ATE145209T1 - Tri-aza-makrocyclen und verfahren zu ihrer herstellung - Google Patents

Tri-aza-makrocyclen und verfahren zu ihrer herstellung

Info

Publication number
ATE145209T1
ATE145209T1 AT90306942T AT90306942T ATE145209T1 AT E145209 T1 ATE145209 T1 AT E145209T1 AT 90306942 T AT90306942 T AT 90306942T AT 90306942 T AT90306942 T AT 90306942T AT E145209 T1 ATE145209 T1 AT E145209T1
Authority
AT
Austria
Prior art keywords
group
integer
zero
hydrogen atom
tri
Prior art date
Application number
AT90306942T
Other languages
English (en)
Inventor
David Parker
Michael Anthony William Eaton
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ATE145209T1 publication Critical patent/ATE145209T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90306942T 1989-06-23 1990-06-25 Tri-aza-makrocyclen und verfahren zu ihrer herstellung ATE145209T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898914543A GB8914543D0 (en) 1989-06-23 1989-06-23 Chemical compounds

Publications (1)

Publication Number Publication Date
ATE145209T1 true ATE145209T1 (de) 1996-11-15

Family

ID=10659003

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90306942T ATE145209T1 (de) 1989-06-23 1990-06-25 Tri-aza-makrocyclen und verfahren zu ihrer herstellung

Country Status (6)

Country Link
EP (1) EP0404605B1 (de)
JP (1) JPH04501569A (de)
AT (1) ATE145209T1 (de)
DE (1) DE69029103T2 (de)
GB (1) GB8914543D0 (de)
WO (1) WO1991000285A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5188816A (en) * 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
AU649001B2 (en) * 1989-11-27 1994-05-12 Chelator Llc MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
GB9008724D0 (en) * 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
US5684135A (en) * 1990-04-18 1997-11-04 Celltech Therapeutics Limited Conjugate compounds containing aza-macro-cycles and processes for their preparation
US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
CA2266656A1 (en) 1996-09-17 1998-03-26 Chiron Corporation Compositions and methods for treating intracellular diseases
EP1025212B1 (de) 1997-10-14 2007-09-26 Darwin Molecular Corporation Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
JP4813660B2 (ja) 1998-11-27 2011-11-09 ダーウィン ディスカバリー リミテッド 骨鉱化作用を増加するための組成物および方法
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
ATE405586T1 (de) 2001-05-08 2008-09-15 Darwin Molecular Corp Verfahren zur regulierung der immunfunktion in primaten unter verwendung des foxp3-proteins
JP5513855B2 (ja) * 2009-11-11 2014-06-04 株式会社東芝 冷蔵庫
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
FR2998298B1 (fr) 2012-11-21 2020-11-20 Univ Bourgogne Synthese de sels d’imidazo[1,2-a]pyrazin-4-ium pour la synthese du 1,4,7-triazacyclononane (tacn) et de ses derives n- et/ou c-fonctionnalises
JP7099967B2 (ja) 2016-07-01 2022-07-12 リサーチ ディベロップメント ファウンデーション 幹細胞由来移植片からの増殖性細胞の排除

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds

Also Published As

Publication number Publication date
EP0404605B1 (de) 1996-11-13
DE69029103D1 (de) 1996-12-19
JPH04501569A (ja) 1992-03-19
EP0404605A3 (de) 1991-01-30
EP0404605A2 (de) 1990-12-27
DE69029103T2 (de) 1997-06-05
GB8914543D0 (en) 1989-08-09
WO1991000285A1 (en) 1991-01-10

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Legal Events

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