ES2039205T3 - Procedimiento para preparar antagonistas de colecistoquinina. - Google Patents

Procedimiento para preparar antagonistas de colecistoquinina.

Info

Publication number
ES2039205T3
ES2039205T3 ES198686310226T ES86310226T ES2039205T3 ES 2039205 T3 ES2039205 T3 ES 2039205T3 ES 198686310226 T ES198686310226 T ES 198686310226T ES 86310226 T ES86310226 T ES 86310226T ES 2039205 T3 ES2039205 T3 ES 2039205T3
Authority
ES
Spain
Prior art keywords
alkyl
antagonists
cholecystocinin
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686310226T
Other languages
English (en)
Inventor
Sun Hyuk Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Bioscience Inc
Original Assignee
Ipsen Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Bioscience Inc filed Critical Ipsen Bioscience Inc
Application granted granted Critical
Publication of ES2039205T3 publication Critical patent/ES2039205T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I) Y SUS SALES ACEPTABLES PARA USO FARMACEUTICO Y VE TERINARIO EN QUE R1 ES INDEPENDIENTEMENTE ALQUILO, ALCOXI, HALOGENO, AMINO, HIDROXI, NITRO, CIANO, CARBOXILO, TRIFLUORMETILO, CARBOXILATO DE ETILO O HIDROGENO; M ES 0, 1 O 2, Y A ES -(CH2)N-C(O)R2 SIENDO N DE 1 A 5 Y R2 HIDROXI, ALCOXI. ARALOXI, ARALQUILO, AMINO, ALQUILO, ALQUILAMINO, DIALQUILAMINO, CICLOALQUILAMINO O MORFOLINO; O BIEN A ES ALQUILO, HIDROXIALQUILO, ALCOXIALQUILO, ARALCOXIALQUILO, ARILO, ARALQUILO O CIALOALQUILO, SON UTILES COMO ANTAGONISTAS DE COLECISTOQUININA EN EL TRATAMIENTO DE LA PANCREATITIS AGUDA, ULCERAS GASTRICA, PEPTICA Y DUODENAL Y EN LA REDUCCION DEL APETITO.
ES198686310226T 1985-12-31 1986-12-31 Procedimiento para preparar antagonistas de colecistoquinina. Expired - Lifetime ES2039205T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/815,217 US4814463A (en) 1985-12-31 1985-12-31 CCK antagonists

Publications (1)

Publication Number Publication Date
ES2039205T3 true ES2039205T3 (es) 1993-09-16

Family

ID=25217199

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686310226T Expired - Lifetime ES2039205T3 (es) 1985-12-31 1986-12-31 Procedimiento para preparar antagonistas de colecistoquinina.

Country Status (8)

Country Link
US (1) US4814463A (es)
EP (1) EP0230151B1 (es)
JP (1) JPH0755927B2 (es)
AT (1) ATE76411T1 (es)
CA (1) CA1294737C (es)
DE (1) DE3685425D1 (es)
ES (1) ES2039205T3 (es)
GR (1) GR3005155T3 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0442878A4 (en) * 1988-04-05 1991-10-23 Abbott Laboratories Derivatives of tryptophan as cck antagonists
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
US5010089A (en) * 1988-08-12 1991-04-23 Biomeasure, Inc. CCK antagonists and their use in treating gastrointestinal disorders
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5278316A (en) * 1989-06-29 1994-01-11 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
FR2667066B2 (fr) * 1990-03-07 1993-06-25 Rhone Poulenc Sante N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant.
HU210581B (en) * 1990-03-07 1995-05-29 Rhone Poulenc Rorer Sa Process for prep. of glycinamide deriv.s and pharmaceutical compn.s contg. them
FR2659966B1 (fr) * 1990-03-26 1992-05-22 Rhone Poulenc Sante Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant.
CA2088195A1 (en) * 1990-08-31 1992-03-01 David C. Horwell Cholecystokinin antagonists, their preparation and therapeutic use
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal
WO1992004321A1 (en) * 1990-09-10 1992-03-19 Rhone-Poulenc Rorer International (Holdings) Inc. Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
EP0511477B1 (en) * 1991-03-11 1996-07-10 Kyowa Hakko Kogyo Co., Ltd. Indole derivatives
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5218123A (en) * 1992-02-18 1993-06-08 Warner-Lambert Company Didehydrotryptophan derivatives and pharmaceutical use thereof
US5328927A (en) * 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
PL181782B1 (pl) * 1993-08-10 2001-09-28 Black James Foundation Nowe zwiazki i sposób wytwarzania nowych zwiazków PL
US6869957B1 (en) 1993-11-17 2005-03-22 Eli Lilly And Company Non-peptide tachykinin receptor antagonists
US6403577B1 (en) * 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US20060258647A1 (en) * 2005-05-04 2006-11-16 The Regents Of The University Of California Treatment of maladaptive substance use with cholecystokinin (CCK) antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH343407A (fr) * 1955-07-01 1959-12-31 Uclaf Societe Anonyme Procédé de préparation de peptides
US4000297A (en) * 1971-05-18 1976-12-28 Rotta Research Laboratorium S.P.A. N-p-chlorobenzoyl tryptophane, salts and compositions thereof
DE2853825A1 (de) * 1978-12-13 1980-07-03 Troponwerke Gmbh & Co Kg Pharmazeutisch wirksame dipeptide
US4356118A (en) * 1981-06-02 1982-10-26 G. D. Searle & Co. Tryptophan derivatives
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
FR2546517B1 (fr) * 1983-05-24 1987-04-24 Panmedica Nouveaux dipeptides du -l-5-hydroxy-tryptophane, procedes pour leur preparation et medicaments les contenant
IT1179866B (it) * 1984-12-12 1987-09-16 Rotta Research Lab Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
ATE76411T1 (de) 1992-06-15
CA1294737C (en) 1992-01-21
GR3005155T3 (es) 1993-05-24
EP0230151A3 (en) 1989-02-01
EP0230151B1 (en) 1992-05-20
JPH0755927B2 (ja) 1995-06-14
EP0230151A2 (en) 1987-07-29
JPS62175461A (ja) 1987-08-01
US4814463A (en) 1989-03-21
DE3685425D1 (de) 1992-06-25

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