ATE123292T1 - Cck-antagonisten. - Google Patents

Cck-antagonisten.

Info

Publication number: ATE123292T1
Authority: AT; Austria
Prior art keywords: inclusive; carbon atoms; group; alkyl group; integer
Prior art date: 1988-04-12

Application number

AT89303644T

Other languages

English (en)

Inventor

Sun Hyuk Kim

Original Assignee

Biomeasure Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-12

Filing date

1989-04-12

Publication date

1995-06-15

1988-04-12 Priority claimed from US07/180,310 external-priority patent/US4902708A/en

1989-04-12 Application filed by Biomeasure Inc filed Critical Biomeasure Inc

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE123292T1 publication Critical patent/ATE123292T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 26
125000000217 alkyl group Chemical group 0.000 abstract 7
-1 amino, hydroxy Chemical group 0.000 abstract 4
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
102100025841 Cholecystokinin Human genes 0.000 abstract 3
101800001982 Cholecystokinin Proteins 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
229940107137 cholecystokinin Drugs 0.000 abstract 3
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 3
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000006310 cycloalkyl amino group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010033645 Pancreatitis Diseases 0.000 abstract 1
206010033647 Pancreatitis acute Diseases 0.000 abstract 1
208000008469 Peptic Ulcer Diseases 0.000 abstract 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
208000007107 Stomach Ulcer Diseases 0.000 abstract 1
201000003229 acute pancreatitis Diseases 0.000 abstract 1
230000036528 appetite Effects 0.000 abstract 1
235000019789 appetite Nutrition 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000000718 duodenal ulcer Diseases 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000001175 peptic effect Effects 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

AT89303644T 1988-04-12 1989-04-12 Cck-antagonisten. ATE123292T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/180,310 US4902708A (en)	1985-12-31	1988-04-12	CCK antagonists
US23149388A	1988-08-12	1988-08-12

Publications (1)

Publication Number	Publication Date
ATE123292T1 true ATE123292T1 (de)	1995-06-15

Family

ID=26876181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89303644T ATE123292T1 (de)	1988-04-12	1989-04-12	Cck-antagonisten.

Country Status (6)

Country	Link
EP (1)	EP0337774B1 (de)
JP (1)	JPH0228152A (de)
AT (1)	ATE123292T1 (de)
CA (1)	CA1326108C (de)
DE (1)	DE68922877T2 (de)
ES (1)	ES2072897T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2659966B1 (fr) *	1990-03-26	1992-05-22	Rhone Poulenc Sante	Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant.
JPH05504968A (ja) *	1990-03-07	1993-07-29	ローン―プーラン・ロレ・ソシエテ・アノニム	グリシンアミド誘導体、その製造及びそれを含む医薬品
GB9206757D0 (en) *	1992-03-27	1992-05-13	Ferring Bv	Novel peptide receptor ligands
CA2167154A1 (en) *	1993-08-10	1995-02-16	Sarkis Barret Kalindjian	Gastrin and cck receptor ligands
US5780498A (en) *	1993-11-01	1998-07-14	Ciba-Geigy Japan Limited	Endothelin receptor antagonists
US7277684B2 (en)	2003-04-25	2007-10-02	Fujitsu Ten Limited	Antenna amplifier and shared antenna amplifier
CN101233121A (zh) *	2005-06-10	2008-07-30	彼帕科学公司	Parp调节剂和癌症的治疗

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4482567A (en) *	1982-10-07	1984-11-13	Research Foundation For Mental Hygiene, Inc.	N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
US4757151A (en) *	1985-11-14	1988-07-12	Warner-Lambert Company	2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) *	1985-12-31	1989-03-21	Biomeasure, Inc.	CCK antagonists
EP0442878A4 (en) *	1988-04-05	1991-10-23	Abbott Laboratories	Derivatives of tryptophan as cck antagonists

1989
- 1989-04-11 CA CA000596292A patent/CA1326108C/en not_active Expired - Fee Related
- 1989-04-12 EP EP89303644A patent/EP0337774B1/de not_active Expired - Lifetime
- 1989-04-12 DE DE68922877T patent/DE68922877T2/de not_active Expired - Fee Related
- 1989-04-12 JP JP1092772A patent/JPH0228152A/ja active Pending
- 1989-04-12 AT AT89303644T patent/ATE123292T1/de not_active IP Right Cessation
- 1989-04-12 ES ES89303644T patent/ES2072897T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2072897T3 (es)	1995-08-01
EP0337774A2 (de)	1989-10-18
DE68922877D1 (de)	1995-07-06
EP0337774B1 (de)	1995-05-31
JPH0228152A (ja)	1990-01-30
DE68922877T2 (de)	1996-01-11
CA1326108C (en)	1994-01-11
EP0337774A3 (en)	1990-08-16

Legal Events

Date	Code	Title	Description
1996-01-15	UEP	Publication of translation of european patent specification
2001-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2039205T3 (es)	1993-09-16	Procedimiento para preparar antagonistas de colecistoquinina.
YU115588A (en)	1988-10-31	Process for obtaining derivatives of pyrimidanone as calcium independent camp inhibitors of phosphodiestheraze
DK0649418T3 (da)	1999-07-12	7-(2-aminoethyl)benzothiazolon
MY131641A (en)	2007-08-30	Indoline derivatives, process of preparation and use
PT82480A (en)	1986-05-01	Process for the preparation of 2-amino thiazoles n-substituted and for the corresponding pharmaceutical compositions
ATE123292T1 (de)	1995-06-15	Cck-antagonisten.
NO165072C (no)	1990-12-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-vinyl-og 3-ethynyl-8-carbolinderivater.
ATE121385T1 (de)	1995-05-15	Harnstoffderivate, ihre herstellung und ihre verwendung bei der therapie.
IE861633L (en)	1987-01-11	Carboxamide indole derivatives
DK666889D0 (da)	1989-12-27	Nephthalenderivater
AU639672B2 (en)	1993-08-05	Acyloxypropanolamines
EP0489767A4 (en)	1992-07-08	Cck antagonists
MY100914A (en)	1991-05-31	Pyrrolo(1,2-a)(4,1)benzoxazepine derivatives
EP0795326A4 (de)	1997-09-17
IE800900L (en)	1980-11-04	Pyrrolidinyl-benzoic acid derivatives.
ES2101269T3 (es)	1997-07-01	Nuevos derivados de 1-fenil-biciclo-(2.2.2)-octano, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
CA2359031A1 (en)	1996-09-06	Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease