PT96143A - Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos - Google Patents

Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Info

Publication number: PT96143A
Authority: PT; Portugal
Prior art keywords: pct; compounds; date jun; sec; derived
Prior art date: 1989-12-12

Application number

PT96143A

Other languages

English (en)

Other versions

PT96143B (pt

Inventor

Peter Edward Cross

Alexander Roderick Mackenzie

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-12

Filing date

1990-12-10

Publication date

1991-09-30

1990-12-10 Application filed by Pfizer filed Critical Pfizer

1991-09-30 Publication of PT96143A publication Critical patent/PT96143A/pt

1997-05-28 Publication of PT96143B publication Critical patent/PT96143B/pt

Links

238000000034 method Methods 0.000 title abstract 2
-1 3-SUBSTITUTED PYRROLIDINE Chemical class 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
210000003205 muscle Anatomy 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
230000003551 muscarinic effect Effects 0.000 abstract 2
210000002460 smooth muscle Anatomy 0.000 abstract 2
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000004899 motility Effects 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1
210000003437 trachea Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

PT96143A 1989-12-12 1990-12-10 Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos PT96143B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898928041A GB8928041D0 (en)	1989-12-12	1989-12-12	Muscarinic receptor antagonists

Publications (2)

Publication Number	Publication Date
PT96143A true PT96143A (pt)	1991-09-30
PT96143B PT96143B (pt)	1997-05-28

Family

ID=10667812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96143A PT96143B (pt)	1989-12-12	1990-12-10	Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Country Status (14)

Country	Link
US (1)	US5281601A (pt)
EP (1)	EP0505377B1 (pt)
JP (1)	JPH0684370B2 (pt)
AT (1)	ATE132488T1 (pt)
CA (1)	CA2067816C (pt)
DE (1)	DE69024663T2 (pt)
DK (1)	DK0505377T3 (pt)
ES (1)	ES2082013T3 (pt)
FI (1)	FI104719B (pt)
GB (1)	GB8928041D0 (pt)
GR (1)	GR3019036T3 (pt)
IE (1)	IE70733B1 (pt)
PT (1)	PT96143B (pt)
WO (1)	WO1991009015A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5932594A (en) *	1988-11-01	1999-08-03	Pfizer, Inc.	Muscarinic receptor antagonists
US6693202B1 (en) *	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
ATE362926T1 (de) *	2000-01-20	2007-06-15	Eisai R&D Man Co Ltd	Stickstoffhaltige cyclische verbindungen und sie enthaltende pharmazeutische zubereitungen
DE60230683D1 (de)	2002-07-08	2009-02-12	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
DE60226906D1 (de) *	2002-07-31	2008-07-10	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen
AU2002321711A1 (en) *	2002-08-09	2004-02-25	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
WO2004018422A1 (en) *	2002-08-23	2004-03-04	Ranbaxy Laboratories Limited	Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
TW200800953A (en) *	2002-10-30	2008-01-01	Theravance Inc	Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
DE60227576D1 (de) *	2002-12-10	2008-08-21	Ranbaxy Lab Ltd	3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
EP1583741A1 (en) *	2002-12-23	2005-10-12	Ranbaxy Laboratories, Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) *	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en)	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7517905B2 (en) *	2003-04-09	2009-04-14	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7560479B2 (en)	2003-04-10	2009-07-14	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006514978A (ja) *	2003-04-10	2006-05-18	ランバクシーラボラトリーズリミテッド	ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体
CA2522071A1 (en) *	2003-04-11	2004-10-21	Ranbaxy Laboratories Limited	Azabicyclo derivatives as muscarinic receptor antagonists
EP1644356A1 (en) *	2003-07-11	2006-04-12	Theravance, Inc.	Substituted 4-amino-1-benzylpiperidine compounds
US7234991B2 (en) *	2004-05-10	2007-06-26	Firecode Ltd.	Moving toy
US20080319002A1 (en) *	2004-06-16	2008-12-25	Ranbaxy Laboratories Limited	Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists
WO2006018708A2 (en) *	2004-08-19	2006-02-23	Ranbaxy Laboratories Limited	Pyrrolidine derivatives as muscarinic receptor antagonists
WO2006032994A2 (en) *	2004-09-24	2006-03-30	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
US20090105221A1 (en) *	2004-09-29	2009-04-23	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
EP1828174A1 (en) *	2004-11-19	2007-09-05	Ranbaxy Laboratories Limited	Azabicyclic muscarinic receptor antagonists
US20100035954A1 (en) *	2004-12-15	2010-02-11	Mohammad Salman	Acid addition salts of muscarinic receptor antagonists
US20080319043A1 (en) *	2005-05-03	2008-12-25	Mohammad Salman	3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
RU2008119323A (ru)	2005-10-19	2009-11-27	Рэнбакси Лабораториз Лимитед (In)	Фармацевтические композиции мускаринового рецептора
US20090010923A1 (en) *	2007-04-24	2009-01-08	University Of Maryland, Baltimore	Treatment of cancer with anti-muscarinic receptor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3125578A (en) *	1962-05-17	1964-03-17		xxviii
GB1455687A (en) *	1972-12-28	1976-11-17	Aspro Nicholas Ltd	Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
DE3835291A1 (de) *	1988-04-19	1989-11-02	Bayer Ag	1,3-disubstituierte pyrrolidine

1989
- 1989-11-28 US US07/859,489 patent/US5281601A/en not_active Expired - Fee Related
- 1989-12-12 GB GB898928041A patent/GB8928041D0/en active Pending
1990
- 1990-11-28 DE DE69024663T patent/DE69024663T2/de not_active Expired - Fee Related
- 1990-11-28 WO PCT/EP1990/002042 patent/WO1991009015A1/en not_active Ceased
- 1990-11-28 EP EP90917074A patent/EP0505377B1/en not_active Expired - Lifetime
- 1990-11-28 JP JP2515785A patent/JPH0684370B2/ja not_active Expired - Fee Related
- 1990-11-28 CA CA002067816A patent/CA2067816C/en not_active Expired - Fee Related
- 1990-11-28 ES ES90917074T patent/ES2082013T3/es not_active Expired - Lifetime
- 1990-11-28 DK DK90917074.8T patent/DK0505377T3/da active
- 1990-11-28 AT AT90917074T patent/ATE132488T1/de not_active IP Right Cessation
- 1990-12-10 PT PT96143A patent/PT96143B/pt not_active IP Right Cessation
- 1990-12-11 IE IE446290A patent/IE70733B1/en not_active IP Right Cessation
1992
- 1992-05-22 FI FI922344A patent/FI104719B/fi active
1996
- 1996-02-21 GR GR960400439T patent/GR3019036T3/el unknown

Also Published As

Publication number	Publication date
FI104719B (fi)	2000-03-31
IE70733B1 (en)	1996-12-11
JPH05501555A (ja)	1993-03-25
IE904462A1 (en)	1991-06-19
PT96143B (pt)	1997-05-28
GB8928041D0 (en)	1990-02-14
US5281601A (en)	1994-01-25
GR3019036T3 (en)	1996-05-31
DK0505377T3 (da)	1996-02-05
CA2067816A1 (en)	1991-06-13
DE69024663D1 (de)	1996-02-15
EP0505377A1 (en)	1992-09-30
DE69024663T2 (de)	1996-05-15
ES2082013T3 (es)	1996-03-16
FI922344A0 (fi)	1992-05-22
ATE132488T1 (de)	1996-01-15
WO1991009015A1 (en)	1991-06-27
CA2067816C (en)	1997-03-25
EP0505377B1 (en)	1996-01-03
JPH0684370B2 (ja)	1994-10-26
FI922344L (fi)	1992-05-22

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Legal Events

Date

Code

Title

Description

1991-09-30

BB1A

Laying open of patent application

Effective date: 19910509

1997-05-30

FG3A

Patent granted, date of granting

Effective date: 19970307

2004-11-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040907