ATE122659T1 - Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridin , ihr verfahren zur herstellung und ihre verwendung. - Google Patents

Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridin , ihr verfahren zur herstellung und ihre verwendung.

Info

Publication number
ATE122659T1
ATE122659T1 AT93102220T AT93102220T ATE122659T1 AT E122659 T1 ATE122659 T1 AT E122659T1 AT 93102220 T AT93102220 T AT 93102220T AT 93102220 T AT93102220 T AT 93102220T AT E122659 T1 ATE122659 T1 AT E122659T1
Authority
AT
Austria
Prior art keywords
treatment
disturbances
hydrogen
compounds
loweralkyl
Prior art date
Application number
AT93102220T
Other languages
German (de)
English (en)
Inventor
Heinrich Dr Englert
Dieter Dr Mania
David Dr Wettlaufer
Erik Dr Klaus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of ATE122659T1 publication Critical patent/ATE122659T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT93102220T 1992-02-20 1993-02-12 Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridin , ihr verfahren zur herstellung und ihre verwendung. ATE122659T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92102828 1992-02-20

Publications (1)

Publication Number Publication Date
ATE122659T1 true ATE122659T1 (de) 1995-06-15

Family

ID=8209352

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93102220T ATE122659T1 (de) 1992-02-20 1993-02-12 Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridin , ihr verfahren zur herstellung und ihre verwendung.

Country Status (17)

Country Link
US (1) US5360808A (fr)
EP (1) EP0556738B1 (fr)
JP (1) JPH069560A (fr)
KR (1) KR930017895A (fr)
CN (1) CN1075480A (fr)
AT (1) ATE122659T1 (fr)
AU (1) AU3375993A (fr)
CA (1) CA2089955A1 (fr)
CZ (1) CZ403592A3 (fr)
DE (1) DE69300152D1 (fr)
FI (1) FI930716L (fr)
HU (1) HU9300463D0 (fr)
IL (1) IL104781A0 (fr)
MA (1) MA22806A1 (fr)
MX (1) MX9300915A (fr)
NO (1) NO930594L (fr)
ZA (1) ZA931185B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0016517A (pt) * 1999-12-21 2002-09-17 Monsanto Technology Llc Derivados diacila de diamina de propileno herbicidas
DE10205219A1 (de) * 2002-02-08 2003-08-21 Bayer Ag Chinoxalinone und ihre Verwendung
US6869966B2 (en) * 2002-09-30 2005-03-22 Banyu Pharmaceutical Co., Ltd. N-substituted-2-oxodihydropyridine derivatives
US20040127129A1 (en) * 2002-12-31 2004-07-01 Shuiyuan Luo Grooved-shape monofilaments and the fabrics made thereof
WO2007008963A1 (fr) * 2005-07-13 2007-01-18 Jenrin Discovery Inhibiteurs de la mao-b utiles pour traiter l'obésité
MX2009008531A (es) 2007-02-16 2009-08-26 Amgen Inc Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
WO2010072599A1 (fr) 2008-12-23 2010-07-01 F. Hoffmann-La Roche Ag Dihydropyridone urées en tant que modulateurs de p2x7
US8153808B2 (en) 2008-12-23 2012-04-10 Roche Palo Alto Llc Dihydropyridone amides as P2X7 modulators
EP2391604A1 (fr) 2008-12-23 2011-12-07 F. Hoffmann-La Roche AG Amides de dihydropyridone utiles comme modulateurs de p2x7
MX2011006843A (es) 2008-12-23 2011-08-04 Hoffmann La Roche Dihidropiridona-amidas como moduladores de p2x7.
CN102264723B (zh) 2008-12-23 2014-12-10 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮酰胺
US8816085B2 (en) 2009-08-26 2014-08-26 Takeda Gmbh Methylpyrrolopyridinecarboxamides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung
NZ195564A (en) * 1979-11-26 1983-09-30 Sterling Drug Inc 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds
US4297360A (en) * 1980-03-28 1981-10-27 Sterling Drug Inc. 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
IT8367883A0 (it) * 1982-08-23 1983-08-22 Rorer Int Overseas Composti cardiotonici del 2 piridone 5 biciclico eteroaril sostituito e relative composizioni farmaceutiche
GB8809481D0 (en) * 1988-04-21 1988-05-25 Smith Kline French Lab Chemical compounds

Also Published As

Publication number Publication date
ZA931185B (en) 1993-09-16
FI930716A0 (fi) 1993-02-18
EP0556738A1 (fr) 1993-08-25
DE69300152D1 (de) 1995-06-22
HU9300463D0 (en) 1993-05-28
KR930017895A (ko) 1993-09-20
IL104781A0 (en) 1993-06-10
JPH069560A (ja) 1994-01-18
NO930594D0 (no) 1993-02-19
CZ403592A3 (en) 1993-12-15
EP0556738B1 (fr) 1995-05-17
NO930594L (no) 1993-08-23
FI930716A7 (fi) 1993-08-21
AU3375993A (en) 1993-08-26
FI930716L (fi) 1993-08-21
MA22806A1 (fr) 1993-10-01
CA2089955A1 (fr) 1993-08-21
US5360808A (en) 1994-11-01
MX9300915A (es) 1993-09-01
CN1075480A (zh) 1993-08-25

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