ATE123955T1 - Radiopharmazeutische zusammensetzungen, verabreichungsmethode und verfahren zur herstellung derselben. - Google Patents

Radiopharmazeutische zusammensetzungen, verabreichungsmethode und verfahren zur herstellung derselben.

Info

Publication number: ATE123955T1
Authority: AT; Austria
Prior art keywords: administration; preparing; same; ligand; frozen
Prior art date: 1990-06-18

Application number

AT91305485T

Other languages

English (en)

Inventor

Jaime Simon

Joseph R Garlich

R Keith Frank

Kenneth Mcmillan

Original Assignee

Dow Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-18

Filing date

1991-06-18

Publication date

1995-07-15

1991-06-18 Application filed by Dow Chemical Co filed Critical Dow Chemical Co

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE123955T1 publication Critical patent/ATE123955T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
229940121896 radiopharmaceutical Drugs 0.000 title abstract 3
239000012217 radiopharmaceutical Substances 0.000 title abstract 3
230000002799 radiopharmaceutical effect Effects 0.000 title abstract 3
238000009472 formulation Methods 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
229940120146 EDTMP Drugs 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
238000003608 radiolysis reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Developing Agents For Electrophotography (AREA)

AT91305485T 1990-06-18 1991-06-18 Radiopharmazeutische zusammensetzungen, verabreichungsmethode und verfahren zur herstellung derselben. ATE123955T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53887190A	1990-06-18	1990-06-18

Publications (1)

Publication Number	Publication Date
ATE123955T1 true ATE123955T1 (de)	1995-07-15

Family

ID=24148781

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91305485T ATE123955T1 (de)	1990-06-18	1991-06-18	Radiopharmazeutische zusammensetzungen, verabreichungsmethode und verfahren zur herstellung derselben.

Country Status (32)

Country	Link
US (1)	US5762907A (de)
EP (1)	EP0462787B1 (de)
JP (2)	JP3636728B2 (de)
KR (1)	KR100219964B1 (de)
CN (1)	CN1033143C (de)
AT (1)	ATE123955T1 (de)
AU (2)	AU651112B2 (de)
BR (2)	BR9102579A (de)
CA (1)	CA2044812C (de)
CS (1)	CS184291A3 (de)
CY (1)	CY1891A (de)
DE (1)	DE69110554T2 (de)
DK (1)	DK0462787T3 (de)
EG (1)	EG19862A (de)
ES (1)	ES2073678T3 (de)
FI (1)	FI101044B (de)
GR (1)	GR3017430T3 (de)
HK (1)	HK80496A (de)
HU (1)	HU226897B1 (de)
IE (1)	IE71023B1 (de)
IL (1)	IL98536A (de)
IS (1)	IS1704B (de)
MC (1)	MC2260A1 (de)
NO (1)	NO302510B1 (de)
NZ (1)	NZ238547A (de)
PH (1)	PH30975A (de)
PL (1)	PL165699B1 (de)
PT (1)	PT97996B (de)
RU (1)	RU2095085C1 (de)
SA (1)	SA92120343B1 (de)
SK (1)	SK279598B6 (de)
ZA (1)	ZA914615B (de)

Families Citing this family (26)

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US5410043A (en) *	1991-12-06	1995-04-25	Schering Aktiengesellschaft	Process for the production of mono-N-substituted tetraaza macrocycles
US5320829A (en) *	1991-12-10	1994-06-14	The Dow Chemical Company	Oral compositions for inhibiting plaque formation
DE4218744C2 (de) *	1992-06-04	1997-11-06	Schering Ag	Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5405601A (en) *	1993-07-02	1995-04-11	Mallinckrodt Medical Inc.	Functionalized tripodal ligands for imaging applications
CN1065769C (zh) *	1997-07-03	2001-05-16	中国原子能科学研究院	一种放射性药物制剂的制备方法
CN1092962C (zh) *	1998-01-26	2002-10-23	贾伟	一种减轻骨及骨关节疾病疼痛的药物
RU2164420C2 (ru) *	1999-02-10	2001-03-27	Государственный научный центр Российской Федерации Физико-энергетический институт им. акад. А.И. Лейпунского	Способ получения радиотерапевтического препарата
JP2003501488A (ja) *	1999-06-11	2003-01-14	ネオルックスコーポレイション	骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) *	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
RU2162714C1 (ru) *	2000-06-20	2001-02-10	Государственный научный центр РФ - Институт биофизики	Радиофармацевтическая композиция
EP1390081A2 (de)	2001-01-08	2004-02-25	Neorx Corporation	Therapeutische und diagnostische verbindungen, zusammenstellungen und methoden
RU2205030C2 (ru) *	2001-02-13	2003-05-27	Осминин Александр Георгиевич	Средство для рентгенологического исследования
RU2182022C1 (ru) *	2001-05-24	2002-05-10	Российская медицинская академия последипломного образования МЗ РФ	Способ лечения онкологических заболеваний щитовидной железы
RU2191033C1 (ru) *	2001-05-24	2002-10-20	Юминов Олег Аркадьевич	Радиофармацевтический препарат "астат-211" для лечения онкологических заболеваний щитовидной железы
US6567492B2 (en)	2001-06-11	2003-05-20	Eastern Isotopes, Inc.	Process and apparatus for production of F-18 fluoride
JP2006505610A (ja)	2002-11-05	2006-02-16	イヨンベアムアプリカスィヨンエッス．アー．	１８−ｆ標識放射性製剤の安定化
US7018614B2 (en) *	2002-11-05	2006-03-28	Eastern Isotopes, Inc.	Stabilization of radiopharmaceuticals labeled with 18-F
RU2297247C2 (ru) *	2005-06-20	2007-04-20	Государственное учреждение "Институт химии твердого тела" Уральского отделения Российской академии наук	Средство для контрастирования при рентгенодиагностике (варианты)
US9636404B2 (en)	2013-05-13	2017-05-02	Vision Global Holdings Ltd.	Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
US10172965B2 (en) *	2013-10-07	2019-01-08	Igl Pharma, Inc.	High purity therapeutic bone agents
AU2015356971B2 (en) *	2014-12-04	2021-09-09	Ge Healthcare Limited	Method of removing acetaldehyde from radioactive pharmaceuticals
RU2593017C1 (ru) *	2015-04-23	2016-07-27	Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ)	Способ получения радиофармацевтического препарата "астат-211"
EP3297684B1 (de)	2015-05-21	2020-12-23	Actinium Pharmaceuticals, Inc.	Infusionsverabreichung von konjugierten monoklonalen antikörpern
US11369700B2 (en) *	2015-05-25	2022-06-28	IGL Pharma Inc.	DOTMP kit formulations for radioisotopes
WO2016191413A1 (en)	2015-05-25	2016-12-01	Iso Therapeutics Group, Llc	Dotmp kit formulations for radioisotopes
RU2757258C1 (ru) *	2020-09-28	2021-10-12	федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ)	Способ получения радиофармацевтического препарата с галлием-68 для визуализации метастазов скелета методом пэт

Family Cites Families (18)

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Publication number	Priority date	Publication date	Assignee	Title
US4018883A (en) *	1975-03-10	1977-04-19	Nichols Institute For Endocrinology	Thyroxine (T4) radioimmunoassay
NL7605447A (nl) *	1975-06-26	1976-12-28	Byk Mallinckrodt Chem Prod	Radioimmunoproefmethode voor de bepaling van thyroxine.
US4301140A (en) *	1979-12-14	1981-11-17	G. D. Searle & Co.	Radiopharmaceutical method for monitoring kidneys
US4341755A (en) *	1980-07-15	1982-07-27	Immuno Nuclear Corporation	Parathyroid radioimmunoassay
US4457602A (en) *	1981-04-20	1984-07-03	Olympus Optical Company Ltd.	Multiple light emission control system utilizing electronic flashes
US4411881A (en) *	1982-07-12	1983-10-25	New England Nuclear Corporation	Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
DE164843T1 (de) *	1984-06-04	1989-12-07	The Dow Chemical Co., Midland, Mich.	Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
US4898724A (en) *	1984-06-04	1990-02-06	The Dow Chemical Company	Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5059412A (en) *	1984-06-04	1991-10-22	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
GB8510726D0 (en) *	1985-04-26	1985-06-26	Amersham Int Plc	Stabilised radio-labelled compounds
US4752464A (en) *	1985-06-07	1988-06-21	Cadema Medical Products, Inc.	Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes
NZ222304A (en) *	1987-05-18	1990-10-26	Dow Chemical Co	Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4853209A (en) *	1987-05-18	1989-08-01	The Dow Chemical Company	Bone marrow suppressing agents
DE3854717T3 (de) *	1987-06-30	1999-04-15	Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo.	Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.
US4882142A (en) *	1988-12-19	1989-11-21	The Dow Chemical Company	Bone marrow suppressing agents
US4937333A (en) *	1989-08-04	1990-06-26	The Dow Chemical Company	Method for purifying aminomethylenephosphonic acids for pharmaceutical use
US5219556A (en) *	1990-07-09	1993-06-15	Mallinckrodt Medical, Inc.	Stabilized therapeutic radiopharmaceutical complexes

1991
- 1991-06-11 MC MC912192A patent/MC2260A1/fr unknown
- 1991-06-14 SK SK1842-91A patent/SK279598B6/sk not_active IP Right Cessation
- 1991-06-14 BR BR919102579A patent/BR9102579A/pt not_active Application Discontinuation
- 1991-06-14 IS IS3717A patent/IS1704B/is unknown
- 1991-06-14 PH PH42625A patent/PH30975A/en unknown
- 1991-06-14 CS CS911842A patent/CS184291A3/cs unknown
- 1991-06-14 NZ NZ238547A patent/NZ238547A/en not_active IP Right Cessation
- 1991-06-17 JP JP14473591A patent/JP3636728B2/ja not_active Expired - Fee Related
- 1991-06-17 CA CA002044812A patent/CA2044812C/en not_active Expired - Lifetime
- 1991-06-17 ZA ZA914615A patent/ZA914615B/xx unknown
- 1991-06-17 RU SU914895658A patent/RU2095085C1/ru not_active IP Right Cessation
- 1991-06-17 CN CN91104343A patent/CN1033143C/zh not_active Expired - Lifetime
- 1991-06-17 KR KR1019910010012A patent/KR100219964B1/ko not_active Expired - Lifetime
- 1991-06-17 AU AU78470/91A patent/AU651112B2/en not_active Expired
- 1991-06-17 HU HU9102011A patent/HU226897B1/hu unknown
- 1991-06-17 NO NO912345A patent/NO302510B1/no not_active IP Right Cessation
- 1991-06-17 PT PT97996A patent/PT97996B/pt not_active IP Right Cessation
- 1991-06-17 FI FI912933A patent/FI101044B/fi not_active IP Right Cessation
- 1991-06-17 IE IE205791A patent/IE71023B1/en not_active IP Right Cessation
- 1991-06-17 IL IL9853691A patent/IL98536A/en not_active IP Right Cessation
- 1991-06-18 EP EP91305485A patent/EP0462787B1/de not_active Expired - Lifetime
- 1991-06-18 PL PL91290717A patent/PL165699B1/pl not_active IP Right Cessation
- 1991-06-18 DE DE69110554T patent/DE69110554T2/de not_active Expired - Lifetime
- 1991-06-18 AT AT91305485T patent/ATE123955T1/de not_active IP Right Cessation
- 1991-06-18 DK DK91305485.4T patent/DK0462787T3/da active
- 1991-06-18 ES ES91305485T patent/ES2073678T3/es not_active Expired - Lifetime
- 1991-06-26 EG EG37491A patent/EG19862A/xx active
1992
- 1992-01-19 SA SA92120343A patent/SA92120343B1/ar unknown
1993
- 1993-10-07 US US08/133,806 patent/US5762907A/en not_active Expired - Lifetime
1994
- 1994-06-06 AU AU64559/94A patent/AU665911B2/en not_active Expired
1995
- 1995-09-18 GR GR950402555T patent/GR3017430T3/el unknown
1996
- 1996-05-09 HK HK80496A patent/HK80496A/en not_active IP Right Cessation
- 1996-08-30 CY CY189196A patent/CY1891A/xx unknown
1997
- 1997-05-14 BR BR1101169-6A patent/BR1101169A/pt active IP Right Grant
2001
- 2001-10-11 JP JP2001314293A patent/JP2002114712A/ja not_active Ceased

Also Published As

Publication number	Publication date
BR1101169A (pt)	2000-08-08
AU651112B2 (en)	1994-07-14
CA2044812C (en)	2002-12-31
ZA914615B (en)	1993-02-24
PT97996A (pt)	1992-03-31
IS1704B (is)	1998-12-10
FI101044B (fi)	1998-04-15
KR100219964B1 (ko)	1999-09-01
DK0462787T3 (da)	1995-10-30
PL290717A1 (en)	1992-02-24
RU2095085C1 (ru)	1997-11-10
SK279598B6 (sk)	1999-01-11
CY1891A (en)	1996-08-30
IS3717A7 (is)	1991-12-19
GR3017430T3 (en)	1995-12-31
HU912011D0 (en)	1991-12-30
NO302510B1 (no)	1998-03-16
EP0462787B1 (de)	1995-06-21
MC2260A1 (fr)	1993-04-26
NO912345D0 (no)	1991-06-17
FI912933L (fi)	1991-12-19
CN1063615A (zh)	1992-08-19
CS184291A3 (en)	1992-02-19
AU6455994A (en)	1994-08-04
EG19862A (en)	1996-06-30
EP0462787A1 (de)	1991-12-27
JP3636728B2 (ja)	2005-04-06
CA2044812A1 (en)	1991-12-19
IE71023B1 (en)	1997-01-15
NZ238547A (en)	1994-05-26
PH30975A (en)	1997-12-23
PT97996B (pt)	1998-11-30
DE69110554D1 (de)	1995-07-27
HUT57994A (en)	1992-01-28
JPH04230224A (ja)	1992-08-19
IL98536A (en)	1996-10-31
NO912345L (no)	1991-12-19
DE69110554T2 (de)	1995-12-14
FI912933A0 (fi)	1991-06-17
HK80496A (en)	1996-05-17
JP2002114712A (ja)	2002-04-16
BR9102579A (pt)	1992-01-21
ES2073678T3 (es)	1995-08-16
US5762907A (en)	1998-06-09
PL165699B1 (pl)	1995-01-31
AU7847091A (en)	1991-12-19
HU226897B1 (en)	2010-01-28
IE912057A1 (en)	1991-12-18
IL98536A0 (en)	1992-07-15
CN1033143C (zh)	1996-10-30
AU665911B2 (en)	1996-01-18
KR920000334A (ko)	1992-01-29
SA92120343B1 (ar)	2004-01-25

Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2010-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE123955T1 (de)	1995-07-15	Radiopharmazeutische zusammensetzungen, verabreichungsmethode und verfahren zur herstellung derselben.
FI884051A0 (fi)	1988-09-02	Menetelmä stabiloitujen humaaniproteiinivalmisteiden valmistamiseksi
DE68908125D1 (de)	1993-09-09	Knochenmark unterdrueckende medikamente.
IE790659L (en)	1979-09-30	Radiographic scanning agents.
US4451451A (en)	1984-05-29	Radiopharmaceutical composition based on technetium-99m and reagent for making it
DE69433052D1 (de)	2003-09-25	Pharmazeutische Zusammensetzungen, enthaltend Diclofenac und 2-Hydroxypropyl-beta-Cyclodextrin
WO1992000759A3 (en)	1992-02-20	Stabilized therapeutic radiopharmaceutical complexes
KR910018346A (ko)	1991-11-30	킬레이트화 화합물 및 그의 용도
SE7706126L (sv)	1977-12-01	Radioaktivt preparat
ATE18549T1 (de)	1986-03-15	1-carboxyalkanoylindolin-2-carbonsaeure-ester, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie ihre therapeutische verwendung.
ES8506193A1 (es)	1985-07-01	Un metodo para preparar un agente explorador de huesos marcado con tecnecio-99m
DK0397452T3 (da)	1993-11-08	Hidtil ukendte præparater
KR880013576A (ko)	1988-12-21	골수억제 조성물 및 이의 용도
ATE23800T1 (de)	1986-12-15	Roentgen-sichtbarmachungsmittel.
FR2328453A1 (fr)	1977-05-20	Peptide marque au 99mtc
EP0127389A3 (en)	1985-08-07	N,n-diethyl-5-methyl-2h-1-benzothiopyrano-(4,3,2-cd)-indazole-2-ethanamine, compositions comprising the same and uses therefor
OUYANG	1983	Efficacy of DMAP Injection in Treatment of HCN Poisoning in Dogs
CHEN	1984	Storage & Distribution of No. Ⅱ Fluorocarbon Blood Substitute in Rats after Its Intravenous Administration
ATE74770T1 (de)	1992-05-15	Tc-99m-w-alkylphosphinico-1-hydroxyalkan-1,1diphosphonate enthaltende praeparate zur knochenszintigraphie sowie verfahren zur herstellung dieser praeparate.
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