ATE123761T1 - Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen. - Google Patents

Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen.

Info

Publication number: ATE123761T1
Authority: AT; Austria
Prior art keywords: amino; isophthalamide; substrate; iodine halide; triiodo
Prior art date: 1989-07-24

Application number

AT90901154T

Other languages

English (en)

Inventor

Gregory D Cross

Robert C Chapman

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-24

Filing date

1989-11-08

Publication date

1995-06-15

1989-11-08 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE123761T1 publication Critical patent/ATE123761T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000758 substrate Substances 0.000 abstract 7
229910052740 iodine Inorganic materials 0.000 abstract 6
239000011630 iodine Substances 0.000 abstract 6
-1 iodine halide Chemical class 0.000 abstract 6
230000001186 cumulative effect Effects 0.000 abstract 3
UXPIWHPHEGRYLB-UHFFFAOYSA-N 5-aminobenzene-1,3-dicarboxamide Chemical compound NC(=O)C1=CC(N)=CC(C(N)=O)=C1 UXPIWHPHEGRYLB-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
GBUPGCQLNMNZPA-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound NC(=O)C1=C(I)C(N)=C(I)C(C(N)=O)=C1I GBUPGCQLNMNZPA-UHFFFAOYSA-N 0.000 abstract 1
239000012431 aqueous reaction media Substances 0.000 abstract 1
238000010790 dilution Methods 0.000 abstract 1
239000012895 dilution Substances 0.000 abstract 1
238000010348 incorporation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000012429 reaction media Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT90901154T 1989-07-24 1989-11-08 Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen. ATE123761T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/383,634 US5013865A (en)	1988-04-06	1989-07-24	Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds

Publications (1)

Publication Number	Publication Date
ATE123761T1 true ATE123761T1 (de)	1995-06-15

Family

ID=23514016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90901154T ATE123761T1 (de)	1989-07-24	1989-11-08	Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen.

Country Status (8)

Country	Link
US (1)	US5013865A (de)
EP (1)	EP0484328B1 (de)
JP (1)	JP2665826B2 (de)
AT (1)	ATE123761T1 (de)
AU (1)	AU638688B2 (de)
CA (1)	CA2005891A1 (de)
DE (1)	DE68923093T2 (de)
WO (1)	WO1991001296A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE123018T1 (de) *	1988-04-06	1995-06-15	Mallinckrodt Inc	Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure.
WO1995035122A1 (en) *	1994-06-21	1995-12-28	Mallinckrodt Medical, Inc.	Improved synthesis of ioversol using phosphoric acid modified co-addition
US5575905A (en) *	1995-05-24	1996-11-19	Nycomed Imaging As	Iodination process
JP3985034B2 (ja) *	1995-05-24	2007-10-03	ジーイー・ヘルスケア・アクスイェ・セルスカプ	ヨウ素化方法
DE19641178C2 (de) *	1996-09-24	2000-01-05	Schering Ag	Verfahren zur Herstellung von 5-Amino-2,4,6-triiod-isophthalsäure-N-(2,3 dihydroxypropyl)-monoamid
GB9710726D0 (en) *	1997-05-23	1997-07-16	Nycomed Imaging As	Compound
GB9710728D0 (en) *	1997-05-23	1997-07-16	Nycomed Imaging As	Method
GB9710725D0 (en) *	1997-05-23	1997-07-16	Nycomed Imaging As	Process
US6137006A (en) *	1997-05-23	2000-10-24	Nycomed Imaging As	Preparation of tri-iodo benzene compounds
ES2391002T3 (es) *	2008-01-14	2012-11-20	Mallinckrodt Llc	Proceso para la preparación de iosimenol
EP2093206A1 (de)	2008-02-20	2009-08-26	BRACCO IMAGING S.p.A.	Verfahren zur Iodierung aromatischer Verbindungen
EP2243767A1 (de)	2009-04-21	2010-10-27	Bracco Imaging S.p.A	Verfahren zur Iodierung aromatischer Verbindungen
JP5661762B2 (ja)	2009-07-07	2015-01-28	ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏＩｍａｇｉｎｇＳ．Ｐ．Ａ．	ヨウ素化剤の製造方法
EP2394984A1 (de)	2010-06-10	2011-12-14	Bracco Imaging S.p.A	Verfahren zur Iodinierung von Phenol-Derivaten
EP2773610B1 (de) *	2011-10-31	2017-09-06	iMAX Diagnostic Imaging Holding Limited	Jodierungsverfahren zur herstellung von aromatischen 3,5-disubstituierten 2,4,6-trijod amin-verbindungen
FR3084668A1 (fr)	2018-08-02	2020-02-07	Guerbet	Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN113563399B (zh) *	2021-07-22	2023-06-27	中国科学院南海海洋研究所	一种制备碘化台勾霉素b和其它几种芳香类碘化产物的方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA616717A (en) *		1961-03-21	Distelmaier Alfred	Halogenated aminoisophthalic acids
SU118225A1 (ru) *	1958-07-23	1958-11-30	Ю.А. Фиалков	Способ йодировани мета-аминобензойной кислоты
US3145197A (en) *	1961-06-26	1964-08-18	Mallinckrodt Chemical Works	5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
FR2614299B1 (fr) *	1987-04-23	1989-08-18	Guerbet Sa	Composes diamino benzeniques iodes, leur procede de preparation et produits de contraste les contenant.
AU612510B2 (en) *	1988-03-01	1991-07-11	Mallinckrodt, Inc.	Nonionic x-ray contrast agents, compositions and methods
ATE123018T1 (de) *	1988-04-06	1995-06-15	Mallinckrodt Inc	Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure.
DE3937118A1 (de) *	1989-11-03	1991-05-08	Schering Ag	Nichtionische roentgenkontrastmittel mit hohem jodgehalt

1989
- 1989-07-24 US US07/383,634 patent/US5013865A/en not_active Expired - Lifetime
- 1989-11-08 DE DE68923093T patent/DE68923093T2/de not_active Expired - Lifetime
- 1989-11-08 AT AT90901154T patent/ATE123761T1/de not_active IP Right Cessation
- 1989-11-08 WO PCT/US1989/005036 patent/WO1991001296A1/en not_active Ceased
- 1989-11-08 JP JP2501211A patent/JP2665826B2/ja not_active Expired - Lifetime
- 1989-11-08 EP EP90901154A patent/EP0484328B1/de not_active Expired - Lifetime
- 1989-11-08 AU AU46615/89A patent/AU638688B2/en not_active Ceased
- 1989-12-18 CA CA002005891A patent/CA2005891A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US5013865A (en)	1991-05-07
AU4661589A (en)	1991-02-22
JPH05500500A (ja)	1993-02-04
DE68923093D1 (de)	1995-07-20
EP0484328A1 (de)	1992-05-13
DE68923093T2 (de)	1995-10-26
CA2005891A1 (en)	1991-01-24
JP2665826B2 (ja)	1997-10-22
AU638688B2 (en)	1993-07-08
EP0484328B1 (de)	1995-06-14
WO1991001296A1 (en)	1991-02-07

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Legal Events

Date	Code	Title	Description
1995-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties