ATE128707T1 - Quinoloncarbonsäurederivat. - Google Patents
Quinoloncarbonsäurederivat.Info
- Publication number
- ATE128707T1 ATE128707T1 AT91913068T AT91913068T ATE128707T1 AT E128707 T1 ATE128707 T1 AT E128707T1 AT 91913068 T AT91913068 T AT 91913068T AT 91913068 T AT91913068 T AT 91913068T AT E128707 T1 ATE128707 T1 AT E128707T1
- Authority
- AT
- Austria
- Prior art keywords
- represents hydrogen
- acid derivative
- carboxylic acid
- lower alkyl
- hydrogen
- Prior art date
Links
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19133990 | 1990-07-19 | ||
| JP7977491 | 1991-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128707T1 true ATE128707T1 (de) | 1995-10-15 |
Family
ID=26420770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91913068T ATE128707T1 (de) | 1990-07-19 | 1991-07-17 | Quinoloncarbonsäurederivat. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5385900A (de) |
| EP (1) | EP0493608B1 (de) |
| JP (2) | JP2613139B2 (de) |
| KR (1) | KR100195070B1 (de) |
| AT (1) | ATE128707T1 (de) |
| CA (1) | CA2065846C (de) |
| DE (1) | DE69113604T2 (de) |
| DK (1) | DK0493608T3 (de) |
| ES (1) | ES2080327T3 (de) |
| GR (1) | GR3017651T3 (de) |
| HK (1) | HK125296A (de) |
| WO (1) | WO1992001676A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW222272B (de) * | 1992-05-26 | 1994-04-11 | Ss Seiyaku Kk | |
| FR2706459B1 (fr) * | 1993-06-17 | 1995-08-04 | Bouchara Sa | Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent. |
| CN1038326C (zh) * | 1993-07-20 | 1998-05-13 | 爱斯制药株式会社 | 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂 |
| US6685958B2 (en) * | 2001-04-25 | 2004-02-03 | Insite Vision Incorporated | Quinolone carboxylic acid compositions and related methods of treatment |
| US6699492B2 (en) | 1999-03-31 | 2004-03-02 | Insite Vision Incorporated | Quinolone carboxylic acid compositions and related methods of treatment |
| US6818654B2 (en) * | 2002-03-12 | 2004-11-16 | Abbott Laboratories | Antibacterial compounds |
| US7576216B2 (en) * | 2004-07-30 | 2009-08-18 | Abbott Laboratories | Preparation of pyridonecarboxylic acid antibacterials |
| EP2816033A1 (de) * | 2004-07-30 | 2014-12-24 | Abbvie Inc. | Herstellung von Pyridoncarboxylischer Säure-Antibakterien |
| EP2286800A1 (de) * | 2005-04-11 | 2011-02-23 | Abbott Laboratories | Pharmazeutische Zubereitungen mit verbesserter Löslichkeit für schwerlösliche Wirkstoffe |
| EP2074111A2 (de) * | 2006-10-06 | 2009-07-01 | Bausch & Lomb Incorporated | Chinoloncarbonsäuren, derivate davon, verfahren zu ihrer herstellung und ihre verwendung als antibakterielle mittel |
| US8252783B2 (en) | 2007-01-24 | 2012-08-28 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
| US7632944B2 (en) | 2007-01-24 | 2009-12-15 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
| US20080200442A1 (en) * | 2007-02-16 | 2008-08-21 | Srini Venkatesh | Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract |
| BRPI0808823A2 (pt) * | 2007-03-21 | 2017-10-10 | Bausch & Lomb | composição e método para tratar, reduzir, melhorar ou prevenir uma infecção. |
| US8173640B1 (en) | 2007-05-18 | 2012-05-08 | Bausch & Lomb Incorporated | Compositions and methods for treating, reducing, ameliorating, or preventing infections |
| CN101678032A (zh) * | 2007-06-11 | 2010-03-24 | 博士伦公司 | 使用氟喹诺酮调节炎症的组合物以及方法 |
| US20090042936A1 (en) * | 2007-08-10 | 2009-02-12 | Ward Keith W | Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation |
| US20090054406A1 (en) * | 2007-08-21 | 2009-02-26 | Ward Keith W | Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones |
| US20110166126A1 (en) * | 2007-08-21 | 2011-07-07 | Ward Keith W | Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones |
| US20090082337A1 (en) * | 2007-09-21 | 2009-03-26 | Srini Venkastesh | Compositions Comprising Quinolone and Methods for Treating or Controlling Infections |
| BRPI0818483A2 (pt) * | 2007-11-01 | 2015-04-14 | Bausch & Lomb | Método para preparar uma composição farmacêutica, composição farmacêutica, e, uso da mesma. |
| JP2011502990A (ja) * | 2007-11-05 | 2011-01-27 | ボーシュ アンド ローム インコーポレイティド | 薬物送達用ビヒクルとしての水非混和性物質 |
| US20090239836A1 (en) * | 2008-03-24 | 2009-09-24 | Mary Lee Ciolkowski | Multifunctional Ophthalmic Compositions |
| US8415342B2 (en) | 2008-10-29 | 2013-04-09 | Bausch & Lomb Incorporated | Besifloxacin ophthalmic composition for the treatment or control of infection |
| US8481526B2 (en) * | 2009-03-25 | 2013-07-09 | Bausch & Lomb Incorporated | Fluoroquinolone carboxylic acid molecular crystals |
| US20110077270A1 (en) * | 2009-04-21 | 2011-03-31 | Pfeffer Bruce A | Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure |
| US8518935B2 (en) * | 2009-12-11 | 2013-08-27 | Bausch & Lomb Incorporated | Amorphous besifloxacin solid |
| US20110319502A1 (en) | 2010-06-25 | 2011-12-29 | Coffey Martin J | Compositions and Methods for Enhancing Reduction of Spore-Forming Microorganisms |
| KR101560073B1 (ko) * | 2011-08-31 | 2015-10-13 | 오쓰까 세이야꾸 가부시키가이샤 | 퀴놀론 화합물 |
| CN102659761B (zh) * | 2012-04-27 | 2017-10-10 | 常州市亚邦医药研究所有限公司 | 盐酸贝西沙星的制备方法 |
| WO2013169458A1 (en) | 2012-05-11 | 2013-11-14 | Bausch & Lomb Incorporated | Pharmaceutical compositions and methods for treating, controlling, ameliorating, or reversing conditions of dry eye |
| CN103044397A (zh) * | 2013-01-06 | 2013-04-17 | 安徽赛诺医药化工有限公司 | 一种合成贝西沙星的新方法 |
| CN104592196A (zh) * | 2015-01-07 | 2015-05-06 | 广州仁恒医药科技有限公司 | 一种盐酸贝西沙星的制备方法 |
| CN104592197A (zh) * | 2015-01-07 | 2015-05-06 | 广州仁恒医药科技有限公司 | 一种盐酸贝西沙星的制备方法 |
| WO2016120813A1 (en) | 2015-01-28 | 2016-08-04 | Mankind Research Centre | Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride |
| CN115246814A (zh) * | 2021-04-27 | 2022-10-28 | 江苏开元药业有限公司 | 一种氟喹诺酮类抗菌药物的合成方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA85853B (en) * | 1984-02-17 | 1986-09-24 | Warner Lambert Co | Antibacterial agents |
| DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3420770A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| JPS63198664A (ja) * | 1986-03-31 | 1988-08-17 | Sankyo Co Ltd | キノロンカルボン酸誘導体 |
| JPS63132885A (ja) * | 1986-11-25 | 1988-06-04 | Hokuriku Seiyaku Co Ltd | キノリン−３−カルボン酸誘導体 |
| DE3641312A1 (de) * | 1986-12-03 | 1988-06-09 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
| JPS63196580A (ja) * | 1987-02-09 | 1988-08-15 | Hokuriku Seiyaku Co Ltd | キノリン−３−カルボン酸誘導体 |
| DE3713672A1 (de) * | 1987-04-24 | 1988-11-17 | Bayer Ag | Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren |
| AU618823B2 (en) * | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
| WO1991001308A1 (en) * | 1989-07-21 | 1991-02-07 | Ss Pharmaceutical Co., Ltd. | Quinolonecarboxylic acid derivatives |
| JPH02115181A (ja) * | 1988-10-21 | 1990-04-27 | Yoshitomi Pharmaceut Ind Ltd | ピリドンカルボン酸化合物 |
| US4945160A (en) * | 1988-11-22 | 1990-07-31 | Warner-Lambert Company | Preparation of certain 7-substituted quinolones |
| US5140033A (en) * | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
-
1991
- 1991-07-15 JP JP3174013A patent/JP2613139B2/ja not_active Expired - Fee Related
- 1991-07-17 DK DK91913068.2T patent/DK0493608T3/da active
- 1991-07-17 ES ES91913068T patent/ES2080327T3/es not_active Expired - Lifetime
- 1991-07-17 EP EP91913068A patent/EP0493608B1/de not_active Expired - Lifetime
- 1991-07-17 DE DE69113604T patent/DE69113604T2/de not_active Expired - Lifetime
- 1991-07-17 AT AT91913068T patent/ATE128707T1/de not_active IP Right Cessation
- 1991-07-17 WO PCT/JP1991/000954 patent/WO1992001676A1/ja not_active Ceased
- 1991-07-17 CA CA002065846A patent/CA2065846C/en not_active Expired - Lifetime
-
1992
- 1992-03-05 KR KR1019920700498A patent/KR100195070B1/ko not_active Expired - Lifetime
-
1993
- 1993-11-08 US US08/149,134 patent/US5385900A/en not_active Expired - Lifetime
-
1994
- 1994-09-16 US US08/305,977 patent/US5447926A/en not_active Expired - Lifetime
-
1995
- 1995-09-04 JP JP7226225A patent/JP2805460B2/ja not_active Expired - Fee Related
- 1995-10-05 GR GR950401501T patent/GR3017651T3/el unknown
-
1996
- 1996-07-11 HK HK125296A patent/HK125296A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH054968A (ja) | 1993-01-14 |
| EP0493608B1 (de) | 1995-10-04 |
| DK0493608T3 (da) | 1996-02-19 |
| CA2065846C (en) | 2002-07-02 |
| US5447926A (en) | 1995-09-05 |
| DE69113604D1 (de) | 1995-11-09 |
| KR920702348A (ko) | 1992-09-03 |
| EP0493608A4 (en) | 1992-08-12 |
| JP2805460B2 (ja) | 1998-09-30 |
| GR3017651T3 (en) | 1996-01-31 |
| EP0493608A1 (de) | 1992-07-08 |
| JP2613139B2 (ja) | 1997-05-21 |
| HK125296A (en) | 1996-07-19 |
| US5385900A (en) | 1995-01-31 |
| KR100195070B1 (ko) | 1999-06-15 |
| CA2065846A1 (en) | 1992-01-20 |
| ES2080327T3 (es) | 1996-02-01 |
| WO1992001676A1 (fr) | 1992-02-06 |
| DE69113604T2 (de) | 1996-05-30 |
| JPH08169880A (ja) | 1996-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |