1982-12-27	1990-10-04	Schering Corp	Pharmazeutische zusammensetzung.
GB8422165D0 (en) *	1984-09-01	1984-10-03	Wellcome Found	Compounds
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
DE3686706T2 (de) *	1985-07-03	1993-01-28	Schering Corp	Glaukomhemmende zusammensetzungen und verfahren zu ihrer herstellung.
US4914090A (en) *	1985-11-01	1990-04-03	Schering Corporation	Ophthalmic compositions
US4906613A (en) *	1985-11-05	1990-03-06	Schering Corporation	Antiglaucoma compositions and methods
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
MY103189A (en) *	1986-10-31	1993-05-29	Pfizer	Nor-statine and nor-cyclostatine polypeptides

1988
- 1988-09-08 US US07/240,567 patent/US4927807A/en not_active Expired - Fee Related
- 1988-09-27 IL IL87858A patent/IL87858A/xx not_active IP Right Cessation
- 1988-09-30 AU AU23308/88A patent/AU611953B2/en not_active Ceased
- 1988-10-04 EP EP88116399A patent/EP0311012B1/de not_active Expired - Lifetime
- 1988-10-04 CA CA000579269A patent/CA1328608C/en not_active Expired - Fee Related
- 1988-10-04 DE DE3853459T patent/DE3853459T2/de not_active Expired - Fee Related
- 1988-10-04 AT AT88116399T patent/ATE120370T1/de not_active IP Right Cessation
- 1988-10-05 KR KR1019880012965A patent/KR890006229A/ko not_active Ceased
- 1988-10-06 DK DK560688A patent/DK560688A/da not_active Application Discontinuation
- 1988-10-06 NZ NZ226479A patent/NZ226479A/en unknown
- 1988-10-06 JP JP63252887A patent/JPH0381257A/ja active Pending

Also Published As

Publication number	Publication date
JPH0381257A (ja)	1991-04-05
DK560688D0 (da)	1988-10-06
US4927807A (en)	1990-05-22
CA1328608C (en)	1994-04-19
EP0311012B1 (de)	1995-03-29
AU2330888A (en)	1989-04-06
EP0311012A2 (de)	1989-04-12
EP0311012A3 (en)	1990-07-11
NZ226479A (en)	1991-04-26
KR890006229A (ko)	1989-06-12
IL87858A0 (en)	1989-03-31
DE3853459D1 (de)	1995-05-04
AU611953B2 (en)	1991-06-27
IL87858A (en)	1993-04-04
DE3853459T2 (de)	1995-11-09
ATE120370T1 (de)	1995-04-15

Legal Events

Date	Code	Title	Description
1996-06-17	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK560688A (da)	1989-04-07	Praeparat til behandling af glaukom
DK20987D0 (da)	1987-01-15	Peptidylaminodioler og fremgangsmaade til deres fremstilling
IE873548L (en)	1988-06-30	Peptidylaminodiols
AU7578894A (en)	1995-05-04	Methods for inhibiting smooth muscle cell proliferation and restinosis
MY120064A (en)	2005-08-30	Indole derivatives as inhibitors or factor xa
UA43391C2 (uk)	2001-12-17	Спосіб інгібування міжклітинного зчеплення і спосіб інгібування запального процесу та порушеного процесу нормальної коагуляції у пацієнтів з розладами васкулярного ендотелію
KR970701722A (ko)	1997-04-12	포스폰산 디에스테르 유도체(phosphonic diester derivative)
WO2002009702A8 (en)	2003-05-08	Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
WO2001012169A3 (en)	2002-02-14	Method of cancer treatment
CA2321188A1 (en)	1999-09-02	Derivatives of azetidine and pyrrolidine
KR880007538A (ko)	1988-08-27	피리다조 디아제핀 유도체
GEP20012389B (en)	2001-03-25	Benzoxazinone Dopamine D4 Receptor Antagonists, Pharmaceutical Composition Containing the Same and Method for Treatment of Psychosis or Schizophrenia
PT986393E (pt)	2004-06-30	Utilizacao de um nitroxido ou de um seu pro-farmaco no tratamento profilactico e terapeutico do cancro
NZ293691A (en)	1999-07-29	Use of a medicament containing an anilide compound for treatment of type i allergic diseases
KR940701407A (ko)	1994-05-28	레닌 억제제로서의 하이드록시아지도 유도체 및 관련 화합물
EA199800665A1 (ru)	1999-08-26	Способы лечения и предупреждения неблагоприятного воздействия активных форм кислорода
CA2228524A1 (en)	1997-02-27	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating human malignancies