ATE133165T1 - Aza-macrozyklen und verfahren zu deren herstellung - Google Patents

Aza-macrozyklen und verfahren zu deren herstellung

Info

Publication number
ATE133165T1
ATE133165T1 AT90301478T AT90301478T ATE133165T1 AT E133165 T1 ATE133165 T1 AT E133165T1 AT 90301478 T AT90301478 T AT 90301478T AT 90301478 T AT90301478 T AT 90301478T AT E133165 T1 ATE133165 T1 AT E133165T1
Authority
AT
Austria
Prior art keywords
group
different
same
hydrogen atom
alkyl
Prior art date
Application number
AT90301478T
Other languages
English (en)
Inventor
David Parker
Thomas Andrew Millican
Nigel Robert Arnold Beeley
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898903024A external-priority patent/GB8903024D0/en
Priority claimed from GB898903025A external-priority patent/GB8903025D0/en
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ATE133165T1 publication Critical patent/ATE133165T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Inorganic Insulating Materials (AREA)
  • Primary Cells (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90301478T 1989-02-10 1990-02-12 Aza-macrozyklen und verfahren zu deren herstellung ATE133165T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898903024A GB8903024D0 (en) 1989-02-10 1989-02-10 Chemical compounds
GB898903025A GB8903025D0 (en) 1989-02-10 1989-02-10 Chemical compounds

Publications (1)

Publication Number Publication Date
ATE133165T1 true ATE133165T1 (de) 1996-02-15

Family

ID=26294939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90301478T ATE133165T1 (de) 1989-02-10 1990-02-12 Aza-macrozyklen und verfahren zu deren herstellung

Country Status (6)

Country Link
US (1) US5565562A (de)
EP (1) EP0382583B1 (de)
JP (1) JPH03504510A (de)
AT (1) ATE133165T1 (de)
DE (1) DE69024826T2 (de)
WO (1) WO1990009379A1 (de)

Families Citing this family (31)

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Publication number Priority date Publication date Assignee Title
CA2092596A1 (en) * 1992-03-27 1993-09-28 Kan Kubomura Tetraazacyclododecane derivative and its use
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE69426811T2 (de) * 1993-12-30 2001-09-13 Guerbet, Villepinte Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
TR28540A (tr) * 1995-03-16 1996-09-30 Guerbet Sa Poliamine edilmis baglayicilar ve bunlarin metal kompleksleri.
US6107482A (en) 1995-03-27 2000-08-22 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
BR0013745A (pt) 1999-09-01 2002-05-14 Unilever Nv Composição alvejante para um têxtil
CN1384837A (zh) * 1999-09-01 2002-12-11 荷兰联合利华有限公司 用于催化漂白底物的配体和配合物
CA2401039A1 (en) 2000-02-29 2001-09-07 Unilever Plc Composition and method for bleaching a substrate
US6565828B2 (en) 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
CZ20032564A3 (cs) 2001-02-23 2004-09-15 Bristol-Myers Squibb Pharma Company Značené antagonisty receptoru makrofágového lapače pro zobrazování atherosklerosy a citlivých plaků
WO2002080856A2 (en) * 2001-04-06 2002-10-17 University And Community College System Of Nevada On Behalf Of The University Of Nevada, Reno Triaza compound immunoregulatory agents
US20030007974A1 (en) * 2001-05-30 2003-01-09 Nanus David M. Endopeptidase/anti-PSMA antibody fusion proteins for treatment of cancer
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
JP4619651B2 (ja) 2001-06-01 2011-01-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 前立腺特異的膜抗原に対する修飾抗体およびその使用
US7666414B2 (en) * 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
IL159422A0 (en) 2001-09-20 2004-06-01 Cornell Res Foundation Inc Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate-specific membrane antigen
US6852854B1 (en) * 2002-10-01 2005-02-08 Psiloquest Inc. Preformed carboxylated active ester for labeling biomolecules
US20040136998A1 (en) * 2002-10-30 2004-07-15 Bander Neil H. Methods and compositions for treating or preventing insulin-related disorders using binding agents specific for prostate specific membrane antigen
ATE408712T1 (de) 2003-01-10 2008-10-15 Millennium Pharm Inc Verfahren zur bestimmung des wiederauftretens von prostata krebs
US20050202020A1 (en) * 2004-01-09 2005-09-15 Jeffrey Ross Diagnosing and treating cancer
WO2005094882A1 (en) * 2004-03-03 2005-10-13 Millennium Pharmaceuticals, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
US9463254B2 (en) 2013-06-07 2016-10-11 The Board Of Regents Of The University Of Texas System Molecular design toward dual-modality probes for radioisotope-based imaging (PET or SPECT) and MRI
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
JP7693317B2 (ja) 2017-05-05 2025-06-17 センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション 二官能性キレートの薬物動態増強及びその使用
MA49398A (fr) 2017-05-05 2020-04-22 Eric Steven Burak Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001212A (en) * 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
EP0188256B1 (de) * 1985-01-14 1991-08-21 NeoRx Metall-Radionuklid markiertes Protein für Diagnose und Therapie
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
EP0232751B1 (de) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-Substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
FR2672051B1 (fr) * 1991-01-24 1993-05-21 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique.

Also Published As

Publication number Publication date
EP0382583A1 (de) 1990-08-16
EP0382583B1 (de) 1996-01-17
JPH03504510A (ja) 1991-10-03
US5565562A (en) 1996-10-15
DE69024826D1 (de) 1996-02-29
WO1990009379A1 (en) 1990-08-23
DE69024826T2 (de) 1996-06-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties