PT96422A - Processo para a preparacao de derivados de piperidina e de pirrolidina uteis como agentes anticolinergicos - Google Patents

Processo para a preparacao de derivados de piperidina e de pirrolidina uteis como agentes anticolinergicos

Info

Publication number: PT96422A
Authority: PT; Portugal
Prior art keywords: preparation; pyrrolidine derivatives; piperidine; utilized; optionally substituted
Prior art date: 1990-01-06

Application number

PT96422A

Other languages

English (en)

Other versions

PT96422B (pt

Inventor

Peter Edward Cross

David Alker

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-06

Filing date

1991-01-04

Publication date

1991-10-15

1991-01-04 Application filed by Pfizer filed Critical Pfizer

1991-10-15 Publication of PT96422A publication Critical patent/PT96422A/pt

1998-06-30 Publication of PT96422B publication Critical patent/PT96422B/pt

Links

NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 4
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0836—Compounds with one or more Si-OH or Si-O-metal linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT96422A 1990-01-06 1991-01-04 Processo para a preparacao de derivados de piperidina e de pirrolidina uteis como agentes anticolinergicos PT96422B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909000305A GB9000305D0 (en)	1990-01-06	1990-01-06	Anticholinergic agents

Publications (2)

Publication Number	Publication Date
PT96422A true PT96422A (pt)	1991-10-15
PT96422B PT96422B (pt)	1998-06-30

Family

ID=10668926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96422A PT96422B (pt)	1990-01-06	1991-01-04	Processo para a preparacao de derivados de piperidina e de pirrolidina uteis como agentes anticolinergicos

Country Status (13)

Country	Link
EP (1)	EP0511222B1 (pt)
JP (1)	JPH0730019B2 (pt)
AT (1)	ATE115130T1 (pt)
CA (1)	CA2072575C (pt)
DE (1)	DE69014903T2 (pt)
DK (1)	DK0511222T3 (pt)
ES (1)	ES2065668T3 (pt)
FI (1)	FI97131C (pt)
GB (1)	GB9000305D0 (pt)
GR (1)	GR3014927T3 (pt)
IE (1)	IE64206B1 (pt)
PT (1)	PT96422B (pt)
WO (1)	WO1991010651A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9020051D0 (en) *	1990-09-13	1990-10-24	Pfizer Ltd	Muscarinic receptor antagonists
DE69325805T2 (de) *	1992-02-06	2000-03-16	Merrell Pharmaceuticals Inc.	Umkehr der mehrfachresistenz gegen medikamente durch triphenyl-piperidin derivate
NZ261414A (en) *	1993-01-21	1997-06-24	Merrell Dow Pharma	N-acyl-2-(diphenylalkyl)piperidine derivatives and pharmaceutical compositions
US5670521A (en) *	1994-08-05	1997-09-23	Merrell Pharmaceuticals Inc.	Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
US5859295A (en) *	1994-12-05	1999-01-12	University Of Kentucky Research Foundation	Canavanine analogs and their use as chemotherapeutic agents
IL117149A0 (en) *	1995-02-23	1996-06-18	Schering Corp	Muscarinic antagonists
US5889006A (en) *	1995-02-23	1999-03-30	Schering Corporation	Muscarinic antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL88063C (pt) *	1950-12-05
DE1049377B (de) *	1952-04-03	1959-01-29	Abbott Laboratories, North Chicago, 111. (V. St. A.)	Verfahren zur Herstellung von substituierten Vinylpiperidinen
GB780027A (en) *	1955-01-20	1957-07-31	Schering Corp	3-piperidyl ethers and thioethers
US2974146A (en) *	1956-02-24	1961-03-07	Lakeside Lab Inc	3-piperidyl benzhydryl ethers
US2838441A (en) *	1957-05-10	1958-06-10	Wm S Merrell Co	1, 1-di-(p-chlorophenyl)-2-(2-piperidyl)-ethylene and therapeutic compositions contaiing said compounds
GB1142030A (en) *	1966-06-14	1969-02-05	Ciba Ltd	Optically active substituted piperidine compounds
US3479370A (en) *	1966-08-08	1969-11-18	Robins Co Inc A H	Esters of 1-substituted-3-disubstituted-pyrrolidinemethanols
BE704683A (pt) *	1966-11-07	1968-02-15
GB1252315A (pt) *	1969-06-05	1971-11-03
US4032642A (en) *	1974-12-11	1977-06-28	A. H. Robins Company, Incorporated	1-Substituted-4-benzylpiperidines
GB1542823A (en) *	1977-01-11	1979-03-28	Ucb Sa	Piperidine derivatives
US4514414A (en) *	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4628095A (en) *	1985-06-05	1986-12-09	G. D. Searle & Co.	Substituted N-benzyl-4-(benzhydryl) piperidines
US4632925A (en) *	1985-10-07	1986-12-30	Hoffmann-La Roche Inc.	N-substituted diphenylpiperidines and antiobesity use thereof
EP0235463A3 (en) *	1985-12-20	1990-01-17	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
AU607735B2 (en) *	1987-05-07	1991-03-14	A.H. Robins Company, Incorporated	Novel cyclic carbamate derivatives
JPH0681068B2 (ja) *	1987-05-29	1994-10-12	日本電気株式会社	無線通信カ−ド

1990
- 1990-01-06 GB GB909000305A patent/GB9000305D0/en active Pending
- 1990-12-18 CA CA002072575A patent/CA2072575C/en not_active Expired - Fee Related
- 1990-12-18 EP EP91900764A patent/EP0511222B1/en not_active Expired - Lifetime
- 1990-12-18 WO PCT/EP1990/002262 patent/WO1991010651A1/en not_active Ceased
- 1990-12-18 DK DK91900764.1T patent/DK0511222T3/da active
- 1990-12-18 AT AT91900764T patent/ATE115130T1/de not_active IP Right Cessation
- 1990-12-18 JP JP3501256A patent/JPH0730019B2/ja not_active Expired - Fee Related
- 1990-12-18 DE DE69014903T patent/DE69014903T2/de not_active Expired - Fee Related
- 1990-12-18 ES ES91900764T patent/ES2065668T3/es not_active Expired - Lifetime
1991
- 1991-01-04 PT PT96422A patent/PT96422B/pt not_active IP Right Cessation
- 1991-01-04 IE IE2191A patent/IE64206B1/en not_active IP Right Cessation
1992
- 1992-06-17 FI FI922835A patent/FI97131C/fi active
1995
- 1995-02-01 GR GR950400191T patent/GR3014927T3/el unknown

Also Published As

Publication number	Publication date
FI97131C (fi)	1996-10-25
FI97131B (fi)	1996-07-15
DE69014903D1 (de)	1995-01-19
GR3014927T3 (en)	1995-05-31
IE64206B1 (en)	1995-07-12
FI922835A0 (fi)	1992-06-17
GB9000305D0 (en)	1990-03-07
ATE115130T1 (de)	1994-12-15
EP0511222B1 (en)	1994-12-07
WO1991010651A1 (en)	1991-07-25
CA2072575C (en)	2000-08-08
DK0511222T3 (da)	1995-02-13
ES2065668T3 (es)	1995-02-16
PT96422B (pt)	1998-06-30
DE69014903T2 (de)	1995-04-27
EP0511222A1 (en)	1992-11-04
IE910021A1 (en)	1991-07-17
JPH0730019B2 (ja)	1995-04-05
JPH05501882A (ja)	1993-04-08
FI922835L (fi)	1992-06-17
CA2072575A1 (en)	1991-07-07

Legal Events

Date

Code

Title

Description

1991-10-15

BB1A

Laying open of patent application

Effective date: 19910531

1998-06-30

FG3A

Patent granted, date of granting

Effective date: 19980330

2004-11-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040930

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