ATE131162T1 - Lipoxygenase inhibierende n- hydroyharnstoffderivate. - Google Patents

Lipoxygenase inhibierende n- hydroyharnstoffderivate.

Info

Publication number: ATE131162T1
Authority: AT; Austria
Prior art keywords: alkyl; carbon atoms; lipoxygenase; hydroyurea; derivatives
Prior art date: 1991-06-13

Application number

AT92911441T

Other languages

English (en)

Inventor

Kazuo Ando

Takafumi Ikeda

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-13

Filing date

1992-05-21

Publication date

1995-12-15

1992-05-21 Application filed by Pfizer filed Critical Pfizer

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE131162T1 publication Critical patent/ATE131162T1/de

Links

102000003820 Lipoxygenases Human genes 0.000 title abstract 3
108090000128 Lipoxygenases Proteins 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)

AT92911441T 1991-06-13 1992-05-21 Lipoxygenase inhibierende n- hydroyharnstoffderivate. ATE131162T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3142123A JPH07100687B2 (ja)	1991-06-13	1991-06-13	新規なｎ−ヒドロキシ尿素化合物および組成物

Publications (1)

Publication Number	Publication Date
ATE131162T1 true ATE131162T1 (de)	1995-12-15

Family

ID=15307927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92911441T ATE131162T1 (de)	1991-06-13	1992-05-21	Lipoxygenase inhibierende n- hydroyharnstoffderivate.

Country Status (13)

Country	Link
US (1)	US5384320A (de)
EP (1)	EP0588850B1 (de)
JP (1)	JPH07100687B2 (de)
AT (1)	ATE131162T1 (de)
CA (1)	CA2109800C (de)
DE (1)	DE69206616T2 (de)
DK (1)	DK0588850T3 (de)
ES (1)	ES2081111T3 (de)
FI (1)	FI935552A7 (de)
GR (1)	GR3018321T3 (de)
IE (1)	IE69369B1 (de)
PT (1)	PT100582A (de)
WO (1)	WO1992022543A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3179286B2 (ja) *	1994-05-19	2001-06-25	ファイザー製薬株式会社	Ｎ−ヒドロキシ尿素系抗炎症剤
WO2020113094A1 (en)	2018-11-30	2020-06-04	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT82200B (pt) *	1985-03-16	1990-02-08	Wellcome Found	Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
CA1336099C (en) *	1987-04-24	1995-06-27	James B. Summers, Jr.	Urea based lipoxygenase compounds
US5068251A (en) *	1988-12-16	1991-11-26	Abbott Laboratories	Lipoxygenase inhibiting compounds
US4981865A (en) *	1989-05-26	1991-01-01	Warner-Lambert Co.	N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

1991
- 1991-06-13 JP JP3142123A patent/JPH07100687B2/ja not_active Expired - Lifetime
1992
- 1992-05-21 FI FI935552A patent/FI935552A7/fi not_active Application Discontinuation
- 1992-05-21 CA CA002109800A patent/CA2109800C/en not_active Expired - Fee Related
- 1992-05-21 EP EP92911441A patent/EP0588850B1/de not_active Expired - Lifetime
- 1992-05-21 AT AT92911441T patent/ATE131162T1/de not_active IP Right Cessation
- 1992-05-21 WO PCT/US1992/004007 patent/WO1992022543A1/en not_active Ceased
- 1992-05-21 DK DK92911441.1T patent/DK0588850T3/da active
- 1992-05-21 ES ES92911441T patent/ES2081111T3/es not_active Expired - Lifetime
- 1992-05-21 DE DE69206616T patent/DE69206616T2/de not_active Expired - Fee Related
- 1992-06-11 PT PT100582A patent/PT100582A/pt not_active Application Discontinuation
- 1992-07-01 IE IE921902A patent/IE69369B1/en not_active IP Right Cessation
1993
- 1993-12-10 US US08/162,104 patent/US5384320A/en not_active Expired - Fee Related
1995
- 1995-12-07 GR GR950403281T patent/GR3018321T3/el unknown

Also Published As

Publication number	Publication date
FI935552L (fi)	1993-12-10
FI935552A0 (fi)	1993-12-10
CA2109800C (en)	1996-03-19
US5384320A (en)	1995-01-24
EP0588850A1 (de)	1994-03-30
JPH07100687B2 (ja)	1995-11-01
FI935552A7 (fi)	1993-12-10
EP0588850B1 (de)	1995-12-06
WO1992022543A1 (en)	1992-12-23
PT100582A (pt)	1993-08-31
DK0588850T3 (da)	1996-01-08
DE69206616T2 (de)	1996-04-25
GR3018321T3 (en)	1996-03-31
JPH04368366A (ja)	1992-12-21
DE69206616D1 (de)	1996-01-18
IE69369B1 (en)	1996-09-04
IE921902A1 (en)	1992-12-16
CA2109800A1 (en)	1992-12-23
ES2081111T3 (es)	1996-02-16

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
1999-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
YU64092A (sh)	1995-03-27	Fluoralkoksibenzamino derivati heterocikličnih jedinjenja koja sadrže azot
EP1403255A4 (de)	2005-04-06	Rho-kinase-inhibitoren
BR0309447A (pt)	2005-02-09	Composto, agente, processos para a preparação dos mesmos, e para o combate do crescimento de plantas indesejadas, e, uso do composto
NO931433L (no)	1993-10-21	4,1-benzoksazepinderivater og deres anvendelse
NZ227436A (en)	1992-10-28	Cell proliferation inhibiting composition comprising a substituted styrene derivative
DK1000034T3 (da)	2003-01-27	Substituerede 6-alkylphenanthridiner
NO930143L (no)	1993-01-18	Piperidinforbindelser, deres fremstilling og bruk
MX9200485A (es)	1992-11-01	Proceso para la obtencion de derivados de tetra hidro piridina y composicion farmaceutica que los contiene.
DE69206616D1 (de)	1996-01-18	Lipoxygenase inhibierende n-hydroyharnstoffderivate.
BG106373A (en)	2002-09-30	Heterocyclic compounds inhibiting angiogenesis
NZ309499A (en)	2000-08-25	Styryl benzimidazole derivatives useful as inhibitors of smooth muscle cell proliferation
ATE132857T1 (de)	1996-01-15	Lipoxygenase inhibierende tetrahydrobenzazepinderivate
MX9709465A (es)	1998-02-28	Derivados de bencimidazol 2-sustituidos como inhibidores de la proliferacion de celulas del musculo liso.
KR950702533A (ko)	1995-07-29	리폭시게나제 억제제로서의 인돌리닐 n-하이드록시우레아 및 n-하이드록삼산 유도체(indolinyl n-hydroxyurea and n-hydroxamic acid derivatives as lipoxygenase inhibitors)
ES8207170A1 (es)	1982-09-01	Procedimiento para la produccion de 2-tercibutil-2(1h-1,2,4-triazolil-metil)-4-oxo metil-1,3dioxolanos substituidos.
DK602383D0 (da)	1983-12-27	1,1-diphenylpropanolderivater
ATE146167T1 (de)	1996-12-15	Cyclopropyl-n-hydroxyharnstoff als lypoxygenaseinhibitoren
EA200300009A1 (ru)	2003-04-24	Производные 4,5-дигидротиазол-2-иламина и их применение в качестве ингибиторов no синтазы