DK0801683T3 - Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering - Google Patents

Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering

Info

Publication number: DK0801683T3
Authority: DK; Denmark
Prior art keywords: heteroatom; substituted amine; primary; enzyme; optically active
Prior art date: 1995-02-03

Application number

DK96900601T

Other languages

English (en)

Inventor

Friedhelm Balkenhohl

Klaus Ditrich

Christoph Nuebling

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-03

Filing date

1996-01-20

Publication date

2002-06-17

1995-06-29 Priority claimed from DE19523151A external-priority patent/DE19523151A1/de

1996-01-20 Application filed by Basf Ag filed Critical Basf Ag

2002-06-17 Application granted granted Critical

2002-06-17 Publication of DK0801683T3 publication Critical patent/DK0801683T3/da

Links

150000001412 amines Chemical class 0.000 title abstract 8
230000010933 acylation Effects 0.000 title abstract 2
238000005917 acylation reaction Methods 0.000 title abstract 2
238000003776 cleavage reaction Methods 0.000 title 1
230000007017 scission Effects 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
238000006470 amide elimination reaction Methods 0.000 abstract 1
VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical compound [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK96900601T 1995-02-03 1996-01-20 Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering DK0801683T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19503605		1995-02-03
DE19523151A DE19523151A1 (de)	1995-02-03	1995-06-29	Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung
PCT/EP1996/000234 WO1996023894A1 (de)	1995-02-03	1996-01-20	Racematspaltung primärer und sekundärer heteroatomsubstituierter amine durch enzym-katalysierte acylierung

Publications (1)

Publication Number	Publication Date
DK0801683T3 true DK0801683T3 (da)	2002-06-17

Family

ID=26012141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96900601T DK0801683T3 (da)	1995-02-03	1996-01-20	Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering

Country Status (9)

Country	Link
US (1)	US6214608B1 (da)
EP (1)	EP0801683B1 (da)
JP (1)	JP3789938B2 (da)
CN (1)	CN1087348C (da)
AT (1)	ATE217024T1 (da)
DK (1)	DK0801683T3 (da)
ES (1)	ES2176429T3 (da)
PT (1)	PT801683E (da)
WO (1)	WO1996023894A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6387692B1 (en) *	1995-12-06	2002-05-14	Bayer Aktiengesellschaft	Process for the preparation of optically active amines
DE19727517A1 (de) *	1997-06-30	1999-01-07	Basf Ag	Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
EP1422217A3 (en)	1998-04-01	2004-06-16	Cardiome Pharma Corp.	Aminocyclohexyl ether compounds and uses thereof
DE19837745A1 (de) *	1998-08-20	2000-02-24	Basf Ag	Enzymkatalysierte Racematspaltung von primären Aminen
AU2528900A (en) *	1999-02-12	2000-08-29	Nortran Pharmaceuticals Inc.	Cycloalkyl amine compounds and uses thereof
US6979685B1 (en)	1999-02-12	2005-12-27	Cardiome Pharma Corp.	Cycloalkyl amine compounds and uses thereof
US7507545B2 (en)	1999-03-31	2009-03-24	Cardiome Pharma Corp.	Ion channel modulating activity method
DE19956786A1 (de)	1999-11-25	2001-05-31	Basf Ag	Verfahren zur Herstellung optisch aktiver Amine
US7057053B2 (en)	2000-10-06	2006-06-06	Cardiome Pharma Corp.	Ion channel modulating compounds and uses thereof
US7524879B2 (en)	2000-10-06	2009-04-28	Cardiome Pharma Corp.	Ion channel modulating compounds and uses thereof
US7067291B2 (en) *	2002-12-20	2006-06-27	Pfizer Inc.	Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
KR101059379B1 (ko)	2003-05-02	2011-08-26	카디오메 파마 코포레이션	아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US7345086B2 (en)	2003-05-02	2008-03-18	Cardiome Pharma Corp.	Uses of ion channel modulating compounds
US7674820B2 (en)	2003-08-07	2010-03-09	Cardiome Pharma Corp.	Ion channel modulating activity I
US7345087B2 (en)	2003-10-31	2008-03-18	Cardiome Pharma Corp.	Aminocyclohexyl ether compounds and uses thereof
US7705036B2 (en)	2004-04-01	2010-04-27	Cardiome Pharma Corp.	Deuterated aminocyclohexyl ether compounds and processes for preparing same
WO2006138673A2 (en)	2005-06-15	2006-12-28	Cardiome Pharma Corp.	Synthetic processes for the preparation of aminocyclohexyl ether compounds
US7977373B2 (en)	2004-04-01	2011-07-12	Cardiome Pharma Corp.	Prodrugs of ion channel modulating compounds and uses thereof
US8058304B2 (en)	2004-04-01	2011-11-15	Cardiome Pharma Corp.	Merged ion channel modulating compounds and uses thereof
US8263638B2 (en)	2004-11-08	2012-09-11	Cardiome Pharma Corp.	Dosing regimens for ion channel modulating compounds
JP5159314B2 (ja)	2004-11-18	2013-03-06	カーディオムファーマコーポレイション	アミノシクロヘキシルエーテル化合物の合成方法
DE102005028492A1 (de) *	2005-06-20	2006-12-28	Basf Ag	Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen
ITMI20051943A1 (it) *	2005-10-14	2007-04-15	Procos Spa	Processo di risoluzione anantiomerica di 2-aminometil-pirrolidine 1-sostitute per ammidazione in presenza di lipasi
JP5039787B2 (ja) *	2006-09-13	2012-10-03	ビーエーエスエフソシエタス・ヨーロピア	光学活性な２−ベンジルオキシシクロヘキシルアミンの製造方法
EP2387556B1 (de) *	2009-01-16	2014-07-30	Basf Se	Trennung eines enantiomerengemischs von (r)- und (s)-3-amino-1-butanol
US20130345475A1 (en)	2012-06-25	2013-12-26	Basf Se	Process for the racemization of optically active arylalkylamines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1191638B (it) *	1985-10-31	1988-03-23	Montedison Spa	Processo per la separazione enzimatica degli isomeri ottici del 2-amminobutanolo
US5057607A (en) *	1990-06-08	1991-10-15	Eli Lilly And Company	Enantiomerically selective biocatalyzed acylation
JP3409353B2 (ja) *	1992-04-30	2003-05-26	住友化学工業株式会社	アミド化合物の製造方法および使用される微生物
DE4332738A1 (de) *	1993-09-25	1995-03-30	Basf Ag	Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
US5512454A (en) *	1994-02-03	1996-04-30	Bristol-Myers Squibb Company	Enzymatic acylation of 3-hydroxymethyl cephalosporins

1996
- 1996-01-20 JP JP52320596A patent/JP3789938B2/ja not_active Expired - Lifetime
- 1996-01-20 DK DK96900601T patent/DK0801683T3/da active
- 1996-01-20 ES ES96900601T patent/ES2176429T3/es not_active Expired - Lifetime
- 1996-01-20 PT PT96900601T patent/PT801683E/pt unknown
- 1996-01-20 WO PCT/EP1996/000234 patent/WO1996023894A1/de not_active Ceased
- 1996-01-20 AT AT96900601T patent/ATE217024T1/de active
- 1996-01-20 EP EP96900601A patent/EP0801683B1/de not_active Expired - Lifetime
- 1996-01-20 US US08/875,417 patent/US6214608B1/en not_active Expired - Lifetime
- 1996-01-20 CN CN96191757A patent/CN1087348C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0801683A1 (de)	1997-10-22
CN1172504A (zh)	1998-02-04
EP0801683B1 (de)	2002-05-02
ATE217024T1 (de)	2002-05-15
WO1996023894A1 (de)	1996-08-08
JP3789938B2 (ja)	2006-06-28
JPH10512759A (ja)	1998-12-08
ES2176429T3 (es)	2002-12-01
US6214608B1 (en)	2001-04-10
CN1087348C (zh)	2002-07-10
PT801683E (pt)	2002-09-30

Publication	Publication Date	Title
ATE217024T1 (de)	2002-05-15	Racematspaltung primärer und sekundärer heteroatomsubstituierter amine durch enzym- katalysierte acylierung
DK0720655T3 (da)	2000-04-10	Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering
DK1418170T3 (da)	2006-10-09	Fremgangsmåde til fremstilling af optisk aktive aminoalkohler ved racematspaltning
DE60031506D1 (de)	2006-12-07	Fasermatrix zum zusammenbringen von chemischen stoffen, sowie verfahren zur herstellung und anwendung davon
DE69432152D1 (de)	2003-03-27	Mikrobielle stämme zur produktion von sphingolipidbasen
ATE221533T1 (de)	2002-08-15	Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten
DE59908211D1 (de)	2004-02-05	Verfahren zur racematspaltung von 2-hydroxypropionsäuren
DK0904348T3 (da)	2005-02-14	Fremgangsmåde til fremstilling af aminoalkoholer og derivater deraf
GB9726229D0 (en)	1998-02-11	Resolution of chiral amines
DK0416282T3 (da)	1994-10-17	Mikrobiologisk fremstillet N-acyl-L-prolinacylase, fremgangsmåde til udvinding heraf og anvendelse heraf
DK0460949T3 (da)	1995-12-11	Enantiomerisk selektiv fremgangsmåde til acylering af racemiske 3-aminoazetidinon-mellemprodukter
DE50009670D1 (de)	2005-04-07	Verfahren zur herstellung optisch aktiver amine
DE59906807D1 (de)	2003-10-02	Verfahren zur racemisierung von optisch aktiven aminen
DE3875291D1 (de)	1992-11-19	Verfahren zur optischen trennung der (+)-cis- oder (+)-trans-permethrinsaeure.
CA2210519A1 (en)	1996-08-08	Resolution of racemates of primary and secondary heteroatom-substituted amines by enzyme-catalyzed acylation
ATE217025T1 (de)	2002-05-15	Verfahren zur herstellung von zwischenprodukten für synthese
ATE267874T1 (de)	2004-06-15	Enzymkatalysierte racematspaltung von primären aminen
ES430453A1 (es)	1976-10-01	Procedimiento para la ramecizacion de las formas optica- mente activas de 1-fenilatilamina.
EA199901059A1 (ru)	2000-08-28	Способ получения энантиомерно обогащенных n-производных лактамов
ATE260984T1 (de)	2004-03-15	Verfahren zur herstellung von acylierten aminosäureestern und racematspaltung von aminosäureestern durch enzym-katalysierte acylierung
PT1140794E (pt)	2004-04-30	Novo processo de preparacao de aminoacidos quirais
ATE253579T1 (de)	2003-11-15	Verfahren zur herstellung eines enantiomers von narwedin
DE59700707D1 (de)	1999-12-23	Verfahren zur Racemisierung optisch aktiver Amine
ATE444272T1 (de)	2009-10-15	Verfahren zur racematsspaltung von 3- aminopentannitril
ATE283362T1 (de)	2004-12-15	Verfahren zur erhöhung der produktion von clavam- antibiotika