ATE145209T1 - Tri-aza-makrocyclen und verfahren zu ihrer herstellung - Google Patents

Tri-aza-makrocyclen und verfahren zu ihrer herstellung

Info

Publication number: ATE145209T1
Authority: AT; Austria
Prior art keywords: group; integer; zero; hydrogen atom; tri
Prior art date: 1989-06-23

Application number

AT90306942T

Other languages

English (en)

Inventor

David Parker

Michael Anthony William Eaton

Original Assignee

Celltech Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-23

Filing date

1990-06-25

Publication date

1996-11-15

1990-06-25 Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE145209T1 publication Critical patent/ATE145209T1/de

Links

238000000034 method Methods 0.000 title abstract 2
150000002678 macrocyclic compounds Chemical class 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
206010028980 Neoplasm Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
239000012216 imaging agent Substances 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT90306942T 1989-06-23 1990-06-25 Tri-aza-makrocyclen und verfahren zu ihrer herstellung ATE145209T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898914543A GB8914543D0 (en)	1989-06-23	1989-06-23	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE145209T1 true ATE145209T1 (de)	1996-11-15

Family

ID=10659003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90306942T ATE145209T1 (de)	1989-06-23	1990-06-25	Tri-aza-makrocyclen und verfahren zu ihrer herstellung

Country Status (6)

Country	Link
EP (1)	EP0404605B1 (de)
JP (1)	JPH04501569A (de)
AT (1)	ATE145209T1 (de)
DE (1)	DE69029103T2 (de)
GB (1)	GB8914543D0 (de)
WO (1)	WO1991000285A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5362476A (en) *	1984-10-18	1994-11-08	Board Of Regents, The University Of Texas System	Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5342606A (en) *	1984-10-18	1994-08-30	Board Of Regents, The University Of Texas System	Polyazamacrocyclic compounds for complexation of metal ions
US5188816A (en) *	1984-10-18	1993-02-23	Board Of Regents, The University Of Texas System	Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
ATE140869T1 (de) *	1989-11-27	1996-08-15	Concat Ltd	Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden
US5236695A (en) *	1989-11-27	1993-08-17	Concat, Ltd.	MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
GB9008724D0 (en) *	1990-04-18	1990-06-13	Celltech Ltd	Chemical compounds
US5684135A (en) *	1990-04-18	1997-11-04	Celltech Therapeutics Limited	Conjugate compounds containing aza-macro-cycles and processes for their preparation
US5462725A (en) *	1993-05-06	1995-10-31	The Dow Chemical Company	2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5409689A (en) *	1993-08-13	1995-04-25	Concat, Ltd.	MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
EP0955044B1 (de)	1995-06-26	2005-11-16	Chelator LLC	Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
EP0935659A1 (de)	1996-09-17	1999-08-18	Chiron Corporation	Zusammensetzungen und verfahren zur behandlung intrazellulärer erkrankungen
DE69838483T2 (de)	1997-10-14	2008-07-03	Darwin Molecular Corp.	Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
US20040009535A1 (en)	1998-11-27	2004-01-15	Celltech R&D, Inc.	Compositions and methods for increasing bone mineralization
DE69942782D1 (de)	1998-11-27	2010-10-28	Ucb Sa	Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung
US6864235B1 (en)	1999-04-01	2005-03-08	Eva A. Turley	Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6911429B2 (en)	1999-04-01	2005-06-28	Transition Therapeutics Inc.	Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
EP1967525B1 (de)	2001-05-08	2012-11-14	Darwin Molecular Corporation	Verfahren zur Regulierung der Immunfunktion in Primaten unter Verwendung des foxp3-Proteins
JP5513855B2 (ja) *	2009-11-11	2014-06-04	株式会社東芝	冷蔵庫
CA2871711A1 (en)	2012-05-04	2013-11-07	Pfizer Inc.	Prostate-associated antigens and vaccine-based immunotherapy regimens
FR2998298B1 (fr)	2012-11-21	2020-11-20	Univ Bourgogne	Synthese de sels d’imidazo[1,2-a]pyrazin-4-ium pour la synthese du 1,4,7-triazacyclononane (tacn) et de ses derives n- et/ou c-fonctionnalises
AU2017290805B2 (en)	2016-07-01	2023-11-16	Research Development Foundation	Elimination of proliferating cells from stem cell-derived grafts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4639365A (en) *	1984-10-18	1987-01-27	The Board Of Regents, The University Of Texas System	Gadolinium chelates as NMR contrast agents
JPS61226751A (ja) *	1985-03-30	1986-10-08	Konishiroku Photo Ind Co Ltd	ハロゲン化銀写真感光材料用処理液及びその処理方法
GB8719041D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds

1989
- 1989-06-23 GB GB898914543A patent/GB8914543D0/en active Pending
1990
- 1990-06-25 WO PCT/GB1990/000982 patent/WO1991000285A1/en not_active Ceased
- 1990-06-25 DE DE69029103T patent/DE69029103T2/de not_active Expired - Fee Related
- 1990-06-25 AT AT90306942T patent/ATE145209T1/de not_active IP Right Cessation
- 1990-06-25 EP EP90306942A patent/EP0404605B1/de not_active Expired - Lifetime
- 1990-06-25 JP JP2509420A patent/JPH04501569A/ja active Pending

Also Published As

Publication number	Publication date
DE69029103D1 (de)	1996-12-19
DE69029103T2 (de)	1997-06-05
GB8914543D0 (en)	1989-08-09
EP0404605A2 (de)	1990-12-27
EP0404605A3 (de)	1991-01-30
JPH04501569A (ja)	1992-03-19
WO1991000285A1 (en)	1991-01-10
EP0404605B1 (de)	1996-11-13

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Legal Events

Date	Code	Title	Description
1997-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties