ATE132488T1 - Muscarin-rezeptor-antagonisten - Google Patents

Muscarin-rezeptor-antagonisten

Info

Publication number: ATE132488T1
Authority: AT; Austria
Prior art keywords: pct; compounds; date jun; sec; derived
Prior art date: 1989-12-12

Application number

AT90917074T

Other languages

English (en)

Inventor

Alexander Roderick Mackenzie

Peter Edward Pfizer Cent Cross

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-12

Filing date

1990-11-28

Publication date

1996-01-15

1990-11-28 Application filed by Pfizer filed Critical Pfizer

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132488T1 publication Critical patent/ATE132488T1/de

Links

UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
230000003551 muscarinic effect Effects 0.000 abstract 2
210000002460 smooth muscle Anatomy 0.000 abstract 2
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000004899 motility Effects 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1
210000003437 trachea Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

AT90917074T 1989-12-12 1990-11-28 Muscarin-rezeptor-antagonisten ATE132488T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898928041A GB8928041D0 (en)	1989-12-12	1989-12-12	Muscarinic receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE132488T1 true ATE132488T1 (de)	1996-01-15

Family

ID=10667812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90917074T ATE132488T1 (de)	1989-12-12	1990-11-28	Muscarin-rezeptor-antagonisten

Country Status (14)

Country	Link
US (1)	US5281601A (de)
EP (1)	EP0505377B1 (de)
JP (1)	JPH0684370B2 (de)
AT (1)	ATE132488T1 (de)
CA (1)	CA2067816C (de)
DE (1)	DE69024663T2 (de)
DK (1)	DK0505377T3 (de)
ES (1)	ES2082013T3 (de)
FI (1)	FI104719B (de)
GB (1)	GB8928041D0 (de)
GR (1)	GR3019036T3 (de)
IE (1)	IE70733B1 (de)
PT (1)	PT96143B (de)
WO (1)	WO1991009015A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5932594A (en) *	1988-11-01	1999-08-03	Pfizer, Inc.	Muscarinic receptor antagonists
US6693202B1 (en) *	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
US6906072B1 (en) *	2000-01-20	2005-06-14	Eisai Co., Ltd.	Piperazine compound and pharmaceutical composition containing the compound
AU2002345266B2 (en)	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh) *	2002-07-31	2006-04-13	Ranbaxy Laboratories Limited	用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
WO2004014363A1 (en) *	2002-08-09	2004-02-19	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (de) *	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
TWI295669B (en) *	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
ATE400553T1 (de) *	2002-12-10	2008-07-15	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
DE60225195T2 (de) *	2002-12-23	2009-02-26	Ranbaxy Laboratories, Ltd.	Flavaxat-derivate als muscarin-rezeptor antagonisten
AU2002347552A1 (en) *	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en)	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (de) *	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru) *	2003-04-10	2007-10-26	Рэнбакси Лабораториз Лимитед	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
JP2006522787A (ja) *	2003-04-11	2006-10-05	ランバクシーラボラトリーズリミテッド	ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
WO2005007645A1 (en) *	2003-07-11	2005-01-27	Theravance, Inc.	Substituted 4-amino-1-benzylpiperidine compounds
US7234991B2 (en) *	2004-05-10	2007-06-26	Firecode Ltd.	Moving toy
WO2006005980A1 (en) *	2004-06-16	2006-01-19	Ranbaxy Laboratories Limited	Xanthine derivatives useful as muscarinic receptor antagonists
US20080262075A1 (en) *	2004-08-19	2008-10-23	Ranbaxy Laboratories Limited	Pyrrolidine Derivatives as Muscarinic Receptor Antagonists
WO2006032994A2 (en) *	2004-09-24	2006-03-30	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
EP1797040A1 (de) *	2004-09-29	2007-06-20	Ranbaxy Laboratories Limited	Muscarin-rezeptor-antagonisten
US20100016400A1 (en) *	2004-11-19	2010-01-21	Naresh Kumar	Azabicyclic muscarinic receptor antagonists
EP1828126A1 (de) *	2004-12-15	2007-09-05	Ranbaxy Laboratories Limited	Säureadditionssalze von antagonisten des muskarinrezeptors
WO2006117754A1 (en) *	2005-05-03	2006-11-09	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
AU2006305619A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
US20090010923A1 (en) *	2007-04-24	2009-01-08	University Of Maryland, Baltimore	Treatment of cancer with anti-muscarinic receptor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE632403A (de) *	1962-05-17	1900-01-01
GB1455687A (en) *	1972-12-28	1976-11-17	Aspro Nicholas Ltd	Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
DE3835291A1 (de) *	1988-04-19	1989-11-02	Bayer Ag	1,3-disubstituierte pyrrolidine

1989
- 1989-11-28 US US07/859,489 patent/US5281601A/en not_active Expired - Fee Related
- 1989-12-12 GB GB898928041A patent/GB8928041D0/en active Pending
1990
- 1990-11-28 ES ES90917074T patent/ES2082013T3/es not_active Expired - Lifetime
- 1990-11-28 EP EP90917074A patent/EP0505377B1/de not_active Expired - Lifetime
- 1990-11-28 CA CA002067816A patent/CA2067816C/en not_active Expired - Fee Related
- 1990-11-28 AT AT90917074T patent/ATE132488T1/de not_active IP Right Cessation
- 1990-11-28 WO PCT/EP1990/002042 patent/WO1991009015A1/en not_active Ceased
- 1990-11-28 DK DK90917074.8T patent/DK0505377T3/da active
- 1990-11-28 DE DE69024663T patent/DE69024663T2/de not_active Expired - Fee Related
- 1990-11-28 JP JP2515785A patent/JPH0684370B2/ja not_active Expired - Fee Related
- 1990-12-10 PT PT96143A patent/PT96143B/pt not_active IP Right Cessation
- 1990-12-11 IE IE446290A patent/IE70733B1/en not_active IP Right Cessation
1992
- 1992-05-22 FI FI922344A patent/FI104719B/fi active
1996
- 1996-02-21 GR GR960400439T patent/GR3019036T3/el unknown

Also Published As

Publication number	Publication date
FI922344L (fi)	1992-05-22
GB8928041D0 (en)	1990-02-14
PT96143A (pt)	1991-09-30
FI104719B (fi)	2000-03-31
JPH05501555A (ja)	1993-03-25
US5281601A (en)	1994-01-25
FI922344A0 (fi)	1992-05-22
JPH0684370B2 (ja)	1994-10-26
IE904462A1 (en)	1991-06-19
DE69024663D1 (de)	1996-02-15
CA2067816A1 (en)	1991-06-13
IE70733B1 (en)	1996-12-11
DE69024663T2 (de)	1996-05-15
WO1991009015A1 (en)	1991-06-27
EP0505377A1 (de)	1992-09-30
DK0505377T3 (da)	1996-02-05
ES2082013T3 (es)	1996-03-16
CA2067816C (en)	1997-03-25
EP0505377B1 (de)	1996-01-03
GR3019036T3 (en)	1996-05-31
PT96143B (pt)	1997-05-28

Legal Events

Date	Code	Title	Description
2004-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69024663D1 (de)	1996-02-15	Muscarin-rezeptor-antagonisten
FI102965B1 (fi)	1999-03-31	Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
DE68910210D1 (de)	1993-12-02	(1-Hydroxy-2-piperidinylalkyl)-2-indolon, 2-quinolinon, 2-benzo[b]azepinon, 2-benzimidazolon und 2-quinazolinon-Derivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung.
BG106508A (en)	2003-02-28	Alkylene diamine-substituted heterocycles
EP0603220A1 (de)	1994-06-29	Azabicyclische Verbindungen als 5-HT4 Rezeptor Antagonisten
EP0625149A1 (de)	1994-11-23	Benzopyran-, Benzothiopyran- und Benzofuran-Derivate als 5-HT4-Antagonisten
ES8503346A1 (es)	1985-03-01	"un procedimiento para preparar un derivado de -(4-(2-piridil)-pi-peracino)-alcanoilanilida".
CO4410319A1 (es)	1997-01-09	Derivados de fenetanolamina
DK0518558T3 (da)	1999-05-31	1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
Gutnov et al.	2001	Bis (5-alkyl-2-furyl)(2-carboxyphenyl) methanes for the synthesis of tetracyclic isochromone derivatives
CA2131381A1 (en)	1993-09-16	Nitrogen containing heterocyclic compounds useful as pharmaceuticals
KR920004394A (ko)	1992-03-27	티에노디아제핀 이의 제조방법 및 paf-길항 활성을 지닌 약제학적 조성물로서의 이의 용도
DE68900117D1 (de)	1991-07-18	Muscarin-rezeptor-antagonisten.
IE780751L (en)	1978-10-26	Isoindoline derivatives
KR910004609A (ko)	1991-03-29	아미노케톤 유도체 및 그의 용도
DE69516100T2 (de)	2000-12-14	Trizyklische Oximether, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69014903D1 (de)	1995-01-19	Disubstituierte piperidine und pyrrolidine als anticholinergische mittel.
DK583084A (da)	1985-06-08	(3-aryl-2,3-dihydrobenzofuran-3-yl)-alkylaminer, deres fremstilling og anvendelse som laegemidler
ATA226688A (de)	1990-03-15	Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE47391T1 (de)	1989-11-15	Neue aromatische verbindungen, ihre herstellung und verwendung.
US6127379A (en)	2000-10-03	Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
Remy et al.	1977	A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10, 11-vinylene bridge
AR021751A1 (es)	2002-08-07	Compuestos monociclicos, composiciones farmaceuticas que los contienen y su uso como antagonistas de receptor nk2 de taquiquinina en el tratamiento depatologias donde hay liberacion de taquiquininas
Piergentili et al.	2003	Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2, 2-Diphenyl-[1, 3]-dioxolan-4-ylmethyl-dimethylamine
Cook	1959	I. THE MERCURIC ACETATE OXIDATION OF SUBSTITUTED PYRROLIDINES. II. THE REACTION OF DIMETHYL MALEATE WITH REPRESENTATIVE ENAMINES.