PT97996A - Processo para a preparacao de uma formulacao radiofarmaceutica compreendendo pelo menos um radionuclideo - Google Patents

Processo para a preparacao de uma formulacao radiofarmaceutica compreendendo pelo menos um radionuclideo

Info

Publication number
PT97996A
PT97996A PT97996A PT9799691A PT97996A PT 97996 A PT97996 A PT 97996A PT 97996 A PT97996 A PT 97996A PT 9799691 A PT9799691 A PT 9799691A PT 97996 A PT97996 A PT 97996A
Authority
PT
Portugal
Prior art keywords
radionuclideo
radiofarmaceutical
comprehending
preparing
formula
Prior art date
Application number
PT97996A
Other languages
English (en)
Other versions
PT97996B (pt
Inventor
Jaime Simon
Joseph R Garlich
R Keith Frank
Kenneth Mcmillan
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of PT97996A publication Critical patent/PT97996A/pt
Publication of PT97996B publication Critical patent/PT97996B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Developing Agents For Electrophotography (AREA)
PT97996A 1990-06-18 1991-06-17 Processo para a preparacao de uma formulacao radiofarmaceutica compreendendo pelo menos um radionuclideo PT97996B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53887190A 1990-06-18 1990-06-18

Publications (2)

Publication Number Publication Date
PT97996A true PT97996A (pt) 1992-03-31
PT97996B PT97996B (pt) 1998-11-30

Family

ID=24148781

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97996A PT97996B (pt) 1990-06-18 1991-06-17 Processo para a preparacao de uma formulacao radiofarmaceutica compreendendo pelo menos um radionuclideo

Country Status (32)

Country Link
US (1) US5762907A (pt)
EP (1) EP0462787B1 (pt)
JP (2) JP3636728B2 (pt)
KR (1) KR100219964B1 (pt)
CN (1) CN1033143C (pt)
AT (1) ATE123955T1 (pt)
AU (2) AU651112B2 (pt)
BR (2) BR9102579A (pt)
CA (1) CA2044812C (pt)
CS (1) CS184291A3 (pt)
CY (1) CY1891A (pt)
DE (1) DE69110554T2 (pt)
DK (1) DK0462787T3 (pt)
EG (1) EG19862A (pt)
ES (1) ES2073678T3 (pt)
FI (1) FI101044B (pt)
GR (1) GR3017430T3 (pt)
HK (1) HK80496A (pt)
HU (1) HU226897B1 (pt)
IE (1) IE71023B1 (pt)
IL (1) IL98536A (pt)
IS (1) IS1704B (pt)
MC (1) MC2260A1 (pt)
NO (1) NO302510B1 (pt)
NZ (1) NZ238547A (pt)
PH (1) PH30975A (pt)
PL (1) PL165699B1 (pt)
PT (1) PT97996B (pt)
RU (1) RU2095085C1 (pt)
SA (1) SA92120343B1 (pt)
SK (1) SK279598B6 (pt)
ZA (1) ZA914615B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
CN1065769C (zh) * 1997-07-03 2001-05-16 中国原子能科学研究院 一种放射性药物制剂的制备方法
CN1092962C (zh) * 1998-01-26 2002-10-23 贾伟 一种减轻骨及骨关节疾病疼痛的药物
RU2164420C2 (ru) * 1999-02-10 2001-03-27 Государственный научный центр Российской Федерации Физико-энергетический институт им. акад. А.И. Лейпунского Способ получения радиотерапевтического препарата
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
RU2162714C1 (ru) * 2000-06-20 2001-02-10 Государственный научный центр РФ - Институт биофизики Радиофармацевтическая композиция
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
RU2205030C2 (ru) * 2001-02-13 2003-05-27 Осминин Александр Георгиевич Средство для рентгенологического исследования
RU2182022C1 (ru) * 2001-05-24 2002-05-10 Российская медицинская академия последипломного образования МЗ РФ Способ лечения онкологических заболеваний щитовидной железы
RU2191033C1 (ru) * 2001-05-24 2002-10-20 Юминов Олег Аркадьевич Радиофармацевтический препарат "астат-211" для лечения онкологических заболеваний щитовидной железы
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
JP2006505610A (ja) 2002-11-05 2006-02-16 イヨン ベアム アプリカスィヨン エッス．アー． １８−ｆ標識放射性製剤の安定化
US7018614B2 (en) * 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
RU2297247C2 (ru) * 2005-06-20 2007-04-20 Государственное учреждение "Институт химии твердого тела" Уральского отделения Российской академии наук Средство для контрастирования при рентгенодиагностике (варианты)
US9636404B2 (en) 2013-05-13 2017-05-02 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
US10172965B2 (en) * 2013-10-07 2019-01-08 Igl Pharma, Inc. High purity therapeutic bone agents
AU2015356971B2 (en) * 2014-12-04 2021-09-09 Ge Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
RU2593017C1 (ru) * 2015-04-23 2016-07-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения радиофармацевтического препарата "астат-211"
EP3297684B1 (en) 2015-05-21 2020-12-23 Actinium Pharmaceuticals, Inc. Infusion administration of conjugated monoclonal antibodies
US11369700B2 (en) * 2015-05-25 2022-06-28 IGL Pharma Inc. DOTMP kit formulations for radioisotopes
WO2016191413A1 (en) 2015-05-25 2016-12-01 Iso Therapeutics Group, Llc Dotmp kit formulations for radioisotopes
RU2757258C1 (ru) * 2020-09-28 2021-10-12 федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ) Способ получения радиофармацевтического препарата с галлием-68 для визуализации метастазов скелета методом пэт

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018883A (en) * 1975-03-10 1977-04-19 Nichols Institute For Endocrinology Thyroxine (T4) radioimmunoassay
NL7605447A (nl) * 1975-06-26 1976-12-28 Byk Mallinckrodt Chem Prod Radioimmunoproefmethode voor de bepaling van thyroxine.
US4301140A (en) * 1979-12-14 1981-11-17 G. D. Searle & Co. Radiopharmaceutical method for monitoring kidneys
US4341755A (en) * 1980-07-15 1982-07-27 Immuno Nuclear Corporation Parathyroid radioimmunoassay
US4457602A (en) * 1981-04-20 1984-07-03 Olympus Optical Company Ltd. Multiple light emission control system utilizing electronic flashes
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
DE164843T1 (de) * 1984-06-04 1989-12-07 The Dow Chemical Co., Midland, Mich. Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4752464A (en) * 1985-06-07 1988-06-21 Cadema Medical Products, Inc. Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes
NZ222304A (en) * 1987-05-18 1990-10-26 Dow Chemical Co Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
DE3854717T3 (de) * 1987-06-30 1999-04-15 Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo. Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes

Also Published As

Publication number Publication date
BR1101169A (pt) 2000-08-08
AU651112B2 (en) 1994-07-14
CA2044812C (en) 2002-12-31
ZA914615B (en) 1993-02-24
IS1704B (is) 1998-12-10
FI101044B (fi) 1998-04-15
KR100219964B1 (ko) 1999-09-01
DK0462787T3 (da) 1995-10-30
PL290717A1 (en) 1992-02-24
RU2095085C1 (ru) 1997-11-10
SK279598B6 (sk) 1999-01-11
CY1891A (en) 1996-08-30
IS3717A7 (is) 1991-12-19
GR3017430T3 (en) 1995-12-31
HU912011D0 (en) 1991-12-30
NO302510B1 (no) 1998-03-16
ATE123955T1 (de) 1995-07-15
EP0462787B1 (en) 1995-06-21
MC2260A1 (fr) 1993-04-26
NO912345D0 (no) 1991-06-17
FI912933L (fi) 1991-12-19
CN1063615A (zh) 1992-08-19
CS184291A3 (en) 1992-02-19
AU6455994A (en) 1994-08-04
EG19862A (en) 1996-06-30
EP0462787A1 (en) 1991-12-27
JP3636728B2 (ja) 2005-04-06
CA2044812A1 (en) 1991-12-19
IE71023B1 (en) 1997-01-15
NZ238547A (en) 1994-05-26
PH30975A (en) 1997-12-23
PT97996B (pt) 1998-11-30
DE69110554D1 (de) 1995-07-27
HUT57994A (en) 1992-01-28
JPH04230224A (ja) 1992-08-19
IL98536A (en) 1996-10-31
NO912345L (no) 1991-12-19
DE69110554T2 (de) 1995-12-14
FI912933A0 (fi) 1991-06-17
HK80496A (en) 1996-05-17
JP2002114712A (ja) 2002-04-16
BR9102579A (pt) 1992-01-21
ES2073678T3 (es) 1995-08-16
US5762907A (en) 1998-06-09
PL165699B1 (pl) 1995-01-31
AU7847091A (en) 1991-12-19
HU226897B1 (en) 2010-01-28
IE912057A1 (en) 1991-12-18
IL98536A0 (en) 1992-07-15
CN1033143C (zh) 1996-10-30
AU665911B2 (en) 1996-01-18
KR920000334A (ko) 1992-01-29
SA92120343B1 (ar) 2004-01-25

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19911216

FG3A Patent granted, date of granting

Effective date: 19980824

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100224